Details of the Drug

General Information of Drug (ID: DMIW453)

Drug Name
Pelitinib
Synonyms EKB-569; EKI-569; WAY-EKB-569
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 2 [1]
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 467.9
Logarithm of the Partition Coefficient (xlogp) 4.5
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C24H23ClFN5O2
IUPAC Name
(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Canonical SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
InChI
InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
InChIKey
WVUNYSQLFKLYNI-AATRIKPKSA-N
Cross-matching ID
PubChem CID
6445562
ChEBI ID
CHEBI:38927
CAS Number
257933-82-7
UNII
X5DWL380Z6
DrugBank ID
DB05524
TTD ID
D0S3PO
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Gene/Protein Processing [3]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) OT251CI0 ATF1_HUMAN Gene/Protein Processing [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lymphoma
ICD Disease Classification 2A80-2A86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 5.84E-05 0.32 0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 0.3006 6.4754 -2.1487 28.4935
EW-24 GDSC1 -2.4957 3.1698 -3.4626 48.5178
NOS-1 [Human HNSCC] GDSC1 -2.2408 6.0299 -4.4033 47.3439
ES7 GDSC1 -1.3128 3.77 -2.4576 38.2535
ES4 GDSC1 -0.7625 15.2265 -7.4356 43.6139
EW-1 GDSC1 0.1064 10.7795 -4.4545 36.7352
EW-13 GDSC1 0.1981 3.9484 -1.0149 22.5723
SK-ES-1 GDSC1 0.7087 8.7211 -2.9004 29.9414
EW-18 GDSC1 0.7966 5.9888 -1.4626 22.7162
CADO-ES1 GDSC1 1.1799 4.328 -0.3011 13.2497
EW-7 GDSC1 1.2357 5.3574 -0.7681 16.4559
ES5 GDSC1 1.4451 6.994 -1.4122 19.8802
ES6 GDSC1 1.5895 3.4306 0.4815 5.7198
ES8 GDSC1 1.8414 6.1214 -0.6599 13.5417
EW-11 GDSC1 1.9459 13.2862 -4.1485 29.8183
HuO9 GDSC1 1.9459 4.176 0.3755 5.4818
EW-3 GDSC1 1.9466 7.5153 -1.2708 17.2582
TC-71 GDSC1 2.1336 5.1178 0.0505 7.416
SJSA-1 GDSC1 2.211 6.1411 -0.3928 10.4692
EW-16 GDSC1 2.4163 16.209 -5.2304 31.2936
A-673 GDSC1 2.4355 4.9104 0.349 4.4497
SK-PN-DW GDSC1 2.5152 8.2088 -1.1847 14.9255
HOS GDSC1 2.5182 4.1981 0.7159 1.815
CHSA8926 GDSC1 2.7216 5.5862 0.2126 4.7792
ES1 GDSC1 3.1964 5.0805 0.6807 1.1414
G-292 clone A141B1 GDSC1 3.3037 14.0671 -3.4839 23.7999
H-EMC-SS GDSC1 3.3292 8.3614 -0.6986 9.6032
CAL-72 GDSC1 3.3704 5.0893 0.7517 0.6882
CAL-78 GDSC1 3.4005 5.3662 0.6591 1.0446
CHSA0011 GDSC1 3.5862 8.8341 -0.7566 9.3747
HuO-3N1 GDSC1 3.5917 6.3993 0.3324 2.4924
SaOS-2 GDSC1 3.7413 6.1616 0.4988 1.4506
MG-63 GDSC1 3.814 5.1055 0.9103 0.1051
NY GDSC1 4.0595 7.2857 0.1946 2.6323
CHSA0108 GDSC1 4.3468 6.7535 0.5286 0.8383
MHH-ES-1 GDSC1 4.979 16.429 -3.444 19.6157
U2OS GDSC1 5.1426 22.9395 -6.4917 27.9348
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.0732 7.6975 -1.2634 16.795
THP-1 GDSC1 -7.8292 1.9527 -8.8441 74.8616
MOLT-16 GDSC1 -4.8162 0.2304 -4.9006 86.873
KE-37 GDSC1 -4.3089 0.8121 -4.421 84.1923
ALL-SIL GDSC1 -4.0281 -1.0407 -4.0339 90.3035
697 GDSC1 -3.7394 -2.0896 -3.7411 63.0917
HEL GDSC1 -3.5827 -0.1115 -3.7184 59.5697
A3/Kawakami GDSC1 -3.2827 0.384 -3.4818 56.2765
CTV-1 GDSC1 -3.2063 -1.446 -3.2064 89.6827
RPMI-8402 GDSC1 -3.1785 0.9384 -3.2457 80.8597
ALL-PO GDSC1 -3.1183 -0.2349 -3.2045 54.9964
P30/OHK GDSC1 -3.1013 1.6557 -3.6004 53.8439
GDM-1 GDSC1 -3.0391 -0.6441 -3.0782 54.2843
MV4-11 GDSC1 -2.9698 1.4621 -3.4008 52.7626
NALM-6 GDSC1 -2.894 0.3595 -3.0565 52.3582
HAL-01 GDSC1 -2.7898 0.6308 -2.9973 51.1977
SIG-M5 GDSC1 -2.7813 -0.5408 -2.8171 51.2399
SU-DHL-16 GDSC1 -2.7588 -1.7712 -2.7589 51.0084
NB4 GDSC1 -2.7015 0.3228 -2.8421 50.2629
PF-382 GDSC1 -2.4928 1.2888 -2.5573 76.8356
Loucy GDSC1 -2.4621 1.1731 -2.516 77.0391
Karpas-45 GDSC1 -2.274 1.4868 -2.3451 75.0919
MOLM-13 GDSC1 -2.2616 1.1344 -2.5393 45.5293
SU-DHL-6 GDSC1 -2.0561 0.3113 -2.146 42.6154
HC-1 GDSC1 -2.018 3.7131 -3.1709 44.6946
EB2 GDSC1 -1.9972 1.3891 -2.3189 42.7015
OCI-Ly19 GDSC1 -1.9835 1.4217 -2.3131 42.572
SU-DHL-10 GDSC1 -1.9795 -1.0249 -1.9799 41.2698
SR GDSC1 -1.9545 1.792 -2.3923 42.5721
MEG-01 GDSC1 -1.7272 2.6306 -2.4364 40.9776
Karpas-231 GDSC1 -1.7061 0.8525 -1.8673 38.6907
MOLT-13 GDSC1 -1.5248 3.1434 -2.4196 39.5105
CTB-1 GDSC1 -1.4882 4.2421 -2.8426 40.5019
CCRF-CEM GDSC1 -1.4499 1.6462 -1.7974 36.5273
CESS GDSC1 -1.3799 1.6571 -1.7246 35.6911
BL-41 GDSC1 -1.2882 1.2406 -1.5048 33.9117
Reh GDSC1 -1.279 3.9412 -2.4963 38.171
MOLT-4 GDSC1 -1.2066 3.6343 -1.5386 63.4949
QIMR-WIL GDSC1 -1.1681 2.7735 -1.8944 35.1056
KG-1 GDSC1 -1.1554 3.5487 -2.1998 36.3268
KOPN-8 GDSC1 -1.0583 2.081 -1.5164 32.4979
RS4;11 GDSC1 -1.0541 4.2479 -2.4005 36.4756
Kasumi-1 GDSC1 -1.0276 1.5808 -1.3173 31.1631
TUR GDSC1 -0.9518 2.5277 -1.5681 32.1207
KMS-12-BM GDSC1 -0.9376 4.5798 -2.432 35.9146
P12-Ichikawa GDSC1 -0.8459 3.743 -1.171 60.7233
SUP-M2 GDSC1 -0.8127 3.2461 -1.715 32.0586
NKM-1 GDSC1 -0.7742 1.6258 -1.0552 28.0094
RPMI-6666 GDSC1 -0.7722 2.5983 -1.4051 30.1338
Hs 445 GDSC1 -0.7611 2.6441 -1.4116 30.1061
Namalwa GDSC1 -0.6813 3.0001 -1.474 29.9991
BE-13 GDSC1 -0.6678 2.6181 -1.3025 28.9235
LAMA-84 GDSC1 -0.6085 3.5989 -1.6578 30.5908
ATN-1 GDSC1 -0.6067 2.9597 -0.7555 59.7105
BC-1 GDSC1 -0.5017 2.3307 -1.0123 26.1669
Farage GDSC1 -0.3825 1.4793 -0.5834 22.6291
OCI-AML-3 GDSC1 -0.3139 4.616 -1.8292 29.8899
Karpas-620 GDSC1 -0.305 4.2834 -1.6647 28.9883
PL-21 GDSC1 -0.1196 4.7747 -1.7154 28.3141
Daudi GDSC1 -0.0047 1.7115 -0.2482 18.221
P32/ISH GDSC1 -0.0007 1.7908 -0.2721 18.3668
NU-DUL-1 GDSC1 0.0071 2.4199 -0.5118 20.0269
SU-DHL-8 GDSC1 0.0224 3.575 -1.0114 23.4026
Mono-Mac-6 GDSC1 0.0847 4.7169 -1.4916 26.0725
SU-DHL-1 GDSC1 0.0854 2.24 -0.3549 18.5025
ARH-77 GDSC1 0.112 3.8583 -1.0558 23.2551
CA46 GDSC1 0.1483 4.2154 -1.1902 23.9444
JSC-1 GDSC1 0.187 5.1132 -1.5863 26.1251
OCI-AML-5 GDSC1 0.1965 3.6946 -0.8961 21.7821
VAL GDSC1 0.2653 3.2394 -0.615 19.4897
BV-173 GDSC1 0.2982 5.7781 -1.8078 26.8139
Sc-1 GDSC1 0.3155 6.983 -2.3856 29.4933
MLMA GDSC1 0.3308 8.1404 -2.9448 31.6306
ST486 GDSC1 0.3462 3.3768 -0.6001 19.0005
MOLP-8 GDSC1 0.3479 4.1003 -0.9439 21.3947
DEL GDSC1 0.3648 4.3998 -1.0728 22.1743
SU-DHL-5 GDSC1 0.3969 1.4419 0.2773 12.357
OCI-M1 GDSC1 0.4199 5.5853 -1.6013 25.1424
WIL2 NS GDSC1 0.4241 5.549 -1.5797 25.0016
BC-3 GDSC1 0.5005 4.1925 -0.8446 20.0233
OPM-2 GDSC1 0.5344 4.8594 -1.1395 21.8433
JURL-MK1 GDSC1 0.5386 5.9529 -1.6749 25.0292
BALL-1 GDSC1 0.5438 2.4679 0.0182 13.4941
SUP-B15 GDSC1 0.5849 3.2489 -0.3083 15.7631
LC4-1 GDSC1 0.6104 8.2847 -2.7688 29.8282
SCC-3 GDSC1 0.6806 2.1708 0.2908 10.7981
NOMO-1 GDSC1 0.6926 6.9398 -2.0273 26.2202
RPMI-8226 GDSC1 0.6999 2.2408 0.2784 10.7993
YT GDSC1 0.7016 2.2876 0.2588 10.9389
H9 GDSC1 0.7069 4.4139 -0.7624 18.5468
SUP-HD1 GDSC1 0.7411 3.783 -0.4208 15.9223
HH [Human lymphoma] GDSC1 0.7898 5.1938 -1.0736 20.3159
KCL-22 GDSC1 0.823 4.0497 -0.4772 15.9948
K-562 GDSC1 0.8596 2.6466 0.2436 10.3406
Ku812 GDSC1 0.9302 2.0213 0.6092 7.2212
KMOE-2 GDSC1 0.9748 4.8387 -0.7335 17.2313
Karpas-422 GDSC1 1.0412 2.8096 0.3329 8.8795
SU-DHL-4 GDSC1 1.0811 1.9095 0.8093 5.0086
DB GDSC1 1.0898 5.6289 -1.028 18.7965
EM-2 GDSC1 1.1222 5.7626 -1.067 18.9278
U266B1 GDSC1 1.1277 5.9956 -1.1787 19.6311
VL51 GDSC1 1.1331 3.4002 0.1215 10.1674
EJM GDSC1 1.2094 2.6518 0.5611 6.4207
GR-ST GDSC1 1.2528 4.5665 -0.3583 13.4064
HL-60 GDSC1 1.306 9.3245 -2.6927 26.8699
RL GDSC1 1.3105 2.1883 0.8792 3.5333
ML-2 GDSC1 1.356 9.3272 -2.6524 26.5208
ME1 GDSC1 1.4251 6.5299 -1.1966 18.6175
KY821 GDSC1 1.4712 4.7417 -0.2652 11.9092
L-428 GDSC1 1.5206 2.8537 0.7146 4.1166
MC116 GDSC1 1.5539 2.7509 0.7904 3.4233
Ramos.2G6.4C10 GDSC1 1.6157 4.707 -0.1325 10.4014
EoL-1 GDSC1 1.6405 6.2013 -0.8576 15.6027
Karpas-299 GDSC1 1.6441 4.3804 0.0522 8.8871
JJN-3 GDSC1 1.7385 4.0095 0.3075 6.6084
HT GDSC1 1.7394 7.3226 -1.338 18.3781
U-698-M GDSC1 1.7806 3.6481 0.5154 4.8787
DND-41 GDSC1 1.7853 6.5647 -0.924 15.5545
Granta-519 GDSC1 1.827 3.9804 0.3865 5.7351
SUP-T1 GDSC1 1.8317 11.1151 -1.3217 41.7495
L-540 GDSC1 1.8945 8.4891 -1.7964 20.4993
WSU-DLCL2 GDSC1 1.9273 6.5019 -0.7825 14.1159
P31/FUJ GDSC1 1.9465 4.1488 0.3891 5.3772
AMO1 GDSC1 1.9637 4.3162 0.32 5.8538
MN-60 GDSC1 1.9647 4.628 0.1691 6.9996
L-1236 GDSC1 2.1129 4.642 0.2658 5.8559
DG-75 GDSC1 2.2 3.9886 0.6299 2.978
WSU-NHL GDSC1 2.3563 5.8692 -0.1581 8.3453
OCI-AML-2 GDSC1 2.3766 4.5629 0.4732 3.6988
TK [Human B-cell lymphoma] GDSC1 2.4911 7.9264 -1.0639 14.2311
LP-1 GDSC1 2.5624 5.396 0.2025 5.2048
A4/Fukuda GDSC1 2.7535 9.8767 -1.829 17.9704
JVM-3 GDSC1 2.8525 5.3559 0.3925 3.2989
KM-H2 GDSC1 2.8721 9.4295 -1.5238 15.9229
ROS-50 GDSC1 2.9062 6.4034 -0.0512 6.2095
L-363 GDSC1 3.0487 8.1604 -0.7874 10.882
JVM-2 GDSC1 3.2201 9.1686 -1.1544 12.7686
Raji GDSC1 3.2313 4.642 0.8607 0.4
MHH-PREB-1 GDSC1 3.4787 5.0715 0.8012 0.451
RPMI-8866 GDSC1 3.5101 5.1751 0.7759 0.5135
SK-MM-2 GDSC1 3.5742 5.1519 0.8088 0.3815
MY-M12 GDSC1 3.6701 5.33 0.7816 0.4127
RC-K8 GDSC1 3.8298 5.2568 0.8649 0.169
HDLM-2 GDSC1 3.869 5.9569 0.6313 0.7872
KMS-11 GDSC1 4.2421 6.338 0.6387 0.5455
Jiyoye GDSC1 4.7177 6.5075 0.751 0.1563
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 -6.1072 1.7902 -6.9183 70.5034
ESO-26 GDSC1 -3.1439 18.5747 -11.26 51.1622
OACP4 C GDSC1 -1.2755 10.8575 -5.7523 43.9427
TE-12 GDSC1 -0.0265 51.0515 -24.6753 47.1585
KYSE-220 GDSC1 0.6127 29.2863 -13.2556 43.7768
KYSE-50 GDSC1 1.5793 4.7678 -0.1915 10.9748
FLO-1 GDSC1 1.9412 10.525 -2.7743 25.0307
ESO-51 GDSC1 2.2305 4.2667 0.5203 3.6896
OACM5.1 C GDSC1 2.632 6.9765 -0.5021 10.054
SK-GT-4 GDSC1 2.8193 9.4651 -1.5792 16.3926
HCE-4 GDSC1 2.9236 6.2067 0.0501 5.469
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 1.3054 2.8805 0.5289 6.3146
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-7 GDSC1 -1.6828 -0.3271 -1.6922 37.6151
CHP-212 GDSC1 0.2994 2.5711 -0.2756 16.8533
KP-N-YS GDSC1 0.355 3.615 -0.7045 19.7049
SJNB-5 GDSC1 0.6968 1.7205 0.5009 9.1662
IMR-5 GDSC1 0.8022 2.6836 0.1709 11.1515
NB69 GDSC1 0.9013 8.603 -2.6748 28.3064
MHH-NB-11 GDSC1 1.5344 3.9521 0.1795 8.2615
SJNB-17 GDSC1 1.6937 4.0433 0.2573 7.1372
SK-N-MC-IXC GDSC1 1.761 2.8594 0.881 2.1716
SJNB-6 GDSC1 1.8908 5.0017 -0.0681 9.0252
SJNB-13 GDSC1 1.9928 6.3517 -0.6581 13.0372
CHP-134 GDSC1 2.0476 3.5702 0.7296 2.605
NB(TU)1 GDSC1 2.0706 4.9283 0.0981 7.2349
SJNB-12 GDSC1 2.1869 7.5401 -1.099 15.3901
TGW GDSC1 2.2432 5.9013 -0.2528 9.356
SJNB-10 GDSC1 2.2591 4.2598 0.5411 3.4765
SK-N-FI GDSC1 2.3034 5.9182 -0.2185 8.9342
Kelly GDSC1 2.4775 3.9873 0.7845 1.4656
NH-12 GDSC1 2.5228 7.1043 -0.6399 11.3131
SiMa GDSC1 2.5373 5.9721 -0.085 7.3353
SK-N-AS GDSC1 2.7047 7.4836 -0.6965 11.192
SK-N-DZ GDSC1 2.7598 4.67 0.6399 1.9022
SK-N-SH GDSC1 2.9034 4.6743 0.7085 1.325
SK-N-BE(2)-M17 GDSC1 2.9079 5.2737 0.4587 2.7763
GI-ME-N GDSC1 2.9958 10.2407 -1.8311 17.2848
CHP-126 GDSC1 3.1007 8.0884 -0.7184 10.2956
SJNB-14 GDSC1 3.3124 4.7575 0.8503 0.3892
GOTO GDSC1 3.4152 6.0888 0.3742 2.5007
LA-N-6 GDSC1 3.511 5.3715 0.7037 0.769
NB1 GDSC1 3.8042 10.0356 -1.1807 11.4808
KP-N-YN GDSC1 3.9928 6.1033 0.6268 0.7221
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 1.5473 15.1361 -5.3983 34.0484
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-175-VII GDSC1 -5.911 -1.3521 -6.0343 77.5704
HCC2218 GDSC1 -4.4753 30.0603 -16.4538 57.5319
BT-474 GDSC1 -4.2631 1.4775 -4.8164 62.5399
OCUB-M GDSC1 -4.0365 -0.7017 -4.1229 64.4617
UACC-893 GDSC1 -2.6698 2.8403 -3.5263 49.9313
AU565 GDSC1 -1.9036 9.6575 -5.7657 46.4932
CAL-85-1 GDSC1 -1.8578 48.1757 -24.8048 49.1018
MDA-MB-468 GDSC1 -1.1954 5.5666 -3.1424 39.5426
ZR-75-30 GDSC1 -1.1719 13.958 -7.1783 44.6999
BT-549 GDSC1 -1.0574 6.2875 -3.3435 39.2945
HCC1419 GDSC1 -0.7359 6.8354 -3.2937 37.5436
HCC1599 GDSC1 -0.3416 3.7026 -0.6128 56.5733
MDA-MB-361 GDSC1 0.4138 5.9184 -1.771 26.0994
T-47D GDSC1 0.8388 17.7039 -7.2751 38.9776
HCC1187 GDSC1 1.0783 4.4403 -0.4447 14.7212
HCC1954 GDSC1 1.0854 13.7114 -5.071 34.7396
COLO 824 GDSC1 1.1821 2.8168 0.455 7.3608
DU4475 GDSC1 1.4174 5.0289 -0.4526 13.5042
HCC1806 GDSC1 1.4728 10.5097 -3.1468 28.0628
CAL-120 GDSC1 1.5339 13.2959 -4.4893 32.0021
HCC1500 GDSC1 1.9187 6.1687 -0.6239 13.0337
CAMA-1 GDSC1 1.9987 4.5412 0.2355 6.3973
HCC1569 GDSC1 2.0255 10.4187 -2.6542 24.245
UACC-812 GDSC1 2.1743 5.0454 0.1138 6.8294
EFM-192A GDSC1 2.4041 4.5872 0.4787 3.6012
MDA-MB-231 GDSC1 2.4111 5.0489 0.2691 5.0802
CAL-148 GDSC1 2.4943 4.8971 0.3912 4.0211
HCC70 GDSC1 2.5378 5.3721 0.1982 5.2928
HCC1937 GDSC1 2.5757 9.621 -1.8347 18.5302
HDQ-P1 GDSC1 2.7946 9.377 -1.554 16.3192
Evsa-T GDSC1 2.9566 4.721 0.7145 1.2321
MDA-MB-453 GDSC1 2.9684 11.3794 -0.3898 34.6061
MDA-MB-330 GDSC1 3.0098 7.0192 -0.273 7.5059
MFM-223 GDSC1 3.051 6.5617 -0.0356 5.7829
MDA-MB-415 GDSC1 3.0875 4.6908 0.7844 0.7773
YMB-1-E GDSC1 3.1461 5.5642 0.4589 2.398
EFM-19 GDSC1 3.4918 5.4425 0.6688 0.9236
HCC38 GDSC1 3.5539 14.715 -3.6178 23.6305
CAL-51 GDSC1 3.597 8.2772 -0.4923 7.6522
BT-20 GDSC1 3.6066 12.784 -2.6347 19.5681
MDA-MB-436 GDSC1 3.6223 5.5102 0.6973 0.7141
HCC2157 GDSC1 3.6309 5.3328 0.7656 0.4792
MCF-7 GDSC1 3.6674 5.3677 0.7671 0.4559
JIMT-1 GDSC1 3.7576 12.1604 -2.2262 17.2721
MRK-nu-1 GDSC1 3.913 5.2817 0.8853 0.1207
Hs 578T GDSC1 3.9585 6.056 0.6305 0.7308
HCC1395 GDSC1 4.1141 5.7579 3.4242 7.8701
MDA-MB-157 GDSC1 4.2879 6.4006 0.6337 0.5376
HCC1428 GDSC1 6.447 16.1377 -2.3761 12.2641
BT-483 GDSC1 7.6514 16.785 0.5989 15.9701
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DK-MG GDSC1 -0.9437 5.1426 -2.6962 36.8641
Daoy GDSC1 0.0228 3.5538 -1.0011 23.3328
ONS-76 GDSC1 0.6931 6.6542 -1.8848 25.4941
KS-1 [Human Krukenberg tumour] GDSC1 0.7651 5.0265 -1.0127 20.0168
MOG-G-CCM GDSC1 0.8596 4.0564 -0.4475 15.6224
NMC-G1 GDSC1 0.8938 4.431 -0.6023 16.6194
8-MG-BA GDSC1 0.9905 5.6215 -1.1099 19.73
GaMG GDSC1 1.3607 3.7923 0.1188 9.3393
AM-38 GDSC1 1.5354 5.7066 -0.6952 14.8403
YKG-1 GDSC1 1.5625 3.6778 0.338 6.9293
DBTRG-05MG GDSC1 1.5708 5.9578 -0.792 15.3943
D-502MG GDSC1 1.5773 8.552 -2.0825 23.0983
D-336MG GDSC1 1.7081 6.1548 -0.7807 14.8377
Onda 11 GDSC1 1.7547 6.172 -0.7526 14.4833
GI-1 GDSC1 2.0433 4.9586 0.0641 7.5698
SF539 GDSC1 2.0822 7.1571 -0.9888 15.0062
A-172 GDSC1 2.1276 5.9895 -0.3792 10.6195
Hs 683 GDSC1 2.1516 4.3405 0.4354 4.4943
D-566MG GDSC1 2.1852 5.4973 -0.0974 8.3748
SF295 GDSC1 2.2175 3.959 0.6538 2.7736
GB-1 GDSC1 2.2271 7.1125 -0.858 13.6775
H4 GDSC1 2.2558 8.9791 -1.759 19.1094
CAS-1 GDSC1 2.2677 17.8691 -6.1773 33.641
Onda 10 GDSC1 2.2712 4.9852 0.2081 5.8716
MOG-G-UVW GDSC1 2.2716 4.2895 0.5351 3.4918
PFSK-1 GDSC1 2.3271 7.788 -1.1165 15.0644
U-251MG GDSC1 2.4276 7.3663 -0.8357 12.9211
SW1783 GDSC1 2.5076 6.0547 -0.1442 7.8403
SF126 GDSC1 2.5378 5.0233 0.3596 4.1486
U-87MG ATCC GDSC1 2.5825 4.3419 0.688 1.8845
LNZTA3WT4 GDSC1 2.6653 4.5331 0.6494 1.9894
D-423MG GDSC1 2.6857 10.9081 -2.3875 20.99
KINGS-1 GDSC1 2.7625 6.4202 -0.1499 7.2382
YH-13 GDSC1 2.854 6.8333 -0.2854 7.9663
KNS-81-FD GDSC1 2.8616 5.488 0.339 3.6344
D283 Med GDSC1 2.8778 4.581 0.7342 1.2216
KNS-42 GDSC1 2.9049 4.3282 0.8454 0.6743
LN-229 GDSC1 2.9342 6.5295 -0.0923 6.4312
LN-405 GDSC1 2.9372 5.1757 0.5164 2.372
SW1088 GDSC1 2.9718 7.0407 -0.3072 7.8315
T98G GDSC1 3.0285 6.9212 -0.2155 7.067
LN-18 GDSC1 3.0663 3.9961 1.0252 0.085
M059J GDSC1 3.1142 4.9599 0.6914 1.1749
U-118MG GDSC1 3.1413 5.0828 0.6548 1.3261
D-263MG GDSC1 3.1479 4.4196 0.9086 0.302
D-392MG GDSC1 3.1943 6.9972 -0.1487 6.2435
SF268 GDSC1 3.2567 8.7973 -0.9523 11.4136
SNB-75 GDSC1 3.297 6.8408 -0.0172 5.1529
42-MG-BA GDSC1 3.4127 11.8219 -2.3041 18.5469
SK-MG-1 GDSC1 3.4296 5.1411 0.7564 0.6298
D-542MG GDSC1 3.498 5.0851 0.8037 0.4334
Becker GDSC1 3.5522 9.9694 -1.3141 12.8815
D-247MG GDSC1 3.6441 5.757 0.6133 1.0288
KALS-1 GDSC1 4.2927 11.7808 -1.6874 13.2144
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 2.0538 15.5078 -5.1707 32.1349
TGBC1TKB GDSC1 2.3076 4.1594 0.6161 2.8487
TGBC24TKB GDSC1 3.4486 10.3547 -1.5685 14.6116
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 0.8447 7.2356 -2.0415 25.6673
KLE GDSC1 1.0556 10.6268 -3.5543 30.9105
RL95-2 GDSC1 2.2369 4.402 0.4612 4.1002
EN GDSC1 2.8845 4.8989 0.6066 1.915
MFE-296 GDSC1 3.0742 5.1443 0.5983 1.7036
AN3-CA GDSC1 3.1794 5.3378 0.5695 1.7257
ESS-1 GDSC1 3.3654 9.4167 -1.1752 12.5207
MFE-319 GDSC1 3.5446 10.2908 -1.4727 13.8217
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P GDSC1 -3.4661 6.9238 -6.0486 53.9265
KTCTL-140 GDSC1 -2.3962 7.7993 -5.3684 48.5692
KTCTL-21 GDSC1 -1.5073 6.6771 -3.9676 42.8642
LB1047-RCC GDSC1 0.4733 7.2294 -2.3657 28.7267
Caki-1 GDSC1 1.0603 13.2937 -4.8834 34.4146
KTCTL-1M GDSC1 1.127 11.4012 -3.8811 31.6563
786-O GDSC1 1.2302 12.7724 -4.4799 32.9298
NCC021 GDSC1 1.4572 8.5746 -2.1923 24.07
KTCTL-195 GDSC1 1.7898 10.6888 -2.9776 26.3524
VMRC-RCZ GDSC1 1.9489 8.8734 -1.9448 21.1101
KTCTL-13 GDSC1 1.9535 5.975 -0.5015 12.0454
KTCTL-26A GDSC1 2.1089 8.6107 -1.6892 19.1947
BB65-RCC GDSC1 2.2742 5.6847 -0.1259 8.3354
VMRC-RCW GDSC1 2.3202 5.383 0.051 6.9052
RXF 393L GDSC1 2.3773 8.8825 -1.6189 17.9428
A-498 GDSC1 2.4316 3.9699 0.7684 1.6314
SN12C GDSC1 2.4989 6.2869 -0.2614 8.7086
LB996-RCC GDSC1 2.5193 6.7712 -0.4809 10.2146
CAL-54 GDSC1 2.6752 7.5244 -0.7368 11.5455
HA7-RCC GDSC1 2.6833 7.9833 -0.9537 12.9603
KMRC-20 GDSC1 2.7077 4.8766 0.5234 2.7094
SW13 GDSC1 2.8314 7.3236 -0.5333 9.7406
BFTC-909 GDSC1 2.9298 4.5459 0.7719 0.979
OS-RC-2 GDSC1 2.9459 11.0035 -2.2411 19.5306
KMRC-1 GDSC1 3.3925 8.4393 -0.6946 9.4269
TK-10 GDSC1 3.4372 15.2311 -3.9581 25.0922
RCC10RGB GDSC1 3.7928 12.0029 -2.126 16.6884
A-704 GDSC1 3.8949 5.4924 0.8075 0.2602
UO-31 GDSC1 4.3462 17.6015 -4.4557 24.4662
LB2241-RCC GDSC1 4.4362 6.3513 0.7056 0.3016
ACHN GDSC1 4.465 34.965 -12.9573 37.4928
SW156 GDSC1 5.1652 18.5699 -4.3472 22.3335
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1 -4.108 0.8535 -4.2135 83.6616
NCI-H747 GDSC1 -3.7975 9.4403 -6.3189 65.9375
SW1463 GDSC1 -1.9579 3.3514 -2.9612 43.9102
SW620 GDSC1 -0.2338 3.7233 -0.5002 42.2206
HCT 116 GDSC1 -0.2324 3.5777 -1.2671 26.3259
LS513 GDSC1 0.1581 31.489 -12.8706 50.2854
SNU-61 GDSC1 0.436 19.3486 -8.4399 41.2055
SNU-1040 GDSC1 0.7773 45.0943 -21.0198 45.7414
SNU-407 GDSC1 0.8726 14.5337 -5.662 36.5255
C2BBe1 GDSC1 0.9571 9.4787 -3.0643 29.6002
RKO GDSC1 1.1096 4.1806 0.8538 41.2668
GP5d GDSC1 1.2187 12.7208 -4.4637 32.9262
LS123 GDSC1 1.2686 10.0557 -3.0895 28.562
LS411N GDSC1 1.301 5.2037 0.7483 40.1772
SW626 GDSC1 1.3968 5.4684 -0.6893 15.2979
SNU-175 GDSC1 1.6305 20.3894 -7.9559 37.8525
LoVo GDSC1 1.9069 4.3969 0.2405 6.6216
HT115 GDSC1 2.141 7.9161 -1.3199 16.9244
LS180 GDSC1 2.1498 8.0079 -1.3586 17.1319
SNU-C2B GDSC1 2.2422 12.925 -1.8156 40.7494
KM12 GDSC1 2.2823 10.3536 -0.5259 38.0508
HT-29 GDSC1 2.3356 9.0726 -1.7444 18.777
LS1034 GDSC1 2.4739 6.7625 -0.5084 10.5351
HCT 15 GDSC1 2.5039 9.5152 -1.8363 18.7571
CW-2 GDSC1 2.7318 17.5476 -3.6587 41.4022
CaR-1 GDSC1 2.8269 8.9303 -1.3127 14.8045
T84 GDSC1 2.9836 12.6492 -3.0236 22.9057
SNU-81 GDSC1 2.9891 12.2657 -2.8303 22.0905
SW837 GDSC1 3.1774 11.7495 -2.438 19.8203
NCI-H716 GDSC1 3.3298 6.7845 2.1903 20.5596
SW1116 GDSC1 3.3354 4.9242 0.7987 0.5416
HT-55 GDSC1 3.4189 5.0068 0.8014 0.4832
MDST8 GDSC1 3.4603 9.3184 -1.0654 11.6111
SW1417 GDSC1 3.4676 12.5858 -2.6374 19.9447
SW948 GDSC1 3.5932 12.0653 -0.1726 31.3694
SNU-C5 GDSC1 3.6711 7.8823 -0.269 6.0582
CL-11 GDSC1 3.8448 5.8598 0.6574 0.7095
COLO 320HSR GDSC1 3.8912 5.7418 3.2274 7.5124
RCM-1 [Human ESC] GDSC1 3.9647 10.4209 -1.2588 11.5676
HCC2998 GDSC1 4.4179 10.9824 1.0713 22.8851
SW48 GDSC1 4.5458 10.6736 1.3307 21.0123
COLO205 GDSC1 4.581 12.3623 -1.7761 13.0397
SNU-C1 GDSC1 4.6486 6.4833 3.4999 5.391
COLO 678 GDSC1 4.9965 14.2085 -2.3768 15.0983
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 0.0868 3.4909 -0.9086 22.3983
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 -4.2655 10.6026 -8.5222 55.6759
SNU-449 GDSC1 0.6191 7.5434 -2.3923 28.2332
HLE GDSC1 1.5544 4.7237 -0.1893 11.0431
SNU-387 GDSC1 1.7574 7.8458 -1.5846 19.7822
JHH-6 GDSC1 1.9543 3.0976 0.8893 1.6895
JHH-2 GDSC1 2.2549 6.473 -0.5235 11.2762
HuH-1 GDSC1 2.3074 3.8703 0.745 1.9858
SNU-423 GDSC1 2.5367 14.3387 -4.2039 28.2699
JHH-7 GDSC1 2.6295 5.5316 0.1814 5.202
Hep 3B2.1-7 GDSC1 2.6416 4.1745 0.7876 1.2251
SK-HEP-1 GDSC1 2.6795 4.3349 0.74 1.4382
SNU-398 GDSC1 2.9995 7.3435 -0.4319 8.6209
Hep-G2/C3A GDSC1 3.1848 4.8728 0.7562 0.8142
SNU-475 GDSC1 3.3091 8.4177 -0.7381 9.9083
Huh-7 GDSC1 3.5951 5.2538 0.7803 0.4534
JHH-4 GDSC1 4.1851 6.0396 0.7228 0.349
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L105 GDSC1 -7.6137 2.4591 -8.7625 73.458
NCI-H1975 GDSC1 -6.3292 9.0687 -8.8723 71.6214
HCC827 GDSC1 -5.2769 11.214 -9.8134 58.3794
NCI-H3255 GDSC1 -5.2464 9.969 -9.2184 58.9285
PaCa-3 GDSC1 -4.0252 15.1478 -10.4312 53.7861
SK-MES-1 GDSC1 -3.4413 4.9211 -5.1632 54.5858
NCI-H1781 GDSC1 -3.2959 1.899 -3.8863 55.3048
PC-14 GDSC1 -3.087 13.6596 -8.8195 51.3112
NCI-H1755 GDSC1 -2.2331 0.667 -2.4006 44.9592
NCI-H358 GDSC1 -2.2187 9.1869 -5.8456 47.8922
CAL-12T GDSC1 -1.8639 3.5132 -2.927 43.1793
EMC-BAC-1 GDSC1 -1.8535 10.1671 -5.9626 46.3975
EPLC-272H GDSC1 -0.1961 5.5864 -2.1777 30.9499
EMC-BAC-2 GDSC1 -0.1912 6.1019 -2.4222 31.9702
Calu-3 GDSC1 -0.1067 9.8323 -4.1756 36.9384
IST-SL2 GDSC1 -0.0007 2.7129 -0.6454 21.0129
NCI-H647 GDSC1 0.1439 5.1795 -1.6591 26.7319
NCI-H1703 GDSC1 0.421 4.8392 -1.2343 22.9532
NCI-H2030 GDSC1 0.7192 8.751 -2.9061 29.9218
SBC-3 GDSC1 0.742 3.0605 -0.0678 13.2471
NCI-H2795 GDSC1 0.8631 1.5984 0.7257 6.6819
NCI-H1563 GDSC1 0.8892 7.3143 -2.0421 25.4908
COR-L23 GDSC1 0.9039 8.0131 -2.3781 27.0235
LC-2/ad GDSC1 0.9211 6.5431 -1.6298 23.1726
LCLC-97TM1 GDSC1 0.997 11.1317 -3.8563 32.031
SHP-77 GDSC1 1.0362 3.8639 -0.1944 12.9955
NCI-H520 GDSC1 1.2222 4.7243 -0.463 14.3028
NCI-H1648 GDSC1 1.3305 13.2631 -2.834 45.5673
HOP-62 GDSC1 1.3318 5.1794 -0.5986 14.8863
NCI-H1694 GDSC1 1.349 2.5533 0.7286 4.5822
NCI-H1869 GDSC1 1.3696 8.9666 -2.4608 25.6386
NCI-H446 GDSC1 1.3716 3.4551 0.2965 7.9069
NCI-H727 GDSC1 1.4519 10.443 -3.1308 28.0756
IST-SL1 GDSC1 1.51 7.1667 -1.4452 19.8416
HARA [Human squamous cell lung carcinoma] GDSC1 1.5172 11.8254 -3.768 30.0173
NCI-H2171 GDSC1 1.5277 3.1874 0.5547 5.3452
NCI-H1944 GDSC1 1.5772 10.634 -3.1232 27.6203
NCI-H209 GDSC1 1.5971 11.0601 -3.3198 28.268
NCI-H596 GDSC1 1.6038 12.7306 -4.1492 30.8696
ABC-1 GDSC1 1.6399 9.5731 -2.5418 25.0432
NCI-H526 GDSC1 1.7018 5.4124 -0.416 12.2443
NCI-H196 GDSC1 1.7302 3.2712 0.663 3.8912
NCI-H3122 GDSC1 1.7462 5.5003 -0.4251 12.1624
NCI-H2085 GDSC1 1.7489 9.9461 -2.6398 25.0982
CPC-N GDSC1 1.7607 4.8289 -0.0806 9.5294
NCI-H226 GDSC1 1.769 4.4427 0.1167 7.9896
NCI-H810 GDSC1 1.8502 3.709 0.5348 4.5347
NCI-H2135 GDSC1 1.8566 4.4851 0.1608 7.3814
NCI-H64 GDSC1 1.8728 3.9564 0.4308 5.2647
COR-L303 GDSC1 1.8768 4.5314 0.1529 7.382
SBC-5 GDSC1 1.8888 2.8089 0.9808 1.2026
NCI-H2087 GDSC1 1.8921 5.1154 1.4178 33.1688
HCC33 GDSC1 1.936 4.8549 0.0374 8.0867
NCI-H1437 GDSC1 1.9409 4.1901 0.3652 5.5739
Ms-1 GDSC1 1.9933 7.2039 -1.08 15.8915
NCI-H650 GDSC1 2.023 6.3488 -0.6339 12.77
HCC78 GDSC1 2.0268 7.8828 -1.3911 17.7293
NCI-H1092 GDSC1 2.029 4.503 0.2752 6.0129
UMC-11 GDSC1 2.0441 3.9046 0.5714 3.7575
NCI-H1876 GDSC1 2.1099 4.7367 0.2182 6.2211
SW1271 GDSC1 2.1112 8.1438 -1.4556 17.8394
NCI-H513 GDSC1 2.1236 14.198 -4.4608 30.172
NCI-H2731 GDSC1 2.1247 4.267 0.4526 4.4339
NCI-H2196 GDSC1 2.1582 3.932 0.6305 3.0649
Lu-65 GDSC1 2.1804 8.692 -1.6744 18.8803
Lu-135 GDSC1 2.2701 6.3462 -0.4505 10.7104
NCI-H1688 GDSC1 2.2872 4.5441 0.4267 4.2327
NCI-H1793 GDSC1 2.2975 5.1139 0.1643 6.1276
NCI-H748 GDSC1 2.2991 4.6045 0.406 4.3545
NCI-H2347 GDSC1 2.3004 5.4088 0.0253 7.1475
BEN GDSC1 2.3052 3.2813 0.9904 0.5761
COR-L311 GDSC1 2.3053 4.3195 0.5418 3.3709
LOU-NH91 GDSC1 2.3126 6.0341 -0.2683 9.2713
IA-LM GDSC1 2.3187 6.4578 -0.4701 10.7085
COR-L95 GDSC1 2.3432 5.3121 0.1004 6.4815
COR-L321 GDSC1 2.3707 5.0843 0.2265 5.4876
COLO 668 GDSC1 2.3813 4.6179 0.4508 3.847
NCI-H2081 GDSC1 2.3848 4.8568 0.3422 4.6144
NCI-H1155 GDSC1 2.3868 4.9822 0.2848 5.0243
Lu-134-A GDSC1 2.3937 4.6052 0.4642 3.7251
NCI-H847 GDSC1 2.4129 6.2808 -0.3177 9.3481
HCC44 GDSC1 2.419 6.6231 -0.4794 10.4863
NCI-H345 GDSC1 2.4482 3.294 1.0449 0.2514
HCC15 GDSC1 2.4486 5.8536 -0.0877 7.5843
NCI-H524 GDSC1 2.4527 9.2687 -1.7529 18.4598
NCI-H841 GDSC1 2.4907 5.5125 0.1022 6.0967
A-427 GDSC1 2.5028 7.1852 -0.6934 11.7373
NCI-H2405 GDSC1 2.5084 8.0358 -1.1049 14.4416
NCI-H290 GDSC1 2.5155 4.6466 0.5174 3.1063
NCI-H2869 GDSC1 2.5464 8.8559 -1.4797 16.6203
RERF-LC-MS GDSC1 2.5743 5.119 0.3378 4.2222
NCI-H441 GDSC1 2.5972 5.6075 0.1258 5.6718
RERF-LC-KJ GDSC1 2.5997 6.1824 -0.1437 7.5993
NCI-H1436 GDSC1 2.6346 4.2594 0.7492 1.4472
LXF 289 GDSC1 2.6463 8.3142 -1.1413 14.2669
NCI-H2369 GDSC1 2.7175 7.2729 -0.5861 10.4046
DMS 273 GDSC1 2.7322 6.2003 -0.066 6.7176
NCI-H187 GDSC1 2.7849 4.9625 0.5278 2.5484
Lu-99A GDSC1 2.7907 6.3581 -0.1026 6.8368
NCI-H1792 GDSC1 2.7991 10.1162 -1.9131 18.2863
NCI-H1304 GDSC1 2.8067 4.537 0.7185 1.3908
NCI-H1836 GDSC1 2.8159 4.3875 0.7832 1.044
NCI-H2141 GDSC1 2.82 4.039 0.9191 0.4509
EBC-1 GDSC1 2.8448 5.9267 0.1309 5.0808
NCI-H661 GDSC1 2.8901 13.6301 -3.5791 25.2619
NCI-H1838 GDSC1 2.8988 5.5603 0.3278 3.6379
NCI-H2009 GDSC1 2.9036 5.7131 0.2623 4.0647
NCI-H2595 GDSC1 2.9173 6.1613 0.0671 5.3655
Lu-139 GDSC1 2.9324 6.6914 -0.1687 6.9661
COR-L88 GDSC1 2.9351 5.5605 0.3481 3.4378
NCI-H23 GDSC1 2.9539 4.6793 0.73 1.1572
NCI-H1568 GDSC1 2.9616 18.1243 -5.755 31.0841
DMS 114 GDSC1 2.9731 5.5178 0.3877 3.1148
NCI-H2444 GDSC1 2.9767 4.3173 0.8791 0.4903
NCI-H211 GDSC1 2.9877 4.8571 0.6742 1.4043
NCI-H838 GDSC1 2.988 4.3515 0.8709 0.5121
NCI-H292 GDSC1 3.0033 9.9198 -1.6691 16.3769
NCI-H69 GDSC1 3.0037 5.0007 0.6232 1.6582
NCI-H1573 GDSC1 3.0111 6.3041 0.0581 5.228
NCI-H1651 GDSC1 3.0164 5.041 0.6127 1.6992
NCI-H2029 GDSC1 3.0347 4.4129 0.8671 0.495
NCI-H2110 GDSC1 3.0454 14.7858 -4.0332 26.3573
NCI-H2291 GDSC1 3.0547 5.0978 0.6079 1.6758
NCI-H1048 GDSC1 3.0596 11.5134 -2.4081 20.0084
NCI-H2228 GDSC1 3.0643 9.1163 -1.2361 13.6816
NCI-H1355 GDSC1 3.0694 5.4203 0.4806 2.3842
NCI-H2342 GDSC1 3.08 6.634 -0.0513 5.8273
LCLC-103H GDSC1 3.0817 8.5918 -0.9716 11.9876
NCI-H2227 GDSC1 3.088 6.683 -0.0689 5.9302
LK-2 GDSC1 3.1094 5.3289 0.5391 1.9862
Lu-165 GDSC1 3.1201 4.6306 0.8208 0.6063
NCI-H2803 GDSC1 3.13 5.6779 0.4022 2.7635
NCI-H522 GDSC1 3.1435 7.163 -0.2562 7.0834
DMS 53 GDSC1 3.1595 5.1158 0.65 1.3301
NCI-H2023 GDSC1 3.1622 5.1741 0.6278 1.4394
NCI-H1435 GDSC1 3.1819 5.2258 0.6162 1.4763
ChaGo-K-1 GDSC1 3.1918 6.8068 -0.0634 5.6735
NCI-H720 GDSC1 3.2325 4.5104 0.908 0.2672
NCI-H460 GDSC1 3.249 4.6367 0.8694 0.3648
LC-1/sq GDSC1 3.2506 16.9422 -4.9449 28.4535
NCI-H2722 GDSC1 3.2589 7.3057 -0.2512 6.794
NCI-H1993 GDSC1 3.2994 20.0378 -6.4434 31.6931
A-549 GDSC1 3.3312 5.5209 0.5669 1.5568
NCI-H1770 GDSC1 3.3618 4.6604 0.903 0.2306
NCI-H82 GDSC1 3.379 4.8684 0.836 0.398
NCI-H1915 GDSC1 3.4511 10.6409 -1.7047 15.3617
SW1573 GDSC1 3.4838 7.7489 -0.3186 6.7603
SK-LU-1 GDSC1 3.5025 12.335 -2.4901 19.1848
NCI-H510A GDSC1 3.516 5.2893 0.7363 0.6445
NCI-H2461 GDSC1 3.5237 5.5284 0.6496 0.9777
DMS 79 GDSC1 3.606 5.1789 0.8111 0.3608
NCI-H1734 GDSC1 3.6267 9.8109 0.9785 26.4676
NCI-H1650 GDSC1 3.6652 8.9942 -0.7816 9.353
HOP-92 GDSC1 3.7007 6.2143 0.4596 1.6827
NCI-H2818 GDSC1 3.7147 5.4514 0.7551 0.4675
NCI-H1299 GDSC1 3.7642 10.1567 -1.2636 12.0661
NCI-H2373 GDSC1 3.769 5.7978 0.6498 0.7877
NCI-H1666 GDSC1 3.7718 13.6829 -0.8245 32.7346
NCI-H2172 GDSC1 3.7851 11.2472 -1.7683 14.8567
NCI-H2591 GDSC1 3.8216 7.2361 0.0966 3.5218
NCI-H1581 GDSC1 3.8474 6.3926 0.4553 1.5487
RERF-LC-Sq1 GDSC1 3.8833 11.4463 -1.7976 14.7708
SBC-1 GDSC1 3.9094 5.2244 0.9031 0.0985
NCI-H1623 GDSC1 3.9768 9.5499 -0.8464 9.0692
NCI-H2170 GDSC1 4.4016 14.1562 -2.7454 18.0945
NCI-H2804 GDSC1 4.5503 6.683 0.6318 0.4283
Calu-6 GDSC1 4.6018 15.6809 -1.126 30.8101
NCI-H2122 GDSC1 4.72 12.333 0.6431 23.9275
NCI-H1693 GDSC1 4.7982 20.0177 -3.1327 34.7647
EKVX GDSC1 5.654 26.7053 -5.78 36.6149
NCI-H322M GDSC1 6.0229 21.9335 -5.3779 23.597
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 0.9973 3.898 -0.2457 13.5428
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 -12.4248 7.5556 -15.7474 74.1981
TE-15 GDSC1 -4.1826 41.6888 -23.6142 51.7954
KYSE-140 GDSC1 -3.4052 3.1624 -4.4351 55.2945
TE-4 GDSC1 -1.4741 3.0444 -2.3264 38.8561
KYSE-270 GDSC1 -0.2476 9.7319 -4.2533 37.6678
OE19 GDSC1 0.7752 3.66 -0.329 15.0892
TE-10 GDSC1 2.3008 9.1301 -1.7994 19.1883
TE-9 GDSC1 2.3341 4.2501 0.5906 2.97
TE-8 GDSC1 2.686 10.9819 -2.4237 21.1586
OE21 GDSC1 3.0723 9.1742 -1.2585 13.7964
TE-6 GDSC1 3.2213 16.2474 -4.6231 27.658
EC-GI-10 GDSC1 3.2684 5.2156 0.6597 1.1679
TE-5 GDSC1 3.5357 11.2092 -1.9205 16.2972
OE33 GDSC1 3.6674 11.3929 -1.9183 15.9465
TE-1 GDSC1 3.6765 12.8126 -2.599 19.2276
T.T GDSC1 4.0012 14.8214 -3.3462 21.5081
KYSE-410 GDSC1 4.0131 18.1442 -4.9654 26.687
KYSE-520 GDSC1 4.1305 6.7951 0.423 1.4243
KYSE-70 GDSC1 4.7314 12.4206 -1.7087 12.3613
COLO 680N GDSC1 5.24 15.7874 -2.9641 17.1548
KYSE-150 GDSC1 5.6462 20.6754 -5.0311 23.3822
KYSE-180 GDSC1 6.0862 29.9736 -9.2533 31.0531
KYSE-510 GDSC1 6.9501 19.8675 -3.7854 16.9759
TE-11 GDSC1 6.9903 18.05 -2.9234 13.6407
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 -1.2575 4.6336 -2.7796 38.9207
OVISE GDSC1 -0.4761 14.3323 -6.7363 42.1276
OC 314 GDSC1 -0.4204 7.3297 -3.2341 35.8735
TOV-21G GDSC1 0.1915 1.3665 0.0757 14.8932
TOV-112D GDSC1 0.7894 7.255 -2.0992 26.1757
RMG-I GDSC1 1.1806 10.5984 -3.4346 30.0827
EFO-21 GDSC1 1.5231 10.9213 -3.3112 28.4851
OVCAR-8 GDSC1 1.5542 5.3036 -0.4788 13.2118
OAW42 GDSC1 1.6031 3.1405 0.635 4.4807
Caov-3 GDSC1 1.6599 4.3135 0.0976 8.4835
JHOS-2 GDSC1 1.7013 6.933 -1.1741 17.4851
SK-OV-3 GDSC1 1.7362 10.8571 -3.105 27.0208
IGROV-1 GDSC1 1.9371 7.0519 -1.0479 15.8676
OVTOKO GDSC1 1.9953 12.2235 -3.5783 27.8827
DOV13 GDSC1 2.1252 4.3163 0.4296 4.6028
FU-OV-1 GDSC1 2.1304 11.2645 -2.9927 25.3142
OVCAR-5 GDSC1 2.3109 10.8955 -2.6677 23.3976
OV56 GDSC1 2.3395 3.8345 0.778 1.7199
ES-2 GDSC1 2.3502 5.9437 -0.1983 8.6561
EFO-27 GDSC1 2.4715 22.2784 -8.2143 36.3015
OVK18 GDSC1 2.5229 6.5706 -0.3815 9.5021
OAW28 GDSC1 2.6585 11.4485 -2.6752 22.3769
Caov-4 GDSC1 2.8329 5.2487 0.4288 3.0979
Kuramochi GDSC1 2.9033 9.2393 -1.4088 15.1629
TYK-nu GDSC1 3.0547 4.9125 0.6831 1.2807
OVCAR-4 GDSC1 3.3499 18.2541 -5.5191 29.6252
OVKATE GDSC1 3.4092 9.1724 -1.0297 11.5166
OVCAR-3 GDSC1 3.583 5.3054 0.757 0.5328
OV-90 GDSC1 5.7247 16.3224 -2.9034 15.9058
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 GDSC1 -2.0731 3.9325 -3.3191 45.292
MZ-PC-1 GDSC1 -1.0402 4.7719 -2.6226 37.1656
HPAC GDSC1 -0.5877 4.6359 -2.1083 32.6595
Panc 03.27 GDSC1 -0.0595 7.1131 -2.7925 32.7773
HPAF-II GDSC1 0.0635 6.8654 -2.5576 31.3279
HuP-T4 GDSC1 0.2352 6.9048 -2.4199 29.9935
KP-3 GDSC1 0.5871 7.1423 -2.2212 27.593
KP-2 GDSC1 1.0675 1.8297 0.8339 4.8816
Panc 08.13 GDSC1 1.1355 9.0579 -2.7025 27.5344
Capan-1 GDSC1 1.3386 6.9395 -1.473 20.6388
KP-4 GDSC1 1.6368 3.633 0.4172 6.0719
Panc 02.03 GDSC1 1.6781 10.0869 -2.7674 25.8777
Panc 10.05 GDSC1 2.0642 11.8932 -3.3586 26.9036
PaTu 8902 GDSC1 2.394 6.8781 -0.6213 11.5543
SU.86.86 GDSC1 2.4218 10.4618 -2.3668 21.6902
HuP-T3 GDSC1 2.506 14.2287 -4.1732 28.2643
PSN1 GDSC1 2.5349 8.3359 -1.2327 15.1657
PaTu 8988t GDSC1 2.6026 6.3185 -0.2066 8.0421
DAN-G GDSC1 2.7302 7.5842 -0.7274 11.3309
CFPAC-1 GDSC1 2.7746 8.0851 -0.9389 12.6075
SW1990 GDSC1 2.8805 6.8503 -0.2764 7.8385
MIA PaCa-2 GDSC1 3.252 4.5519 0.9006 0.278
Hs 766T GDSC1 3.5339 5.6729 0.5982 1.1938
BxPC-3 GDSC1 3.7762 11.3184 -1.8085 15.0936
PL4 GDSC1 3.8658 5.6785 0.7314 0.4617
QGP-1 GDSC1 3.9924 11.9163 -1.949 15.2976
Panc 04.03 GDSC1 4.012 5.572 0.8218 0.1986
Capan-2 GDSC1 5.7909 18.3278 -3.8071 19.2409
YAPC GDSC1 6.1997 15.5602 -2.26 12.1827
AsPC-1 GDSC1 6.4797 18.6385 -3.5082 16.8282
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 2.7561 6.913 -0.3877 8.927
MPP 89 GDSC1 2.8931 5.0774 0.5354 2.3257
NCI-H28 GDSC1 2.9197 8.2139 -0.9005 11.9605
MSTO-211H GDSC1 4.1034 5.9066 0.7394 0.3403
NCI-H2452 GDSC1 4.3094 6.5105 0.6025 0.6189
NCI-H2052 GDSC1 5.8703 15.6516 -2.5005 13.8836
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 1.6882 3.149 0.6927 3.7826
LNCaP clone FGC GDSC1 2.0121 8.4109 -1.6651 19.3779
PC-3 GDSC1 2.4971 6.1983 -0.22 8.4154
DU145 GDSC1 2.5721 4.6061 0.5675 2.6656
22Rv1 GDSC1 3.1879 5.846 0.3605 2.926
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 1.208 11.2283 -3.7265 30.9194
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHL-1 GDSC1 -1.9413 6.8081 -4.4578 45.7372
A-431 GDSC1 -1.9275 7.8489 -4.9298 46.0535
WM1552C GDSC1 0.7595 5.5784 -1.2914 21.8343
RPMI-7951 GDSC1 1.2799 4.8289 -0.4667 14.1137
A-388 GDSC1 1.3601 7.8958 -1.9332 23.1214
G-mel GDSC1 1.3632 6.5174 -1.2415 19.1312
RVH-421 GDSC1 1.404 11.7212 -3.8095 30.5157
IGR-1 GDSC1 1.5561 2.9553 0.6912 4.1877
G-361 GDSC1 1.6785 4.7858 -0.1226 10.1167
SK-MEL-3 GDSC1 1.7512 3.7994 0.4202 5.6984
MZ-MEL-2 GDSC1 1.9408 6.3773 -0.7103 13.5709
A2058 GDSC1 1.9503 4.8989 0.0262 8.1288
CP66-MEL GDSC1 2.0531 3.9173 0.5712 3.7367
SK-MEL-30 GDSC1 2.0638 6.6963 -0.7748 13.6231
LB373-MEL-D GDSC1 2.2192 4.6279 0.3436 5.0032
SK-MEL-28 GDSC1 2.2289 3.405 0.9039 1.1283
SK-MEL-2 GDSC1 2.3475 4.15 0.6435 2.5829
Hs 940.T GDSC1 2.3709 9.0591 -1.711 18.481
COLO 679 GDSC1 2.3813 7.5389 -0.9539 13.8455
IST-MEL1 GDSC1 2.4155 9.5849 -1.9374 19.5681
SH-4 GDSC1 2.4551 7.948 -1.1007 14.5743
UACC-62 GDSC1 2.4715 4.4273 0.5903 2.7017
MMAc-SF GDSC1 2.5202 4.8855 0.412 3.8198
COLO 792 GDSC1 2.6303 9.9168 -1.9398 18.9262
LOX-IMVI GDSC1 2.6794 5.1402 0.3903 3.6438
VMRC-MELG GDSC1 2.7481 4.9668 0.506 2.7502
CP50-MEL-B GDSC1 2.7666 4.7259 0.6197 2.0121
COLO 829 GDSC1 2.7782 6.2145 -0.0434 6.4488
451Lu GDSC1 2.8429 4.8509 0.6058 1.9802
UACC-257 GDSC1 2.8622 6.7272 -0.2302 7.5611
LB2518-MEL GDSC1 2.8776 4.4711 0.778 1.0037
SK-MEL-1 GDSC1 2.9106 4.3738 0.8304 0.7329
IGR-37 GDSC1 2.9875 4.3422 0.8742 0.5006
MeWo GDSC1 3.0152 8.4275 -0.938 11.9477
SK-MEL-5 GDSC1 3.0273 7.1458 -0.3211 7.7954
WT2-iPS GDSC1 3.063 4.3262 0.9097 0.3397
COLO 783 GDSC1 3.0692 4.5972 0.8123 0.6775
DJM-1 GDSC1 3.1385 6.9462 -0.1592 6.4352
WM793 GDSC1 3.1427 11.8621 -2.5185 20.2883
A101D GDSC1 3.1545 4.3786 0.9255 0.2548
Mel JuSo GDSC1 3.1697 11.5369 -2.3395 19.3769
IPC-298 GDSC1 3.3373 10.9355 -1.9264 16.8519
Hs 938.T GDSC1 3.3741 5.0576 0.765 0.636
GAK GDSC1 3.3832 4.9697 0.801 0.5051
WM115 GDSC1 3.397 11.1272 -1.9775 16.9581
Mel Ho GDSC1 3.4344 4.9394 0.8316 0.3832
A-375 GDSC1 3.4764 4.889 0.8651 0.2768
MZ-MEL-7 GDSC1 3.5606 10.5019 -1.563 14.293
WM35 GDSC1 3.6597 8.8532 -0.7195 8.9726
HMV-II GDSC1 3.8009 12.6911 -2.4527 18.2409
SK-MEL-24 GDSC1 3.9502 5.546 0.8089 0.2402
M14 GDSC1 4.0834 5.7007 0.8031 0.2135
WM278 GDSC1 4.5809 6.3711 0.7497 0.1849
HT-144 GDSC1 4.6286 11.9729 -1.5649 11.8143
COLO 800 GDSC1 4.8787 13.5538 -2.1448 14.2499
EquiPSC Line K2 GDSC1 3.2495 6.5004 0.1078 4.4239
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -0.503 5.0943 -2.2394 32.7762
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN GDSC1 -0.4354 5.8048 -2.5116 33.5261
A-204 GDSC1 1.2392 5.7256 -0.9492 17.6905
EW-8 GDSC1 1.4244 6.6622 -1.2633 19.0411
Hs 633.T GDSC1 1.4386 5.3359 -0.5887 14.4238
MES-SA GDSC1 1.4427 3.9918 0.0863 9.3033
Rh41 GDSC1 1.5161 2.9025 0.687 4.3468
SW982 GDSC1 1.5973 8.1362 -1.8585 21.8657
SK-LMS-1 GDSC1 1.6092 5.8431 -0.7039 14.6427
TE 441.T GDSC1 1.978 3.6968 0.6266 3.5133
SW872 GDSC1 2.1474 4.253 0.474 4.2208
SK-UT-1 GDSC1 2.2302 4.1099 0.5925 3.1759
SW684 GDSC1 2.6017 4.1949 0.7598 1.4323
Rh30 GDSC1 2.657 6.4997 -0.2566 8.2588
MFH-ino GDSC1 2.7145 4.9595 0.4907 2.9091
HT-1080 GDSC1 2.7746 8.1944 -0.9919 12.95
KYM-1 GDSC1 3.041 4.6319 0.7871 0.8056
G-401 GDSC1 3.093 12.965 -3.0976 22.8984
VA-ES-BJ GDSC1 3.3126 5.0561 0.7403 0.7759
GCT GDSC1 3.7 5.3707 0.7784 0.4077
RD GDSC1 3.983 7.9396 -0.1208 4.5654
G-402 GDSC1 4.7082 13.522 -2.2396 15.08
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 GDSC1 -6.3925 8.3749 -9.6954 63.1178
Hs 746.T GDSC1 -0.0359 2.5671 -0.6188 21.0052
IM95 GDSC1 0.6262 17.5755 -7.3917 39.6723
RF-48 GDSC1 1.0216 4.5702 -0.5588 15.7868
GCIY GDSC1 1.2622 11.3737 -3.7538 30.819
SNU-1 GDSC1 1.4644 7.5706 -1.6845 21.3925
ECC10 GDSC1 1.5889 7.0132 -1.3044 18.7011
MKN45 GDSC1 1.6728 4.1501 0.1885 7.7374
Fu97 GDSC1 1.896 3.6713 0.5844 4.0366
MKN1 GDSC1 2.1539 9.3097 -2.0016 20.7316
23132/87 GDSC1 2.2198 5.0938 0.1216 6.6481
RERF-GC-1B GDSC1 2.3723 8.4516 -1.4099 16.738
AGS GDSC1 2.3931 5.7698 -0.0851 7.7121
SCH GDSC1 2.7347 4.8647 0.5432 2.5359
HSC-39 GDSC1 2.7998 10.4314 -2.0675 19.0857
SNU-5 GDSC1 3.1754 4.7449 0.8006 0.6431
OCUM-1 GDSC1 3.2811 5.8477 0.4079 2.499
SNU-16 GDSC1 3.398 4.7292 0.8922 0.2421
TGBC11TKB GDSC1 3.4498 5.3786 0.6754 0.931
NUGC-4 GDSC1 3.5881 13.6913 -3.0909 21.549
TMK-1 GDSC1 3.6022 5.685 0.6231 1.0231
MKN28 GDSC1 3.7628 11.4163 -1.8645 15.4234
HGC-27 GDSC1 3.8878 8.9127 -0.6082 7.7781
MKN7 GDSC1 4.2271 6.0794 0.7243 0.3305
NUGC-3 GDSC1 5.71 28.4848 -8.7986 31.0059
SNG-M GDSC1 -1.9778 1.1756 -2.2403 42.2962
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 0.2607 7.6721 -2.7758 31.3058
ML-1 [Human leukemia] GDSC1 1.1962 5.43 -0.8378 17.0923
CGTH-W-1 GDSC1 1.6224 3.2328 0.6039 4.6633
CAL-62 GDSC1 1.9035 3.9678 0.4467 5.0579
TT2609-C02 GDSC1 2.0237 7.5926 -1.2495 16.8703
KMH-2 GDSC1 2.093 6.0232 -0.4212 11.0294
IHH-4 GDSC1 2.1421 5.104 0.0631 7.2971
ASH-3 GDSC1 2.685 4.0421 0.8607 0.8059
B-CPAP GDSC1 2.7248 9.5499 -1.6895 17.2898
8505C GDSC1 2.7767 7.3276 -0.5721 10.1498
BHT-101 GDSC1 2.9147 5.2652 0.4661 2.7187
8305C GDSC1 3.1272 8.19 -0.7492 10.4312
WRO GDSC1 3.3573 4.8761 0.8249 0.4431
TT GDSC1 3.4728 5.1022 0.7878 0.4963
K5 GDSC1 3.7003 5.2601 0.8175 0.3058
FTC-133 GDSC1 3.9417 5.3299 0.879 0.1239
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 -4.8764 32.5585 -19.7212 53.2066
SCC-9 GDSC1 -3.8984 9.4008 -7.603 54.8499
PCI-04B GDSC1 -1.457 24.3018 -12.5588 47.4234
CAL-27 GDSC1 -1.0252 11.661 -5.9138 43.1578
BB30-HNC GDSC1 -0.6373 25.0891 -12.2314 45.695
BHY GDSC1 -0.5789 11.2895 -5.3228 40.8063
SCC-25 GDSC1 -0.4707 8.8106 -4.0043 38.0508
CAL-33 GDSC1 0.0726 10.8279 -4.5086 36.9754
SAT [Human HNSCC] GDSC1 0.9679 12.0976 -4.3637 33.4953
JHU-011 GDSC1 0.9779 21.0299 -8.8202 40.266
PCI-15A GDSC1 1.4183 21.1732 -8.5235 38.9749
SAS GDSC1 1.4938 16.5888 -6.1688 35.6377
PCI-06A GDSC1 1.6249 24.3935 -9.9623 39.8854
SCC-15 GDSC1 1.6474 22.9658 -9.23 39.1812
LB771-HNC GDSC1 1.8286 6.9243 -1.069 16.3689
BICR 10 GDSC1 1.92 3.815 0.5317 4.3698
DOK GDSC1 2.1557 19.5535 -7.1087 35.4761
Ca9-22 GDSC1 2.2924 21.5937 -8.017 36.4361
BICR 31 GDSC1 2.6249 15.5399 -4.7325 29.5079
SKN-3 GDSC1 2.7058 8.8754 -1.3728 15.5146
OSC-20 GDSC1 2.7084 14.4799 -4.1403 27.6027
PE/CA-PJ15 GDSC1 2.8279 18.6434 -6.118 32.1546
Detroit 562 GDSC1 2.981 10.4316 -1.9351 17.8796
HO-1-u-1 GDSC1 2.9923 7.2006 -0.3692 8.2091
HSC-3 GDSC1 2.9962 8.9783 -1.2167 13.749
OSC-19 GDSC1 3.0316 20.5892 -6.9266 33.1694
KON GDSC1 3.1313 4.9156 0.7165 1.0385
SCC-4 GDSC1 3.158 8.7174 -0.9802 11.8431
BICR 22 GDSC1 3.2798 4.6368 0.881 0.3175
PCI-38 GDSC1 3.4408 10.1947 -1.497 14.2257
BB49-HNC GDSC1 3.444 6.0132 0.4199 2.203
HO-1-N-1 GDSC1 3.6695 10.8335 -1.6483 14.4927
PCI-30 GDSC1 4.3753 11.4516 -1.4807 11.9032
HSC-4 GDSC1 4.4081 14.4695 -2.8916 18.7055
KOSC-2 GDSC1 4.943 7.4143 0.5201 0.5506
JHU-022 GDSC1 4.9851 15.4551 -2.9744 17.7461
FaDu GDSC1 5.8809 22.9255 -5.9567 25.3207
BICR 78 GDSC1 6.0343 20.4558 -4.6598 21.5436
HSC-2 GDSC1 8.3665 23.7002 -4.6834 17.5468
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1 0.8448 4.975 -0.916 19.032
CAL-29 GDSC1 0.9612 6.8204 -1.7334 23.5877
5637 GDSC1 1.3309 9.1677 -2.5935 26.3601
HT-1197 GDSC1 1.7072 2.9574 0.7987 2.922
UM-UC-3 GDSC1 1.7409 6.5721 -0.9627 15.966
RT-4 GDSC1 1.7865 8.6858 -1.9804 21.8463
BFTC-905 GDSC1 2.1026 4.5856 0.2859 5.7325
639V GDSC1 2.1532 4.8901 0.1741 6.4348
TCCSUP GDSC1 2.5549 4.8814 0.4345 3.593
SW1710 GDSC1 2.5695 11.1775 -2.6087 22.3483
KU-19-19 GDSC1 2.86 4.3844 0.8042 0.8967
J82 GDSC1 2.8778 7.1517 -0.4206 8.8459
SW780 GDSC1 3.027 4.7867 0.7206 1.125
T24 GDSC1 3.4896 12.5599 -2.609 19.7598
RT-112 GDSC1 3.4915 5.1508 0.7774 0.5192
HT-1376 GDSC1 3.5113 5.4588 0.6708 0.8994
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -7.8793 1.9775 -8.9061 74.9218
OVMIU GDSC1 -4.2299 3.8552 -5.5778 59.5085
DSH1 GDSC1 -3.3833 1.095 -3.7529 56.615
PA-1 GDSC1 -1.3805 1.2383 -1.6049 35.0748
SW954 GDSC1 -0.7942 11.2349 -5.4924 41.8314
ME-180 GDSC1 -0.6402 13.8884 -6.6631 42.5755
C-33 A GDSC1 0.0287 10.9336 -4.6 37.3259
Ca Ski GDSC1 0.2333 11.3592 -4.6305 36.6446
JAR GDSC1 0.38 7.8364 -2.7501 30.7029
DoTc2 4510 GDSC1 0.9323 13.5856 -5.1376 35.3525
OMC-1 [Human cervical carcinoma] GDSC1 1.1239 5.7447 -1.0566 18.8526
ACC-OV7 GDSC1 1.6592 3.5448 0.4775 5.5331
KGN GDSC1 1.6625 8.022 -1.7487 21.0389
HeLa GDSC1 2.2108 4.1969 0.5404 3.5895
SW756 GDSC1 2.2254 4.6898 0.3184 5.1735
OVCA420 GDSC1 2.3496 9.1899 -1.7918 18.9933
C-4-I GDSC1 2.3561 4.9659 0.2729 5.1849
SW962 GDSC1 2.3676 5.2867 0.1286 6.2114
SKN GDSC1 2.3764 5.3641 0.0977 6.416
MS751 GDSC1 2.4588 8.3244 -1.2829 15.7037
HEC-1 GDSC1 2.5296 4.5033 0.5893 2.6004
HEY GDSC1 2.6009 10.0135 -2.0095 19.3777
SiHa GDSC1 2.8165 4.4549 0.7565 1.1781
JEG-3 GDSC1 2.8667 4.4474 0.7825 0.9933
OVCA433 GDSC1 3.0745 7.2487 -0.3393 7.8086
PEO1 GDSC1 3.1497 5.2324 0.5984 1.6082
LB831-BLC GDSC1 3.2263 5.262 0.6223 1.3948
HT-3 GDSC1 3.2546 10.9626 -1.9981 17.448
CAL-39 GDSC1 3.3166 10.0227 -1.4992 14.5624
SKG-IIIa GDSC1 3.4952 5.9552 0.4683 1.8756
NEC8 GDSC1 3.6396 5.773 0.6053 1.0668
UWB1.289 GDSC1 3.9212 13.0776 -2.5559 18.4131
SiSo GDSC1 4.3841 14.8468 -3.0899 19.5813
NT2-D1 GDSC1 4.4552 12.8825 -2.1021 14.9806
JHOS-3 GDSC1 4.506 16.3251 -3.7203 21.6873
OV17R GDSC1 5.0187 14.5408 -2.519 15.7019
NCC-IT GDSC1 5.1716 16.829 -3.5055 19.4293
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

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2 EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma.Radiat Res.2013 Mar;179(3):304-12.
3 Irreversible EGFR inhibitor EKB-569 targets low-LET -radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011;6(12):e29705. doi: 10.1371/journal.pone.0029705. Epub 2011 Dec 29.
4 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.