Details of the Drug Pharmacogenomic Perturbation Atlas

Semagacestat Drug Info

DAPT; AN-37124; AN-44989; LY-374973; LY-411575; LY-424354; LY-450139; LY-4501395; Gamma-secretase inhibitors (Alzheimer's disease), Elan Pharmaceuticals/Eli Lilly

Cross-matching ID

PubChem CID

9843750

ChEBI ID

CHEMBL520733

CAS Number

CAS 425386-60-3

TTD Drug ID

D01LXD

INTEDE Drug ID

DR1888

General Information of Drug (ID: DML83IW)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.16	0.00e+0	34/36 (94.44%)	PCNA;MCM2;MCM5;...
Bile secretion	1.99	0.00e+0	68/90 (75.56%)	UGT2B15;ABCG2;ATP1A1;...
Drug metabolism	1.96	3.17e-3	78/151 (51.66%)	UGT2B15;CYP1A2;DPYD;...
Base excision repair	1.77	2.85e-2	29/33 (87.88%)	PCNA;FEN1;LIG1;...
Systemic lupus erythematosus	1.77	2.28e-2	45/135 (33.33%)	C1QA;FCGR2A;SNRPB;...
Retinol metabolism	1.74	3.17e-2	41/68 (60.29%)	UGT2B15;CYP1A2;CYP2A6;...
Primary bile acid biosynthesis	1.74	2.85e-2	15/17 (88.24%)	SLC27A5;CYP7A1;BAAT;...
Arginine and proline metabolism	-1.69	4.19e-2	39/50 (78%)	SMS;CKM;PYCR1;...
Pentose phosphate pathway	-1.69	4.48e-2	25/30 (83.33%)	TKTL1;ALDOC;PFKL;...
Rheumatoid arthritis	-1.74	2.83e-2	78/93 (83.87%)	ATP6V1F;ATP6V1H;TEK;...
Bladder cancer	-1.76	2.45e-2	40/41 (97.56%)	HBEGF;KRAS;MMP1;...
Mucin type O-glycan biosynthesis	-1.80	1.18e-2	20/36 (55.56%)	ST6GALNAC4;GCNT1;GALNT10;...
TGF-beta signaling pathway	-1.80	1.35e-2	81/94 (86.17%)	TGIF2;SMAD2;PITX2;...
Glutathione metabolism	-1.83	1.40e-2	43/57 (75.44%)	ANPEP;GSTA1;PGD;...
Other types of O-glycan biosynthesis	-1.90	4.19e-3	29/47 (61.7%)	MFNG;GALNT6;GALNT3;...
TNF signaling pathway	-1.93	5.24e-3	103/112 (91.96%)	IKBKB;BCL3;MAP2K3;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.93	6.99e-3	62/70 (88.57%)	CHUK;ATP6V1B1;ATP6V0A4;...
IL-17 signaling pathway	-1.93	1.05e-2	84/94 (89.36%)	FOSL1;CSF2;CHUK;...
Steroid biosynthesis	-2.19	0.00e+0	19/20 (95%)	LIPA;DHCR24;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H