Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK7F9S)

Drug Name
Amitriptyline Drug Info
Synonyms
Adepress; Adepril; Amitril; Amitriprolidine; Amitriptilina; Amitriptylin; Amitriptylinum; Amitryptiline; Amitryptyline; Amytriptiline; Amytriptylin; Damilan; Damilen; Damitriptyline; Elanil; Elavil; Flavyl; Lantron; Laroxil; Laroxyl; Proheptadiene; Redomex; Sarotex; Seroten; Sylvemid; Triptanol; Triptilin; Triptisol; Tryptanol; Amitriptilina [Italian]; Amitriptylin [German]; MK 230; N 750; TP0; Amitriptilina [INN-Spanish]; Amitriptyline (INN); Amitriptyline [INN:BAN]; Amitriptylinum [INN-Latin]; Elavil (TN); Laroxyl (TN); Ro 4-1575; [3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine; 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine; 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine; 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene; 5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene; 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene; 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
2160
ChEBI ID
CHEMBL629
CAS Number
CAS 50-48-6
TTD Drug ID
D0Y5UG
VARIDT Drug ID
DR00470
INTEDE Drug ID
DR0095
ACDINA Drug ID
D00032

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.57 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Terpenoid backbone biosynthesis 2.24 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Complement and coagulation cascades 2.05 0.00e+0 76/85 (89.41%) CD55;CFI;F5;...
PPAR signaling pathway 1.99 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Lysosome 1.95 6.86e-3 115/128 (89.84%) NPC1;NEU1;CTSA;...
Biosynthesis of unsaturated fatty acids 1.93 7.15e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Ferroptosis 1.93 6.13e-3 36/41 (87.8%) TFRC;ACSL3;HMOX1;...
Valine, leucine and isoleucine degradation 1.91 6.43e-3 42/48 (87.5%) HMGCS1;ACAT2;BCAT1;...
Butanoate metabolism 1.88 7.62e-3 23/28 (82.14%) HMGCS1;ACAT2;AACS
Amino sugar and nucleotide sugar metabolism 1.87 6.86e-3 38/48 (79.17%) GNPDA1;HEXB;PMM2;...
Synthesis and degradation of ketone bodies 1.87 7.02e-3 9/10 (90%) HMGCS1;ACAT2
Peroxisome 1.80 1.79e-2 72/82 (87.8%) ACSL3;SOD2;IDH1;...
Cysteine and methionine metabolism 1.77 2.70e-2 43/50 (86%) ADI1;BCAT1;ENOPH1;...
alpha-Linolenic acid metabolism 1.74 3.19e-2 17/25 (68%) FADS2;PLAAT3;PLA2G4C;...
Collecting duct acid secretion 1.73 3.32e-2 22/27 (81.48%) ATP6V1D;ATP6V1B2;ATP6V1E1;...
Thyroid hormone signaling pathway -1.74 4.32e-2 112/121 (92.56%) THRA;HDAC3;SLCO1C1;...
Estrogen signaling pathway -1.74 4.72e-2 119/137 (86.86%) HSP90AB1;ADCY7;CREB3L2;...
Proximal tubule bicarbonate reclamation -1.76 3.83e-2 21/23 (91.3%) ATP1B1;ATP1B2;CA4;...
Hedgehog signaling pathway -1.82 3.14e-2 43/56 (76.79%) CCND2;GRK2;GSK3B;...
Vasopressin-regulated water reabsorption -2.00 5.90e-3 40/44 (90.91%) DYNC1I1;ARHGDIB;NSF;...
Type I diabetes mellitus -2.07 0.00e+0 38/43 (88.37%) GZMB;HLA-DRA;TNF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293T CVCL_0063 Homo sapiens 0.125uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H