Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMH4PEY)

Drug Name
Lofepramine Drug Info
Synonyms Lopramine; DB-2182; Leo-640; WHR-2908A
Cross-matching ID
PubChem CID
3947
ChEBI ID
CHEMBL87708
CAS Number
CAS 23047-25-8
TTD Drug ID
D0K3MC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis 2.14 0.00e+0 36/41 (87.8%) ACSL1;HMOX1;SAT1;...
Proximal tubule bicarbonate reclamation -1.91 2.14e-2 21/23 (91.3%) PCK1;ATP1B3;GLUD2;...
Cell cycle -1.95 2.85e-2 110/124 (88.71%) CHEK1;CDKN2B;MDM2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H