Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHJTR2)

Drug Name
XL880 Drug Info
Synonyms GSK 089; GSK 1363089; GSK1363089; XL 880; GSK1363089, GSK089, foretinib, EXEL-2880, XL880; 88Z; MET inhibitors
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
42642645
ChEBI ID
CHEMBL91418
CAS Number
CAS 849217-64-7
TTD Drug ID
D0D1GF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.28 0.00e+0 19/20 (95%) SQLE;MSMO1;HSD17B7;...
Oxidative phosphorylation 2.22 0.00e+0 93/133 (69.92%) NDUFA4L2;COX5B;NDUFA3;...
Metabolism of xenobiotics by cytochrome P450 1.98 2.18e-3 49/77 (63.64%) UGT2B28;CBR3;GSTA4;...
Ovarian steroidogenesis 1.95 3.27e-3 41/51 (80.39%) HSD17B7;ADCY9;HSD17B2;...
Terpenoid backbone biosynthesis 1.92 3.93e-3 18/22 (81.82%) HMGCS1;ACAT2;FDPS;...
Steroid hormone biosynthesis 1.89 5.45e-3 43/61 (70.49%) HSD17B7;UGT2B28;HSD17B2;...
Thermogenesis 1.77 2.34e-2 173/232 (74.57%) MGLL;NDUFA4L2;ADCY9;...
Sulfur metabolism 1.76 2.13e-2 9/10 (90%) TST;MPST;PAPSS2;...
Synthesis and degradation of ketone bodies 1.75 1.96e-2 9/10 (90%) HMGCS1;ACAT2;BDH2;...
Valine, leucine and isoleucine degradation 1.73 2.55e-2 42/48 (87.5%) HMGCS1;ACAT2;ABAT;...
Diabetic cardiomyopathy 1.69 3.09e-2 162/203 (79.8%) NDUFA4L2;PLCB1;PTEN;...
Lipid and atherosclerosis -1.68 4.59e-2 190/215 (88.37%) PRKCA;IKBKB;IL6;...
NOD-like receptor signaling pathway -1.68 4.64e-2 145/181 (80.11%) RHOA;PSTPIP1;CHUK;...
Ribosome biogenesis in eukaryotes -1.70 4.58e-2 52/108 (48.15%) GAR1;RPP40;EIF6;...
Proteasome -1.71 4.38e-2 44/46 (95.65%) PSMD3;PSMF1;PSMD12;...
RNA transport -1.79 1.18e-2 128/186 (68.82%) NXF3;EIF2B4;MAGOH;...
Rheumatoid arthritis -1.82 8.29e-3 78/93 (83.87%) IL6;ANGPT1;ICAM1;...
Bladder cancer -1.84 7.58e-3 40/41 (97.56%) CDKN1A;CDH1;FGFR3;...
Viral protein interaction with cytokine and cytokine re... -1.86 2.21e-3 84/100 (84%) CCL7;IL18R1;PF4;...
Epithelial cell signaling in Helicobacter pylori infect... -1.88 0.00e+0 62/70 (88.57%) SRC;MET;HBEGF;...
Spliceosome -1.90 0.00e+0 101/150 (67.33%) SRSF4;PPIH;SNU13;...
Arginine and proline metabolism -1.95 0.00e+0 39/50 (78%) CKM;AMD1;SMOX;...
TNF signaling pathway -2.04 0.00e+0 103/112 (91.96%) CXCL10;AKT1;PIK3CD;...
IL-17 signaling pathway -2.24 0.00e+0 84/94 (89.36%) IKBKB;IL6;RELA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H