Details of the Drug

General Information of Drug (ID: DMHSY1I)

Drug Name
Regorafenib
Synonyms
Regorafenib; 755037-03-7; BAY 73-4506; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY73-4506; Regorafenib (BAY 73-4506); UNII-24T2A1DOYB; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY-73-4506; 24T2A1DOYB; CHEMBL1946170; CHEBI:68647; Stivarga (TN); BAY73-4506 hydrochloride; Regorafenib [USAN:INN]
Indication
Disease Entry ICD 11 Status REF
Gastrointestinal stromal tumour 2B5B Approved [1]
Metastasis from malignant tumor of colon N.A. Approved [1]
Metastatic colorectal cancer 2B91 Approved [2]
Affected Organisms
Humans and other mammals
ATC Code
L01EX05: Regorafenib
L01EX: Other protein kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 482.8
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 70.4 mgh/L []
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 2.5 mg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 4 h []
Half-life
The concentration or amount of drug in body reduced by one-half in 28 hours [3]
Metabolism
The drug is metabolized via the CYP3A4 and UGT1A9 [4]
Chemical Identifiers
Formula
C21H15ClF4N4O3
IUPAC Name
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Canonical SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
InChI
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey
FNHKPVJBJVTLMP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11167602
ChEBI ID
CHEBI:68647
CAS Number
755037-03-7
UNII
24T2A1DOYB
DrugBank ID
DB08896
TTD ID
D09GDD
VARIDT ID
DR00136
INTEDE ID
DR1401
ACDINA ID
D00586
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Modulator [5]
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Modulator [5]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [6]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [9]
UDP-glucuronosyltransferase 1A9 (UGT1A9)
Main DME 		DE85D2P UD19_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [11]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [11]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [11]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [11]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [11]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [11]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [11]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Gastrointestinal stromal tumour
ICD Disease Classification 2B5B
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase Kit (KIT) DTT KIT 2.06E-01 -0.1 -0.14
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
P-glycoprotein 1 (ABCB1) DTP P-GP 9.39E-02 1.07E-01 2.80E-01
Breast cancer resistance protein (ABCG2) DTP BCRP 9.45E-01 -5.34E-02 -9.01E-02
Multidrug resistance-associated protein 2 (ABCC2) DTP MRP2 7.16E-01 -1.28E-02 -6.06E-02
Organic anion transporting polypeptide 1B1 (SLCO1B1) DTP OATP1B1 8.15E-01 6.20E-03 5.61E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 139 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 2.3973 3.1943 2.3973 24.2976
JM1 CTRP2 5.8917 13.2362 2.3205 15.6902
EoL-1 CTRP2 -10.958 -9.426 -10.958 99.7406
MV4-11 CTRP2 -2.4677 -0.0737 -2.4686 56.693
MOLM-13 CTRP2 -2.1987 0.1614 -2.1997 74.1574
Ku812 CTRP2 0.1098 1.4933 0.1097 39.5374
NCO2 CTRP2 0.2074 1.8008 0.2069 53.0115
ALL-SIL CTRP2 0.3885 2.3026 0.3858 51.3651
KMS-26 CTRP2 0.5755 1.432 0.5755 36.4347
JURL-MK1 CTRP2 0.6053 1.4838 0.6053 49.4003
EM-2 CTRP2 0.6561 2.2852 0.6551 48.9402
Peer CTRP2 0.9406 2.6009 0.9389 46.3602
KO52 CTRP2 1.3937 6.0888 0.9567 32.4024
CML-T1 CTRP2 1.3957 3.1432 1.3911 42.2406
MOLM-6 CTRP2 1.5144 3.8098 1.4874 30.2696
THP-1 CTRP2 1.8859 3.8833 1.8673 27.7666
EB1 CTRP2 1.9338 4.2886 1.8885 27.5379
697 CTRP2 1.9411 3.7706 1.9291 27.3768
OPM-2 CTRP2 2.0024 4.2903 1.9603 27.0697
KMS-21-BM CTRP2 2.0167 3.7603 2.0068 36.6255
Pfeiffer CTRP2 2.0651 3.5717 2.061 26.5245
KYO-1 CTRP2 2.0816 2.9183 2.0815 26.401
SIG-M5 CTRP2 2.1014 3.2265 2.1009 26.2706
HuT 78 CTRP2 2.1106 6.7452 1.5414 28.1577
K-562 CTRP2 2.1545 3.0115 2.1544 25.9153
AML-193 CTRP2 2.1605 3.6382 2.1563 25.8892
KMS-34 CTRP2 2.1619 3.4117 2.1607 25.8699
SUP-M2 CTRP2 2.1727 3.6471 2.1685 25.8079
GA-10 CTRP2 2.1968 3.9642 2.1834 25.6782
NU-DUL-1 CTRP2 2.2381 3.8383 2.2304 25.3838
DEL CTRP2 2.2786 3.6116 2.2762 34.2137
BL-70 CTRP2 2.32 4.1998 2.2983 24.885
MOLT-3 CTRP2 2.364 5.0039 2.2567 24.884
TF-1 CTRP2 2.372 3.1993 2.3719 24.4664
BV-173 CTRP2 2.3827 4.1201 2.3675 24.4457
A3/Kawakami CTRP2 2.3897 2.8936 2.3897 24.348
KMS-11 CTRP2 2.4092 4.63 2.3553 24.3999
KMS-18 CTRP2 2.4662 4.0362 2.4567 23.87
Daudi CTRP2 2.5314 6.9905 1.916 25.562
L-428 CTRP2 2.6129 4.2892 2.5961 22.9171
KMS-12-BM CTRP2 2.6255 4.4328 2.6001 22.8627
P12-Ichikawa CTRP2 2.7385 4.6343 2.7019 30.1926
KMS-27 CTRP2 2.7622 4.7646 2.7137 22.0302
U-937 CTRP2 2.8405 4.7792 2.7949 21.4987
SEM CTRP2 2.8425 5.3751 2.7074 21.7945
KMS-20 CTRP2 2.8466 3.6751 2.8464 21.3049
CA46 CTRP2 2.8561 6.2949 2.4934 22.5135
M-07e CTRP2 2.8911 4.6775 2.8581 21.1186
KE-37 CTRP2 2.9603 4.1046 2.9575 28.0241
F-36P CTRP2 2.9723 4.2249 2.9672 20.4838
DND-41 CTRP2 3.1229 7.9186 2.2026 22.7926
Kasumi-2 CTRP2 3.1861 3.9699 3.1858 19.0433
RS4;11 CTRP2 3.2536 5.4676 3.1346 19.0005
NU-DHL-1 CTRP2 3.3354 4.8304 3.3105 18.1314
Mono-Mac-1 CTRP2 3.4617 14.8147 -0.6433 30.5531
JJN-3 CTRP2 3.4852 4.8794 3.4631 17.1238
HDLM-2 CTRP2 3.551 8.6546 2.341 21.0906
OCI-AML-5 CTRP2 3.5817 4.9725 3.5563 16.4925
SUP-T11 CTRP2 3.6237 5.2949 3.5631 16.3326
TALL-1 [Human adult T-ALL] CTRP2 3.6286 6.6339 3.2263 17.5319
U266B1 CTRP2 3.6811 5.7718 3.5343 16.2525
DB CTRP2 3.763 8.3637 2.6857 19.2121
Namalwa CTRP2 3.8825 6.9604 3.384 16.2093
KE-97 CTRP2 4.4385 9.2762 2.9519 16.4382
Karpas-620 CTRP2 4.5345 7.0131 4.0589 11.8093
NALM-6 CTRP2 4.598 8.7971 3.3332 14.5235
GDM-1 CTRP2 4.7933 10.8505 2.5329 17.2421
HH [Human lymphoma] CTRP2 4.937 10.3167 2.9273 15.3534
Toledo CTRP2 4.9427 6.3258 4.7549 8.0116
OCI-Ly19 CTRP2 4.9828 14.7469 0.7796 23.0119
MOLP-8 CTRP2 5.1069 12.0752 2.216 17.7498
MOLP-2 CTRP2 5.2597 6.4663 5.0447 6.0135
ST486 CTRP2 5.2776 10.7672 3.017 14.2313
SUP-B15 CTRP2 5.3596 9.1588 3.8852 10.4874
DoHH2 CTRP2 5.5745 10.6031 3.3625 16.4449
PL21 CTRP2 5.6775 10.1835 3.6617 10.7358
P31/FUJ CTRP2 5.8364 9.1104 4.3348 10.3488
HT CTRP2 5.8719 11.3202 3.2615 16.1242
ME1 CTRP2 5.9324 12.1691 2.8882 13.3852
KCL-22 CTRP2 5.9328 7.6512 5.1462 3.9967
RL CTRP2 6.0108 6.8091 5.6337 1.792
Mino CTRP2 6.021 9.235 4.4295 6.8327
Ci-1 CTRP2 6.0502 6.776 5.6835 1.5059
WSU-DLCL2 CTRP2 6.1076 12.4298 2.9042 17.2776
Ki-JK CTRP2 6.2689 10.1557 4.1727 10.1212
Karpas-422 CTRP2 6.427 10.8841 3.9355 8.1461
Jurkat CTRP2 6.5218 8.3581 5.2572 2.4932
Ri-1 CTRP2 6.532 11.433 3.7448 8.7506
JVM-3 CTRP2 6.5442 10.0085 4.4619 7.8254
LP-1 CTRP2 6.5579 11.5126 3.7256 8.7844
JVM-2 CTRP2 6.6016 14.9731 2.0354 15.383
Hs 611.T CTRP2 6.6018 12.0254 3.5048 9.6164
Mono-Mac-6 CTRP2 6.6993 12.8328 3.1793 10.7689
SET-2 CTRP2 6.7142 8.8155 5.1695 2.5679
OCI-Ly3 CTRP2 6.7797 16.6418 1.3453 17.4952
KMS-28BM CTRP2 6.7923 12.6618 3.3364 9.9698
Granta-519 CTRP2 6.8109 13.2611 3.0532 11.079
MOTN-1 CTRP2 6.8164 12.4432 3.4634 9.4114
KMM-1 CTRP2 6.8435 9.7514 4.8072 5.241
RPMI-8402 CTRP2 6.8783 9.586 4.9111 4.5992
MOLT-16 CTRP2 6.9421 11.3249 4.1098 6.5502
MC116 CTRP2 6.949 7.9903 5.682 0.4365
SU-DHL-1 CTRP2 6.9685 9.7729 4.8826 4.5815
Raji CTRP2 7.0046 8.9472 5.2937 1.7131
KHM-1B CTRP2 7.0237 8.7134 5.4106 1.7235
RCH-ACV CTRP2 7.0867 11.4881 4.1347 6.2207
KM-H2 CTRP2 7.2091 15.3223 2.3368 13.1701
NB4 CTRP2 7.2436 8.8061 5.4885 0.8049
NCI-H929 CTRP2 7.2548 11.1976 4.3934 4.9206
Reh CTRP2 7.287 10.9266 4.5451 4.2681
SKM-1 CTRP2 7.2941 9.218 5.3383 1.2547
CMK CTRP2 7.3107 13.0754 3.5203 8.3661
HEL CTRP2 7.4137 8.5821 5.6559 0.26
SU-DHL-10 CTRP2 7.4561 8.3672 5.7502 0.0903
SUP-HD1 CTRP2 7.5079 13.1646 3.6179 7.6688
RPMI-6666 CTRP2 7.5325 14.9081 2.7833 10.9254
PF-382 CTRP2 7.56 13.466 3.5082 8.0284
L-540 CTRP2 7.6887 10.1063 5.1647 1.4839
SU-DHL-8 CTRP2 7.6923 9.7783 5.3062 1.0267
EHEB CTRP2 7.8305 10.2941 5.1587 1.8846
AMO1 CTRP2 7.8837 9.1539 5.6318 0.1567
L-363 CTRP2 7.9155 9.0731 5.6717 0.0992
MM1.S CTRP2 7.9203 9.4872 5.5249 0.3304
REC-1 CTRP2 7.9713 12.1901 4.3904 3.9931
SU-DHL-4 CTRP2 7.9923 9.4256 5.576 0.214
MOLT-13 CTRP2 8.0025 9.379 5.5965 0.1794
Karpas-299 CTRP2 8.0785 9.7962 5.4741 0.3725
MOLM-16 CTRP2 8.0857 9.6828 5.519 0.2836
EJM CTRP2 8.0889 22.7083 -0.6511 21.1454
HPB-ALL CTRP2 8.1221 13.1658 4.0305 5.1855
P3HR-1 CTRP2 8.124 9.6957 5.5293 0.2534
RPMI-8226 CTRP2 8.1615 10.105 5.3918 0.5149
SUP-T1 CTRP2 8.1996 10.4408 5.2775 0.7755
SU-DHL-6 CTRP2 8.3991 9.7984 5.5951 0.1039
SR CTRP2 8.4355 10.2042 5.466 0.2682
MHH-CALL-4 CTRP2 8.6549 10.5944 5.4099 0.2979
MHH-CALL-3 CTRP2 8.6965 11.11 5.235 0.6267
JeKo-1 CTRP2 9.076 19.5516 1.6199 12.7831
OCI-Ly10 CTRP2 9.6624 21.5108 1.0792 13.7164
⏷ Show the Full List of 139 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 3.1321 4.9149 3.0885 19.5492
TE15 CTRP2 5.4719 11.8841 2.6347 15.3392
TE-5 CTRP2 1.8254 4.7647 1.7158 28.4772
KYSE-150 CTRP2 2.5275 2.9658 2.5275 23.4303
EC-GI-10 CTRP2 2.5828 5.5106 2.3979 23.6973
KYSE-510 CTRP2 2.9869 3.7473 2.9868 20.3699
OE21 CTRP2 3.2636 5.4792 3.1431 18.9396
KYSE-30 CTRP2 3.3919 4.2331 3.3912 17.6735
TE-11 CTRP2 3.7746 5.861 3.6148 15.6764
TE-6 CTRP2 3.9256 6.0684 1.3243 1.2289
KYSE-410 CTRP2 4.1262 6.6191 3.7701 14.0582
TE-4 CTRP2 4.155 6.1202 3.9612 13.2678
TE-14 CTRP2 4.6243 7.0912 4.1218 11.3203
KYSE-140 CTRP2 6.0649 9.9378 4.1148 8.069
KYSE-450 CTRP2 6.3699 7.3694 5.6296 1.2064
COLO 680N CTRP2 6.6414 8.7628 5.1449 3.7796
KYSE-180 CTRP2 7.3601 9.3178 5.3304 1.2211
KYSE-520 CTRP2 7.5007 12.5401 3.9155 6.4859
OE19 CTRP2 7.8315 11.7746 4.4964 3.7574
OE33 CTRP2 7.8574 10.4778 5.094 1.5711
KYSE-70 CTRP2 8.332 9.7896 5.5741 0.1383
TE-9 CTRP2 8.3734 9.7221 5.6121 0.091
TE-1 CTRP2 8.5022 10.0428 5.5479 0.1382
TE-10 CTRP2 8.839 10.415 5.54 0.0961
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.9675 8.5877 5.4347 1.2355
KP-4 CTRP2 2.7135 5.0262 2.6282 30.6418
Hs 766T CTRP2 2.929 7.8622 2.0196 24.0145
PSN1 CTRP2 3.2463 7.4519 2.5172 21.2781
BxPC-3 CTRP2 3.5364 8.9837 2.1815 29.044
SU.86.86 CTRP2 3.7248 5.325 3.6669 15.6504
MIA PaCa-2 CTRP2 4.0092 7.3844 3.3543 15.9688
QGP-1 CTRP2 4.0213 21.2074 -3.2827 39.4624
PaTu 8988s CTRP2 4.0965 6.5283 3.7692 14.1474
Panc 08.13 CTRP2 4.3942 6.4826 4.1073 12.0212
HuP-T3 CTRP2 4.7405 11.6711 2.0821 19.0845
PaTu 8902 CTRP2 4.9251 6.5933 4.6389 8.4997
Capan-1 CTRP2 5.7797 10.3448 3.6698 10.4928
Panc 04.03 CTRP2 5.79 10.6475 3.5275 11.0621
DAN-G CTRP2 6.1064 8.8988 4.6685 5.6647
SUIT-2 CTRP2 7.2054 8.9339 5.414 1.0789
PK-45H CTRP2 7.274 12.6968 3.6789 7.7834
KP-3 CTRP2 7.2788 11.8182 4.1103 6.0286
Panc 05.04 CTRP2 7.3511 8.8573 5.5201 0.633
PaTu 8988t CTRP2 7.5381 12.7676 3.8316 6.7676
L3.3 CTRP2 7.855 8.9262 5.7006 0.0782
TCC-Pan2 CTRP2 7.8983 9.3289 5.5745 0.2446
SNU-410 CTRP2 7.9237 11.0986 4.8583 2.3189
Panc 02.03 CTRP2 7.9834 11.6254 4.6563 2.9849
CFPAC-1 CTRP2 8.0002 9.6954 5.4796 0.5345
SNU-213 CTRP2 8.0213 9.3352 5.6191 0.1955
HPAC CTRP2 8.0839 9.4611 5.598 0.1582
KP-2 CTRP2 8.1491 13.992 3.6581 6.593
YAPC CTRP2 8.1715 9.5888 5.5855 0.156
SW1990 CTRP2 8.3288 22.2768 -0.2556 19.6992
HuP-T4 CTRP2 8.416 13.8419 3.9003 5.317
HPAF-II CTRP2 8.5157 10.0092 5.5643 0.1607
PK-59 CTRP2 8.6504 10.33 5.502 0.1657
AsPC-1 CTRP2 9.1639 22.5114 0.2437 16.9841
Panc 03.27 CTRP2 9.5669 23.1852 0.2026 16.507
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.9325 10.2391 4.2838 0.4637
WM266-4 CTRP2 2.2761 3.5664 2.2742 25.111
WM115 CTRP2 2.2973 4.1818 2.2758 25.0359
UACC-62 CTRP2 2.367 3.5913 2.3655 24.5041
SK-MEL-1 CTRP2 2.6917 11.7809 0.06 30.8756
HT-144 CTRP2 2.7125 13.1044 -0.5391 32.2947
Hs 944.T CTRP2 2.7323 4.936 2.6611 22.3073
WM88 CTRP2 3.266 8 2.3206 21.953
SK-MEL-30 CTRP2 3.3376 8.0908 2.3586 21.6113
MeWo CTRP2 3.3411 6.6829 2.8981 19.5895
LOX-IMVI CTRP2 3.5715 7.2241 2.9517 18.7247
Hs 940.T CTRP2 3.8582 6.1034 3.6421 15.3226
RPMI-7951 CTRP2 4.0013 5.289 3.9665 18.7167
UACC-257 CTRP2 4.1496 7.1786 3.5852 14.694
IGR-37 CTRP2 4.7746 10.0153 2.9219 15.7506
WT2-iPS CTRP2 4.8303 12.6243 1.6949 20.2904
Hs 934.T CTRP2 4.9897 7.4561 4.3414 9.4935
Hs 688(A).T CTRP2 5.9588 7.1364 5.4255 2.7715
CJM [Human melanoma] CTRP2 6.0229 6.9599 5.5686 2.0417
Mel JuSo CTRP2 6.1359 9.0163 4.634 5.7538
RVH-421 CTRP2 6.2165 12.2592 3.0792 12.0622
COLO 800 CTRP2 6.2214 12.6726 2.8766 12.8668
Mel Ho CTRP2 6.247 11.4023 3.5324 10.1505
SK-MEL-24 CTRP2 6.39 12.3113 3.1941 11.2701
Hs 895.T CTRP2 6.566 14.5429 2.2216 14.7566
HMCB CTRP2 6.892 8.998 5.2001 2.2073
K029AX CTRP2 6.8952 13.3031 3.0974 10.7549
WM983B CTRP2 7.1232 15.9284 1.9702 14.6757
A2058 CTRP2 7.1605 8.4306 5.6032 0.5216
SK-MEL-28 CTRP2 7.3416 8.2508 5.7487 0.1174
COLO 829 CTRP2 7.3871 13.0197 3.6025 7.9157
A101D CTRP2 7.4238 9.706 5.1952 1.6268
SK-MEL-2 CTRP2 7.4528 8.7307 5.616 0.3296
COLO 792 CTRP2 7.6502 12.3087 4.1282 5.4256
IPC-298 CTRP2 7.7508 9.0985 5.6006 0.2454
SK-MEL-31 CTRP2 7.7832 9.1077 5.6099 0.2184
SK-MEL-5 CTRP2 7.9394 9.1531 5.6527 0.1172
Hs 936.T CTRP2 8.0104 9.1035 5.6948 0.0631
MDA-MB-435S CTRP2 8.0106 9.4729 5.566 0.2253
Hs 852.T CTRP2 8.0869 9.5963 5.5509 0.2282
Hs 294T CTRP2 8.1369 17.094 2.1515 12.3333
G-361 CTRP2 8.1581 9.6864 5.5458 0.2168
WM793 CTRP2 8.2702 9.6132 5.6127 0.1054
WM1799 CTRP2 8.5796 17.157 2.4327 10.6407
A-375 CTRP2 8.6545 10.1416 5.5682 0.0943
SK-MEL-3 CTRP2 8.9955 16.919 2.8261 8.615
IGR-1 CTRP2 10.3776 21.9188 1.3628 11.8483
Hs 839.T CTRP2 10.6276 21.8757 1.5446 10.9472
IGR-39 CTRP2 12.6413 24.0443 1.766 8.0152
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-BE(2) CTRP2 2.9448 4.7984 2.9031 20.7905
SK-N-AS CTRP2 3.0016 6.9783 2.4288 22.3135
SiMa CTRP2 3.1226 6.8849 2.5923 28.9938
MHH-NB-11 CTRP2 3.2413 5.0411 3.1895 25.6981
NH-6 CTRP2 3.4629 6.1162 3.2072 18.0948
KP-N-YN CTRP2 7.0189 13.2978 3.1944 10.1546
CHP-126 CTRP2 7.3494 10.0999 4.9735 2.5187
Kelly CTRP2 7.6669 10.5072 4.9762 2.1596
NB1 CTRP2 8.1313 9.4465 5.6204 0.1203
KP-N-SI9s CTRP2 8.3931 10.7407 5.2461 0.7492
SK-N-SH CTRP2 9.7445 20.493 1.6224 11.8379
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CTRP2 4.0929 5.8632 3.9612 18.3469
SNU-245 CTRP2 4.7094 8.8799 3.4034 18.9515
SNU-1079 CTRP2 6.2594 8.2572 5.1117 4.8052
SNU-1196 CTRP2 7.7485 10.8956 4.8487 3.4543
SNU-308 CTRP2 7.986 9.5337 5.5341 0.289
HuH-28 CTRP2 8.0111 9.5202 5.549 0.2539
SNU-478 CTRP2 8.2665 9.8797 5.5179 0.2316
SNU-869 CTRP2 8.5134 15.7814 3.048 8.4394
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-ES-1 CTRP2 3.2083 4.4004 3.2025 18.914
A-673 CTRP2 3.4446 7.6981 2.6313 20.2906
CADO-ES1 CTRP2 3.8581 4.9585 3.8455 19.9147
Hs 888.T CTRP2 4.2259 6.1638 4.026 12.8188
SJSA-1 CTRP2 4.4994 7.0598 4.003 12.121
CAL-78 CTRP2 4.5202 6.7486 4.1468 11.512
SaOS-2 CTRP2 4.7962 7.0192 4.3319 10.0383
Hs 822.T CTRP2 6.0409 8.4119 4.8577 4.9947
TC71 CTRP2 6.1551 7.5215 5.396 2.5192
SK-N-MC CTRP2 6.4727 8.6201 5.0937 3.2414
MHH-ES-1 CTRP2 7.4677 13.3511 3.4986 8.208
G-292 clone A141B1 CTRP2 7.6969 12.133 4.2425 4.9116
SW1353 CTRP2 8.2976 9.8329 5.5463 0.2475
U2OS CTRP2 8.6972 10.7539 5.3685 0.4855
MG-63 CTRP2 8.9351 20.1854 1.2141 14.338
HOS CTRP2 9.4275 16.4554 3.3153 6.2838
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 1.654 2.8105 1.6538 29.25
MDA-MB-361 CTRP2 3.351 5.2821 3.2725 18.2112
MDA-MB-453 CTRP2 3.364 4.648 3.3522 17.8967
CAL-120 CTRP2 4.3327 5.4031 4.3045 15.6767
HCC1428 CTRP2 4.5814 8.5732 3.4211 14.2115
CAL-85-1 CTRP2 4.6066 9.9797 2.7796 16.7128
BT-20 CTRP2 5.154 9.0967 3.7249 11.6116
KPL-1 CTRP2 5.4322 9.5063 3.7801 14.6196
T-47D CTRP2 5.8281 9.6092 4.0787 8.6878
Hs 578T CTRP2 6.0076 13.3678 2.352 15.3374
Hs 578Bst CTRP2 6.0279 8.2547 4.9254 4.7354
CAL-148 CTRP2 6.3078 7.6146 5.4665 1.9656
MCF-7 CTRP2 6.5572 8.4191 5.2525 3.3529
HCC1500 CTRP2 6.926 11.0102 4.2524 5.9894
CAMA-1 CTRP2 6.9889 8.8363 5.335 2.15
HCC38 CTRP2 7.0464 12.6756 3.5223 8.7844
JIMT-1 CTRP2 7.1008 8.8677 5.3856 1.739
HDQ-P1 CTRP2 7.1348 10.9478 4.4312 6.7242
HCC202 CTRP2 7.2558 13.4348 3.3037 9.3238
MDA-MB-468 CTRP2 7.3166 10.2241 4.8957 2.8544
HCC1395 CTRP2 7.679 10.7134 4.8905 2.4573
HMC-1-8 CTRP2 7.724 12.7928 3.9465 6.0437
BT-474 CTRP2 7.853 16.3869 2.292 12.2678
HCC1419 CTRP2 7.9379 9.3311 5.5891 0.208
MDA-MB-231 CTRP2 8.0636 12.836 4.1477 4.8081
HCC1806 CTRP2 8.0877 9.6484 5.5323 0.3535
ZR-75-1 CTRP2 8.2154 9.4283 5.6564 0.0713
CAL-51 CTRP2 8.2831 12.2978 4.5275 3.1336
HCC1937 CTRP2 8.3213 10.937 5.1344 1.0925
SK-BR-3 CTRP2 8.3433 10.2566 5.4103 0.3998
HCC1954 CTRP2 8.4323 10.0602 5.5162 0.2628
BT-549 CTRP2 8.5911 9.9692 5.6043 0.0714
HCC1143 CTRP2 8.9651 10.8676 5.4295 0.1944
ZR-75-30 CTRP2 9.8113 26.3608 -1.1712 19.8012
BT 286 CTRP2 1.1447 7.3585 0.2883 35.19
BT 145 CTRP2 1.1977 5.4885 0.8958 33.2625
BT 428 CTRP2 1.2729 7.7586 0.2856 34.7473
BT 440 CTRP2 1.5411 6.0715 1.1224 31.383
BT 504 CTRP2 2.3979 6.6489 1.8848 26.0795
BT 239 CTRP2 2.4289 8.4422 1.2584 28.1181
BT 482 CTRP2 2.9527 7.5279 2.1745 23.385
BT 172 CTRP2 2.9833 6.7188 2.498 22.115
BT 139 CTRP2 3.1908 7.1718 2.5632 21.2671
BT147 CTRP2 3.3489 11.3508 0.9092 26.6097
BT 271 CTRP2 3.3683 11.2771 0.9628 26.389
BT 416 CTRP2 3.3911 5.5333 3.2706 18.0901
BT 216 CTRP2 4.0099 12.2721 1.1066 24.2651
BT 232 CTRP2 4.698 7.8073 3.8881 12.0478
BT 422 CTRP2 4.71 12.5536 1.6203 20.8322
BT 333 CTRP2 4.7254 9.1477 3.2919 14.3803
BT 231 CTRP2 4.8105 9.0511 3.4201 13.6586
BT 444 CTRP2 4.9601 18.1394 -0.9289 27.7338
BT 179 CTRP2 5.2022 9.6684 3.4902 12.4676
BT 359 CTRP2 5.2875 10.1827 3.3149 12.9979
BT 131 CTRP2 5.6579 8.3958 4.5328 7.1411
BT 328 CTRP2 5.6792 9.0196 4.2425 8.309
BT 245 CTRP2 5.8088 10.1066 3.8137 9.8344
BT 187 CTRP2 5.9528 9.7354 4.1221 8.2567
BT 112 CTRP2 6.0552 11.1858 3.4827 10.7218
BT 248 CTRP2 6.4414 10.2517 4.2618 6.7593
BT 330 CTRP2 6.662 15.8795 1.6316 16.7248
BT 320 CTRP2 6.8126 11.5127 3.921 7.5389
BT 228 CTRP2 8.1475 12.4674 4.3703 3.8616
BT 224 CTRP2 8.2466 16.7834 2.3811 11.3252
BT 159 CTRP2 8.4443 14.1461 3.7762 5.7539
BT 340 CTRP2 8.5574 18.6839 1.6768 13.361
BT 498 CTRP2 10.3827 35.1486 -5.0694 26.5723
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.8368 8.8772 5.7108 0.0708
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 CTRP2 2.3212 3.5481 2.3197 24.8095
D283 Med CTRP2 2.4625 4.3626 2.4354 23.9541
KNS-42 CTRP2 2.5845 2.9395 2.5845 23.0504
KNS-60 CTRP2 2.839 4.3569 2.8258 21.399
Daoy CTRP2 2.874 4.2159 2.8672 21.1442
SF268 CTRP2 3.1437 4.2866 3.1398 19.3379
ONS-76 CTRP2 3.26 5.9945 3.0192 26.4206
GaMG CTRP2 3.5675 5.7188 3.4228 17.0012
GB-1 CTRP2 3.6339 5.6109 3.5181 16.4573
SF126 CTRP2 3.8174 6.5417 3.4621 16.1043
KNS-81 CTRP2 4.4245 6.2119 4.2281 11.4858
CAS-1 CTRP2 4.4817 5.9433 4.3654 14.7444
42-MG-BA CTRP2 4.4902 9.4266 2.9314 16.3923
SW1088 CTRP2 4.9164 8.0771 3.9832 11.1182
Hs 683 CTRP2 4.9943 9.134 3.5561 12.672
KG-1-C CTRP2 5.0594 8.2884 4.0238 10.6067
KALS-1 CTRP2 5.277 6.633 4.9959 6.1544
SNB-75 CTRP2 5.302 7.0335 4.8478 6.6742
U-251MG CTRP2 5.7945 8.5732 4.5662 6.7131
SNU-738 CTRP2 6.0216 9.5288 4.2831 10.1382
YKG-1 CTRP2 6.16 9.5559 4.3841 6.7585
U-118MG CTRP2 6.3583 8.871 4.8834 4.3069
SNU-626 CTRP2 6.5339 10.0915 4.4129 8.1253
DK-MG CTRP2 6.5886 8.573 5.1999 2.6268
SF295 CTRP2 6.8788 13.0412 3.2147 10.3121
LN-229 CTRP2 6.9938 10.7253 4.4402 5.1152
U-87MG ATCC CTRP2 7.0068 8.6418 5.433 1.6383
SNU-1105 CTRP2 7.0551 8.5889 5.4829 1.3387
Becker CTRP2 7.1503 13.0334 3.4233 9.0147
SNU-201 CTRP2 7.1913 15.637 2.1672 17.9305
SW1783 CTRP2 7.2139 11.0811 4.4215 4.8662
SNU-489 CTRP2 7.352 8.732 5.5711 0.6703
TM-31 CTRP2 7.5245 9.7176 5.2453 1.3602
SNU-466 CTRP2 7.5312 8.4072 5.7633 0.0631
LN-18 CTRP2 7.6962 8.7904 5.6903 0.1182
DBTRG-05MG CTRP2 8.1051 10.0241 5.3987 0.5252
8-MG-BA CTRP2 8.1747 15.8018 2.8068 9.8403
GOS-3 CTRP2 8.3247 16.9159 2.3718 11.2413
CCF-STTG1 CTRP2 9.0124 19.6933 1.5073 13.2549
YH-13 CTRP2 9.5692 19.2739 2.0862 10.4979
A-172 CTRP2 9.6821 19.4662 2.0691 10.4074
M059K CTRP2 10.9559 21.497 1.9265 9.3111
GMS-10 CTRP2 11.1942 21.0851 2.2588 7.9546
T98G CTRP2 11.9939 28.2346 -0.5704 15.3913
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP2 0.4436 9.0391 -1.0843 40.6448
JHUEM-1 CTRP2 2.6754 4.3609 2.6567 22.5074
HEC-151 CTRP2 2.8131 3.7106 2.8128 21.5285
HEC-1-A CTRP2 3.708 6.0998 3.4793 16.3673
JHUEM-3 CTRP2 4.2686 8.072 3.3329 15.3582
MFE-296 CTRP2 4.6366 7.4112 3.9998 11.7647
JHUEM-2 CTRP2 5.5286 10.293 3.4763 11.8151
AN3-CA CTRP2 5.8716 13.8306 2.0064 16.9113
EFE-184 CTRP2 5.8724 9.6331 4.1048 8.4892
HEC-6 CTRP2 6.5373 8.4351 5.2307 2.5779
RL95-2 CTRP2 6.6284 8.6969 5.1677 3.6794
HEC-59 CTRP2 6.749 8.6704 5.262 2.1516
HEC-108 CTRP2 6.8381 8.515 5.3912 1.5389
EN CTRP2 6.8764 10.8782 4.281 5.9506
HEC-251 CTRP2 7.105 8.7719 5.4302 1.1161
HEC-1-B CTRP2 7.3484 11.7155 4.2082 7.5087
MFE-319 CTRP2 7.7541 14.2019 3.2877 8.6085
ESS-1 CTRP2 8.0118 14.6183 3.2656 8.3139
KLE CTRP2 8.5108 10.5995 5.3506 0.4561
HEC-50B CTRP2 8.8471 10.4955 5.5155 0.1178
Ishikawa (Heraklio) 02 ER- CTRP2 6.8537 7.9035 5.6712 0.5371
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 1.5101 3.0918 1.5075 30.2167
BFTC-909 CTRP2 4.3791 5.891 4.2665 15.6573
786-O CTRP2 4.5899 8.7403 3.3518 14.4687
CAL-54 CTRP2 4.677 8.0933 3.7373 12.7043
RCC10RGB CTRP2 5.1378 6.9007 4.7379 7.5363
KMRC-2 CTRP2 6.1872 9.3071 4.5305 6.0929
TUHR4TKB CTRP2 6.8063 10.0913 4.6154 6.3832
KMRC-20 CTRP2 6.9513 9.4386 5.0306 3.8115
OS-RC-2 CTRP2 7.0218 11.1056 4.2749 7.8127
KMRC-1 CTRP2 7.1896 10.5549 4.6573 3.9549
A-498 CTRP2 7.2821 9.267 5.3102 1.3625
TUHR10TKB CTRP2 7.388 8.5158 5.6702 0.2408
ACHN CTRP2 7.4899 12.3608 3.9946 6.1844
KMRC-3 CTRP2 8.0962 12.1837 4.4693 3.5507
TUHR14TKB CTRP2 8.1339 11.2329 4.915 1.9244
VMRC-RCW CTRP2 8.1715 12.6002 4.3239 4.0082
769-P CTRP2 8.2031 9.5731 5.6025 0.1749
SNU-1272 CTRP2 8.3939 9.6974 5.6275 0.0746
Caki-2 CTRP2 8.6045 10.0783 5.5721 0.0972
Caki-1 CTRP2 9.2639 15.9627 3.4423 6.0115
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW948 CTRP2 0.2998 7.2188 -0.5808 40.3309
CL-11 CTRP2 2.4002 5.9503 2.0927 25.3418
SNU-407 CTRP2 2.457 3.87 2.4521 23.9161
LS123 CTRP2 2.715 4.3124 2.7002 22.2306
SK-CO-1 CTRP2 2.7751 4.5426 2.748 29.817
LS513 CTRP2 2.8905 4.7095 2.8546 28.8093
KM12 CTRP2 3.0986 5.5186 2.9563 20.1146
SNU-C5 CTRP2 3.1182 6.4604 2.7284 20.8727
SNU-61 CTRP2 3.1455 6.0304 2.8845 20.2246
RKO CTRP2 3.1737 4.9658 3.1268 19.2832
HCT 15 CTRP2 3.1843 5.366 3.0787 19.4155
C2BBe1 CTRP2 3.219 6.4182 2.8514 20.1225
NCI-H747 CTRP2 3.562 5.8764 3.3793 17.1731
T84 CTRP2 3.8279 5.2207 3.7907 14.8923
SNU-C4 CTRP2 4.0882 5.7409 3.9841 13.3913
DLD-1 CTRP2 4.1078 5.3141 4.0765 17.7333
LS1034 CTRP2 4.3996 7.0231 3.912 12.7469
SW48 CTRP2 4.8985 9.0907 3.4857 17.8869
HCT 8 CTRP2 5.0981 6.1556 4.9793 6.7244
SW1417 CTRP2 5.943 15.8965 1.0336 20.1561
SNU-C1 CTRP2 6.3685 9.3399 4.6583 5.2298
COLO 678 CTRP2 6.4514 13.492 2.6541 13.3112
RCM-1 [Human ESC] CTRP2 6.5674 8.5732 5.1849 2.7196
SNU-503 CTRP2 6.6448 10.8847 4.1046 7.062
SNU-1033 CTRP2 7.3063 12.7626 3.6701 7.7688
OUMS-23 CTRP2 7.3174 8.5802 5.6155 0.5408
SNU-175 CTRP2 7.5969 11.6503 4.4056 5.9866
COLO205 CTRP2 7.6823 9.6041 5.3734 1.1359
HT-29 CTRP2 7.6828 8.9188 5.6394 0.1983
LS180 CTRP2 7.7136 9.6671 5.3626 0.8431
MDST8 CTRP2 7.9047 9.2769 5.5958 0.2064
HT115 CTRP2 7.922 9.137 5.6519 0.1215
COLO201 CTRP2 8.0388 9.6696 5.5051 0.3256
HCC-56 CTRP2 8.0953 11.8201 4.6337 2.9474
CCK-81 CTRP2 8.1369 10.027 5.4112 0.4823
LS411N CTRP2 8.1526 9.639 5.5607 0.2665
NCI-H508 CTRP2 8.1826 9.6772 5.5584 0.1914
HT-55 CTRP2 8.2033 9.7105 5.5543 0.1923
HCT 116 CTRP2 8.2057 9.6294 5.5838 0.151
LoVo CTRP2 8.227 14.1296 3.644 6.5431
CW-2 CTRP2 8.2457 13.5581 3.9253 5.4337
SW620 CTRP2 8.5921 10.0749 5.5689 0.102
SNU-C2A CTRP2 8.867 10.7559 5.4325 0.2875
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-6 CTRP2 1.9836 4.5478 1.9137 27.2893
SNU-886 CTRP2 2.2058 4.132 2.1841 25.6462
JHH-5 CTRP2 2.3812 5.732 2.1274 25.2791
SNU-761 CTRP2 2.6071 4.2021 1.4118 2.5673
Li-7 CTRP2 2.7012 5.3311 2.5629 30.993
SNU-182 CTRP2 2.8784 5.7616 2.6622 21.8409
SNU-878 CTRP2 2.9607 7.0893 2.3453 30.7804
SNU-449 CTRP2 4.224 6.1163 4.0376 12.7821
SNU-423 CTRP2 6.2354 11.6802 3.384 10.7835
JHH-6 CTRP2 6.6953 8.9305 5.1012 2.8703
SNU-387 CTRP2 7.1181 15.9057 1.9775 14.6582
HLF CTRP2 7.2252 10.1717 4.8623 3.0985
HuH-1 CTRP2 7.2417 9.1745 5.3286 1.3375
SNU-398 CTRP2 7.2459 12.1517 3.9249 6.8299
JHH-1 CTRP2 7.3766 9.1973 5.391 1.008
SNU-475 CTRP2 7.6962 14.9228 2.8951 10.2319
JHH-2 CTRP2 7.809 14.7694 3.0507 9.4532
Hep-G2 CTRP2 7.8303 9.2987 5.5585 0.2974
JHH-4 CTRP2 8.3749 15.3102 3.1803 8.1278
PLC/PRF/5 CTRP2 10.1498 20.8058 1.7405 10.9102
SK-HEP-1 CTRP2 10.7949 18.4282 3.2198 5.1744
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 130 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LC-1F CTRP2 -0.4934 31.747 -17.596 41.6654
NCI-H1703 CTRP2 -0.0039 4.7914 -0.2613 40.94
NCI-H1666 CTRP2 0.4919 5.6549 0.0865 38.123
NCI-H1581 CTRP2 0.7113 4.449 0.5694 48.5565
NCI-H2087 CTRP2 0.8929 4.9627 0.6765 35.0017
HCC44 CTRP2 1.7069 3.9043 1.6811 28.9833
NCI-H1341 CTRP2 1.9693 3.6317 1.9624 27.172
NCI-H211 CTRP2 2.0678 4.2307 2.0337 26.6072
NCI-H2106 CTRP2 2.2092 5.9606 1.8815 36.1626
NCI-H1568 CTRP2 2.3041 4.4397 2.2635 25.0552
NCI-H446 CTRP2 2.3477 4.8526 2.2619 24.9188
NCI-H1155 CTRP2 2.3995 4.4407 2.3635 33.267
SBC-5 CTRP2 2.4053 2.8853 2.4053 24.2441
NCI-H2029 CTRP2 2.4078 4.4301 2.373 24.3446
COLO 668 CTRP2 2.5537 4.7818 2.4909 23.4678
NCI-H1573 CTRP2 2.6828 4.5582 2.6502 22.5052
NCI-H1693 CTRP2 2.7145 3.895 2.7123 22.1915
Lu-99 CTRP2 2.7439 3.9807 2.7407 29.9916
NCI-H1563 CTRP2 2.7634 3.4007 2.7634 21.8584
NCI-H1975 CTRP2 2.8768 4.381 2.8635 28.8303
NCI-H2196 CTRP2 2.9074 4.6188 2.8801 20.9907
NCI-H2444 CTRP2 3.0108 4.2657 1.622 0.9121
Sq-1 CTRP2 3.012 4.3656 3.0031 20.2321
NCI-H647 CTRP2 3.1369 5.4458 3.0125 19.7967
NCI-H1694 CTRP2 3.179 4.0388 3.1785 19.0913
NCI-H2228 CTRP2 3.316 5.2008 3.2475 18.4098
KNS-62 CTRP2 3.3852 4.0048 3.3852 17.7161
RERF-LC-A1 CTRP2 3.4481 5.8099 3.2714 17.9098
PC-14 CTRP2 3.4563 6.1234 3.1979 18.1484
NCI-H1355 CTRP2 3.5078 5.7018 3.3616 17.4036
SW1271 CTRP2 3.5333 6.811 3.062 18.4204
HCC1195 CTRP2 3.6021 5.6084 3.4842 16.6762
NCI-H358 CTRP2 3.6791 6.1994 3.4191 22.7246
HCC15 CTRP2 3.7129 8.5416 2.5568 26.7279
ChaGo-K-1 CTRP2 3.7353 7.362 3.073 17.8044
NCI-H2405 CTRP2 3.7667 14.6831 -0.2942 35.6175
HOP-62 CTRP2 3.7818 5.0284 3.7611 15.1432
NCI-H838 CTRP2 3.8956 6.9111 3.4164 16.05
NCI-H226 CTRP2 3.9811 5.9599 3.8152 14.3238
COR-L95 CTRP2 4.0032 6.2645 3.753 14.4826
HARA [Human squamous cell lung carcinoma] CTRP2 4.1191 5.9479 3.9689 18.1992
NCI-H522 CTRP2 4.1239 10.3355 2.1447 20.3357
NCI-H1650 CTRP2 4.1487 7.4324 3.4817 15.0953
Calu-3 CTRP2 4.1529 5.994 3.9937 13.157
HCC1438 CTRP2 4.2929 5.2631 4.2764 11.7241
DMS 114 CTRP2 4.3233 6.7857 3.922 12.9221
T3M-10 CTRP2 4.3643 6.0126 4.2194 11.6991
SK-MES-1 CTRP2 4.3793 6.966 3.9128 12.7998
HOP-92 CTRP2 4.4073 6.5448 4.0999 12.0112
Calu-1 CTRP2 4.5442 6.795 4.1548 11.4142
HCC1588 CTRP2 4.5718 8.9241 3.248 14.9297
NCI-H2170 CTRP2 4.6375 6.8782 4.2217 10.8983
EPLC-272H CTRP2 4.7081 6.1242 4.5635 9.4115
HCC4006 CTRP2 4.7965 7.9485 3.9233 11.6575
EKVX CTRP2 4.9343 7.8654 4.0991 10.606
HCC1833 CTRP2 5.0454 11.048 2.668 16.1385
NCI-H146 CTRP2 5.1531 10.376 3.0973 14.1807
HCC827 CTRP2 5.3766 6.5691 5.1269 5.3756
NCI-H841 CTRP2 5.4824 10.418 3.3732 12.3379
NCI-H2081 CTRP2 5.4887 18.0216 -0.4134 25.335
IA-LM CTRP2 5.7001 9.5185 4.0126 9.2264
HCC2935 CTRP2 5.7957 7.4227 5.1384 4.3173
LXF 289 CTRP2 6.0079 7.0428 5.5144 2.299
NCI-H520 CTRP2 6.0804 9.2999 4.4466 6.6467
LC-1/sq-SF CTRP2 6.3675 7.83 5.4045 2.1267
NCI-H1105 CTRP2 6.4536 18.0831 0.3625 21.2404
NCI-H2110 CTRP2 6.4556 12.3975 3.2038 11.1098
NCI-H2126 CTRP2 6.4901 7.9677 5.4241 1.8622
CAL-12T CTRP2 6.5989 11.4016 3.8127 8.3515
NCI-H2030 CTRP2 6.653 8.704 5.1812 2.6082
NCI-H1395 CTRP2 6.668 13.8569 2.6449 12.9478
HCC2279 CTRP2 6.7328 9.9423 4.6352 4.7195
HCC2108 CTRP2 6.8592 10.261 4.5706 4.7877
NCI-H2342 CTRP2 6.8784 10.3235 4.5538 4.827
NCI-H889 CTRP2 6.9824 11.6964 3.9569 7.113
RERF-LC-Ad1 CTRP2 7.0286 7.8842 5.7592 0.1993
COR-L105 CTRP2 7.0524 9.6816 4.9816 2.8551
NCI-H1869 CTRP2 7.1188 9.1886 5.2518 1.7407
NCI-H526 CTRP2 7.1532 8.6773 5.4968 0.851
NCI-H69 CTRP2 7.1717 14.3505 2.7893 11.4993
NCI-H727 CTRP2 7.2144 9.8779 4.9928 3.553
BEN CTRP2 7.2405 8.2406 5.7127 0.2883
RERF-LC-Ad2 CTRP2 7.2639 12.6412 3.6989 7.7183
Lu-65 CTRP2 7.3656 16.721 1.7632 14.9952
RERF-LC-MS CTRP2 7.371 10.3982 4.8487 2.9681
HCC95 CTRP2 7.4594 9.1514 5.4517 1.0332
A-549 CTRP2 7.4865 11.3632 4.4694 4.2984
MOR/CPR CTRP2 7.4975 8.3675 5.7649 0.0664
NCI-H1915 CTRP2 7.5607 12.6 3.9281 6.3485
LCLC-103H CTRP2 7.6669 8.8023 5.6751 0.1989
NCI-H196 CTRP2 7.7339 14.2523 3.249 8.7913
NCI-H650 CTRP2 7.7719 12.8212 3.965 7.9816
SHP-77 CTRP2 7.7909 9.0692 5.6269 0.2562
LUDLU-1 CTRP2 7.8121 19.3186 0.8168 17.4002
NCI-H460 CTRP2 7.8345 9.0644 5.6451 0.1493
HCC78 CTRP2 7.8632 9.4411 5.5186 0.4986
HCC1171 CTRP2 7.8827 13.4472 3.7403 6.637
NCI-H2122 CTRP2 7.9082 9.4994 5.5153 0.3546
NCI-H1339 CTRP2 7.9085 15.0726 2.9737 9.6003
NCI-H2291 CTRP2 7.9215 12.0337 4.432 3.8944
COR-L88 CTRP2 7.9665 26.7686 -2.7627 26.0899
NCI-H1435 CTRP2 7.9897 9.4713 5.5584 0.2442
NCI-H2009 CTRP2 7.9977 12.8832 4.0836 6.9568
NCI-H2286 CTRP2 8.0377 9.7277 5.483 0.3701
NCI-H1838 CTRP2 8.0868 10.1245 5.3517 0.6479
NCI-H441 CTRP2 8.1033 10.0432 5.3905 0.5452
NCI-H1755 CTRP2 8.1906 14.1219 3.6237 6.6703
SK-LU-1 CTRP2 8.224 9.8027 5.5293 0.2251
LOU-NH91 CTRP2 8.2299 11.3383 4.9204 1.8224
NCI-H1623 CTRP2 8.2514 14.1308 3.6594 6.4511
NCI-H1734 CTRP2 8.2677 12.3358 4.5015 3.2442
NCI-H1944 CTRP2 8.3494 21.3086 0.2378 18.2707
COLO 699 CTRP2 8.3635 9.9914 5.5148 0.2879
Calu-6 CTRP2 8.4119 9.9519 5.5468 0.1566
NCI-H1792 CTRP2 8.4236 9.9583 5.5488 0.1518
NCI-H1299 CTRP2 8.4954 10.1228 5.5176 0.1771
NCI-H1651 CTRP2 8.5358 10.8331 5.2725 0.6148
NCI-H1373 CTRP2 8.57 10.3105 5.4792 0.2133
HCC366 CTRP2 8.5813 13.9588 3.9484 6.6604
NCI-H292 CTRP2 8.5881 10.4515 5.4357 0.2746
NCI-H2172 CTRP2 8.5901 10.2343 5.5133 0.1634
NCI-H2023 CTRP2 8.6287 10.2931 5.507 0.1638
EBC-1 CTRP2 8.6656 10.467 5.4595 0.2188
NCI-H2085 CTRP2 8.7215 10.7279 5.3874 0.316
NCI-H661 CTRP2 8.9327 11.0305 5.3597 0.3016
NCI-H1184 CTRP2 8.9505 10.7997 5.4478 0.1747
NCI-H23 CTRP2 9.5603 25.1132 -0.7424 19.0924
DMS 273 CTRP2 10.0989 22.5882 0.8588 13.8008
NCI-H322 CTRP2 10.8117 21.9975 1.6044 10.5281
Hs 888.Lu CTRP2 6.6448 14.5976 2.2572 14.4764
⏷ Show the Full List of 130 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 3.5443 16.0024 -1.1457 31.4759
A2780 CTRP2 1.7257 3.9102 1.7002 28.8569
OV7 CTRP2 2.524 9.4219 0.9487 28.8207
COV434 CTRP2 2.6404 4.8074 2.5797 22.8832
TYK-nu CTRP2 2.7519 5.9418 2.4787 22.8851
SNU-119 CTRP2 3.6161 5.7464 3.4694 16.6847
OVCAR-5 CTRP2 3.6849 5.5773 3.5802 16.0788
COV362 CTRP2 4.1559 7.2594 3.5596 14.7748
HEY A8 CTRP2 4.3084 9.8556 2.5515 18.3289
OC 314 CTRP2 4.3418 5.9548 4.21 11.8016
EFO-21 CTRP2 4.5125 9.6968 2.8247 16.7606
JHOS-2 CTRP2 4.9681 9.3395 3.4319 13.2396
SNU-840 CTRP2 4.9686 7.9539 4.0922 10.5493
EFO-27 CTRP2 5.1302 7.2412 4.5804 8.1804
JHOM-1 CTRP2 5.9313 10.9256 3.5089 10.8564
OVCAR-8 CTRP2 6.3643 7.6985 5.4664 1.8772
OV56 CTRP2 6.8644 8.9939 5.1842 2.3054
COV644 CTRP2 6.9958 11.2126 4.2039 6.0788
OV-90 CTRP2 7.1393 9.829 4.9682 2.7955
OAW42 CTRP2 7.1809 11.7098 4.0939 6.2423
SNU-8 CTRP2 7.2466 8.8893 5.4548 1.2396
TOV-21G CTRP2 7.2546 9.0195 5.4032 1.0714
ES2 CTRP2 7.3534 9.3068 5.3316 1.6675
JHOC-5 CTRP2 7.481 9.0669 5.4964 0.6158
FU-OV-1 CTRP2 7.5572 11.0688 4.6532 3.491
DOV13 CTRP2 7.5921 10.0067 5.1559 2.1832
IGROV-1 CTRP2 7.7313 11.8658 4.3908 4.2877
OVISE CTRP2 7.8586 8.9015 5.7102 0.0933
SK-OV-3 CTRP2 8.1167 10.1567 5.3523 0.6305
TOV-112D CTRP2 8.1462 14.7465 3.2958 8.004
ONCO-DG-1 CTRP2 8.212 9.8586 5.5044 0.3673
OVK18 CTRP2 8.2806 11.9479 4.6821 2.5862
Caov-3 CTRP2 8.4532 9.64 5.6669 0.0414
RMG-I CTRP2 8.5041 10.4646 5.398 0.366
Kuramochi CTRP2 8.533 12.9634 4.3728 4.6561
OVTOKO CTRP2 8.6864 10.3722 5.5004 0.2192
OVCAR-4 CTRP2 8.7454 10.5188 5.4709 0.1861
MCAS CTRP2 8.8263 10.4867 5.5111 0.1253
OVSAHO CTRP2 8.9346 10.2076 5.6408 0.0357
OAW28 CTRP2 9.4164 11.1122 5.5045 0.0647
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.1983 9.1858 5.2992 1.4842
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 7.2548 14.9561 2.5527 12.2729
SYO-1 CTRP2 10.3515 20.5003 2.0131 9.746
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.7362 12.8565 3.9242 6.115
Aska-SS CTRP2 7.9228 14.175 3.4181 7.8471
A-204 CTRP2 -0.0276 4.3704 -0.2116 40.9272
G-402 CTRP2 0.9917 7.0216 0.2355 35.8745
TE 617.T CTRP2 2.2669 3.9493 2.256 25.2026
HT-1080 CTRP2 2.5449 2.9874 2.5449 23.3139
TE 441.T CTRP2 2.6369 9.2025 1.1597 27.8183
KYM-1 CTRP2 3.0296 3.8032 3.0294 20.0856
GCT CTRP2 3.042 4.0327 3.0408 20.0065
Rh18 CTRP2 3.342 4.543 3.3343 18.0294
G-401 CTRP2 3.5165 9.1401 2.0917 22.1101
TTC-709 CTRP2 3.9134 12.7766 0.7711 25.5718
Hs 729.T CTRP2 4.8898 10.9963 2.5508 16.9502
BT-12 CTRP2 7.0276 7.8297 5.7792 0.1593
MES-SA CTRP2 7.0438 8.9683 5.3075 1.6178
Rh41 CTRP2 7.2075 13.4256 3.2726 12.7273
SK-LMS-1 CTRP2 7.388 14.4397 2.9071 10.6793
RKN CTRP2 7.4957 8.7577 5.6238 0.2942
SW982 CTRP2 7.5097 8.9395 5.5599 0.4338
SK-UT-1 CTRP2 7.8005 16.1533 2.3683 12.069
Tm87-16 CTRP2 7.9328 19.241 0.9462 16.7874
BT-16 CTRP2 8.0661 9.264 5.6599 0.088
RD CTRP2 9.6669 19.7995 1.901 11.004
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 2.7012 5.2966 2.5695 30.9628
NCI-H2452 CTRP2 3.6112 6.278 3.3217 17.2315
MPP 89 CTRP2 4.5766 9.2682 3.0905 15.5486
JL-1 CTRP2 6.6067 13.1785 2.9344 11.9177
IST-Mes1 CTRP2 7.4 10.5143 4.8128 3.0705
MSTO-211H CTRP2 7.9318 11.3153 4.7661 2.6404
NCI-H2052 CTRP2 8.1207 10.2234 5.328 0.6894
ACC-MESO-1 CTRP2 8.6672 16.4669 2.8236 11.9035
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 2.2364 5.5977 2.0015 26.1753
PaCa-3 CTRP2 3.891 5.8858 3.7357 14.8857
DU145 CTRP2 6.135 11.6887 3.2973 11.3304
VCaP CTRP2 6.2201 7.7909 5.3129 2.752
22Rv1 CTRP2 8.9149 10.6394 5.4903 0.1816
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 4.5181 9.8508 2.7566 17.0161
YD-15 CTRP2 7.4708 8.5333 5.6967 0.1644
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 -0.7561 1.6308 -0.7603 45.3161
HGC-27 CTRP2 2.6211 4.1676 2.6104 22.8423
GSS CTRP2 2.9106 4.5377 2.8893 28.56
KATO III CTRP2 3.8396 11.2293 1.4446 23.5658
MKN7 CTRP2 3.8793 7.1276 3.3174 16.471
NUGC-4 CTRP2 3.9006 8.5331 2.7529 18.5878
MKN1 CTRP2 3.932 6.0645 3.7335 20.1325
Hs 746.T CTRP2 3.9711 12.3468 1.0338 24.5979
SNU-601 CTRP2 4.0322 6.7158 3.6343 14.8384
SNU-216 CTRP2 4.6488 6.5922 4.3432 10.403
SNU-1 CTRP2 4.7953 11.3365 2.2969 18.1472
HuG1-N CTRP2 5.2532 9.7435 3.5002 12.313
SH-10-TC CTRP2 6.0407 8.7551 4.686 5.717
KE-39 CTRP2 6.2074 10.8117 3.7952 9.134
GSU CTRP2 6.7124 7.4331 5.7963 0.3653
23132/87 CTRP2 6.8967 8.4363 5.4619 1.6518
ECC12 CTRP2 6.9852 8.384 5.5344 1.188
MKN45 CTRP2 7.1335 8.67 5.4896 1.2143
SNU-719 CTRP2 7.2504 10.6045 4.6741 3.8055
AGS CTRP2 7.3361 8.8738 5.5061 0.6836
SNU-5 CTRP2 7.4014 12.3798 3.924 6.5984
LMSU CTRP2 7.4987 17.8767 1.2922 16.3891
MKN74 CTRP2 7.5103 10.6472 4.8196 2.9116
SNU-620 CTRP2 7.7088 8.9245 5.6474 0.2422
SNU-668 CTRP2 8.0435 9.5374 5.5554 0.2332
NUGC-3 CTRP2 8.4869 10.0997 5.5226 0.1724
IM95 CTRP2 8.618 15.2263 3.3802 7.0384
SNG-M CTRP2 4.7841 6.8078 4.4052 9.7874
SNU-1077 CTRP2 6.8909 8.623 5.3736 2.1047
SNU-685 CTRP2 10.9829 20.9736 2.1836 8.4354
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 CTRP2 0.1284 6.6555 -0.5886 52.7186
SW579 CTRP2 0.7429 7.355 -0.1457 37.7162
8505C CTRP2 2.5335 5.2514 2.3966 23.858
ML-1 [Human leukemia] CTRP2 4.3017 6.1932 4.0999 12.3215
FTC-133 CTRP2 4.6249 7.7689 3.831 12.463
B-CPAP CTRP2 6.6525 13.9547 2.5839 17.3854
8305C CTRP2 6.7355 13.858 2.6975 16.65
TT CTRP2 6.9786 10.7936 4.3961 5.3186
FTC-238 CTRP2 7.5802 14.5526 2.9924 10.0361
BHT-101 CTRP2 7.6911 9.3273 5.4885 0.5157
TT2609-C02 CTRP2 8.2588 15.9153 2.8103 9.7028
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-4 CTRP2 2.5029 2.9598 2.5029 23.5941
YD-8 CTRP2 3.5074 5.7358 3.3534 17.4341
SCC-4 CTRP2 3.5967 5.808 3.4338 16.8713
FaDu CTRP2 3.8536 5.4338 3.7883 14.8181
PE/CA-PJ49 CTRP2 4.9684 7.8814 4.1256 10.4146
CAL-33 CTRP2 5.3633 7.5305 4.6783 7.2077
BICR 16 CTRP2 5.6667 7.4109 5.0256 5.0718
BICR 22 CTRP2 6.0386 7.7705 5.1765 3.6591
BICR 6 CTRP2 6.1344 9.4444 4.4188 6.6606
BICR 56 CTRP2 6.5678 9.8004 4.5828 5.2043
SNU-1076 CTRP2 6.7825 8.0662 5.5622 1.321
PE/CA-PJ34 (clone C12) CTRP2 6.9227 10.0262 4.7294 4.0446
BHY CTRP2 7.0924 9.3713 5.152 2.9247
BICR 31 CTRP2 7.1372 9.4387 5.1484 2.1063
CAL-27 CTRP2 7.3754 9.1408 5.4143 0.9347
HSC-3 CTRP2 7.3849 9.0153 5.4715 1.0248
Detroit 562 CTRP2 7.4151 9.3054 5.3648 1.4459
SNU-1041 CTRP2 7.5109 9.3247 5.4052 1.172
BICR 18 CTRP2 7.6273 16.8669 1.889 14.1027
SNU-1066 CTRP2 7.9529 9.6036 5.4946 0.5177
YD-10B CTRP2 8.0519 9.9154 5.4176 0.5064
SCC-25 CTRP2 8.0526 10.5602 5.1591 1.2074
SNU-899 CTRP2 8.2516 9.3541 5.6935 0.0408
PE/CA-PJ41 (clone D2) CTRP2 8.2699 9.8061 5.5454 0.1892
PE/CA-PJ15 CTRP2 8.2908 14.0713 3.7131 6.1921
SNU-46 CTRP2 8.625 10.1078 5.5693 0.0971
SNU-1214 CTRP2 8.9157 10.7729 5.4445 0.1854
SCC-9 CTRP2 11.0481 23.151 1.2148 11.4733
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP2 2.4417 2.9783 2.4417 24.0016
253J CTRP2 2.7417 3.3474 2.7417 29.9964
U-BLC1 CTRP2 3.0629 4.5031 3.0492 19.9088
VM-CUB-1 CTRP2 3.6972 5.6604 3.5766 21.8839
TCCSUP CTRP2 4.3282 7.0665 3.819 13.3017
KMBC-2 CTRP2 4.4249 6.2546 4.2154 11.5312
BC-3C CTRP2 4.6456 10.93 2.3563 18.2689
CAL-29 CTRP2 4.8933 5.9521 4.8121 10.8389
UM-UC-1 CTRP2 4.9745 11.8304 2.2177 18.0395
JMSU-1 CTRP2 5.6592 11.4079 3.0353 17.8788
T24 CTRP2 6.2153 13.6951 2.3605 14.8973
5637 CTRP2 6.5193 10.6676 4.1156 7.2323
647V CTRP2 7.3824 10.1562 4.9676 2.5022
SCaBER CTRP2 7.5398 10.2737 5.0077 2.179
RT-112 CTRP2 7.6579 10.4219 5.0091 2.0512
KU-19-19 CTRP2 7.6744 16.694 2.0094 17.4943
HT-1197 CTRP2 7.832 15.916 2.5075 11.4981
639V CTRP2 8.0248 13.924 3.6078 9.3386
HT-1376 CTRP2 8.3726 10.3531 5.3862 0.4373
RT-4 CTRP2 8.4723 10.0264 5.5428 0.1498
SW1710 CTRP2 8.5417 10.6243 5.354 0.4375
J82 CTRP2 13.7003 27.696 0.7373 9.9618
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4268 8.4294 5.7172 0.1435

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Regorafenib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Regorafenib and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [12]
Arn-509 DMT81LZ Moderate Increased metabolism of Regorafenib caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [13]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Regorafenib and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [14]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Regorafenib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [12]
Pexidartinib DMS2J0Z Major Decreased metabolism of Regorafenib caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [15]
Talazoparib DM1KS78 Moderate Decreased clearance of Regorafenib due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [16]
Tucatinib DMBESUA Moderate Decreased metabolism of Regorafenib caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [12]
Levomilnacipran DMV26S8 Moderate Increased risk of bleeding by the combination of Regorafenib and Levomilnacipran. Chronic pain [MG30] [17]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Regorafenib caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [18]
Vortioxetine DM6F1PU Moderate Increased risk of bleeding by the combination of Regorafenib and Vortioxetine. Depression [6A70-6A7Z] [17]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Regorafenib and Cannabidiol. Epileptic encephalopathy [8A62] [19]
Tazemetostat DMWP1BH Major Increased risk of bleeding by the combination of Regorafenib and Tazemetostat. Follicular lymphoma [2A80] [19]
Avapritinib DMK2GZX Major Increased risk of bleeding by the combination of Regorafenib and Avapritinib. Gastrointestinal stromal tumour [2B5B] [19]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Regorafenib caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [12]
Dolutegravir DMCZGRE Minor Decreased metabolism of Regorafenib caused by Dolutegravir mediated inhibition of UGT. Human immunodeficiency virus disease [1C60-1C62] [20]
Berotralstat DMWA2DZ Major Decreased clearance of Regorafenib due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [21]
Naloxegol DML0B41 Minor Decreased clearance of Regorafenib due to the transporter inhibition by Naloxegol. Large intestine motility disorder [DB32] [22]
Ceritinib DMB920Z Moderate Decreased metabolism of Regorafenib caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [12]
PF-06463922 DMKM7EW Moderate Increased metabolism of Regorafenib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [23]
Selpercatinib DMZR15V Moderate Decreased metabolism of Regorafenib caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [24]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Regorafenib and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [25]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Regorafenib and Idelalisib. Mature B-cell leukaemia [2A82] [26]
GDC-0199 DMH0QKA Major Decreased clearance of Regorafenib due to the transporter inhibition by GDC-0199. Mature B-cell leukaemia [2A82] [12]
IPI-145 DMWA24P Moderate Decreased metabolism of Regorafenib caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [27]
Acalabrutinib DM7GCVW Major Increased risk of bleeding by the combination of Regorafenib and Acalabrutinib. Mature B-cell lymphoma [2A85] [19]
Ibrutinib DMHZCPO Major Increased risk of bleeding by the combination of Regorafenib and Ibrutinib. Mature B-cell lymphoma [2A85] [19]
Ponatinib DMYGJQO Major Increased risk of bleeding by the combination of Regorafenib and Ponatinib. Mature B-cell lymphoma [2A85] [19]
Arry-162 DM1P6FR Major Increased risk of bleeding by the combination of Regorafenib and Arry-162. Melanoma [2C30] [19]
LGX818 DMNQXV8 Major Increased risk of bleeding by the combination of Regorafenib and LGX818. Melanoma [2C30] [19]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Regorafenib caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [19]
Ubrogepant DM749I3 Moderate Decreased clearance of Regorafenib due to the transporter inhibition by Ubrogepant. Migraine [8A80] [28]
Rimegepant DMHOAUG Moderate Decreased clearance of Regorafenib due to the transporter inhibition by Rimegepant. Migraine [8A80] [29]
Fedratinib DM4ZBK6 Major Increased risk of bleeding by the combination of Regorafenib and Fedratinib. Myeloproliferative neoplasm [2A20] [19]
Vorapaxar DMA16BR Major Increased risk of bleeding by the combination of Regorafenib and Vorapaxar. Myocardial infarction [BA41-BA43] [19]
Abametapir DM2RX0I Moderate Decreased metabolism of Regorafenib caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [30]
Lefamulin DME6G97 Moderate Decreased metabolism of Regorafenib caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [31]
Enzalutamide DMGL19D Moderate Increased metabolism of Regorafenib caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [13]
Larotrectinib DM26CQR Moderate Decreased metabolism of Regorafenib caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [12]
Fostamatinib DM6AUHV Moderate Decreased clearance of Regorafenib due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [32]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Regorafenib due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [33]
Betrixaban DM2C4RF Major Increased risk of bleeding by the combination of Regorafenib and Betrixaban. Venous thromboembolism [BD72] [19]
⏷ Show the Full List of 41 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Regorafenib 40 mg tablet 40 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Regorafenib FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5891).
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Stegeman BH, Vos HL, Helmerhorst FM, Rosendaal FR, Reitsma PH, van Hylckama Vlieg A: Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk. Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019. Epub 2017 Jun 1.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2. Biol Pharm Bull. 2015;38(4):582-6.
7 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913)
8 Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). Pharm Res. 2015 Jul;32(7):2205-16.
9 FDA Label of Regorafenib. The 2020 official website of the U.S. Food and Drug Administration.
10 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
11 Regorefenib induces extrinsic/intrinsic apoptosis and inhibits MAPK/NF-B-modulated tumor progression in bladder cancer in vitro and in vivo. Environ Toxicol. 2019 Jun;34(6):679-688. doi: 10.1002/tox.22734. Epub 2019 Feb 25.
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16 Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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21 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
22 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
23 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
24 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
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26 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
27 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
28 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
29 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
30 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
31 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
32 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
33 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".