Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIK6C9)

Drug Name
Zibotentan Drug Info
Synonyms
ZD4054; ZD-4054; ZD4054, Zibotentan; Zibotentan (JAN/INN); Trans,trans-2(4-methoxyphenyl)-4-(1-3-benzodiazol-5-yl)-1-(dibutylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid; N-(3-methoxy-5-methyl-pyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
Cross-matching ID
PubChem CID
9910224
ChEBI ID
CHEMBL1628688
CAS Number
CAS 186497-07-4
TTD Drug ID
D02HVW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PD-L1 expression and PD-1 checkpoint pathway in cancer 2.09 0.00e+0 79/89 (88.76%) STAT3;RASGRP1;PTEN;...
T cell receptor signaling pathway 2.01 0.00e+0 93/104 (89.42%) RASGRP1;PRKCQ;NFATC3;...
Ferroptosis -1.62 4.46e-2 36/41 (87.8%) GPX4;ACSL1;GCLM;...
Glycerophospholipid metabolism -1.62 4.37e-2 71/98 (72.45%) DGKD;LPIN2;CDS2;...
Alanine, aspartate and glutamate metabolism -1.62 4.57e-2 27/37 (72.97%) GFPT1;NIT2;ASPA;...
Folate biosynthesis -1.63 4.38e-2 23/26 (88.46%) FPGS;GGH;MOCOS;...
Retinol metabolism -1.65 3.92e-2 41/68 (60.29%) DGAT1;UGT2B4;UGT2B15;...
Mineral absorption -1.67 3.46e-2 48/60 (80%) ATP7A;MT1HL1;ATP7B;...
Vitamin digestion and absorption -1.68 3.05e-2 17/24 (70.83%) APOB;SLC19A3;LMBRD1;...
Ether lipid metabolism -1.68 3.22e-2 32/49 (65.31%) GDPD3;PLA2G2D;PLPP2;...
Porphyrin and chlorophyll metabolism -1.69 2.97e-2 23/43 (53.49%) ALAS1;ALAS2;UGT2B28;...
Amino sugar and nucleotide sugar metabolism -1.73 2.04e-2 38/48 (79.17%) CYB5R3;CYB5R1;UGP2;...
Glutathione metabolism -1.73 2.25e-2 43/57 (75.44%) PRDX6;GSTO1;GSTM2;...
Staphylococcus aureus infection -1.74 2.41e-2 72/95 (75.79%) DEFA5;CFB;DEFA4;...
Linoleic acid metabolism -1.75 1.94e-2 21/29 (72.41%) CYP2C8;PLA2G2D;CYP3A4;...
Cholesterol metabolism -1.79 1.55e-2 44/50 (88%) APOA2;ABCA1;APOB;...
Fructose and mannose metabolism -1.84 1.03e-2 30/33 (90.91%) PFKP;AKR1B10;ALDOA;...
Galactose metabolism -1.85 1.09e-2 26/31 (83.87%) UGP2;G6PC3;GAA;...
Metabolism of xenobiotics by cytochrome P450 -1.89 1.94e-3 49/77 (63.64%) UGT2B4;GSTA3;UGT2B15;...
PPAR signaling pathway -1.92 2.58e-3 66/74 (89.19%) ACSL1;APOC3;PLIN2;...
Steroid hormone biosynthesis -2.10 0.00e+0 43/61 (70.49%) CYP11A1;HSD17B6;COMT;...
Arachidonic acid metabolism -2.10 0.00e+0 48/61 (78.69%) PTGS2;CYP2C9;CBR3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H