Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI6KQM)

Drug Name
GSK1059615 Drug Info
Synonyms KS-00001CUQ; CTK8F0346; HMS3654N17; BCP02498; AKOS026750445; NCGC00346509-01; FT-0669060
Cross-matching ID
PubChem CID
23582824
ChEBI ID
CHEMBL71955
CAS Number
CAS 958852-01-2
TTD Drug ID
D0L0ZC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Starch and sucrose metabolism -1.76 3.80e-3 25/36 (69.44%) GBE1;AGL;G6PC3;...
Folate biosynthesis -1.77 3.93e-3 23/26 (88.46%) CBR1;AKR1C3;FPGS;...
Ferroptosis -1.77 4.06e-3 36/41 (87.8%) VDAC2;GCLC;NCOA4;...
Peroxisome -1.79 3.27e-3 72/82 (87.8%) PEX26;CAT;NOS2;...
Diabetic cardiomyopathy -1.80 2.64e-3 162/203 (79.8%) MAPK9;NCF4;NDUFB8;...
Tryptophan metabolism -1.82 1.57e-3 35/42 (83.33%) MAOB;KMO;DDC;...
Glycine, serine and threonine metabolism -1.83 1.64e-3 31/40 (77.5%) GLDC;ALAS1;MAOB;...
Amyotrophic lateral sclerosis -1.83 1.71e-3 267/364 (73.35%) SIGMAR1;ACTB;COX7A2;...
Fatty acid elongation -1.84 1.78e-3 19/27 (70.37%) ECHS1;ELOVL1;ELOVL5;...
Ribosome biogenesis in eukaryotes -1.85 1.40e-3 52/108 (48.15%) CSNK2A1;NAT10;RRP7A;...
Galactose metabolism -1.85 1.47e-3 26/31 (83.87%) GLB1;G6PC3;HKDC1;...
Cysteine and methionine metabolism -1.88 1.55e-3 43/50 (86%) MDH2;LDHC;GCLC;...
Pyruvate metabolism -1.92 1.09e-3 41/47 (87.23%) PDHA1;ALDH1B1;LDHA;...
Amino sugar and nucleotide sugar metabolism -2.00 0.00e+0 38/48 (79.17%) GFPT1;HEXB;CYB5R2;...
Pentose phosphate pathway -2.02 0.00e+0 25/30 (83.33%) ALDOB;PRPS1;PGM1;...
Valine, leucine and isoleucine degradation -2.02 0.00e+0 42/48 (87.5%) ALDH1B1;DBT;ECHS1;...
Terpenoid backbone biosynthesis -2.07 0.00e+0 18/22 (81.82%) MVD;MVK;ACAT1;...
Huntington disease -2.10 0.00e+0 233/306 (76.14%) VDAC2;CREB5;AP2M1;...
Citrate cycle (TCA cycle) -2.10 0.00e+0 30/30 (100%) PDHA1;ACO2;OGDH;...
Arginine and proline metabolism -2.11 0.00e+0 39/50 (78%) ALDH18A1;ALDH2;CNDP2;...
Fructose and mannose metabolism -2.16 0.00e+0 30/33 (90.91%) FPGT;HK1;ALDOB;...
Biosynthesis of unsaturated fatty acids -2.17 0.00e+0 21/27 (77.78%) HACD3;SCP2;HSD17B4;...
Glutathione metabolism -2.18 0.00e+0 43/57 (75.44%) ANPEP;GSR;PRDX6;...
PPAR signaling pathway -2.19 0.00e+0 66/74 (89.19%) APOA2;SCP2;PPARG;...
Prion disease -2.29 0.00e+0 209/273 (76.56%) MAPK9;NCF4;NCAM1;...
Oxidative phosphorylation -2.32 0.00e+0 93/133 (69.92%) ATP6V0C;COX7A2;ATP5F1A;...
Glycolysis / Gluconeogenesis -2.35 0.00e+0 56/67 (83.58%) PDHA1;HKDC1;ALDH1B1;...
Parkinson disease -2.39 0.00e+0 176/249 (70.68%) KIF5B;GNAI3;ATP5F1A;...
Steroid biosynthesis -2.50 0.00e+0 19/20 (95%) HSD17B7;SOAT1;LIPA;...
Proteasome -2.55 0.00e+0 44/46 (95.65%) PSMC5;PSMB7;PSMB9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 3.33uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H