Details of the Drug

General Information of Drug (ID: DMK2XB7)

Drug Name
AR-00341677
Synonyms GDC-0879; Anticancer program, Array/Genentech; B-Raf kinase inhibitors (cancer), Array/Genentech
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 334.4
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C19H18N4O2
IUPAC Name
2-[4-[(1Z)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol
Canonical SMILES
C1C/C(=N/O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
InChI
InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18-
InChIKey
DEZZLWQELQORIU-PYCFMQQDSA-N
Cross-matching ID
PubChem CID
25093303
ChEBI ID
CHEBI:91434
CAS Number
905281-76-7
TTD ID
D03TTT

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [3]
Tissue factor (F3) OT3MSU3B TF_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase B-raf (BRAF) DTT BRAF 3.00E-01 0.1 0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 5.0996 7.2043 4.5658 8.3169
MEC1 CTRP2 7.4824 8.7496 5.6213 0.3051
JM1 CTRP2 6.1966 7.7323 5.3237 2.7481
SKM-1 CTRP2 -3.7472 10.9928 -6.3073 57.6758
SIG-M5 CTRP2 -0.3201 4.5778 -0.563 42.9284
OCI-AML-3 CTRP2 2.2933 4.1891 2.2713 25.064
OCI-AML-2 CTRP2 2.7982 6.1829 2.4629 22.7992
Ku812 CTRP2 3.563 5.387 3.4834 16.8028
HuT 78 CTRP2 3.643 5.9309 3.4538 16.6569
KMS-21-BM CTRP2 3.9951 6.3034 3.7322 14.583
MOLM-6 CTRP2 4.3722 6.8922 3.9339 12.7389
LAMA-84 CTRP2 4.4133 5.9447 4.2905 11.2937
JURL-MK1 CTRP2 4.5345 5.5932 4.4943 10.1958
SK-MM-2 CTRP2 4.5403 6.1416 1.553 0.2191
ME1 CTRP2 4.6209 8.3365 3.5697 13.5171
NCO2 CTRP2 4.7064 6.0504 4.5826 9.3473
NB4 CTRP2 4.7208 7.8283 3.9017 11.9353
MV4-11 CTRP2 4.7966 7.3234 4.2029 10.543
NCI-H929 CTRP2 4.9636 8.0158 4.0584 10.6978
THP-1 CTRP2 4.9868 7.3376 4.3915 9.3011
RS4;11 CTRP2 4.9925 6.7095 1.5195 0.1663
KYO-1 CTRP2 5.0645 6.5726 4.7955 7.5114
NU-DUL-1 CTRP2 5.1373 24.3471 -5.1813 30.3543
KMS-20 CTRP2 5.1488 6.5414 4.8974 6.8865
MOLP-8 CTRP2 5.1718 8.3936 4.0818 10.1032
SU-DHL-1 CTRP2 5.1719 6.4364 4.9624 6.5735
MOLM-13 CTRP2 5.1974 7.5277 4.5167 8.2678
P31/FUJ CTRP2 5.1978 8.3846 4.1109 9.923
Kasumi-1 CTRP2 5.3483 6.8347 4.9835 6.0143
HL-60 CTRP2 5.4007 8.5673 4.2133 9.036
KMS-27 CTRP2 5.4094 9.6053 3.7105 11.1019
OPM-2 CTRP2 5.4756 6.7512 5.1504 5.0223
EM-2 CTRP2 5.5139 7.8712 4.6584 6.9375
KO52 CTRP2 5.531 9.2577 3.9921 9.669
A4/Fukuda CTRP2 5.5565 6.7122 5.25 4.4181
CML-T1 CTRP2 5.5754 9.1321 4.0942 9.1486
KMS-26 CTRP2 5.7079 7.004 5.2618 4.0023
HD-MY-Z CTRP2 5.8449 8.3964 4.6983 6.0554
BV-173 CTRP2 5.8497 8.0117 4.8941 5.2246
AML-193 CTRP2 5.8837 9.2465 4.3075 7.6162
NU-DHL-1 CTRP2 5.8954 22.5081 -2.312 28.8099
OCI-AML-5 CTRP2 5.9435 7.4669 5.2474 3.5501
F-36P CTRP2 5.9971 7.6151 5.2192 3.5608
P12-Ichikawa CTRP2 5.9984 9.3821 4.337 7.2655
NALM-6 CTRP2 6.0723 8.392 4.8938 4.7828
Ri-1 CTRP2 6.0734 8.9516 4.6149 5.953
SUP-B15 CTRP2 6.0978 7.6416 5.2899 3.0698
OCI-Ly19 CTRP2 6.1019 9.5501 4.3392 7.0563
SEM CTRP2 6.1065 7.1977 5.5186 2.093
Karpas-422 CTRP2 6.1333 9.2735 4.5033 6.3079
SUP-M2 CTRP2 6.1446 7.4962 5.4002 2.5206
TALL-1 [Human adult T-ALL] CTRP2 6.158 8.9776 4.6713 5.5559
KMS-34 CTRP2 6.169 8.9666 4.6858 5.4747
MOLT-3 CTRP2 6.2056 7.0509 5.6684 1.2952
TF-1 CTRP2 6.2233 8.459 4.9827 4.1291
MOLT-16 CTRP2 6.2423 8.0158 5.2184 3.1085
HEL 92.1.7 CTRP2 6.2788 7.9318 5.2882 2.7537
OCI-M1 CTRP2 6.3028 7.3295 5.6024 1.4145
CMK CTRP2 6.3042 7.3984 5.5698 1.5457
SET-2 CTRP2 6.3158 7.5311 5.5133 1.76
LP-1 CTRP2 6.3363 7.7944 5.3992 2.1981
KMS-18 CTRP2 6.3506 8.0352 5.2913 2.6215
JJN-3 CTRP2 6.3804 8.4149 5.1262 3.2574
SU-DHL-8 CTRP2 6.3825 9.0208 4.8277 4.4976
MHH-CALL-3 CTRP2 6.4758 8.5226 5.1438 3.0296
HEL CTRP2 6.4953 9.902 4.4772 5.7663
697 CTRP2 6.5142 8.1876 5.3346 2.1896
DND-41 CTRP2 6.5828 11.8515 3.5764 9.3557
OCI-Ly10 CTRP2 6.6013 9.8455 4.5857 5.1366
KE-37 CTRP2 6.6145 9.0194 5.0011 3.3995
RPMI-8226 CTRP2 6.628 8.5911 5.2185 2.4939
U266B1 CTRP2 6.7045 8.2519 5.4303 1.5505
WSU-DLCL2 CTRP2 6.7157 9.0501 5.0575 3.0176
Peer CTRP2 6.733 8.1501 5.4951 1.2695
K-562 CTRP2 6.7652 8.8658 5.1798 2.4559
Daudi CTRP2 6.775 8.0698 5.5563 0.9979
SU-DHL-6 CTRP2 6.8075 8.7905 5.2433 2.1479
RCH-ACV CTRP2 6.8082 9.3532 4.9752 3.2163
MOLP-2 CTRP2 6.8092 9.894 4.7138 4.2781
GDM-1 CTRP2 6.8244 9.7376 4.8005 3.9009
EJM CTRP2 6.83 8.8271 5.2406 2.1291
MOTN-1 CTRP2 6.8584 8.6448 5.3437 1.6951
JVM-2 CTRP2 6.8619 9.2675 5.0526 2.8297
L-540 CTRP2 6.8712 9.1691 5.1057 2.6061
REC-1 CTRP2 6.8834 8.5905 5.384 1.5135
KMS-12-BM CTRP2 6.9141 9.5158 4.9691 3.0911
U-937 CTRP2 6.9365 9.6277 4.9306 3.2141
M-07e CTRP2 6.941 10.2892 4.6148 4.4831
SUP-T11 CTRP2 6.9622 9.7185 4.9044 3.2829
RPMI-6666 CTRP2 6.9714 8.6397 5.4137 1.3074
SU-DHL-10 CTRP2 6.9756 8.0745 5.6603 0.4812
P3HR-1 CTRP2 6.977 8.8157 5.3372 1.582
DB CTRP2 6.9826 9.9931 4.7866 3.7267
ST486 CTRP2 6.9864 8.6198 5.4312 1.2289
HT CTRP2 6.9867 9.1261 5.2001 2.089
Karpas-299 CTRP2 6.9909 9.8295 4.8707 3.378
RPMI-8402 CTRP2 7.0586 9.8117 4.9241 3.0735
MHH-CALL-4 CTRP2 7.0801 11.7846 3.985 6.8428
Karpas-620 CTRP2 7.0959 8.4884 5.5475 0.7355
Namalwa CTRP2 7.1428 8.5644 5.5393 0.7247
SUP-HD1 CTRP2 7.1486 9.1522 5.2857 1.5842
SR CTRP2 7.2163 8.8514 5.4553 0.933
KE-97 CTRP2 7.2301 8.9173 5.4342 0.99
KMS-11 CTRP2 7.2375 13.4095 3.3027 9.3576
Reh CTRP2 7.243 9.0877 5.3674 1.2025
L-363 CTRP2 7.2493 8.7644 5.5088 0.7378
Ci-1 CTRP2 7.3477 8.0923 5.8059 0.0477
RL CTRP2 7.4051 9.3914 5.3226 1.2074
A3/Kawakami CTRP2 7.4287 8.5612 5.6699 0.2264
OCI-Ly3 CTRP2 7.4946 9.1987 5.4492 0.7408
SUP-T1 CTRP2 7.5207 9.2671 5.4337 0.7681
Granta-519 CTRP2 7.5216 9.2831 5.4276 0.7854
Mono-Mac-1 CTRP2 7.5415 10.0734 5.0984 1.8513
DEL CTRP2 7.5544 8.517 5.7338 0.0915
KHM-1B CTRP2 7.5622 10.42 4.9547 2.3482
BL-70 CTRP2 7.5744 8.567 5.7237 0.1001
KCL-22 CTRP2 7.5801 10.3416 5.0005 2.1625
EHEB CTRP2 7.6353 10.955 4.7542 3.0122
L-428 CTRP2 7.6887 10.2674 5.0946 1.7218
PF-382 CTRP2 7.7005 12.6606 3.9939 5.8884
Hs 611.T CTRP2 7.7027 11.0174 4.7663 2.8896
AMO1 CTRP2 7.7654 12.816 3.9632 5.9202
Jurkat CTRP2 7.7792 11.8181 4.4434 4.0241
HuNS1 CTRP2 7.8126 9.2148 5.5824 0.2582
JeKo-1 CTRP2 7.8294 9.2549 5.5743 0.2675
SU-DHL-4 CTRP2 7.958 9.2756 5.6166 0.161
MM1.S CTRP2 7.9814 10.0865 5.3189 0.7937
HPB-ALL CTRP2 8.0456 9.3637 5.618 0.1397
Ki-JK CTRP2 8.1337 10.5622 5.1978 1.0357
Toledo CTRP2 8.154 9.9349 5.4531 0.3858
EB1 CTRP2 8.1721 9.9704 5.4472 0.3908
MC116 CTRP2 8.2098 14.9357 3.2482 8.098
Raji CTRP2 8.2189 9.3258 5.6919 0.0445
CA46 CTRP2 8.2338 10.0501 5.4427 0.3765
HDLM-2 CTRP2 8.2894 10.2958 5.3732 0.4994
JVM-3 CTRP2 8.3658 15.5371 3.0656 8.5787
KM-H2 CTRP2 8.4632 10.4001 5.4055 0.366
MOLM-16 CTRP2 8.5049 10.1427 5.5141 0.1797
MJ CTRP2 9.7719 26.5554 -1.2949 20.1572
Kasumi-2 CTRP2 10.0371 19.3328 2.3598 8.9505
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 5.3287 6.8851 1.5758 0.0642
TE15 CTRP2 6.6169 9.3132 4.8591 3.9803
TE-4 CTRP2 4.2354 5.9035 1.5226 0.3862
TE-6 CTRP2 4.4434 6.331 1.4482 0.4766
OE21 CTRP2 6.2626 7.5968 5.4417 2.1419
TE-14 CTRP2 6.7202 8.5782 5.2868 2.092
TE-11 CTRP2 6.744 8.8622 5.1673 2.535
TE-5 CTRP2 6.8367 9.5809 4.885 3.54
KYSE-140 CTRP2 6.9462 9.767 4.8704 3.4415
KYSE-510 CTRP2 7.1466 9.5697 5.0937 2.3027
OE19 CTRP2 7.1957 17.6637 1.1641 17.3467
KYSE-410 CTRP2 7.505 9.9608 5.1278 1.7836
KYSE-30 CTRP2 7.5138 12.32 4.0307 6.0054
TE-9 CTRP2 7.7709 9.3458 5.516 0.4112
KYSE-180 CTRP2 7.9255 10.196 5.2477 1.0334
KYSE-450 CTRP2 7.9562 9.1803 5.6493 0.1181
KYSE-150 CTRP2 8.4255 9.7713 5.6136 0.0828
OE33 CTRP2 8.4283 10.567 5.3285 0.5372
TE-1 CTRP2 8.5315 10.9041 5.2433 0.6851
TE-10 CTRP2 8.5509 10.5657 5.3795 0.3847
COLO 680N CTRP2 8.6632 10.63 5.4002 0.3116
KYSE-70 CTRP2 8.6722 10.1869 5.559 0.1004
KYSE-520 CTRP2 8.7828 10.6654 5.4332 0.2289
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.3142 9.8617 5.5423 0.1834
SU.86.86 CTRP2 4.098 5.8508 1.4867 0.5478
HuP-T4 CTRP2 4.1551 7.4454 3.4831 15.0725
QGP-1 CTRP2 4.3096 8.9053 2.9974 16.5786
TCC-Pan2 CTRP2 4.7877 7.5319 4.1022 10.965
Hs 766T CTRP2 4.9366 7.9201 4.0762 10.6928
SNU-213 CTRP2 5.745 9.5039 4.0592 8.9389
PK-59 CTRP2 6.0294 9.3028 4.4027 6.9292
MIA PaCa-2 CTRP2 6.1596 7.1054 5.6065 1.6298
HuP-T3 CTRP2 6.2157 8.6784 4.8673 4.6271
Capan-1 CTRP2 6.2662 7.8176 5.3352 2.5794
PSN1 CTRP2 6.3545 10.6917 3.9738 8.1175
Panc 03.27 CTRP2 6.3858 19.287 -0.2946 23.23
BxPC-3 CTRP2 6.4366 11.2213 3.7751 8.7957
Panc 10.05 CTRP2 6.5054 9.5506 4.6591 4.9914
Panc 08.13 CTRP2 6.508 9.951 4.4628 5.8048
SUIT-2 CTRP2 6.5592 8.0147 5.4482 1.6692
AsPC-1 CTRP2 6.6731 9.7589 4.6815 4.6234
SW1990 CTRP2 6.7549 10.144 4.5523 5.0259
KP-2 CTRP2 6.8296 8.2402 5.5112 1.1035
KP-3 CTRP2 6.8497 9.8979 4.7406 4.1075
Capan-2 CTRP2 6.9101 8.7078 5.3463 1.6243
PaTu 8988s CTRP2 6.9419 10.1195 4.6977 4.1449
L3.3 CTRP2 7.2415 9.4498 5.2056 1.7765
PaTu 8902 CTRP2 7.3843 8.9407 5.5019 0.6629
PaTu 8988t CTRP2 7.4385 9.1464 5.4435 0.7971
HPAF-II CTRP2 7.479 11.6886 4.3097 4.9406
Panc 04.03 CTRP2 7.4852 9.6654 5.2468 1.3904
HPAC CTRP2 7.5228 14.6092 2.9229 10.3989
YAPC CTRP2 7.574 8.8068 5.6374 0.237
Panc 05.04 CTRP2 7.749 11.3119 4.6593 3.2376
KP-4 CTRP2 7.8772 13.9156 3.5117 7.5452
PANC-1 CTRP2 7.8806 9.3878 5.5457 0.304
SNU-410 CTRP2 8.0645 12.3581 4.37 3.9595
CFPAC-1 CTRP2 8.3918 9.9915 5.5254 0.1892
Panc 02.03 CTRP2 8.416 9.7177 5.6283 0.0714
DAN-G CTRP2 12.1929 45.2125 -8.6816 29.0852
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.046 14.5615 -1.8772 36.7855
WM115 CTRP2 -1.1972 5.017 -1.6036 48.4755
WM88 CTRP2 -1.0671 2.8195 -1.1294 47.4524
Mel Ho CTRP2 0.316 4.4585 0.1435 38.6599
WM983B CTRP2 1.018 9.0274 -0.469 37.4203
Malme-3M CTRP2 1.205 12.19 -1.6204 38.8716
WT2-iPS CTRP2 1.22 4.6617 1.0823 32.594
WM266-4 CTRP2 1.898 12.2418 -0.9442 35.5246
COLO 800 CTRP2 2.3219 8.7735 1.0108 29.2366
SK-MEL-1 CTRP2 2.4544 6.244 2.0702 25.2525
SK-MEL-24 CTRP2 2.5218 11.1817 0.1654 31.0869
UACC-257 CTRP2 2.5289 9.6043 0.8751 29.0336
UACC-62 CTRP2 2.6155 11.0146 0.3357 30.3518
WM1799 CTRP2 2.6861 13.1883 -0.6044 32.5177
COLO 829 CTRP2 2.8628 13.7321 -0.6913 32.2313
G-361 CTRP2 3.1326 7.8416 2.2437 22.6142
HT-144 CTRP2 3.224 11.9103 0.5236 28.1127
SK-MEL-30 CTRP2 3.7736 7.2901 3.1418 17.4354
SK-MEL-2 CTRP2 4.2861 7.1295 3.7494 13.6857
LOX-IMVI CTRP2 4.5081 7.7061 3.7392 13.1298
IPC-298 CTRP2 4.6727 7.6972 3.9116 12.0193
WM793 CTRP2 4.783 14.1221 0.9116 23.0464
K029AX CTRP2 4.8887 14.6001 0.769 23.2566
IGR-37 CTRP2 5.2223 13.7089 1.5072 20.0745
Mel JuSo CTRP2 5.5144 8.9227 4.1428 9.0775
COLO 741 CTRP2 5.8473 20.6528 -1.4247 27.0531
Hs 944.T CTRP2 5.8544 8.8246 4.4929 6.8974
COLO 792 CTRP2 5.9953 6.8745 5.5878 2.0162
A-375 CTRP2 6.2477 16.807 0.8316 20.1991
MeWo CTRP2 6.3293 9.9906 4.3034 6.7855
RVH-421 CTRP2 6.3381 24.5743 -2.9769 29.2362
Hs 940.T CTRP2 6.4578 7.9873 5.3922 2.0388
Hs 839.T CTRP2 6.6532 8.1298 5.4549 1.5197
Hs 895.T CTRP2 6.8075 8.5163 5.3717 1.6496
HMCB CTRP2 6.8123 8.6357 5.3191 1.8461
IGR-1 CTRP2 6.9357 15.6944 1.9405 15.1174
MDA-MB-435S CTRP2 7.2679 17.1103 1.4951 16.1019
RPMI-7951 CTRP2 7.3432 8.8333 5.5261 0.6209
Hs 934.T CTRP2 7.553 8.7051 5.6664 0.1914
IGR-39 CTRP2 7.6254 11.7342 4.3845 4.4487
A2058 CTRP2 7.6961 8.5017 5.7883 0.0268
Hs 852.T CTRP2 7.7062 11.1088 4.7266 3.0341
Hs 936.T CTRP2 7.7084 8.8889 5.66 0.1582
CJM [Human melanoma] CTRP2 7.7162 8.6423 5.7483 0.0527
SK-MEL-31 CTRP2 7.7378 12.7487 3.9769 5.9041
SK-MEL-5 CTRP2 7.9081 17.1339 1.9658 13.3662
A101D CTRP2 7.9391 16.0422 2.5231 11.2709
SK-MEL-28 CTRP2 7.9451 18.3923 1.374 15.3625
Hs 688(A).T CTRP2 7.9602 9.0537 5.6942 0.0699
SK-MEL-3 CTRP2 8.0822 20.7616 0.3074 18.5027
Hs 294T CTRP2 9.1708 21.1905 0.8922 15.0152
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 7.7082 10.1311 5.1644 1.4678
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SiMa CTRP2 3.9567 6.3433 3.678 14.8963
SK-N-BE(2) CTRP2 4.7846 6.9977 4.3286 10.0824
SK-N-FI CTRP2 5.2614 10.4581 3.1552 13.7067
CHP-212 CTRP2 5.3614 6.973 4.9352 6.1733
SK-N-AS CTRP2 5.6744 9.6223 3.9384 9.5898
MHH-NB-11 CTRP2 5.6784 8.7647 4.3684 7.7846
SK-N-DZ CTRP2 6.1155 8.0758 5.0873 3.8877
Kelly CTRP2 6.157 7.4418 5.4372 2.3431
NB1 CTRP2 6.246 7.9697 5.2441 2.9942
KP-N-SI9s CTRP2 6.5304 10.4243 4.2451 6.6735
NH-6 CTRP2 6.8176 8.2926 5.4806 1.2284
SK-N-SH CTRP2 7.6135 10.3325 5.0237 2.0442
KP-N-YN CTRP2 7.7752 10.6275 4.9839 2.0233
CHP-126 CTRP2 7.9822 13.6473 3.7114 6.6127
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-245 CTRP2 4.8034 7.7671 4.0128 11.2813
SNU-1079 CTRP2 5.5912 7.0114 5.1458 4.7537
SNU-478 CTRP2 6.4012 9.578 4.5654 5.561
HuCC-T1 CTRP2 6.4427 10.4299 4.1741 7.1231
SNU-869 CTRP2 6.9433 10.1776 4.6705 4.2531
SNU-308 CTRP2 7.7445 9.7705 5.3351 0.9022
SNU-1196 CTRP2 7.7853 9.4285 5.4904 0.4636
HuH-28 CTRP2 8.0834 9.3498 5.6366 0.1101
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJSA-1 CTRP2 4.1527 5.8234 1.5192 0.4317
U2OS CTRP2 5.2638 7.8481 4.431 8.4555
TC71 CTRP2 6.3304 7.9846 5.3011 2.6141
G-292 clone A141B1 CTRP2 6.4636 8.2427 5.272 2.5216
SK-N-MC CTRP2 6.7501 8.2824 5.4445 1.4406
SK-ES-1 CTRP2 6.883 9.0846 5.1535 2.4019
CAL-78 CTRP2 6.8882 8.5821 5.3907 1.4828
HOS CTRP2 7.0998 9.1008 5.2804 1.6559
SaOS-2 CTRP2 7.284 8.9555 5.446 0.9071
MHH-ES-1 CTRP2 7.3467 10.5748 4.7508 3.3776
Hs 822.T CTRP2 7.4072 8.2369 5.7776 0.0672
MG-63 CTRP2 7.5448 9.4553 5.3675 0.9494
A-673 CTRP2 7.8824 16.0398 2.4834 11.5087
SW1353 CTRP2 8.1994 9.6686 5.5677 0.174
Hs 888.T CTRP2 8.5266 10.1872 5.5065 0.1852
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 0.6432 2.2164 0.6425 35.9859
HMC-1-8 CTRP2 4.9945 8.2159 3.9951 10.8797
MDA-MB-157 CTRP2 5.1239 8.9897 3.7485 11.5835
Hs 578T CTRP2 6.496 10.2256 4.3172 6.4325
MDA-MB-231 CTRP2 6.5592 10.9608 4.0009 7.64
BT-474 CTRP2 6.6698 8.1286 5.4659 1.4563
CAL-85-1 CTRP2 6.7961 9.1043 5.0865 2.7857
HCC1500 CTRP2 6.9049 9.6563 4.8955 3.3993
AU565 CTRP2 6.967 9.4363 5.0419 2.7302
T-47D CTRP2 7.0096 9.4739 5.0519 2.6354
KPL-1 CTRP2 7.1455 8.3437 5.6313 0.453
MDA-MB-361 CTRP2 7.2361 9.1826 5.3219 1.3663
HDQ-P1 CTRP2 7.3802 9.2007 5.3913 1.0039
CAL-120 CTRP2 7.396 9.8923 5.096 2.0109
MDA-MB-453 CTRP2 7.4914 13.6224 3.3832 8.6323
ZR-75-1 CTRP2 7.793 9.0144 5.6472 0.1561
CAMA-1 CTRP2 7.9164 9.4196 5.5484 0.2862
HCC38 CTRP2 7.9833 9.7618 5.4472 0.4704
HCC1428 CTRP2 8.0105 9.5543 5.5363 0.2768
BT-20 CTRP2 8.013 9.2794 5.6355 0.1241
ZR-75-30 CTRP2 8.0172 9.8664 5.4216 0.5136
EFM-192A CTRP2 8.1393 9.6185 5.5629 0.1954
CAL-148 CTRP2 8.1487 9.2649 5.6883 0.0533
CAL-51 CTRP2 8.1914 9.7702 5.5285 0.2353
HCC1395 CTRP2 8.2003 9.7892 5.525 0.2384
HCC1419 CTRP2 8.3112 9.6808 5.6042 0.108
HCC1937 CTRP2 8.3124 10.0677 5.4676 0.3025
MDA-MB-468 CTRP2 8.3175 9.9417 5.5152 0.2223
HCC1806 CTRP2 8.3542 10.6584 5.2611 0.7324
JIMT-1 CTRP2 8.5068 14.3456 3.7225 5.8801
HCC1954 CTRP2 8.5503 10.8064 5.2889 0.5714
MCF-7 CTRP2 8.5591 10.249 5.4968 0.1912
HCC1143 CTRP2 8.6034 11.633 4.9849 1.3342
BT-549 CTRP2 8.8104 10.6108 5.4625 0.1836
HCC2218 CTRP2 8.8768 10.7357 5.4432 0.1948
SK-BR-3 CTRP2 9.0396 10.787 5.484 0.1212
BT 428 CTRP2 3.2824 9.2122 1.8208 23.7296
BT 286 CTRP2 4.5857 6.8304 4.1854 11.1812
BT 482 CTRP2 5.4861 7.8946 4.6209 7.1561
BT 145 CTRP2 5.5698 9.4234 3.9447 9.7837
BT 239 CTRP2 5.6119 9.5138 3.9373 9.7254
BT 440 CTRP2 5.6496 6.7026 5.3477 3.7918
BT 330 CTRP2 6.5081 8.1876 5.3303 2.2159
BT 320 CTRP2 6.5309 8.6919 5.1009 3.1197
BT 444 CTRP2 6.5421 9.3187 4.8012 4.3399
BT 228 CTRP2 6.6627 8.3583 5.3532 1.9062
BT164 CTRP2 6.6645 9.9195 4.5962 4.9897
BT 328 CTRP2 6.6771 8.3293 5.3764 1.7956
BT 179 CTRP2 6.6886 8.1107 5.486 1.3561
BT 416 CTRP2 6.6918 8.1331 5.4776 1.3845
BT 245 CTRP2 6.7185 8.6065 5.2722 2.1521
BT 159 CTRP2 6.7301 8.6416 5.2632 2.1721
BT 359 CTRP2 6.7482 9.2762 4.9708 3.3216
BT 172 CTRP2 6.7723 10.1689 4.5529 4.9962
BT 333 CTRP2 6.8002 8.2092 5.5082 1.146
BT 340 CTRP2 6.8203 8.2117 5.5187 1.0864
BT 232 CTRP2 6.8617 9.211 5.0795 2.7231
BT 231 CTRP2 6.9177 10.1613 4.6605 4.3317
BT147 CTRP2 7.0057 16.8246 1.433 16.7823
BT 504 CTRP2 7.0637 9.6282 5.0141 2.7132
BT 248 CTRP2 7.1041 9.3472 5.1703 2.062
BT 131 CTRP2 7.1613 8.4424 5.5988 0.5336
BT 216 CTRP2 7.2145 10.3045 4.7928 3.3846
BT 498 CTRP2 7.2573 8.3692 5.6711 0.2937
BT 187 CTRP2 7.3276 10.0562 4.9803 2.5184
BT 271 CTRP2 7.3648 11.6404 4.2556 5.317
BT 139 CTRP2 7.3942 9.1271 5.4296 0.8722
BT 422 CTRP2 7.3993 8.5831 5.6496 0.2791
BT 224 CTRP2 7.8262 9.0892 5.6332 0.1688
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 5.3228 7.6773 4.5693 7.7496
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KNS-60 CTRP2 3.5012 4.7176 1.6662 0.3647
KNS-81 CTRP2 3.7659 4.6517 1.7879 0.0541
ONS-76 CTRP2 5.013 8.3911 3.93 11.1001
DBTRG-05MG CTRP2 5.9267 15.9411 0.9976 20.3063
AM-38 CTRP2 5.927 11.7999 3.0682 12.6706
KG-1-C CTRP2 5.9935 16.6728 0.6877 21.1563
CAS-1 CTRP2 6.3123 8.637 4.964 4.0499
D283 Med CTRP2 6.358 8.058 5.2855 2.6335
42-MG-BA CTRP2 6.5296 9.1758 4.8624 4.1069
M059K CTRP2 6.5553 8.1963 5.3587 2.0325
YKG-1 CTRP2 6.5742 7.9727 5.478 1.5314
TM-31 CTRP2 6.5798 7.884 5.5233 1.3468
Hs 683 CTRP2 6.7521 8.482 5.3529 1.7909
Becker CTRP2 6.7551 9.3911 4.92 3.5181
SF539 CTRP2 6.7978 8.344 5.4453 1.3819
SNU-489 CTRP2 6.831 8.2332 5.5152 1.0876
SW1088 CTRP2 6.8354 8.3311 5.4736 1.2346
U-251MG CTRP2 6.8844 8.4746 5.4374 1.3142
SW1783 CTRP2 7.0204 12.2875 3.6942 8.1269
SNU-201 CTRP2 7.0256 9.7312 4.9406 3.0526
LN-229 CTRP2 7.0743 10.3057 4.6989 3.9493
U-118MG CTRP2 7.0856 8.9815 5.326 1.5047
KALS-1 CTRP2 7.1716 9.6804 5.0579 2.409
YH-13 CTRP2 7.206 8.8245 5.4614 0.9215
8-MG-BA CTRP2 7.2439 8.5901 5.5779 0.539
SF126 CTRP2 7.3406 10.1637 4.9386 2.661
NMC-G1 CTRP2 7.3695 11.0472 4.5424 4.1664
GOS-3 CTRP2 7.4558 8.9296 5.5397 0.5143
A-172 CTRP2 7.5053 9.4347 5.3563 1.0149
SNB-75 CTRP2 7.5234 13.9741 3.2344 9.1734
SF295 CTRP2 7.53 8.7887 5.6263 0.2752
Daoy CTRP2 7.542 15.632 2.4342 12.2423
SF268 CTRP2 7.5512 10.8933 4.731 3.2001
GMS-10 CTRP2 7.5898 8.5782 5.7254 0.095
GaMG CTRP2 7.6654 9.5803 5.375 0.84
SNU-1105 CTRP2 7.6673 8.9303 5.6291 0.221
SNU-626 CTRP2 7.7154 9.2486 5.5296 0.4058
LN-18 CTRP2 7.7358 8.6505 5.7523 0.0473
CCF-STTG1 CTRP2 7.7977 8.8501 5.7063 0.081
SNU-466 CTRP2 7.8703 8.8297 5.7384 0.0441
SNU-738 CTRP2 7.9683 9.2276 5.6373 0.1307
KNS-42 CTRP2 8.2624 9.4499 5.6653 0.059
GB-1 CTRP2 8.2838 13.1214 4.1524 4.522
T98G CTRP2 8.5338 13.8393 3.9744 4.8955
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP2 5.8271 9.0737 4.345 7.5734
RL95-2 CTRP2 6.0708 9.4888 4.3441 7.0954
HEC-1-B CTRP2 6.7399 10.5004 4.3661 5.8194
AN3-CA CTRP2 6.7734 11.5416 3.8772 7.7855
HEC-1-A CTRP2 6.8152 8.6086 5.3336 1.7866
EFE-184 CTRP2 7.0898 8.7676 5.4237 1.1528
MFE-296 CTRP2 7.1376 9.6808 5.0365 2.533
HEC-265 CTRP2 7.1496 8.2968 5.652 0.3955
ESS-1 CTRP2 7.2596 9.7536 5.078 2.2292
HEC-6 CTRP2 7.3293 8.8667 5.5058 0.6894
HEC-59 CTRP2 7.4539 11.7122 4.2816 5.0872
HEC-50B CTRP2 7.5218 9.8705 5.1771 1.5951
HEC-108 CTRP2 7.5933 9.1066 5.5316 0.4604
MFE-319 CTRP2 7.6002 9.1644 5.512 0.5053
JHUEM-1 CTRP2 7.6704 11.5399 4.5046 3.9235
EN CTRP2 7.7959 9.0459 5.6371 0.1705
JHUEM-2 CTRP2 7.9077 11.9153 4.4783 3.7352
HEC-251 CTRP2 8.1831 9.5039 5.6192 0.1125
KLE CTRP2 9.0385 10.9622 5.4233 0.1878
Ishikawa (Heraklio) 02 ER- CTRP2 7.6556 8.5187 5.7689 0.0429
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR14TKB CTRP2 6.3261 8.4495 5.0677 7.7099
CAL-54 CTRP2 6.441 9.6533 4.5589 5.5192
KMRC-2 CTRP2 6.5354 7.6998 5.5814 1.1774
KMRC-3 CTRP2 6.6902 11.7848 3.693 8.6874
VMRC-RCZ CTRP2 6.7071 8.1902 5.4606 1.4308
UO-31 CTRP2 6.7261 19.6374 -0.1927 22.3099
RCC10RGB CTRP2 7.13 8.6721 5.4869 0.9025
KMRC-1 CTRP2 7.1422 8.5634 5.5393 0.7249
Caki-2 CTRP2 7.3105 9.3092 5.3073 1.3455
ACHN CTRP2 7.3205 9.0753 5.4138 0.9805
BFTC-909 CTRP2 7.4639 10.0781 5.0517 2.0996
TUHR4TKB CTRP2 7.517 8.8798 5.5863 0.3678
KMRC-20 CTRP2 7.6436 10.1089 5.1393 1.6106
786-O CTRP2 7.7153 10.3781 5.0606 1.8138
Caki-1 CTRP2 7.8193 10.1146 5.2289 1.1687
OS-RC-2 CTRP2 7.937 10.0359 5.3186 0.8221
VMRC-RCW CTRP2 8.103 9.6743 5.5289 0.2606
SNU-1272 CTRP2 8.3285 9.6763 5.6119 0.0975
769-P CTRP2 8.4027 10.173 5.4646 0.28
TUHR10TKB CTRP2 11.521 33.8243 -3.5882 22.6253
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO201 CTRP2 1.0366 5.2328 0.7775 34.1875
SK-CO-1 CTRP2 3.0722 6.785 2.5721 21.581
COLO205 CTRP2 3.1289 9.5952 1.4944 25.2953
LS513 CTRP2 3.6999 4.8278 3.6893 15.6547
LoVo CTRP2 3.994 7.7176 3.2012 16.6014
SW620 CTRP2 4.2191 6.8324 3.7928 13.7067
NCI-H747 CTRP2 4.2518 6.9959 3.7655 13.7192
CL-11 CTRP2 4.2793 8.3222 3.2325 15.7265
T84 CTRP2 4.6406 7.0952 4.1372 11.2163
HT115 CTRP2 4.8392 7.7586 4.0527 11.0309
NCI-H508 CTRP2 5.0464 6.4709 4.8149 7.4882
RKO CTRP2 5.3725 9.185 3.8841 10.4632
SNU-61 CTRP2 5.6203 7.3006 5.0354 5.1374
SNU-407 CTRP2 5.7221 8.7054 4.4366 7.4067
HT-55 CTRP2 5.7962 7.3821 5.1589 4.2304
SW948 CTRP2 6.0833 7.9947 5.1014 3.8892
LS180 CTRP2 6.1563 7.7125 5.3016 2.9128
MDST8 CTRP2 6.1921 11.1728 3.6022 9.9652
HCT 116 CTRP2 6.331 7.6467 5.4677 1.9235
SNU-1033 CTRP2 6.468 11.0851 3.8678 8.3547
C2BBe1 CTRP2 6.5013 8.2698 5.2856 2.408
LS123 CTRP2 6.581 8.9042 5.0333 3.3196
COLO 678 CTRP2 6.6747 8.4802 5.3033 2.0879
SW48 CTRP2 6.6881 8.398 5.3511 1.8807
HT-29 CTRP2 6.7544 8.2007 5.4848 1.2836
LS411N CTRP2 6.7557 11.5231 3.8729 7.8331
LS1034 CTRP2 6.8318 13.5644 2.9187 11.5775
KM12 CTRP2 6.9654 8.7099 5.3785 1.4424
DLD-1 CTRP2 7.0055 7.9863 5.7098 0.3266
HCT 8 CTRP2 7.0387 10.2221 4.7148 3.9359
SW1417 CTRP2 7.3423 12.8601 3.6483 7.8005
HCC-56 CTRP2 7.4781 8.475 5.7204 0.1256
GP2d CTRP2 7.5527 9.7164 5.2608 1.2839
SNU-C5 CTRP2 7.6472 18.6817 1.0067 17.0738
HCT 15 CTRP2 7.8084 9.2632 5.5628 0.2969
SNU-C4 CTRP2 8.0268 9.0917 5.7044 0.0536
RCM-1 [Human ESC] CTRP2 8.1195 9.3673 5.6435 0.0967
SNU-C1 CTRP2 8.2028 9.8051 5.5203 0.2455
CCK-81 CTRP2 8.2741 10.1286 5.4298 0.387
NCI-H716 CTRP2 8.2878 10.0598 5.4608 0.3229
SNU-C2A CTRP2 8.3625 12.9393 4.2837 3.9396
SNU-175 CTRP2 8.4117 10.0699 5.5051 0.2137
COLO 320 CTRP2 9.0374 16.0597 3.2571 6.9662
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CTRP2 2.6983 6.7333 2.1838 24.1044
Hep 3B2.1-7 CTRP2 2.751 4.2461 2.7403 21.977
JHH-5 CTRP2 4.1063 6.0447 3.9293 13.531
SNU-761 CTRP2 4.2185 5.6902 1.5927 0.2408
JHH-4 CTRP2 5.9197 6.9789 5.4695 2.6683
SNU-886 CTRP2 6.1205 9.6485 4.3054 7.1632
Li-7 CTRP2 6.2186 9.2943 4.5623 5.9016
SNU-878 CTRP2 6.2258 8.116 5.1556 3.4001
SNU-387 CTRP2 6.582 8.3514 5.3023 2.2214
JHH-1 CTRP2 6.6959 8.6039 5.2584 2.2375
JHH-2 CTRP2 7.0236 8.553 5.4815 1.016
HuH-6 CTRP2 7.0481 10.5342 4.5709 4.5032
SNU-182 CTRP2 7.1066 10.5803 4.589 4.3452
JHH-6 CTRP2 7.3206 7.9997 5.8277 0.0329
SNU-398 CTRP2 7.3932 11.4265 4.3775 4.7892
SNU-423 CTRP2 7.8587 9.4798 5.5021 0.4034
HLF CTRP2 7.937 9.5127 5.5222 0.3296
HuH-1 CTRP2 8.0186 9.6472 5.5052 0.3328
SNU-475 CTRP2 8.0222 9.4331 5.5847 0.1922
PLC/PRF/5 CTRP2 8.1066 9.6158 5.5514 0.2219
SK-HEP-1 CTRP2 11.9044 20.9401 2.727 5.7339
SNU-449 CTRP2 15.4279 32.395 -0.3762 11.2256
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 133 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2405 CTRP2 -1.7377 12.9389 -4.9759 50.9399
NCI-H2228 CTRP2 3.2976 7.1988 0.4428 6.5176
NCI-H2444 CTRP2 3.6385 4.9144 1.6487 0.3421
HCC1588 CTRP2 3.6629 5.1493 3.624 15.9974
NCI-H2087 CTRP2 3.733 7.9225 2.8427 18.6915
SW1271 CTRP2 3.7936 7.2052 0.7573 4.0045
NCI-H226 CTRP2 4.0744 5.364 1.654 0.1721
Calu-6 CTRP2 4.2019 6.6031 3.8575 13.5121
NCI-H727 CTRP2 4.2692 8.664 3.0678 16.4029
NCI-H23 CTRP2 4.5683 10.7559 2.3684 18.4054
PC-14 CTRP2 4.6423 6.3953 1.5016 0.2823
NCI-H1666 CTRP2 5.4084 11.7488 2.6463 15.4287
HCC44 CTRP2 5.4537 8.6368 4.2282 8.856
HOP-92 CTRP2 5.4813 32.2334 -7.5222 36.5122
Lu-65 CTRP2 5.4825 9.0366 4.0576 9.5016
NCI-H1734 CTRP2 5.5688 9.2826 4.0137 9.4985
DV-90 CTRP2 5.7015 7.7997 4.8668 5.6539
NCI-H1568 CTRP2 5.816 9.1111 4.3168 7.7144
NCI-H1792 CTRP2 5.9407 8.0031 4.9774 4.6892
HOP-62 CTRP2 6.0032 9.0249 4.5197 6.4887
SK-MES-1 CTRP2 6.0281 7.1704 5.4677 2.4555
DMS 53 CTRP2 6.0812 8.0054 5.0944 3.9228
Lu-99 CTRP2 6.1336 9.091 4.5948 5.9232
DMS 454 CTRP2 6.137 8.4186 4.9335 4.4938
NCI-H2030 CTRP2 6.2068 9.3227 4.5385 6.023
NCI-H1299 CTRP2 6.2093 9.8947 4.2549 7.2085
NCI-H1944 CTRP2 6.2528 7.6137 5.4259 2.2241
NCI-H1755 CTRP2 6.2551 8.9717 4.7524 5.0373
NCI-H2009 CTRP2 6.3219 8.9113 4.8351 4.5722
RERF-LC-MS CTRP2 6.322 8.5953 4.9922 3.9152
NCI-H322 CTRP2 6.332 7.8453 5.371 2.3216
CAL-12T CTRP2 6.3663 9.6199 4.5173 5.8236
COR-L105 CTRP2 6.3772 8.0131 5.3218 2.4522
NCI-H1355 CTRP2 6.382 9.3995 4.6392 5.286
NCI-H838 CTRP2 6.4256 7.592 5.5606 1.4046
EPLC-272H CTRP2 6.4376 7.8619 5.4388 1.8794
HCC15 CTRP2 6.524 11.1912 3.8589 8.292
NCI-H2141 CTRP2 6.5302 10.5111 4.2018 6.8543
NCI-H1341 CTRP2 6.5476 8.4631 5.2244 2.5882
NCI-H1703 CTRP2 6.5563 8.4725 5.226 2.5689
NCI-H1339 CTRP2 6.5717 8.4177 5.2633 2.3944
EKVX CTRP2 6.5751 10.0906 4.4447 5.766
COR-L51 CTRP2 6.5822 8.4222 5.2684 2.3582
NCI-H647 CTRP2 6.6039 9.9046 4.5585 5.2452
Calu-3 CTRP2 6.6993 8.7399 5.1956 2.484
SK-LU-1 CTRP2 6.7176 8.7225 5.2163 2.3759
COLO 668 CTRP2 6.7537 9.3309 4.9481 3.4057
NCI-H1693 CTRP2 6.7657 9.1484 5.0446 2.9973
NCI-H2081 CTRP2 6.7683 9.1537 5.0439 2.9966
NCI-H1915 CTRP2 6.7698 9.4817 4.8863 3.6332
NCI-H2286 CTRP2 6.8191 8.7152 5.2862 1.9651
NCI-H2122 CTRP2 6.8218 8.7094 5.2906 1.9445
LXF 289 CTRP2 6.8467 9.8667 4.7536 4.0588
KNS-62 CTRP2 6.8747 9.3091 5.0414 2.8569
HCC1171 CTRP2 6.884 11.1724 4.1421 6.5104
HCC2935 CTRP2 6.8899 9.5184 4.9514 3.1957
NCI-H69 CTRP2 6.9413 9.0572 5.2037 2.1313
NCI-H2110 CTRP2 6.9674 10.2868 4.6345 4.364
NCI-H650 CTRP2 6.9704 10.5936 4.4877 4.9569
HCC4006 CTRP2 6.9902 8.8803 5.3157 1.6472
HCC95 CTRP2 7.0368 9.1163 5.2356 1.8943
A-549 CTRP2 7.054 8.9885 5.3044 1.6181
LOU-NH91 CTRP2 7.0749 9.1718 5.2332 1.8593
DMS 114 CTRP2 7.0799 10.8935 4.4192 5.0715
NCI-H1373 CTRP2 7.0875 9.0261 5.307 1.5718
LCLC-97TM1 CTRP2 7.11 9.6623 5.0277 2.6015
NCI-H1838 CTRP2 7.1741 9.6833 5.0581 2.4055
Calu-1 CTRP2 7.2386 10.3168 4.8026 3.3143
HCC1438 CTRP2 7.2417 9.4811 5.1916 1.8277
EBC-1 CTRP2 7.242 12.1677 3.9144 6.8786
NCI-H1581 CTRP2 7.2477 12.746 3.6358 7.999
BEN CTRP2 7.2818 8.2992 5.7077 0.206
MOR/CPR CTRP2 7.292 11.2307 4.4029 4.8296
NCI-H1395 CTRP2 7.3055 9.4352 5.2489 1.5548
Sq-1 CTRP2 7.3218 8.8125 5.5244 0.6402
NCI-H1155 CTRP2 7.323 10.1275 4.9445 2.6598
NCI-H1650 CTRP2 7.3399 9.6008 5.1945 1.7134
RERF-LC-A1 CTRP2 7.3684 10.1559 4.9592 2.5502
NCI-H522 CTRP2 7.4067 10.6648 4.7468 3.317
HCC366 CTRP2 7.4154 11.0588 4.567 4.008
RERF-LC-Ad1 CTRP2 7.4169 8.4307 5.7129 0.1532
NCI-H661 CTRP2 7.436 10.7366 4.7318 3.3383
NCI-H292 CTRP2 7.4703 9.9322 5.1209 1.8434
NCI-H1694 CTRP2 7.5039 10.031 5.0959 1.8982
HCC1195 CTRP2 7.5047 10.664 4.8084 2.9608
NCI-H520 CTRP2 7.5374 10.0539 5.1047 1.8332
SBC-5 CTRP2 7.5822 8.4338 5.7721 0.0484
LUDLU-1 CTRP2 7.5976 9.108 5.533 0.4547
NCI-H196 CTRP2 7.6304 9.0559 5.5672 0.3596
NCI-H441 CTRP2 7.6577 11.0789 4.7109 3.1497
LC-1/sq-SF CTRP2 7.6703 8.7995 5.6775 0.1417
NCI-H841 CTRP2 7.6707 11.1239 4.698 3.1829
NCI-H2196 CTRP2 7.6853 9.2658 5.51 0.4662
NCI-H460 CTRP2 7.7339 9.0842 5.5991 0.2539
RERF-LC-Ad2 CTRP2 7.7833 9.1584 5.5915 0.2513
SHP-77 CTRP2 7.8619 9.4396 5.5187 0.3663
DMS 273 CTRP2 7.8704 9.4239 5.5281 0.3431
LCLC-103H CTRP2 7.9035 8.9863 5.6972 0.0747
NCI-H1563 CTRP2 7.9067 9.524 5.5054 0.3758
NCI-H2029 CTRP2 7.9123 9.2519 5.6077 0.1855
HCC1833 CTRP2 7.9527 13.9198 3.5611 7.2433
IA-LM CTRP2 7.9843 9.4057 5.5801 0.2096
NCI-H810 CTRP2 8.0269 9.6135 5.521 0.2995
NCI-H1092 CTRP2 8.0747 9.9011 5.4328 0.4617
NCI-H1869 CTRP2 8.1054 10.0784 5.3779 0.5741
NCI-H2172 CTRP2 8.1145 9.4547 5.6114 0.1342
COR-L88 CTRP2 8.1216 9.865 5.466 0.3722
NCI-H1793 CTRP2 8.1268 9.6968 5.53 0.2515
NCI-H1435 CTRP2 8.1323 15.6766 2.8378 9.7854
NCI-H2126 CTRP2 8.1741 9.8704 5.4852 0.3161
HCC78 CTRP2 8.1784 9.8788 5.4838 0.3172
NCI-H526 CTRP2 8.1848 9.462 5.6342 0.0963
COR-L95 CTRP2 8.2103 9.5176 5.6242 0.1027
NCI-H2170 CTRP2 8.2619 9.6047 5.6127 0.1067
COLO 699 CTRP2 8.3383 9.9183 5.5313 0.1933
NCI-H2106 CTRP2 8.3412 9.9012 5.5384 0.1826
NCI-H1184 CTRP2 8.3459 10.3181 5.3883 0.4435
HARA [Human squamous cell lung carcinoma] CTRP2 8.5048 10.172 5.5037 0.1938
VMRC-LCD CTRP2 8.554 10.1647 5.5244 0.1567
HCC2279 CTRP2 8.5732 10.7226 5.3302 0.4736
HCC827 CTRP2 8.5811 10.0938 5.5586 0.1137
NCI-H446 CTRP2 8.613 10.2221 5.5259 0.1441
NCI-H2023 CTRP2 8.6321 10.4022 5.4699 0.2119
NCI-H358 CTRP2 8.6531 16.4542 2.8202 9.1024
ChaGo-K-1 CTRP2 8.6733 10.319 5.5141 0.147
HCC2108 CTRP2 8.7055 16.4448 2.8598 8.8821
NCI-H2342 CTRP2 8.8485 10.4796 5.5214 0.1119
NCI-H211 CTRP2 8.9928 10.5527 5.5467 0.0738
NCI-H2085 CTRP2 9.0069 10.8367 5.4554 0.156
LC-1F CTRP2 9.2692 12.7655 4.8399 1.3122
NCI-H1105 CTRP2 9.361 19.3954 1.8896 11.4594
LK2 CTRP2 13.7662 32.3038 -1.3432 15.253
Hs 888.Lu CTRP2 6.7494 8.5041 5.3407 1.8417
⏷ Show the Full List of 133 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 0.5456 2.0257 -2.4186 0.2354
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.2702 7.5348 5.478 1.9787
Aska-SS CTRP2 6.4273 8.5621 5.0886 3.3361
G-401 CTRP2 5.5686 7.7538 4.7667 6.3654
TE 617.T CTRP2 5.771 8.9333 4.3663 7.5995
A-204 CTRP2 6.2557 9.3091 4.5846 5.7401
HT-1080 CTRP2 6.3676 7.4005 5.6131 1.2757
TTC-709 CTRP2 6.6396 9.9651 4.5553 5.1998
SK-LMS-1 CTRP2 6.6551 8.4692 5.2954 2.1464
G-402 CTRP2 6.7164 9.564 4.8083 4.0332
Tm87-16 CTRP2 6.7216 8.6187 5.2685 2.1627
RD CTRP2 6.7394 12.0237 3.6124 8.9339
BT-12 CTRP2 7.1283 8.0097 5.7531 0.1735
Hs 729.T CTRP2 7.2086 9.6569 5.0915 2.2375
KYM-1 CTRP2 7.2174 9.2461 5.2831 1.522
Rh41 CTRP2 7.3293 9.8352 5.0826 2.1332
SW982 CTRP2 7.5072 9.1397 5.4793 0.6469
SK-UT-1 CTRP2 7.5681 10.8198 4.7754 3.011
GCT CTRP2 7.6259 13.3748 3.5989 7.5678
RKN CTRP2 7.9298 9.4961 5.5254 0.3259
BT-16 CTRP2 7.9773 9.4246 5.5705 0.2274
TE 441.T CTRP2 7.9827 9.6548 5.4877 0.3823
Rh18 CTRP2 8.1074 9.5179 5.5866 0.1686
MES-SA CTRP2 8.8048 21.5975 0.4312 16.9799
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.6223 10.5318 4.2623 6.4449
MCAS CTRP2 4.4496 7.4774 3.7775 13.1333
HEY A8 CTRP2 4.5871 8.6752 3.3794 14.3647
A2780 CTRP2 4.8861 7.6873 4.1324 10.5931
TYK-nu CTRP2 5.4805 9.2415 3.9546 9.9345
FU-OV-1 CTRP2 5.7761 8.095 4.7877 5.824
OV-90 CTRP2 5.8524 9.8429 3.9829 9.0396
IGROV-1 CTRP2 6.3453 7.7502 5.4274 2.0674
COV434 CTRP2 6.4654 8.3479 5.2219 2.7245
OVCAR-5 CTRP2 6.5613 11.2321 3.8678 8.1893
OVK18 CTRP2 6.5668 8.2841 5.3243 2.1547
JHOS-2 CTRP2 6.6894 9.8254 4.6608 4.6828
SNU-8 CTRP2 6.6952 9.497 4.8258 3.9941
Kuramochi CTRP2 6.9508 10.0961 4.7151 4.0614
Caov-3 CTRP2 6.9981 9.0893 5.2243 1.9829
TOV-112D CTRP2 7.0175 10.0151 4.7998 3.6246
EFO-21 CTRP2 7.0286 9.0433 5.2641 1.7964
OC 314 CTRP2 7.0362 8.9868 5.2945 1.6742
SNU-840 CTRP2 7.2269 9.9584 4.9632 2.7051
EFO-27 CTRP2 7.3845 10.1654 4.9647 2.5108
SNU-119 CTRP2 7.4678 9.1082 5.4734 0.6891
JHOC-5 CTRP2 7.4705 10.0205 5.0815 1.9846
OVISE CTRP2 7.5273 8.5553 5.7104 0.1283
TOV-21G CTRP2 7.6037 9.0677 5.5512 0.4081
OV56 CTRP2 7.7517 8.6338 5.7633 0.0378
OVTOKO CTRP2 7.7836 10.5925 5.004 1.945
OAW42 CTRP2 7.8446 8.7427 5.7586 0.0331
RMG-I CTRP2 7.8506 11.21 4.7664 2.7259
OVCAR-8 CTRP2 7.8693 9.5664 5.4735 0.4631
JHOM-1 CTRP2 7.9422 9.3935 5.5681 0.2419
OVSAHO CTRP2 8.0022 9.6704 5.4899 0.3699
COV362 CTRP2 8.0411 9.7398 5.4799 0.3752
DOV13 CTRP2 8.0488 9.6845 5.5036 0.3249
ONCO-DG-1 CTRP2 8.0599 9.4685 5.5864 0.1803
SK-OV-3 CTRP2 8.1688 9.7584 5.524 0.2492
OVCAR-4 CTRP2 8.2781 9.9489 5.4974 0.2616
OAW28 CTRP2 8.4996 10.4658 5.3958 0.3717
COV644 CTRP2 8.5853 21.9717 0.0864 18.3311
ES2 CTRP2 9.6112 17.6887 2.8583 7.7146
OV7 CTRP2 10.353 24.1159 0.2983 15.1263
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 7.1169 8.6543 5.4877 0.9112
H-STS CTRP2 7.437 11.4793 4.3816 4.7127
P-STS CTRP2 7.8254 9.5449 5.4628 0.5098
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 4.3502 11.5152 1.7945 21.0642
NCI-H2452 CTRP2 4.3954 6.3838 1.4091 0.6052
MSTO-211H CTRP2 5.617 12.4574 2.4751 15.6582
NCI-H2052 CTRP2 6.6008 9.2436 4.8815 3.9131
IST-Mes1 CTRP2 6.8429 8.6509 5.3313 1.7614
MPP 89 CTRP2 6.8464 8.8367 5.2466 2.0845
ACC-MESO-1 CTRP2 7.2419 8.6667 5.5457 0.6328
JL-1 CTRP2 15.4044 28.5291 1.3112 6.8749
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 6.9942 8.8593 5.3276 1.5985
DU145 CTRP2 7.7464 9.6192 5.3976 0.7229
PaCa-3 CTRP2 7.8189 8.8972 5.6976 0.0868
22Rv1 CTRP2 7.9794 10.9343 4.9615 1.9069
VCaP CTRP2 8.1832 9.6721 5.5604 0.1882
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 4.6523 10.9253 2.3649 18.2201
YD-15 CTRP2 7.5693 8.7242 5.6658 0.1874
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GSU CTRP2 4.5102 6.0839 4.3592 10.7505
NUGC-4 CTRP2 5.0455 7.56 4.3505 9.3159
SNU-5 CTRP2 5.0633 7.9863 4.1704 10.0003
SNU-620 CTRP2 5.3554 6.5504 5.1124 5.4894
SNU-719 CTRP2 5.5275 8.4389 4.3931 8.0077
SNU-1 CTRP2 5.7437 8.4644 4.5755 6.7802
SNU-668 CTRP2 5.8282 9.0948 4.3355 7.6112
KE-39 CTRP2 5.9807 10.2886 3.869 9.2613
GSS CTRP2 5.9962 9.4948 4.2789 7.5139
Fu97 CTRP2 6.0068 15.5804 1.245 19.3266
HuG1-N CTRP2 6.2584 9.2186 4.6319 5.5367
SNU-601 CTRP2 6.577 8.3194 5.3143 2.1805
Hs 746.T CTRP2 6.6548 10.1205 4.49 5.4453
SNU-216 CTRP2 6.6584 8.8666 5.1065 2.903
AGS CTRP2 6.8409 9.3666 4.9911 3.1055
HGC-27 CTRP2 6.9683 8.4428 5.4994 1.0064
MKN45 CTRP2 6.9717 8.0317 5.6759 0.4388
23132/87 CTRP2 7.0217 8.8965 5.327 1.5699
ECC10 CTRP2 7.1821 8.8266 5.4479 0.9862
MKN1 CTRP2 7.3128 9.7369 5.1175 2.0225
IM95 CTRP2 7.3458 10.1728 4.9377 2.6586
KATO III CTRP2 7.4059 9.1784 5.4139 0.912
LMSU CTRP2 7.7189 9.3072 5.5085 0.4529
MKN74 CTRP2 7.9228 9.8605 5.3822 0.6598
ECC12 CTRP2 7.9353 9.8075 5.4087 0.5858
NUGC-3 CTRP2 8.03 10.1809 5.3035 0.8059
SNU-16 CTRP2 8.4643 18.7262 1.5896 13.8029
NCI-N87 CTRP2 8.4919 11.289 5.0722 1.1574
MKN7 CTRP2 9.006 10.5235 5.561 0.0627
SH-10-TC CTRP2 9.1014 14.9644 3.8011 4.8884
SNU-1077 CTRP2 6.5728 7.8807 5.5204 1.3669
SNG-M CTRP2 6.8407 10.2957 4.5403 4.9406
SNU-685 CTRP2 7.9055 9.1501 5.6413 0.1386
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 3.7526 12.3277 0.8353 25.7805
ML-1 [Human leukemia] CTRP2 4.1158 5.9857 1.4429 0.6674
CAL-62 CTRP2 4.4923 6.7715 4.1084 11.7365
BHT-101 CTRP2 5.0182 11.1817 2.5774 16.5553
TT2609-C02 CTRP2 6.2519 8.0569 5.2054 3.1457
FTC-238 CTRP2 6.4406 7.4975 5.6156 1.1659
TT CTRP2 6.5093 10.0295 4.4248 5.9611
SW579 CTRP2 6.646 9.4142 4.8307 4.0511
CGTH-W-1 CTRP2 6.8283 10.1026 4.6257 4.6096
8305C CTRP2 6.9491 14.8065 2.3926 13.4137
B-CPAP CTRP2 7.0623 20.2696 -0.2387 21.8195
FTC-133 CTRP2 7.5154 8.8193 5.6087 0.3182
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 5.0993 8.4136 4.0027 10.598
SCC-25 CTRP2 6.1122 8.4309 4.9071 4.6512
SCC-4 CTRP2 6.1735 9.1259 4.6099 5.7851
BICR 22 CTRP2 6.2617 8.1563 5.1636 3.3034
CAL-27 CTRP2 6.354 8.5383 5.0451 3.6394
BICR 56 CTRP2 6.6261 9.8342 4.6098 4.996
BICR 16 CTRP2 6.6287 8.216 5.3984 1.773
PE/CA-PJ34 (clone C12) CTRP2 6.6628 9.002 5.0439 3.1512
BICR 18 CTRP2 6.6646 8.9494 5.0707 3.0394
BICR 31 CTRP2 6.7687 8.6199 5.2987 1.9812
PE/CA-PJ15 CTRP2 6.7909 8.8104 5.2231 2.2494
BHY CTRP2 6.86 10.1572 4.6218 4.577
FaDu CTRP2 6.8904 9.3369 5.0386 2.8465
PE/CA-PJ49 CTRP2 6.9628 9.339 5.0852 2.5655
CAL-33 CTRP2 6.9672 9.3498 5.0829 2.5687
SNU-46 CTRP2 6.9837 9.7433 4.907 3.2427
PE/CA-PJ41 (clone D2) CTRP2 6.9931 8.8062 5.3511 1.5128
SCC-9 CTRP2 7.0494 9.7575 4.9438 3.0081
BICR 6 CTRP2 7.0644 10.5083 4.5947 4.383
SNU-1214 CTRP2 7.2016 10.0207 4.9181 2.9112
HSC-4 CTRP2 7.3461 10.7896 4.6491 3.7763
SNU-899 CTRP2 7.3978 10.7291 4.711 3.4672
HSC-2 CTRP2 7.399 8.8054 5.5633 0.4851
HSC-3 CTRP2 7.5635 9.1221 5.5122 0.5249
YD-8 CTRP2 7.6458 11.662 4.4317 4.2377
Detroit 562 CTRP2 8.1616 9.8989 5.4696 0.3501
SNU-1066 CTRP2 8.3323 9.7657 5.5825 0.1284
SNU-1041 CTRP2 8.8128 10.4396 5.5225 0.1159
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 CTRP2 2.8211 5.8501 2.5778 22.3184
JMSU-1 CTRP2 4.7986 7.686 4.0445 11.1668
RT-4 CTRP2 5.2278 9.1979 3.7443 11.3643
U-BLC1 CTRP2 5.4673 9.4005 3.8641 10.3393
SCaBER CTRP2 6.1921 8.3148 5.0298 3.9881
UM-UC-1 CTRP2 6.1931 9.5106 4.4336 6.4886
RT-112 CTRP2 6.3326 8.6971 4.9499 4.0735
647V CTRP2 6.6098 7.9225 5.5243 1.3056
253J CTRP2 6.8199 8.8298 5.2328 2.1727
SW1710 CTRP2 6.8367 8.8086 5.2536 2.0697
5637 CTRP2 6.8966 13.7288 2.8872 11.5885
UM-UC-3 CTRP2 7.1488 11.6938 4.0788 6.353
BC-3C CTRP2 7.1599 9.9602 4.9197 2.9581
CAL-29 CTRP2 7.3164 9.2166 5.3509 1.1914
KMBC-2 CTRP2 7.3727 9.3695 5.3148 1.2625
TCCSUP CTRP2 7.4937 10.4802 4.8864 2.6791
VM-CUB-1 CTRP2 7.5371 11.7611 4.3139 4.8446
639V CTRP2 7.5725 8.6415 5.6967 0.1373
HT-1197 CTRP2 8.0132 9.2597 5.6424 0.1158
J82 CTRP2 8.1525 9.8589 5.4808 0.3318
HT-1376 CTRP2 8.1626 10.0797 5.4019 0.4915
T24 CTRP2 10.2212 20.8047 1.7872 10.6639
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.5766 8.6477 5.6961 0.1372

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5681).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5681).
3 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
4 Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.