Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMITSEH)

• Drug Name: Isoetharine Drug Info
• Synonyms: Bronkosol; Dilabron; Etyprenaline; Etyprenalinum; Isoetarin; Isoetarina; Isoetarine; Isoetarinum; Neoisuprel; Isoetharine Hcl; Win 3406; Bronkometer (TN); Bronkosol (TN); Dey-Lute Isoetharine; Isoetarina [INN-Spanish]; Isoetarine (INN); Isoetarinum [INN-Latin]; Isoetharine (USP); Isoetharine HCl S/F; Isoetharine [USAN:BAN]; 3,4-Dihydroxy-alpha-(1-(isopropylamino)propyl)benzyl alcohol; 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol
• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 3762
  ChEBI ID: CHEMBL1201213
  CAS Number: CAS 530-08-5
  TTD Drug ID: D08HUC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Lysosome	2.14	0.00e+0	115/128 (89.84%)	ACP2;TCIRG1;GAA;...
Regulation of lipolysis in adipocytes	1.93	1.07e-2	52/55 (94.55%)	ADCY1;GNAI2;AKT1;...
ECM-receptor interaction	1.90	7.11e-3	80/88 (90.91%)	LAMB1;COL6A2;COL1A1;...
Endocrine and other factor-regulated calcium reabsorpti...	1.79	2.66e-2	49/53 (92.45%)	DNM1;PRKCB;AP2A2;...
Glycosaminoglycan degradation	1.76	3.41e-2	19/19 (100%)	HGSNAT;GUSB;GNS;...
Protein digestion and absorption	1.74	4.26e-2	78/103 (75.73%)	COL5A2;COL6A2;COL1A1;...
Systemic lupus erythematosus	-1.75	4.46e-2	45/135 (33.33%)	HLA-DPB1;SNRPB;HLA-DMB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲