Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMILWZR)

Drug Name
Rosiglitazone Drug Info
Cross-matching ID
PubChem CID
77999
ChEBI ID
CHEMBL121
CAS Number
CAS 122320-73-4
VARIDT Drug ID
DR01221

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.14 0.00e+0 101/150 (67.33%) LSM5;SNRPB;LSM7;...
Ribosome biogenesis in eukaryotes 2.12 3.35e-3 52/108 (48.15%) DKC1;NOP56;NVL;...
Hedgehog signaling pathway 1.90 8.94e-3 43/56 (76.79%) GAS1;CSNK1A1;CSNK1G2;...
Steroid biosynthesis 1.88 1.01e-2 19/20 (95%) NSDHL;SQLE;DHCR7;...
VEGF signaling pathway -1.76 3.36e-2 50/59 (84.75%) NRAS;PLCG1;RAC2;...
Antigen processing and presentation -1.79 2.04e-2 60/78 (76.92%) TAP2;HLA-DMB;PSME2;...
Type I diabetes mellitus -1.81 1.84e-2 38/43 (88.37%) HLA-DOA;CD80;HLA-A;...
Proximal tubule bicarbonate reclamation -1.86 1.12e-2 21/23 (91.3%) GLS2;GLUD1;ATP1B2;...
Lysosome -1.86 1.27e-2 115/128 (89.84%) TPP1;AP1B1;SLC17A5;...
Tryptophan metabolism -1.88 1.27e-2 35/42 (83.33%) ECHS1;ALDH7A1;AOX1;...
Other glycan degradation -1.88 1.27e-2 13/18 (72.22%) MAN2B1;GLB1;MANBA;...
Intestinal immune network for IgA production -1.89 1.27e-2 38/48 (79.17%) CCR9;HLA-DMB;HLA-DPB1;...
Mitophagy -1.89 1.70e-2 56/68 (82.35%) RELA;MRAS;TAX1BP1;...
Autoimmune thyroid disease -1.91 1.91e-2 46/53 (86.79%) FASLG;HLA-DMB;HLA-DPB1;...
Allograft rejection -1.95 3.82e-2 32/38 (84.21%) IL10;HLA-DOA;CD80;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 80uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 80uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 80uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 80uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 80uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H