Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK2XB7)

Drug Name
AR-00341677 Drug Info
Synonyms GDC-0879; Anticancer program, Array/Genentech; B-Raf kinase inhibitors (cancer), Array/Genentech
Cross-matching ID
PubChem CID
25093303
ChEBI ID
CHEMBL91434
CAS Number
CAS 905281-76-7
TTD Drug ID
D03TTT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.57 0.00e+0 34/36 (94.44%) PCNA;POLE2;RFC5;...
Mismatch repair 2.14 0.00e+0 22/23 (95.65%) PCNA;RFC5;RPA3;...
AGE-RAGE signaling pathway in diabetic complications 1.88 1.10e-2 97/100 (97%) TGFBR2;CXCL8;SMAD3;...
Drug metabolism 1.85 1.65e-2 78/151 (51.66%) CDA;HPRT1;GSTA4;...
Nucleotide excision repair 1.84 1.76e-2 40/47 (85.11%) PCNA;POLE2;RFC5;...
Base excision repair 1.83 1.65e-2 29/33 (87.88%) PCNA;POLE2;FEN1;...
Cell cycle 1.82 1.57e-2 110/124 (88.71%) E2F2;PCNA;SMAD3;...
Fructose and mannose metabolism 1.81 2.07e-2 30/33 (90.91%) PFKFB3;SORD;AKR1B10;...
Glycolysis / Gluconeogenesis 1.79 2.08e-2 56/67 (83.58%) PCK1;GPI;FBP1;...
Folate biosynthesis 1.79 1.98e-2 23/26 (88.46%) DHFR;AKR1C3;AKR1B10;...
Pyrimidine metabolism 1.78 2.00e-2 40/56 (71.43%) NT5E;TYMS;CDA;...
Asthma 1.76 2.30e-2 25/31 (80.65%) HLA-DPB1;HLA-DRA;RNASE3;...
ECM-receptor interaction 1.74 2.46e-2 80/88 (90.91%) SPP1;COL6A3;TNC;...
Primary bile acid biosynthesis 1.74 2.36e-2 15/17 (88.24%) CH25H;AKR1D1;CYP39A1;...
PPAR signaling pathway 1.73 2.35e-2 66/74 (89.19%) PPARG;FABP4;FABP5;...
Tyrosine metabolism 1.71 2.76e-2 30/36 (83.33%) TPO;FAH;TYRP1;...
Other types of O-glycan biosynthesis 1.68 4.02e-2 29/47 (61.7%) GALNT7;C1GALT1C1;GALNT10;...
Aminoacyl-tRNA biosynthesis 1.67 3.92e-2 15/66 (22.73%) FARSA;WARS2;DARS2;...
Cardiac muscle contraction -1.79 3.22e-2 64/87 (73.56%) SLC8A2;SLC9A6;COX7C;...
Leukocyte transendothelial migration -1.82 3.80e-2 90/114 (78.95%) CDH5;CLDN1;MAPK13;...
Ovarian steroidogenesis -1.85 4.47e-2 41/51 (80.39%) ALOX5;LDLR;STAR;...
Selenocompound metabolism -1.91 4.47e-2 11/17 (64.71%) PAPSS2;TXNRD1;SEPHS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
HEK293T CVCL_0063 Homo sapiens 0.125uM - 10uM 6H, 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H