Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKA2YS)

Drug Name
MG-132 Drug Info
Synonyms
MG-132; Z-Leu-leu-leu-al; MG132; Zlllal; MG 132; Z-LLL-CHO; Zlll-cho; Z-Leu-leu-leucinal; Z-Leu-Leu-Leu-H; Z-Leu-Leu-Leu-CHO; Carbobenzoxy-leucyl-leucyl-leucinal; UNII-RF1P63GW3K; Benzyloxycarbonyl-leu-leu-leu-aldehyde; Benzyloxycarbonyl-leucyl-leucyl-leucinal; Lll cpd; Carbobenzoxyl-leucinyl-leucinyl-leucinal-H; Cbz-Leu-Leu-Leu-H; Benzyloxycarbonylleucyl-leucyl-leucine aldehyde; benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate; RF1P63GW3K
Cross-matching ID
PubChem CID
462382
ChEBI ID
CHEMBL64925
CAS Number
CAS 133407-82-6
VARIDT Drug ID
DR01613

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.73 0.00e+0 127/171 (74.27%) HSPA1A;HSPA6;DNAJB1;...
Antigen processing and presentation 2.33 0.00e+0 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Legionellosis 2.15 0.00e+0 51/57 (89.47%) HSPA1A;HSPA6;HSPD1;...
Spliceosome 1.93 5.89e-3 101/150 (67.33%) HSPA1A;HSPA6;HSPA8;...
Lipid and atherosclerosis 1.88 4.71e-3 190/215 (88.37%) HSPA1A;HSPA6;HSPD1;...
Proteasome 1.88 3.92e-3 44/46 (95.65%) PSMD2;PSMD12;PSME4;...
Ferroptosis 1.87 3.36e-3 36/41 (87.8%) HMOX1;SAT1;SLC7A11;...
Longevity regulating pathway 1.85 2.94e-3 90/151 (59.6%) HSPA1A;HSPA6;HSPA8;...
Spinocerebellar ataxia 1.84 6.54e-3 128/143 (89.51%) PSMD2;PSMD12;PSMD14;...
IL-17 signaling pathway 1.77 2.12e-2 84/94 (89.36%) HSP90AA1;MMP1;HSP90B1;...
Phagosome 1.76 2.78e-2 118/152 (77.63%) SFTPA2;TUBB2A;OLR1;...
Protein export 1.73 3.73e-2 17/23 (73.91%) HSPA5;SEC62;SEC63;...
beta-Alanine metabolism -1.64 3.58e-2 25/30 (83.33%) EHHADH;ALDH3A1;ALDH1B1;...
p53 signaling pathway -1.64 3.75e-2 63/73 (86.3%) THBS1;CYCS;CASP8;...
Oocyte meiosis -1.64 3.93e-2 90/129 (69.77%) RPS6KA2;ADCY1;FBXO5;...
Nucleotide excision repair -1.64 4.12e-2 40/47 (85.11%) POLD1;MNAT1;CUL4B;...
Pantothenate and CoA biosynthesis -1.66 3.84e-2 14/21 (66.67%) COASY;PPCS;ALDH1B1;...
Citrate cycle (TCA cycle) -1.67 3.53e-2 30/30 (100%) MDH1;ACO1;OGDH;...
Cell cycle -1.68 3.38e-2 110/124 (88.71%) MCM3;CDC7;RB1;...
Base excision repair -1.69 3.49e-2 29/33 (87.88%) PARP4;NEIL1;APEX2;...
Histidine metabolism -1.69 3.72e-2 16/22 (72.73%) ALDH3A1;ALDH1B1;FTCD;...
Thiamine metabolism -1.69 3.86e-2 12/15 (80%) AK2;NFS1;AK5;...
Sulfur metabolism -1.69 4.16e-2 9/10 (90%) MPST;PAPSS1;TST
ECM-receptor interaction -1.71 3.72e-2 80/88 (90.91%) ITGB3;ITGA7;SV2A;...
Glycolysis / Gluconeogenesis -1.73 3.43e-2 56/67 (83.58%) MINPP1;ALDH3A1;ALDH1B1;...
Arachidonic acid metabolism -1.77 2.58e-2 48/61 (78.69%) PLA2G6;PLA2G4A;PLA2G12A;...
Fructose and mannose metabolism -1.84 7.63e-3 30/33 (90.91%) AKR1B10;KHK;HK2;...
Pentose phosphate pathway -1.86 6.44e-3 25/30 (83.33%) RPIA;PGD;ALDOA;...
DNA replication -1.87 4.91e-3 34/36 (94.44%) POLD1;RNASEH1;POLE3;...
Valine, leucine and isoleucine degradation -1.87 5.72e-3 42/48 (87.5%) ACAT1;MCCC1;AUH;...
Pyrimidine metabolism -1.90 6.87e-3 40/56 (71.43%) DHODH;NME7;DCTPP1;...
Purine metabolism -1.93 2.15e-3 102/129 (79.07%) AK2;XDH;FHIT;...
Drug metabolism -1.97 2.86e-3 78/151 (51.66%) TK2;UGT2B17;CYP1A2;...
Metabolism of xenobiotics by cytochrome P450 -2.05 0.00e+0 49/77 (63.64%) CYP3A4;GSTO1;CBR1;...
Glutathione metabolism -2.09 0.00e+0 43/57 (75.44%) GSTO1;GGT1;GSTT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 20uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 20uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 1.11uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 1.11uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 20uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 20uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 20uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 20uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 20uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 20uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 20uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 20uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 20uM 24H
HT-29 CVCL_0320 Homo sapiens 0.12uM - 20uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 20uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 20uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 20uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 20uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 20uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 20uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 20uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 20uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 20uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 20uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 20uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 20uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 20uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 20uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 20uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 20uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM 24H
HCC95 CVCL_1276 Homo sapiens 10uM - 20uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 20uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 20uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 20uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 20uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 20uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 20uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 1.11uM - 20uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 20uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 20uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 20uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 20uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 20uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM - 20uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 20uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 20uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 20uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 20uM 24H
PC-3 CVCL_0035 Homo sapiens 0.12uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.12uM - 20uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 20uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 20uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 20uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 20uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 20uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 20uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 20uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 20uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 20uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 20uM 24H