Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIW453)

Drug Name
Pelitinib Drug Info
Synonyms EKB-569; EKI-569; WAY-EKB-569
Cross-matching ID
PubChem CID
6445562
ChEBI ID
CHEMBL38927
CAS Number
CAS 257933-82-7
TTD Drug ID
D0S3PO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.24 0.00e+0 31/40 (77.5%) PHGDH;PSAT1;CBS;...
Cysteine and methionine metabolism 2.05 0.00e+0 43/50 (86%) PHGDH;PSAT1;CBS;...
Alanine, aspartate and glutamate metabolism 2.03 0.00e+0 27/37 (72.97%) ASNS;ASS1;GOT1;...
Oxidative phosphorylation 1.85 1.33e-2 93/133 (69.92%) ATP5MC2;COX7A2L;NDUFA6;...
JAK-STAT signaling pathway -1.64 4.24e-2 146/162 (90.12%) IL2;PRLR;IL4;...
p53 signaling pathway -1.66 3.83e-2 63/73 (86.3%) TSC2;EI24;TP53AIP1;...
Steroid biosynthesis -1.67 3.74e-2 19/20 (95%) CYP24A1;CYP51A1;CYP27B1;...
Th17 cell differentiation -1.67 3.76e-2 95/107 (88.79%) SMAD4;HLA-DRB1;STAT5B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.68 4.00e-2 62/70 (88.57%) CHUK;ADAM17;LYN;...
Small cell lung cancer -1.70 3.75e-2 90/92 (97.83%) NFKBIA;TRAF3;CDK6;...
Cholesterol metabolism -1.70 4.02e-2 44/50 (88%) APOH;APOC2;CETP;...
AGE-RAGE signaling pathway in diabetic complications -1.72 3.56e-2 97/100 (97%) EDN1;IL1A;COL1A1;...
Malaria -1.72 3.49e-2 44/50 (88%) TGFB2;ICAM1;IL6;...
Colorectal cancer -1.73 3.71e-2 84/86 (97.67%) CDKN1A;TGFB2;RPS6KB1;...
Dilated cardiomyopathy -1.74 3.64e-2 86/96 (89.58%) ATP2A1;ITGB8;MYL2;...
Proteoglycans in cancer -1.87 1.10e-2 172/205 (83.9%) KDR;MTOR;HOXD10;...
Hypertrophic cardiomyopathy -1.89 8.27e-3 81/90 (90%) ATP2A1;ITGB8;PRKAG2;...
IL-17 signaling pathway -1.93 6.30e-3 84/94 (89.36%) LCN2;IKBKB;HSP90B1;...
Glycosaminoglycan biosynthesis -1.93 7.35e-3 40/58 (68.97%) ST3GAL1;CHST2;ST3GAL2;...
Focal adhesion -1.96 8.82e-3 180/201 (89.55%) FLT4;PPP1R12B;ITGB8;...
Complement and coagulation cascades -2.08 2.76e-3 76/85 (89.41%) F5;C4BPA;CR2;...
Arrhythmogenic right ventricular cardiomyopathy -2.09 3.67e-3 70/77 (90.91%) ATP2A1;ITGB8;DSC2;...
Amoebiasis -2.13 5.51e-3 99/102 (97.06%) COL1A1;PRDX1;PTK2;...
ECM-receptor interaction -2.25 0.00e+0 80/88 (90.91%) COL6A1;COL1A1;ITGA10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H