Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHSY1I)

Drug Name
Regorafenib Drug Info
Synonyms
Regorafenib; 755037-03-7; BAY 73-4506; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY73-4506; Regorafenib (BAY 73-4506); UNII-24T2A1DOYB; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY-73-4506; 24T2A1DOYB; CHEMBL1946170; CHEBI:68647; Stivarga (TN); BAY73-4506 hydrochloride; Regorafenib [USAN:INN]
Cross-matching ID
PubChem CID
11167602
ChEBI ID
CHEMBL1946170
CAS Number
CAS 755037-03-7
TTD Drug ID
D09GDD
VARIDT Drug ID
DR00136
INTEDE Drug ID
DR1401
ACDINA Drug ID
D00586

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.22 0.00e+0 31/40 (77.5%) PHGDH;PSAT1;GATM;...
DNA replication 2.07 4.16e-3 34/36 (94.44%) PRIM1;POLE2;RNASEH2A;...
Cysteine and methionine metabolism 1.99 5.55e-3 43/50 (86%) PHGDH;PSAT1;CBS;...
One carbon pool by folate 1.79 3.95e-2 15/20 (75%) SHMT2;MTHFD2;MTHFD1;...
Oxidative phosphorylation 1.78 3.16e-2 93/133 (69.92%) ATP5MC2;COX7A2L;NDUFB5;...
Glutathione metabolism 1.78 2.91e-2 43/57 (75.44%) GSTP1;CHAC1;GPX3;...
Ribosome 1.77 2.62e-2 113/158 (71.52%) MRPS16;MRPL15;RSL24D1;...
Histidine metabolism 1.73 3.75e-2 16/22 (72.73%) ALDH2;HNMT;HAL;...
Citrate cycle (TCA cycle) 1.72 3.70e-2 30/30 (100%) PCK2;SUCLG1;PCK1;...
Pentose and glucuronate interconversions 1.71 3.75e-2 17/34 (50%) CRYL1;UGT2B17;AKR1A1;...
Proximal tubule bicarbonate reclamation 1.69 3.78e-2 21/23 (91.3%) PCK2;SLC4A4;PCK1;...
Th17 cell differentiation -1.63 4.75e-2 95/107 (88.79%) HLA-DOB;MAPK1;RXRA;...
Hematopoietic cell lineage -1.64 4.30e-2 90/99 (90.91%) IL1R1;GP9;CD3E;...
Tuberculosis -1.65 3.54e-2 159/180 (88.33%) ATP6V0C;IL10RA;NFKB1;...
Synaptic vesicle cycle -1.66 3.47e-2 63/78 (80.77%) SLC1A3;ATP6V0B;STX3;...
Lipid and atherosclerosis -1.72 1.88e-2 190/215 (88.37%) FASLG;CALML3;PLCB3;...
Yersinia infection -1.73 1.92e-2 120/137 (87.59%) MAP2K1;MAPK1;PIK3CA;...
Toxoplasmosis -1.77 1.55e-2 103/112 (91.96%) PIK3CG;IL10RA;NFKB1;...
Steroid biosynthesis -1.79 1.48e-2 19/20 (95%) CYP27B1;NSDHL;TM7SF2;...
Phagosome -1.83 1.00e-2 118/152 (77.63%) ATP6V1A;TCIRG1;C1R;...
Chagas disease -1.87 5.47e-3 93/102 (91.18%) PPP2R2A;FASLG;PLCB3;...
IL-17 signaling pathway -1.91 2.41e-3 84/94 (89.36%) FOS;CXCL3;CXCL6;...
Legionellosis -1.93 1.34e-3 51/57 (89.47%) HSPA8;ITGAM;CASP9;...
Neutrophil extracellular trap formation -1.95 0.00e+0 101/189 (53.44%) TLR8;PIK3R3;NFKB1;...
Osteoclast differentiation -1.95 0.00e+0 117/127 (92.13%) JUND;IL1R1;PIK3R3;...
Leishmaniasis -1.95 0.00e+0 67/77 (87.01%) FOS;ITGB1;NCF4;...
Amoebiasis -1.99 0.00e+0 99/102 (97.06%) IL1R1;COL4A1;PIK3R3;...
Malaria -2.00 0.00e+0 44/50 (88%) SDC2;MYD88;SELP;...
Staphylococcus aureus infection -2.03 0.00e+0 72/95 (75.79%) SELP;KRT31;ITGAM;...
ECM-receptor interaction -2.24 0.00e+0 80/88 (90.91%) LAMC2;ITGA1;LAMB3;...
Complement and coagulation cascades -2.37 0.00e+0 76/85 (89.41%) ITGAX;CD46;F9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H