General Information of Drug (ID: DMJS8VQ)

Drug Name
WH-4-023 Drug Info
Synonyms
WH-4-023; 837422-57-8; 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate; KIN001-112; 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate; SCHEMBL5755186; KIN112; CHEMBL213100; GTPL8068; CHEBI:94644; 2-aminopyrimidine carbamate, 28; KS-00001CWM; BDBM17729; AOB6574; MolPort-035-789-690; HMS3653D15; C32H36N6O4; EX-A1078; BCP10090; s7565; ZINC14965418; 2801AH; AKOS025142111; CS-3292; NCGC00346959-01
Cross-matching ID
PubChem CID
11844351
ChEBI ID
CHEMBL213100
TTD Drug ID
D0Y1SR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.31 0.00e+0 93/133 (69.92%) PPA2;NDUFB5;COX7B;...
DNA replication 2.18 0.00e+0 34/36 (94.44%) POLE2;PRIM1;RPA3;...
Propanoate metabolism 2.07 0.00e+0 30/34 (88.24%) LDHB;SUCLG2;DLD;...
Non-alcoholic fatty liver disease 2.00 0.00e+0 126/155 (81.29%) NDUFB5;CXCL8;COX7B;...
Nucleotide excision repair 1.95 1.67e-3 40/47 (85.11%) POLE2;RPA3;RFC3;...
Diabetic cardiomyopathy 1.95 1.40e-3 162/203 (79.8%) CYBA;CYBB;NDUFB5;...
Valine, leucine and isoleucine degradation 1.93 3.59e-3 42/48 (87.5%) ALDH9A1;AUH;DLD;...
Ribosome 1.90 5.23e-3 113/158 (71.52%) RPL26L1;MRPL33;MRPL22;...
Thermogenesis 1.88 5.58e-3 173/232 (74.57%) SMARCD3;NDUFB5;COA1;...
Base excision repair 1.82 1.51e-2 29/33 (87.88%) POLE2;PARP2;FEN1;...
Staphylococcus aureus infection 1.82 1.37e-2 72/95 (75.79%) C3;HLA-DMB;CFI;...
Viral protein interaction with cytokine and cytokine re... 1.80 1.33e-2 84/100 (84%) TNFSF10;CXCL5;CCR1;...
Pertussis 1.79 1.42e-2 64/76 (84.21%) CXCL5;CASP1;CD14;...
Parkinson disease 1.77 1.56e-2 176/249 (70.68%) NDUFB5;COX7B;NDUFB3;...
Tryptophan metabolism 1.75 1.67e-2 35/42 (83.33%) KYNU;ALDH9A1;MAOB;...
Prion disease 1.74 1.73e-2 209/273 (76.56%) CYBA;CYBB;NDUFB5;...
Terpenoid backbone biosynthesis 1.73 1.92e-2 18/22 (81.82%) PDSS1;ACAT2;IDI1;...
Complement and coagulation cascades 1.73 1.81e-2 76/85 (89.41%) TFPI;SERPINA1;F13A1;...
Mismatch repair 1.72 1.76e-2 22/23 (95.65%) RPA3;RFC3;SSBP1;...
Peroxisome 1.71 1.72e-2 72/82 (87.8%) PHYH;ECI2;SOD2;...
Systemic lupus erythematosus 1.71 1.71e-2 45/135 (33.33%) C3;HLA-DMB;FCGR2A;...
Drug metabolism 1.66 2.47e-2 78/151 (51.66%) ADH5;MGST2;FMO1;...
N-Glycan biosynthesis 1.66 2.44e-2 38/50 (76%) ALG5;DPM3;ALG8;...
Steroid biosynthesis 1.65 2.41e-2 19/20 (95%) DHCR7;LIPA;HSD17B7;...
beta-Alanine metabolism 1.64 2.55e-2 25/30 (83.33%) ALDH9A1;DPYD;ALDH3A1;...
Amyotrophic lateral sclerosis 1.60 3.80e-2 267/364 (73.35%) CASP1;NDUFB5;COX7B;...
Citrate cycle (TCA cycle) 1.58 4.75e-2 30/30 (100%) SDHD;IDH1;SUCLG2;...
Huntington disease 1.57 4.94e-2 233/306 (76.14%) NDUFB5;COX7B;GPX1;...
Insulin secretion -1.72 1.14e-2 75/86 (87.21%) KCNN1;PLCB4;RAB3A;...
Colorectal cancer -1.73 1.14e-2 84/86 (97.67%) TGFBR1;BAX;EREG;...
PI3K-Akt signaling pathway -1.73 1.18e-2 317/354 (89.55%) EREG;BDNF;TCL1B;...
Human papillomavirus infection -1.75 9.94e-3 284/331 (85.8%) RBPJL;ATP6V1D;TNXB;...
Bacterial invasion of epithelial cells -1.75 1.03e-2 59/77 (76.62%) PIK3CA;ILK;ARPC5L;...
Arrhythmogenic right ventricular cardiomyopathy -1.76 1.07e-2 70/77 (90.91%) ACTN3;CACNG2;ITGA2;...
Synaptic vesicle cycle -1.76 1.12e-2 63/78 (80.77%) SLC6A11;ATP6V1G1;AP2M1;...
Melanogenesis -1.80 7.95e-3 74/101 (73.27%) CREBBP;FZD7;TYRP1;...
Axon guidance -1.80 7.21e-3 151/182 (82.97%) RAC1;PIK3CD;MAPK3;...
Endocytosis -1.82 3.48e-3 198/252 (78.57%) NEDD4L;CHMP1A;ARF5;...
ErbB signaling pathway -1.82 3.66e-3 79/85 (92.94%) CAMK2A;EREG;ERBB4;...
Breast cancer -1.83 3.21e-3 119/147 (80.95%) SP1;RPS6KB1;FGF4;...
Glioma -1.84 3.39e-3 67/75 (89.33%) E2F2;CAMK2A;BAX;...
GnRH signaling pathway -1.84 3.59e-3 80/93 (86.02%) PLCB4;MMP2;CAMK2A;...
Estrogen signaling pathway -1.86 3.81e-3 119/137 (86.86%) GNAO1;PLCB4;SP1;...
Bladder cancer -1.87 2.44e-3 40/41 (97.56%) MAP2K1;HRAS;DAPK3;...
Endometrial cancer -1.88 1.74e-3 56/58 (96.55%) PIK3CD;MAPK3;RAF1;...
MAPK signaling pathway -1.90 1.88e-3 272/294 (92.52%) RAP1A;EFNA1;HSPB1;...
MicroRNAs in cancer -1.90 2.03e-3 146/310 (47.1%) SERPINB5;MAP2K2;APC2;...
TGF-beta signaling pathway -1.93 1.11e-3 81/94 (86.17%) SP1;RPS6KB1;HAMP;...
Chronic myeloid leukemia -1.93 1.22e-3 72/76 (94.74%) E2F2;TGFBR1;BAX;...
ECM-receptor interaction -1.94 1.35e-3 80/88 (90.91%) LAMA3;COL9A1;CD36;...
Gastric cancer -1.95 1.52e-3 122/149 (81.88%) RPS6KB1;FGF4;E2F2;...
Thyroid cancer -1.96 1.74e-3 36/37 (97.3%) CCND1;KRAS;MAP2K2;...
Signaling pathways regulating pluripotency of stem cell... -1.96 2.03e-3 110/143 (76.92%) HOXB1;PAX6;PIK3CD;...
Adherens junction -1.97 2.44e-3 63/71 (88.73%) SORBS1;FARP2;SNAI1;...
Renal cell carcinoma -1.98 3.05e-3 68/69 (98.55%) RAC1;PIK3CD;MAPK3;...
Proteoglycans in cancer -1.99 4.06e-3 172/205 (83.9%) RPS6KB1;MMP2;FZD9;...
Regulation of actin cytoskeleton -2.05 6.10e-3 185/218 (84.86%) CHRM4;RAC1;PIK3CD;...
Focal adhesion -2.07 1.22e-2 180/201 (89.55%) RAC1;PIK3CD;MAPK3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.08uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.08uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H