Details of the Drug

General Information of Drug (ID: DMILWZR)

Drug Name
Rosiglitazone
Indication
Disease Entry ICD 11 Status REF
Chronic kidney disease GB61 Terminated []
Affected Organisms
Humans and other mammals
ATC Code
A10BG02: Rosiglitazone
A10BG: Thiazolidinediones
A10B: BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10: DRUGS USED IN DIABETES
A: ALIMENTARY TRACT AND METABOLISM
ADMET Property
Clearance
The apparent oral clearance of drug is 3.03 +/- 0.87 L/h []
Half-life
The concentration or amount of drug in body reduced by one-half in 3 - 4 hours [1]
Metabolism
The drug is metabolized via the hepatic []
Vd
The volume of distribution (Vd) of drug is 17.6 L []
Chemical Identifiers
Formula
C18H19N3O3S
IUPAC Name
5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Canonical SMILES
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
InChI
InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChIKey
YASAKCUCGLMORW-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
77999
ChEBI ID
CHEBI:50122
CAS Number
122320-73-4
UNII
05V02F2KDG
DrugBank ID
DB00412
VARIDT ID
DR01221
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [4]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) OT5CTQKO PLCD_HUMAN Gene/Protein Processing [6]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [7]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [8]
2-acylglycerol O-acyltransferase 3 (MOGAT3) OTPGLUBS MOGT3_HUMAN Gene/Protein Processing [9]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Gene/Protein Processing [9]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [10]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Gene/Protein Processing [9]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Gene/Protein Processing [9]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Gene/Protein Processing [9]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Gene/Protein Processing [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 8.6484 12.1921 6.4606 11.9353
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.4966 7.9541 4.5622 1.0268
GaMG CTRP1 6.5122 9.5693 3.869 5.9466
LN-229 CTRP1 8.9941 12.0109 6.7975 7.9716
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 CTRP1 5.9031 8.5635 3.9504 6.9626
HEC-6 CTRP1 6.3195 8.0392 4.4419 2.0356
HEC-108 CTRP1 6.4514 8.4911 4.3172 2.6695
HEC-265 CTRP1 6.8575 7.832 4.7476 0.1088
HEC-251 CTRP1 7.1149 8.5168 4.604 0.3563
HEC-151 CTRP1 7.4016 10.6598 6.1769 19.6026
KLE CTRP1 7.4406 9.4888 4.3772 0.9959
HEC-59 CTRP1 7.6017 8.9737 4.6208 0.1507
JHUEM-2 CTRP1 8.0691 9.3227 7.4355 5.5767
Ishikawa (Heraklio) 02 ER- CTRP1 5.7167 6.9109 4.6066 2.0259
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BL-70 CTRP1 6.134 7.1993 4.6971 0.716
NU-DUL-1 CTRP1 6.4622 33.8446 -6.1875 46.2139
HT CTRP1 6.4678 10.5602 3.3753 9.9481
MC116 CTRP1 6.5441 7.3296 4.8083 0.0795
Ku812 CTRP1 6.7337 8.4458 4.4746 1.2269
KE-97 CTRP1 6.739 8.0097 4.6424 0.4404
P3HR-1 CTRP1 6.9139 8.8244 4.4062 1.3897
SU-DHL-5 CTRP1 7.1661 8.2456 7.0279 13.8107
GDM-1 CTRP1 7.3223 10.4731 6.1938 19.8718
SKM-1 CTRP1 7.5428 8.2774 7.4239 8.2973
RPMI-8226 CTRP1 7.5626 10.099 6.6006 15.2946
WSU-DLCL2 CTRP1 7.6933 9.1242 7.1975 9.4223
KMS-11 CTRP1 7.7399 9.7634 6.9281 11.5847
LP-1 CTRP1 7.7674 8.8926 7.3797 7.4454
PL21 CTRP1 7.7823 8.4845 7.5872 5.5548
OCI-AML-3 CTRP1 7.839 9.3201 7.2369 8.3723
U-937 CTRP1 7.968 9.4443 7.2891 7.3243
THP-1 CTRP1 7.9972 9.1699 7.4512 5.7385
MOLM-16 CTRP1 8.1686 9.2929 7.5308 4.3255
NOMO-1 CTRP1 8.1686 9.7767 7.2896 6.4926
EJM CTRP1 8.2903 10.0862 7.231 6.5557
SU-DHL-4 CTRP1 8.4881 10.9147 6.9711 8.1468
AMO1 CTRP1 8.5086 10.6258 7.1282 6.6951
OCI-Ly10 CTRP1 9.4502 12.8493 6.7002 7.4464
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.3028 9.0159 4.4968 0.6094
RCC10RGB CTRP1 8.8326 10.8298 7.253 4.6141
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 CTRP1 6.7774 8.5018 4.4721 1.1895
DLD-1 CTRP1 6.8596 7.8179 4.7531 0.0995
SNU-C2A CTRP1 6.8636 11.2074 3.327 9.2031
COLO205 CTRP1 6.8823 8.1147 4.6593 0.3045
SW620 CTRP1 7.0041 8.6591 6.7022 17.4354
LS513 CTRP1 7.1524 8.6136 4.5838 0.3994
LS411N CTRP1 7.1996 8.1675 4.7518 0.0486
GP2d CTRP1 7.2759 8.8583 4.5433 0.463
SW48 CTRP1 7.3786 9.0915 4.4989 0.554
SW403 CTRP1 7.4312 9.559 4.3467 1.1446
C2BBe1 CTRP1 7.4525 9.1409 4.5094 0.4767
SW480 CTRP1 7.5101 10.4359 6.387 17.357
HCT 116 CTRP1 7.7492 10.0613 6.7892 12.7678
COLO 320 CTRP1 7.8554 10.0723 6.878 11.4998
CW-2 CTRP1 7.8588 9.5081 7.1615 8.956
LS180 CTRP1 7.9598 9.0717 7.4677 5.7533
SNU-1040 CTRP1 8.1276 10.7602 6.7651 11.3335
SNU-81 CTRP1 8.1381 9.3421 7.4821 4.8808
HCT 8 CTRP1 8.1685 9.7299 7.3129 6.2838
SNU-175 CTRP1 8.1822 9.4523 7.4621 4.8897
SNU-C4 CTRP1 8.1991 10.496 6.9551 9.3672
SNU-61 CTRP1 8.231 10.7784 6.8398 10.2626
HT-55 CTRP1 8.2671 10.0915 7.2105 6.8254
LS123 CTRP1 8.3131 9.934 7.3239 5.6439
SNU-C5 CTRP1 8.7001 10.4134 7.3636 4.0566
MDST8 CTRP1 8.749 10.82 7.2025 5.2828
NCI-H508 CTRP1 8.7908 10.4098 7.423 3.316
RCM-1 [Human ESC] CTRP1 8.7988 10.3181 7.4702 2.9131
COLO 678 CTRP1 8.8436 10.7816 7.2828 4.3341
LoVo CTRP1 8.887 10.8561 7.2755 4.2771
KM12 CTRP1 8.9225 11.0006 7.2304 4.5554
HT115 CTRP1 8.9547 10.4895 7.484 2.4424
HT-29 CTRP1 9.122 12.0008 6.8879 6.8407
SW948 CTRP1 9.6039 10.9219 7.6207 0.6286
CL-40 CTRP1 9.6242 11.0653 7.5748 0.8242
CL-34 CTRP1 9.9591 11.5024 7.549 0.6492
RKO CTRP1 10.0109 11.4661 7.5827 0.484
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 5.7795 6.9153 4.6401 1.6363
SNU-449 CTRP1 6.9216 10.6097 3.6393 6.7096
SNU-398 CTRP1 8.0816 9.3139 7.4502 5.393
Hep-G2 CTRP1 8.743 11.402 6.9174 7.7487
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2286 CTRP1 5.9374 7.5894 4.4291 2.9066
BEN CTRP1 6.0591 6.9476 4.7619 0.4675
NCI-H727 CTRP1 6.0873 8.2985 4.1948 4.4143
NCI-H1048 CTRP1 6.1713 8.3169 4.2371 3.8702
HCC44 CTRP1 6.2207 8.916 3.9912 5.7209
NCI-H1568 CTRP1 6.2973 8.6717 4.1504 4.2538
NCI-H661 CTRP1 6.3318 10.13 3.4896 9.4561
NCI-H2029 CTRP1 6.3525 8.2084 4.3867 2.3609
SHP-77 CTRP1 6.3969 8.8692 4.1195 4.2626
NCI-H1435 CTRP1 6.4243 8.4685 4.3125 2.7546
LC-1/sq-SF CTRP1 6.5578 8.3493 4.4313 1.7189
LCLC-97TM1 CTRP1 6.6006 9.1302 4.1191 3.8178
NCI-H1573 CTRP1 6.6192 8.2943 4.4827 1.3229
HCC33 CTRP1 6.6477 8.3031 4.4922 1.233
NCI-H23 CTRP1 6.6599 8.8681 4.265 2.6543
VMRC-LCD CTRP1 6.6675 8.9943 4.2148 2.9904
NCI-H650 CTRP1 6.7305 8.4717 4.4629 1.2958
NCI-H1944 CTRP1 6.7406 8.8042 4.3326 2.0689
NCI-H3255 CTRP1 6.7425 12.2166 4.8019 31.8389
COR-L279 CTRP1 6.743 7.9889 4.6515 0.4052
EPLC-272H CTRP1 6.807 9.1346 4.2275 2.6543
HCC2108 CTRP1 6.8331 11.7645 5.1065 29.8019
Calu-3 CTRP1 6.8381 8.5743 4.4706 1.1292
NCI-H1793 CTRP1 6.8535 8.532 4.4938 0.9946
NCI-H2405 CTRP1 6.8597 8.9551 4.3283 1.9184
HCC78 CTRP1 6.8662 8.6692 4.446 1.2286
HARA [Human squamous cell lung carcinoma] CTRP1 6.9144 8.6673 4.4679 1.062
NCI-H1915 CTRP1 6.9209 8.5415 4.5187 0.8117
NCI-H2126 CTRP1 6.9219 8.1356 4.6666 0.2661
Lu-99 CTRP1 6.924 8.0487 4.6974 0.1888
LCLC-103H CTRP1 6.9326 8.1487 4.6659 0.2634
RERF-LC-KJ CTRP1 6.9349 8.7489 4.4452 1.1564
DMS 273 CTRP1 6.9444 8.7357 4.4544 1.0989
NCI-H1930 CTRP1 6.9536 8.7884 4.438 1.1735
NCI-H810 CTRP1 6.9655 8.1584 4.6745 0.228
NCI-H522 CTRP1 7.0113 8.8312 4.4464 1.0702
Lu-65 CTRP1 7.0761 8.7075 4.5201 0.6786
NCI-H1373 CTRP1 7.0883 9.7679 4.1033 3.0102
EBC-1 CTRP1 7.0968 8.7849 4.4997 0.7474
NCI-H1792 CTRP1 7.1149 10.898 3.6226 6.3815
COLO 668 CTRP1 7.2559 8.9063 4.5184 0.5608
KNS-62 CTRP1 7.2907 8.7979 4.5703 0.3714
NCI-H1666 CTRP1 7.3064 8.959 4.5188 0.5281
NCI-H1975 CTRP1 7.3299 9.2162 4.4339 0.8407
NCI-H1355 CTRP1 7.3699 9.4656 4.3564 1.1566
NCI-H1299 CTRP1 7.4812 10.1774 4.1259 2.2718
NCI-H2009 CTRP1 7.5085 9.3364 4.4606 0.6094
NCI-H2342 CTRP1 7.5735 9.6147 6.8469 13.1025
NCI-H1437 CTRP1 7.5809 9.5393 4.4151 0.7301
COR-L88 CTRP1 7.6412 9.2154 4.5526 0.2747
NCI-H82 CTRP1 7.686 9.0983 4.608 0.1528
NCI-H1963 CTRP1 7.6863 8.7789 7.3554 8.073
LXF 289 CTRP1 7.716 9.6226 4.4374 0.5666
NCI-H1694 CTRP1 7.7795 9.041 7.3192 7.9209
NCI-H596 CTRP1 7.7944 9.6541 7.0314 10.4128
ChaGo-K-1 CTRP1 7.812 9.4126 4.5457 0.2349
NCI-H841 CTRP1 7.8271 9.3847 7.1942 8.8088
NCI-H2122 CTRP1 7.8695 9.1338 7.3564 7.1619
NCI-H2030 CTRP1 7.9144 11.9416 5.9958 18.5875
SCLC-21H CTRP1 7.9202 9.195 7.3715 6.7948
HCC4006 CTRP1 7.9651 10.5906 6.7141 12.4628
DV-90 CTRP1 7.9771 9.6675 4.517 0.2448
NCI-H358 CTRP1 8.0129 9.9582 4.4296 0.4418
NCI-H2081 CTRP1 8.0728 9.6404 7.2797 6.9656
NCI-H1836 CTRP1 8.095 9.1182 7.559 4.3583
NCI-H2141 CTRP1 8.1006 9.3365 7.4545 5.2779
HCC1833 CTRP1 8.1492 9.4863 7.419 5.4047
COLO 699 CTRP1 8.1629 10.058 7.1446 7.8173
NCI-H1876 CTRP1 8.1885 10.3858 7.0017 8.9948
HCC2935 CTRP1 8.2026 11.1824 6.6152 12.3303
NCI-H1755 CTRP1 8.2353 14.1841 5.142 22.9308
NCI-H2172 CTRP1 8.268 10.8582 6.8295 10.2086
A-549 CTRP1 8.2747 9.8434 4.5601 0.1122
HCC1195 CTRP1 8.4194 10.3762 7.1852 6.4993
T3M-10 CTRP1 8.4336 11.254 6.7619 10.1701
HCC15 CTRP1 8.4713 10.1807 7.319 5.1429
NCI-H2023 CTRP1 8.4933 12.3478 6.2648 14.1005
Calu-6 CTRP1 8.51 17.3707 1.4867 16.2398
HCC1359 CTRP1 8.5207 9.654 7.6055 2.5238
NCI-H2110 CTRP1 8.6063 12.3396 6.3559 12.9437
NCI-H441 CTRP1 8.6728 11.6347 6.7532 9.3906
NCI-H1105 CTRP1 8.7078 12.7916 6.2091 13.7424
COR-L23 CTRP1 8.7821 11.0615 7.1092 5.9806
HCC827 CTRP1 8.8097 12.0644 6.6422 9.8648
SK-LU-1 CTRP1 8.8388 11.0781 7.1394 5.5547
COR-L51 CTRP1 8.8655 10.6055 7.3785 3.4874
CAL-12T CTRP1 9.0024 11.3027 7.1397 5.0895
NCI-H2073 CTRP1 9.0956 14.5096 5.6515 16.4432
NCI-H460 CTRP1 9.1932 15.7307 5.1224 19.4521
NCI-H1781 CTRP1 9.6911 16.7195 5.0021 18.5107
Sq-1 CTRP1 10.2684 11.6893 7.6001 0.2984
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 7.0446 8.4308 4.6082 0.3791
KYSE-140 CTRP1 7.1919 9.3801 4.3117 1.5782
KYSE-410 CTRP1 7.645 9.5147 4.4489 0.5684
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVMANA CTRP1 5.9721 8.6977 3.9327 6.9042
HEY A8 CTRP1 6.2639 8.4997 4.2087 3.8758
OVCAR-8 CTRP1 6.5675 9.3946 5.9408 26.0696
COV318 CTRP1 6.8357 7.6948 4.7858 0.059
JHOS-4 CTRP1 7.0167 9.0856 4.3491 1.5836
SK-OV-3 CTRP1 7.0569 8.6899 4.5189 0.6982
COV434 CTRP1 7.129 14.1767 4.1942 32.4514
EFO-21 CTRP1 7.5638 9.2595 4.5091 0.4211
OVK18 CTRP1 7.5959 12.6815 5.3513 24.4849
OVKATE CTRP1 7.6425 9.6683 6.8854 12.4268
A2780 CTRP1 7.6774 10.1039 6.7033 13.8552
OV-90 CTRP1 7.7983 10.1755 6.7763 12.6564
TYK-nu CTRP1 7.9686 9.9092 7.0575 9.4022
OVCAR-4 CTRP1 7.973 9.3479 7.3415 6.8303
JHOC-5 CTRP1 8.0145 14.4053 4.8486 25.4815
RMUG-S CTRP1 8.0416 9.4168 7.3655 6.3216
JHOM-1 CTRP1 8.0555 8.9067 7.6322 3.8606
IGROV-1 CTRP1 8.2742 11.0305 6.7485 10.8933
SNU-840 CTRP1 8.428 9.9105 7.4198 4.4007
COV644 CTRP1 8.6529 10.3768 7.3498 4.3099
RMG-I CTRP1 8.9343 11.9594 6.7812 8.2934
OV7 CTRP1 9.2726 11.5763 7.1791 4.0872
Caov-3 CTRP1 9.5814 11.2212 7.4946 1.303
OAW42 CTRP1 9.6306 13.4507 6.5333 8.2654
EFO-27 CTRP1 10.0614 15.0305 6.0673 10.5604
COV362 CTRP1 10.2293 12.3984 7.3213 1.4827
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 CTRP1 6.0919 8.5408 4.0851 5.2973
QGP-1 CTRP1 6.5572 8.0283 4.56 0.9696
HPAC CTRP1 6.6525 10.4842 3.5314 8.2197
HuP-T4 CTRP1 6.7505 9.1099 4.2088 2.8804
Panc 10.05 CTRP1 6.7932 8.8805 4.3268 2.0259
CFPAC-1 CTRP1 6.8486 10.2899 3.7415 6.1124
Panc 03.27 CTRP1 7.2343 8.8533 4.5292 0.5356
Capan-2 CTRP1 7.4346 9.1786 4.4891 0.5545
PaTu 8902 CTRP1 7.5727 8.7641 4.6804 0.0747
KP-3 CTRP1 7.5928 13.3872 2.7694 11.2032
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP1 6.4965 10.2207 3.5552 8.4636
NCI-H2052 CTRP1 6.7321 8.6734 4.3824 1.7686
MSTO-211H CTRP1 6.8111 11.6838 3.0683 11.2471
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 7.5406 13.9282 2.4827 13.1705
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 852.T CTRP1 6.8984 8.6492 4.4679 1.0785
G-361 CTRP1 6.9972 8.4943 4.5671 0.5501
Hs 936.T CTRP1 7.2891 8.4991 4.6724 0.1359
COLO 741 CTRP1 7.3061 9.0541 4.4842 0.6549
Hs 944.T CTRP1 7.3575 8.9192 4.5524 0.3922
SK-MEL-5 CTRP1 7.7352 10.2464 6.6849 13.7455
SK-MEL-1 CTRP1 8.0819 9.3674 7.4237 5.6307
A-375 CTRP1 8.142 10.507 6.9034 10.0545
SK-MEL-28 CTRP1 9.3877 10.3994 7.7271 0.3572
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 6.6782 12.2776 2.6937 14.2582
HT-1080 CTRP1 8.1331 12.2042 6.0478 17.2468
RKN CTRP1 8.2293 9.9243 7.2641 6.4881
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-10-TC CTRP1 5.8756 8.0976 4.1544 5.3202
Fu97 CTRP1 6.3276 8.556 4.2203 3.6422
MKN7 CTRP1 6.5244 8.7411 4.248 3.026
NUGC-4 CTRP1 6.5636 9.2558 4.0422 4.4788
MKN74 CTRP1 7.3912 9.2527 4.445 0.7477
AGS CTRP1 8.6841 10.202 7.4528 3.3524
SNG-M CTRP1 6.8967 8.5006 4.5241 0.8086
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.4149 7.7937 4.5888 0.9774
SCC-9 CTRP1 8.2308 9.9439 7.2556 6.559
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 CTRP1 6.4945 10.4489 3.4459 9.3229
HT-1376 CTRP1 6.7434 10.5856 3.5414 7.9013
UM-UC-3 CTRP1 6.7602 8.8591 4.3195 2.1231
5637 CTRP1 7.6949 9.4989 4.4734 0.4636
KMBC-2 CTRP1 7.9779 9.5484 4.5575 0.1705

References

1 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
2 ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):231-43.
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