Details of the Drug

General Information of Drug (ID: DML83IW)

Drug Name
Semagacestat
Synonyms DAPT; AN-37124; AN-44989; LY-374973; LY-411575; LY-424354; LY-450139; LY-4501395; Gamma-secretase inhibitors (Alzheimer's disease), Elan Pharmaceuticals/Eli Lilly
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 361.4
Logarithm of the Partition Coefficient (xlogp) 1.3
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H27N3O4
IUPAC Name
(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide
Canonical SMILES
C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
InChI
InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
InChIKey
PKXWXXPNHIWQHW-RCBQFDQVSA-N
Cross-matching ID
PubChem CID
9843750
ChEBI ID
CHEBI:131158
CAS Number
425386-60-3
UNII
3YN0602W4W
DrugBank ID
DB12463
TTD ID
D01LXD
INTEDE ID
DR1888

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN ; APH1B_HUMAN ; PEN2_HUMAN ; NICA_HUMAN ; PSN1_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Parkinson disease
ICD Disease Classification 8A00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 9.96E-01 -3.17E-03 -1.84E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 149 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 7.4354 10.6502 4.7718 3.185
MEC1 CTRP2 7.4873 11.0645 4.6109 3.743
JM1 CTRP2 8.6071 14.7087 3.6163 6.1573
Granta-519 CTRP2 6.1126 9.6154 4.3154 7.1363
SUP-M2 CTRP2 6.2361 7.8751 5.2835 2.8471
MOLT-3 CTRP2 6.4866 7.7391 5.5312 1.4381
BDCM CTRP2 6.7335 14.1905 2.5304 13.2726
SKM-1 CTRP2 6.8639 11.741 3.8469 7.759
DEL CTRP2 6.9123 8.948 5.2364 2.0411
P31/FUJ CTRP2 6.9712 9.1095 5.1981 2.1157
Ci-1 CTRP2 7.0121 7.8499 5.7653 0.1932
KE-37 CTRP2 7.0132 8.558 5.4736 1.0529
OCI-Ly3 CTRP2 7.0584 11.5035 4.1069 6.3784
HL-60 CTRP2 7.0719 10.1338 4.7796 3.6296
A3/Kawakami CTRP2 7.0932 8.4273 5.5718 0.6618
GA-10 CTRP2 7.1003 10.8949 4.4328 4.986
NOMO-1 CTRP2 7.1244 9.065 5.3109 1.5183
WSU-DLCL2 CTRP2 7.1329 8.8146 5.4268 1.1016
TF-1 CTRP2 7.1379 8.5965 5.5233 0.7788
SIG-M5 CTRP2 7.1728 8.927 5.3993 1.1583
U-937 CTRP2 7.1785 9.3959 5.1929 1.8925
OCI-AML-5 CTRP2 7.1787 15.3891 2.2804 13.434
JJN-3 CTRP2 7.1817 9.4736 5.1593 2.0136
MC116 CTRP2 7.2006 8.1553 5.7283 0.1956
KMM-1 CTRP2 7.2348 9.7371 5.0706 2.2858
HEL CTRP2 7.2403 8.5585 5.589 0.5104
OCI-AML-2 CTRP2 7.2417 8.9516 5.4257 1.0082
KE-97 CTRP2 7.2453 10.5786 4.6831 3.7768
SU-DHL-10 CTRP2 7.2743 8.4549 5.6454 0.3456
MOLM-16 CTRP2 7.2903 9.8189 5.0667 2.2364
SUP-T1 CTRP2 7.291 15.1652 2.4766 12.5014
JeKo-1 CTRP2 7.297 9.945 5.0128 2.4314
KMS-20 CTRP2 7.3074 9.4398 5.2478 1.5565
KYO-1 CTRP2 7.3079 8.9812 5.4473 0.884
K-562 CTRP2 7.3374 9.8075 5.0999 2.06
SU-DHL-8 CTRP2 7.3407 10.4927 4.7855 3.2502
SET-2 CTRP2 7.3512 9.2585 5.3514 1.1591
Jurkat CTRP2 7.3513 9.5221 5.236 1.5545
SUP-B15 CTRP2 7.392 9.8978 5.0912 2.0327
SUP-T11 CTRP2 7.3974 11.0196 4.5738 4.005
HT CTRP2 7.4111 9.0923 5.4525 0.7898
Reh CTRP2 7.4232 11.9297 4.1564 5.6315
OCI-M1 CTRP2 7.4545 8.6865 5.6335 0.2905
KMS-26 CTRP2 7.456 8.5367 5.6897 0.1807
A4/Fukuda CTRP2 7.4717 13.3026 3.525 8.0961
AML-193 CTRP2 7.5066 8.6301 5.6755 0.1898
KMS-34 CTRP2 7.5241 12.2994 4.0476 5.9231
OCI-AML-3 CTRP2 7.5288 8.8684 5.5957 0.3411
KMS-21-BM CTRP2 7.5353 13.9988 3.2309 9.1687
ALL-SIL CTRP2 7.5496 8.999 5.5543 0.4273
HEL 92.1.7 CTRP2 7.5596 14.0396 3.2285 9.1404
JVM-3 CTRP2 7.562 12.0625 4.1868 5.3147
KM-H2 CTRP2 7.5671 11.6695 4.3772 4.5544
MJ CTRP2 7.5746 10.4384 4.9536 2.3389
MOTN-1 CTRP2 7.5752 9.2712 5.458 0.663
TALL-1 [Human adult T-ALL] CTRP2 7.5834 13.5098 3.5035 8.0115
Mono-Mac-1 CTRP2 7.5837 10.0923 5.1136 1.7562
697 CTRP2 7.6098 9.5982 5.3402 0.9843
MOLT-16 CTRP2 7.6127 12.3384 4.089 5.6332
PF-382 CTRP2 7.6146 18.2611 1.1902 16.5295
KMS-27 CTRP2 7.615 13.9173 3.3277 8.6622
EJM CTRP2 7.6255 10.0669 5.1478 1.5983
CMK CTRP2 7.6329 8.7474 5.6819 0.1443
MHH-CALL-4 CTRP2 7.6351 12.4113 4.0691 5.6809
DND-41 CTRP2 7.6424 16.7929 1.9368 13.9062
NB4 CTRP2 7.6502 8.7758 5.6783 0.1454
Ri-1 CTRP2 7.6538 11.7884 4.3773 4.4397
THP-1 CTRP2 7.6559 9.5899 5.3665 0.8717
Hs 611.T CTRP2 7.6647 10.6535 4.9092 2.4043
EoL-1 CTRP2 7.6709 9.2611 5.5055 0.4844
Mino CTRP2 7.6719 9.4951 5.4128 0.7276
MV4-11 CTRP2 7.6731 9.6466 5.3514 0.9042
OPM-2 CTRP2 7.6875 9.0022 5.6107 0.248
PL21 CTRP2 7.7011 12.0556 4.2819 4.7515
Karpas-299 CTRP2 7.7071 14.0076 3.349 8.4379
RPMI-6666 CTRP2 7.7188 9.4216 5.4638 0.5632
Daudi CTRP2 7.7208 14.1802 3.2748 8.71
U266B1 CTRP2 7.7237 9.5534 5.4136 0.6932
RPMI-8402 CTRP2 7.7271 19.5968 0.6144 18.1744
Raji CTRP2 7.7353 15.7247 2.5309 11.5638
MM1.S CTRP2 7.7355 10.4407 5.0442 1.8513
DB CTRP2 7.8117 10.6802 4.9809 1.9981
Kasumi-1 CTRP2 7.8122 13.8861 3.4812 7.7598
P12-Ichikawa CTRP2 7.8138 9.6663 5.4098 0.6496
P3HR-1 CTRP2 7.8354 9.4977 5.4854 0.4515
L-363 CTRP2 7.8443 8.9117 5.7017 0.0786
RPMI-8226 CTRP2 7.8571 9.6353 5.4414 0.5456
EHEB CTRP2 7.8628 13.2227 3.8342 6.2948
AMO1 CTRP2 7.8727 9.1881 5.6155 0.1839
SU-DHL-4 CTRP2 7.8868 9.3174 5.5742 0.2488
KMS-12-BM CTRP2 7.9079 9.451 5.5333 0.3183
KCL-22 CTRP2 7.9244 9.8677 5.3801 0.6643
MOLP-8 CTRP2 7.9381 9.4516 5.5452 0.2847
HPB-ALL CTRP2 7.9408 15.8051 2.64 10.8275
Peer CTRP2 7.9425 13.4921 3.7589 6.4806
HDLM-2 CTRP2 7.9717 10.4586 5.1612 1.2618
M-07e CTRP2 7.9873 9.5433 5.5311 0.2942
BL-70 CTRP2 7.9917 9.1974 5.6562 0.1037
SUP-HD1 CTRP2 8.003 10.0722 5.3345 0.7388
NCI-H929 CTRP2 8.0425 9.918 5.4126 0.5225
ST486 CTRP2 8.049 9.8097 5.4568 0.4206
MOLP-2 CTRP2 8.0948 9.9761 5.4127 0.4979
JURL-MK1 CTRP2 8.112 10.0051 5.409 0.4985
LP-1 CTRP2 8.1305 9.7272 5.5204 0.2668
CML-T1 CTRP2 8.1324 9.5022 5.6014 0.1433
RL CTRP2 8.1447 9.5489 5.5896 0.1562
HuNS1 CTRP2 8.1631 9.7235 5.5344 0.2336
Karpas-422 CTRP2 8.192 15.0544 3.1792 8.3896
L-428 CTRP2 8.2449 9.6759 5.582 0.1455
F-36P CTRP2 8.2468 11.0245 5.062 1.3592
EM-2 CTRP2 8.2589 14.6662 3.41 7.4047
NU-DHL-1 CTRP2 8.3208 10.1089 5.4559 0.3209
RS4;11 CTRP2 8.3399 15.5818 3.0265 8.7641
Karpas-620 CTRP2 8.3439 9.8444 5.5594 0.1542
RCH-ACV CTRP2 8.3639 9.9808 5.5188 0.2053
NU-DUL-1 CTRP2 8.3765 17.4071 2.1698 11.8987
HD-MY-Z CTRP2 8.3826 9.9312 5.5432 0.1671
Namalwa CTRP2 8.3925 16.1352 2.7964 9.5609
MOLM-6 CTRP2 8.3952 15.178 3.2569 7.8066
MOLM-13 CTRP2 8.4081 9.8778 5.5711 0.1282
SR CTRP2 8.4301 10.0176 5.5304 0.174
SK-MM-2 CTRP2 8.4519 19.6938 1.1073 15.428
HH [Human lymphoma] CTRP2 8.4644 10.4248 5.3968 0.382
CA46 CTRP2 8.4919 19.1456 1.4046 14.3857
MOLT-13 CTRP2 8.5363 16.3782 2.7777 9.4252
NCO2 CTRP2 8.5396 10.2462 5.4905 0.2042
GDM-1 CTRP2 8.5413 15.8316 3.0427 8.4209
KHM-1B CTRP2 8.5887 10.2984 5.4904 0.1934
SU-DHL-1 CTRP2 8.6581 15.5032 3.2756 7.3823
OCI-Ly10 CTRP2 8.6606 16.9237 2.6004 9.908
LAMA-84 CTRP2 8.6706 10.2215 5.5466 0.1125
L-540 CTRP2 8.6787 10.4203 5.4808 0.1869
HuT 78 CTRP2 8.8322 10.7594 5.4183 0.2385
BV-173 CTRP2 8.8742 10.2857 5.5952 0.052
Pfeiffer CTRP2 8.8796 20.4731 1.0347 15.0006
SU-DHL-6 CTRP2 9.0629 18.5258 2.1048 11.1271
KMS-11 CTRP2 9.0643 18.6331 2.0542 11.3029
Ku812 CTRP2 9.1313 20.2173 1.3365 13.6474
MHH-CALL-3 CTRP2 9.1399 11.0634 5.4249 0.1675
Ki-JK CTRP2 9.2404 21.2645 0.9054 14.8712
KMS-18 CTRP2 9.2939 17.1317 2.9183 7.8908
KO52 CTRP2 9.31 16.6449 3.1555 7.005
EB1 CTRP2 9.8689 22.7135 0.6417 14.7798
NALM-6 CTRP2 9.8727 18.7777 2.5151 8.6116
Toledo CTRP2 9.8749 21.6468 1.1584 13.17
Kasumi-2 CTRP2 9.9719 17.5157 3.1571 6.2337
REC-1 CTRP2 10.1403 20.8171 1.729 10.9607
OCI-Ly19 CTRP2 10.5091 23.298 0.7947 13.4481
ME1 CTRP2 11.3247 22.1652 1.8438 9.1578
⏷ Show the Full List of 149 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 7.6932 25.0951 -2.1442 25.2905
TE15 CTRP2 8.2451 10.1453 5.4116 0.4354
TE-6 CTRP2 6.5496 8.9675 4.1497 1.7821
KYSE-70 CTRP2 7.2359 11.6954 3.3192 4.2312
TE-4 CTRP2 7.3107 12.5119 3.7956 7.2542
OE21 CTRP2 7.8045 11.6473 4.5386 3.6292
OE19 CTRP2 7.9607 9.1061 5.6765 0.0868
EC-GI-10 CTRP2 7.9752 11.0359 4.9147 2.0711
TE-14 CTRP2 7.9966 10.105 5.3185 0.7856
OE33 CTRP2 8.0248 10.028 5.362 0.6553
TE-5 CTRP2 8.1093 15.6255 2.8465 9.7865
KYSE-30 CTRP2 8.1717 9.4103 5.6472 0.0853
KYSE-450 CTRP2 8.1726 10.1957 5.3616 0.5798
KYSE-510 CTRP2 8.2276 9.4949 5.6381 0.0863
KYSE-150 CTRP2 8.4269 9.8465 5.5885 0.1064
KYSE-520 CTRP2 8.6521 10.6575 5.3859 0.3396
TE-10 CTRP2 8.7986 16.3774 2.9536 8.4056
KYSE-410 CTRP2 9.0879 16.489 3.0882 7.5277
TE-1 CTRP2 9.1333 17.4363 2.6712 8.9989
TE-11 CTRP2 9.2254 16.7741 3.0421 7.5241
KYSE-140 CTRP2 9.9013 24.2479 -0.0779 16.8208
COLO 680N CTRP2 11.0704 23.7035 0.9697 12.1997
TE-9 CTRP2 12.7781 25.5533 1.1662 9.6702
KYSE-180 CTRP2 14.2981 27.8517 1.0084 8.6393
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 11.2481 18.8411 3.2856 4.5464
Panc 02.03 CTRP2 0.7109 2.3686 -2.4775 0.3139
BxPC-3 CTRP2 4.1924 16.2802 -0.6885 28.8829
HuP-T4 CTRP2 5.8516 20.804 -1.4967 27.2045
YAPC CTRP2 6.838 8.5746 4.4567 0.555
TCC-Pan2 CTRP2 7.1666 13.6803 2.3414 8.3292
MIA PaCa-2 CTRP2 7.4592 9.482 5.3123 1.1947
Capan-1 CTRP2 7.5236 9.5067 5.3352 1.067
KP-2 CTRP2 7.5864 10.0625 5.1283 1.7023
PaTu 8902 CTRP2 7.6263 8.9519 5.6047 0.2819
SU.86.86 CTRP2 7.6839 9.217 5.5282 0.4236
Panc 08.13 CTRP2 7.7591 12.1261 4.2862 4.6589
PaTu 8988t CTRP2 7.8053 8.7989 5.7264 0.0607
QGP-1 CTRP2 7.8105 10.6286 5.003 1.9225
HPAC CTRP2 7.8136 12.1056 4.3309 4.4156
PSN1 CTRP2 7.8244 9.7969 5.3624 0.7715
KP-3 CTRP2 7.943 11.6717 4.6114 3.1952
KP-4 CTRP2 8.1076 10.5848 5.176 1.1174
Hs 766T CTRP2 8.1089 9.519 5.5868 0.168
Panc 10.05 CTRP2 8.1433 11.3932 4.8502 2.1351
DAN-G CTRP2 8.2596 9.7365 5.5661 0.1629
SNU-410 CTRP2 8.3117 11.0152 5.0978 1.2053
AsPC-1 CTRP2 8.3767 11.068 5.1074 1.133
SW1990 CTRP2 8.4085 12.4234 4.5431 2.9491
SUIT-2 CTRP2 8.4604 9.8894 5.5857 0.1043
Panc 04.03 CTRP2 8.4871 11.3088 5.0618 1.1902
HuP-T3 CTRP2 8.6261 10.4555 5.4487 0.2442
Panc 03.27 CTRP2 8.7578 15.3313 3.4206 6.7063
SNU-213 CTRP2 8.8812 17.286 2.5758 9.6889
PK-45H CTRP2 9.0167 18.2017 2.2289 10.7524
Capan-2 CTRP2 9.0945 10.8425 5.4844 0.1134
Panc 05.04 CTRP2 10.7707 24.7978 -0.5653 13.5608
PaTu 8988s CTRP2 10.8108 46.0009 -10.1139 32.0144
PK-59 CTRP2 12.2621 22.7804 2.114 7.3182
L3.3 CTRP2 12.3759 21.1244 2.8981 4.7975
HPAF-II CTRP2 12.7534 28.5607 -0.2345 13.6192
CFPAC-1 CTRP2 12.8917 26.3359 0.8777 10.3908
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 10.4901 22.6828 1.0746 12.6127
G-361 CTRP2 6.8363 8.5402 4.4693 0.5235
CJM [Human melanoma] CTRP2 7.0615 9.7488 4.9558 2.9447
SK-MEL-28 CTRP2 7.1167 8.3445 5.6175 0.5098
Hs 895.T CTRP2 7.1453 9.2799 5.226 1.8068
Hs 839.T CTRP2 7.1847 8.0778 5.7505 0.1591
SK-MEL-5 CTRP2 7.1913 9.6767 5.0718 2.3328
Hs 934.T CTRP2 7.1966 8.21 5.7061 0.2429
SK-MEL-2 CTRP2 7.2097 11.3892 4.2698 5.4852
A2058 CTRP2 7.3251 8.2234 5.7522 0.1163
WM266-4 CTRP2 7.4447 8.6738 5.6342 0.293
SK-MEL-30 CTRP2 7.446 9.4665 5.3119 1.2072
IGR-1 CTRP2 7.5114 9.6482 5.2683 1.295
UACC-62 CTRP2 7.5242 13.4472 3.492 8.1477
IGR-37 CTRP2 7.546 17.2211 1.6527 15.0746
SK-MEL-1 CTRP2 7.6625 8.793 5.6768 0.1445
K029AX CTRP2 7.7415 8.9244 5.6598 0.1502
A101D CTRP2 7.8303 8.8938 5.7029 0.0795
WT2-iPS CTRP2 7.8394 8.8338 5.7264 0.0566
RPMI-7951 CTRP2 7.8564 9.555 5.4723 0.472
COLO 829 CTRP2 7.8591 10.2904 5.1749 1.3071
Hs 688(A).T CTRP2 7.862 9.0928 5.6453 0.1427
COLO 792 CTRP2 7.8806 12.5795 4.1511 5.028
COLO 741 CTRP2 7.8816 9.7635 5.402 0.6317
IGR-39 CTRP2 7.9345 9.1875 5.6388 0.1357
SK-MEL-3 CTRP2 7.9351 10.0598 5.308 0.8528
Hs 936.T CTRP2 7.9356 9.4862 5.5314 0.3118
IPC-298 CTRP2 7.9593 15.8947 2.6096 10.9138
Hs 852.T CTRP2 7.9713 14.5635 3.2642 8.3787
Hs 940.T CTRP2 7.9717 14.9264 3.089 9.0592
RVH-421 CTRP2 8.0307 9.4098 5.5962 0.1729
LOX-IMVI CTRP2 8.0373 9.4657 5.5788 0.1974
HMCB CTRP2 8.2948 9.3874 5.697 0.0357
MeWo CTRP2 8.3016 9.601 5.628 0.0857
Mel JuSo CTRP2 8.3352 12.0213 4.6801 2.5404
HT-144 CTRP2 8.3503 10.2884 5.4013 0.4152
COLO 800 CTRP2 8.8023 14.431 3.8657 4.9879
Malme-3M CTRP2 8.8107 11.2604 5.2259 0.5967
SK-MEL-31 CTRP2 9.2397 17.7362 2.5988 9.1208
SK-MEL-24 CTRP2 10.0286 19.2945 2.3722 8.9178
Hs 944.T CTRP2 11.0202 21.722 1.8622 9.4463
WM793 CTRP2 11.8035 23.4255 1.5553 9.5365
A-375 CTRP2 11.8167 27.8819 -0.5196 15.4766
WM1799 CTRP2 11.9586 25.3569 0.7592 11.7657
Mel Ho CTRP2 12.0087 25.4668 0.7394 11.7657
UACC-257 CTRP2 12.5062 25.4053 1.072 10.235
WM983B CTRP2 12.6697 24.2886 1.673 8.2686
WM88 CTRP2 12.6812 25.8001 0.9965 10.2693
WM115 CTRP2 12.7242 26.4869 0.708 11.0569
Hs 294T CTRP2 13.3653 22.8166 2.6876 4.6405
MDA-MB-435S CTRP2 13.6258 26.6387 1.1685 8.8181
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 8.655 32.945 -5.297 29.2465
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 6.6641 9.8953 4.6078 4.9424
SK-N-DZ CTRP2 6.9609 10.5795 4.4878 4.9708
CHP-126 CTRP2 7.2387 9.8897 5.0025 2.5398
SiMa CTRP2 7.3609 11.2415 4.4442 4.5682
NH-6 CTRP2 7.3945 19.8906 0.2118 19.9556
SK-N-FI CTRP2 7.5129 11.5778 4.385 4.5961
SK-N-AS CTRP2 7.6714 9.5612 5.3857 0.8049
MHH-NB-11 CTRP2 7.8129 9.5316 5.4625 0.5168
NB1 CTRP2 8.1224 10.4597 5.2342 0.9396
KP-N-YN CTRP2 8.1561 15.6918 2.8471 9.7147
SK-N-BE(2) CTRP2 8.165 21.6704 -0.0793 19.4782
SK-N-SH CTRP2 8.2585 10.4061 5.3174 0.6431
CHP-212 CTRP2 8.3547 15.3815 3.1325 8.3386
Kelly CTRP2 9.316 19.5451 1.7876 11.8714
KP-N-SI9s CTRP2 10.9459 21.3349 1.9952 9.0978
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1196 CTRP2 7.6206 9.5579 5.3624 0.9088
SNU-1079 CTRP2 7.958 16.9559 2.0896 12.8402
SNU-308 CTRP2 8.0049 10.0051 5.362 0.666
SNU-245 CTRP2 8.3022 14.3772 3.576 6.7057
HuCC-T1 CTRP2 8.3566 9.783 5.5853 0.1211
HuH-28 CTRP2 8.6145 17.2227 2.425 10.6181
SNU-478 CTRP2 9.7818 20.7488 1.5253 12.109
SNU-869 CTRP2 10.6689 21.2812 1.8486 9.9064
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 7.0469 9.2828 5.1649 2.151
TC71 CTRP2 7.26 8.4788 5.6297 0.3915
Hs 822.T CTRP2 7.2728 8.1799 5.7479 0.1368
A-673 CTRP2 7.9323 10.049 5.3111 0.846
Hs 888.T CTRP2 7.9435 9.5695 5.5035 0.3649
SK-ES-1 CTRP2 8.1281 9.4929 5.6031 0.1421
SJSA-1 CTRP2 8.1587 10.2724 5.3256 0.6747
HOS CTRP2 8.1815 9.4059 5.6522 0.0793
CAL-78 CTRP2 8.4244 10.1975 5.4642 0.2745
G-292 clone A141B1 CTRP2 8.4965 11.0315 5.1778 0.8669
CADO-ES1 CTRP2 8.7382 10.3226 5.536 0.1133
SW1353 CTRP2 10.4851 21.4757 1.6412 10.8116
MHH-ES-1 CTRP2 12.5091 24.492 1.4887 8.988
MG-63 CTRP2 13.1605 24.7718 1.7353 7.6093
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 72 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ZR-75-30 CTRP2 0.9878 2.502 -2.426 0.1385
ZR-75-1 CTRP2 6.004 7.5771 4.4601 1.1881
KPL-1 CTRP2 6.4294 12.8446 2.9596 12.143
HMC-1-8 CTRP2 7.3241 8.7943 5.5329 0.6141
HCC38 CTRP2 7.4942 12.9223 3.7259 7.2566
HCC1419 CTRP2 7.5296 9.0408 5.5291 0.5003
HCC1428 CTRP2 7.5749 9.85 5.2149 1.417
CAL-148 CTRP2 7.6334 8.9258 5.6173 0.2545
Hs 578Bst CTRP2 7.6847 9.5079 5.4137 0.717
MDA-MB-415 CTRP2 7.7267 11.4521 4.5809 3.5614
HCC1500 CTRP2 7.8232 9.6432 5.4232 0.6095
CAL-120 CTRP2 7.8587 9.0781 5.6493 0.138
MCF-7 CTRP2 7.8934 9.7055 5.43 0.5548
JIMT-1 CTRP2 7.9319 9.3191 5.5911 0.2065
HDQ-P1 CTRP2 8.0228 14.99 3.0937 8.9652
MDA-MB-157 CTRP2 8.056 9.9171 5.4188 0.5019
CAMA-1 CTRP2 8.1369 9.5599 5.5828 0.1672
HCC2218 CTRP2 8.1642 10.1089 5.3915 0.5145
HCC1806 CTRP2 8.1728 10.7692 5.1316 1.2031
HCC1954 CTRP2 8.1864 10.3756 5.2974 0.7315
T-47D CTRP2 8.1888 10.6395 5.1926 1.014
CAL-51 CTRP2 8.1994 11.7038 4.7447 2.4467
BT-474 CTRP2 8.2743 9.8206 5.5419 0.1932
AU565 CTRP2 8.2974 11.0767 5.0653 1.3118
BT-20 CTRP2 8.3871 10.2742 5.4215 0.3623
MDA-MB-453 CTRP2 8.4792 12.0522 4.7448 2.187
DU4475 CTRP2 8.5041 17.4077 2.2592 11.3838
HCC1395 CTRP2 8.5163 15.0402 3.4021 7.0887
HCC1569 CTRP2 8.5244 11.5832 4.967 1.4432
HCC202 CTRP2 8.5321 10.8298 5.2722 0.6173
SK-BR-3 CTRP2 8.6601 10.2605 5.5296 0.1319
Hs 578T CTRP2 8.8707 31.3537 -4.339 27.4934
BT-549 CTRP2 9.3207 19.5072 1.8089 11.792
HCC1937 CTRP2 9.3935 17.8813 2.6301 8.8074
MDA-MB-231 CTRP2 9.3957 19.3406 1.9392 11.2409
CAL-85-1 CTRP2 9.5231 17.6563 2.8181 7.9669
MDA-MB-468 CTRP2 9.8025 19.3316 2.2109 9.7607
HCC1143 CTRP2 10.0591 20.7761 1.6955 11.177
BT 239 CTRP2 4.888 15.8617 0.1416 25.1231
BT 248 CTRP2 7.0498 10.9791 4.3564 5.3724
BT 504 CTRP2 7.1321 11.95 3.9417 6.9377
BT 228 CTRP2 7.1581 19.0843 0.4278 19.7369
BT 172 CTRP2 7.1973 13.1774 3.3872 9.0836
BT 422 CTRP2 7.3391 9.1371 5.3971 1.019
BT 359 CTRP2 7.393 13.5368 3.354 8.9028
BT 320 CTRP2 7.4585 8.4305 5.7288 0.1181
BT 179 CTRP2 7.5191 9.4095 5.3738 0.9495
BT 333 CTRP2 7.5262 8.9204 5.5746 0.3906
BT 145 CTRP2 7.5612 9.7634 5.245 1.3288
BT 232 CTRP2 7.6397 8.9935 5.5946 0.2972
BT 444 CTRP2 7.6443 9.0018 5.5934 0.2978
BT 271 CTRP2 7.6691 9.1663 5.5414 0.4001
BT 330 CTRP2 7.7056 9.1517 5.5624 0.338
BT 498 CTRP2 7.7636 9.0811 5.6119 0.221
BT 328 CTRP2 7.7717 9.0256 5.6352 0.18
BT 416 CTRP2 7.8034 9.2357 5.571 0.2829
BT 286 CTRP2 7.8588 13.9409 3.4868 7.6698
BT 340 CTRP2 7.8722 11.8534 4.485 3.7519
BT 440 CTRP2 7.8917 9.4145 5.5403 0.3105
BT 482 CTRP2 7.9073 9.3567 5.5679 0.2534
BT 131 CTRP2 7.922 9.5585 5.4988 0.3837
BT147 CTRP2 7.9334 9.8394 5.3953 0.6204
BT 216 CTRP2 8.0506 9.6941 5.5008 0.3298
BT 224 CTRP2 8.0678 9.5493 5.5605 0.2181
BT 245 CTRP2 8.0814 9.5545 5.5638 0.2091
BT 428 CTRP2 8.4113 9.8316 5.5881 0.1092
BT 139 CTRP2 8.6418 15.1301 3.4408 6.7779
BT 112 CTRP2 10.1715 19.3283 2.4458 8.49
BT164 CTRP2 10.4066 19.3736 2.569 7.7911
BT 231 CTRP2 10.7022 22.3874 1.3521 11.47
BT 187 CTRP2 10.9026 23.1566 1.1191 11.9498
BT 159 CTRP2 11.428 22.5963 1.7085 9.4735
⏷ Show the Full List of 72 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.5611 8.5381 5.7289 0.0962
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KNS-60 CTRP2 6.164 7.396 4.6189 0.5095
SW1783 CTRP2 6.614 24.5164 -2.7213 28.28
LN-18 CTRP2 7.2072 8.6197 5.5482 0.6498
DK-MG CTRP2 7.2703 8.903 5.4612 0.8698
KNS-81 CTRP2 7.3902 8.6947 5.6029 0.3901
SNU-738 CTRP2 7.4564 8.6929 5.6319 0.2932
M059K CTRP2 7.526 10.1526 5.0542 2.0252
CCF-STTG1 CTRP2 7.5776 11.045 4.677 3.3745
D283 Med CTRP2 7.5883 12.2575 4.1112 5.5786
CAS-1 CTRP2 7.5983 15.621 2.4813 11.9723
SNU-489 CTRP2 7.6817 8.7902 5.685 0.1284
42-MG-BA CTRP2 7.6963 9.5779 5.3908 0.7739
GMS-10 CTRP2 7.7334 9.1817 5.5626 0.3263
A-172 CTRP2 7.735 11.6835 4.4784 3.9443
Hs 683 CTRP2 7.7429 9.2202 5.552 0.3446
SF126 CTRP2 7.7531 10.0105 5.2392 1.1881
NMC-G1 CTRP2 7.7628 9.2227 5.5593 0.3214
KG-1-C CTRP2 7.7773 8.9224 5.6739 0.1227
KNS-42 CTRP2 7.7832 9.2969 5.5398 0.3538
SF295 CTRP2 7.8372 9.4477 5.5052 0.4058
SF539 CTRP2 7.9085 10.1539 5.2568 1.0184
ONS-76 CTRP2 7.934 11.541 4.6655 3.0052
GOS-3 CTRP2 7.9587 9.9789 5.3515 0.7197
SNU-626 CTRP2 8.0058 9.1146 5.6895 0.0683
U-87MG ATCC CTRP2 8.0523 9.4626 5.5856 0.1833
U-118MG CTRP2 8.1318 9.8559 5.4735 0.3533
YKG-1 CTRP2 8.1866 9.2326 5.7118 0.035
YH-13 CTRP2 8.2029 10.8551 5.1107 1.2438
U-251MG CTRP2 8.2091 9.5676 5.6066 0.1224
GaMG CTRP2 8.2474 12.8856 4.2388 4.2391
Becker CTRP2 8.32 10.1433 5.4429 0.3452
Daoy CTRP2 8.4776 9.9326 5.577 0.1105
T98G CTRP2 8.5039 11.0666 5.1673 0.8902
LN-229 CTRP2 8.5193 13.9331 3.9222 5.1092
SNB-75 CTRP2 8.5628 10.2785 5.4878 0.2028
8-MG-BA CTRP2 8.7028 10.9644 5.2928 0.4996
KALS-1 CTRP2 8.9981 11.1348 5.3473 0.3035
SF268 CTRP2 9.5275 11.1857 5.5176 0.0495
SNU-466 CTRP2 10.4161 22.76 0.989 12.975
GB-1 CTRP2 10.8553 19.3172 2.859 6.3196
TM-31 CTRP2 10.866 17.4745 3.6713 3.6469
SNU-201 CTRP2 11.0469 26.5649 -0.4057 16.153
SW1088 CTRP2 11.1175 21.1744 2.1726 8.3215
SNU-1105 CTRP2 11.6467 23.6862 1.3401 10.3785
DBTRG-05MG CTRP2 13.4903 27.281 0.8021 9.99
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN CTRP2 7.1338 9.0898 5.3052 1.5292
JHUEM-7 CTRP2 7.2853 13.5994 3.2445 9.5128
JHUEM-1 CTRP2 7.5514 11.5868 4.406 4.4618
HEC-6 CTRP2 7.6124 11.1931 4.6299 3.5125
KLE CTRP2 7.7381 11.809 4.4217 4.1591
HEC-251 CTRP2 7.8575 12.2057 4.3119 4.4337
HEC-265 CTRP2 7.9035 9.0139 5.6877 0.084
HEC-59 CTRP2 8.015 10.8193 5.0303 1.6455
HEC-1-B CTRP2 8.0902 10.1644 5.3375 0.6818
EFE-184 CTRP2 8.0955 9.8006 5.4794 0.3553
AN3-CA CTRP2 8.1745 10.7812 5.1275 1.2141
MFE-319 CTRP2 8.1943 10.123 5.3989 0.4844
HEC-1-A CTRP2 8.6883 10.2261 5.5513 0.1055
MFE-296 CTRP2 8.7016 10.3798 5.5033 0.1545
RL95-2 CTRP2 8.7399 14.8911 3.6148 5.9981
HEC-50B CTRP2 8.8856 10.8715 5.3986 0.2543
HEC-151 CTRP2 8.9129 10.1745 5.6444 0.0258
JHUEM-2 CTRP2 9.1234 15.1092 3.7483 5.0559
JHUEM-3 CTRP2 9.647 20.2917 1.6533 11.8673
ESS-1 CTRP2 12.695 23.8074 1.9018 7.551
HEC-108 CTRP2 14.688 27.8964 1.2033 7.7565
Ishikawa (Heraklio) 02 ER- CTRP2 7.659 8.5456 5.761 0.0487
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-20 CTRP2 7.3243 12.9288 3.6018 8.0161
TUHR10TKB CTRP2 7.3345 8.6232 5.6062 0.4107
KMRC-2 CTRP2 7.5851 9.7228 5.275 1.2099
KMRC-1 CTRP2 7.7469 9.1138 5.5934 0.2601
RCC10RGB CTRP2 7.8145 9.2675 5.5637 0.293
TUHR4TKB CTRP2 7.9414 9.2636 5.6146 0.1678
769-P CTRP2 7.9979 9.478 5.5592 0.2404
BFTC-909 CTRP2 8.0733 9.239 5.6709 0.0764
TUHR14TKB CTRP2 8.1764 11.0933 4.9973 1.6176
SNU-1272 CTRP2 8.383 10.0379 5.5056 0.2201
OS-RC-2 CTRP2 8.4228 10.3141 5.421 0.3509
UO-31 CTRP2 8.5159 10.2695 5.4733 0.2351
786-O CTRP2 8.5864 10.5458 5.4009 0.3339
Caki-1 CTRP2 8.6185 10.4897 5.4336 0.2697
VMRC-RCZ CTRP2 8.6587 10.616 5.4036 0.3073
Caki-2 CTRP2 8.6944 17.4435 2.3736 10.6902
VMRC-RCW CTRP2 8.7609 10.2445 5.5703 0.0798
ACHN CTRP2 8.7855 10.2997 5.5603 0.0852
CAL-54 CTRP2 9.956 17.8183 3.0097 6.7706
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 CTRP2 -0.4798 16.4522 -5.2526 47.0507
NCI-H508 CTRP2 7.2666 10.2422 4.8556 3.0716
HCC-56 CTRP2 7.3088 8.4247 5.6717 0.2696
DLD-1 CTRP2 7.3105 8.5087 5.6403 0.34
HT115 CTRP2 7.3627 11.0126 4.5544 4.1282
T84 CTRP2 7.3973 11.4701 4.3593 4.856
CCK-81 CTRP2 7.4348 16.5759 1.8878 14.4323
HCT 15 CTRP2 7.505 9.2228 5.4444 0.7477
HCT 8 CTRP2 7.5251 8.8778 5.5905 0.3544
SNU-C5 CTRP2 7.6421 12.8282 3.874 6.4476
SNU-C4 CTRP2 7.6435 8.6821 5.7088 0.1051
SNU-61 CTRP2 7.6513 18.5146 1.0925 16.7881
HT-29 CTRP2 7.6668 10.0281 5.1869 1.4294
SW948 CTRP2 7.7448 8.906 5.6676 0.1383
NCI-H716 CTRP2 7.7537 11.873 4.4016 4.2174
C2BBe1 CTRP2 7.7542 11.4377 4.6044 3.4389
LS411N CTRP2 7.7652 9.306 5.5288 0.3852
OUMS-23 CTRP2 7.77 8.8621 5.6922 0.1013
SW48 CTRP2 7.8398 17.116 1.9243 13.6257
RCM-1 [Human ESC] CTRP2 7.8799 9.904 5.3451 0.7845
SNU-503 CTRP2 7.9253 12.7242 4.1118 5.1232
SNU-C1 CTRP2 7.9455 10.2153 5.2494 1.0142
SK-CO-1 CTRP2 8.0105 9.7933 5.4468 0.4592
COLO 320 CTRP2 8.1224 11.4014 4.8352 2.2062
LS123 CTRP2 8.1281 11.808 4.658 2.8252
KM12 CTRP2 8.1381 9.5528 5.5858 0.1629
RKO CTRP2 8.2222 9.9645 5.4697 0.3285
LS513 CTRP2 8.3447 9.9 5.5401 0.1795
COLO205 CTRP2 8.351 9.4568 5.693 0.0341
CL-11 CTRP2 8.4496 10.6584 5.3026 0.5858
HCT 116 CTRP2 8.4901 16.0831 2.888 9.0766
CW-2 CTRP2 8.5528 13.0825 4.3307 3.5603
SW620 CTRP2 8.594 10.5855 5.3893 0.3521
LoVo CTRP2 8.6197 24.5401 -1.1547 21.5547
COLO201 CTRP2 8.7081 10.1583 5.5811 0.077
HT-55 CTRP2 9.4245 19.9658 1.6594 12.1541
SNU-407 CTRP2 9.493 18.8218 2.2505 10.0263
GP2d CTRP2 9.5535 19.5406 1.9491 10.992
SW1417 CTRP2 9.6797 30.2183 -3.1628 24.282
LS1034 CTRP2 9.8516 19.6256 2.1041 10.0662
SNU-C2A CTRP2 10.055 23.7344 0.2776 15.5958
SW1116 CTRP2 10.2015 34.6704 -4.9691 26.655
MDST8 CTRP2 10.4963 23.4178 0.7291 13.663
COLO 678 CTRP2 10.6735 24.2807 0.4358 14.2994
LS180 CTRP2 10.8185 26.2702 -0.4195 16.4901
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 CTRP2 0.9354 2.2434 -2.3584 0.067
HuH-6 CTRP2 6.5029 8.5061 5.1716 2.8726
Hep-G2 CTRP2 6.5783 11.9242 2.7838 7.3825
SNU-886 CTRP2 6.9209 8.9214 4.3571 0.7789
SNU-761 CTRP2 7.4715 8.8792 4.5931 0.1024
PLC/PRF/5 CTRP2 7.6562 9.8346 5.2641 1.1866
Hep 3B2.1-7 CTRP2 7.7888 9.6682 5.3976 0.697
SNU-387 CTRP2 7.888 9.6454 5.4511 0.5067
SK-HEP-1 CTRP2 7.9755 9.2704 5.6249 0.1455
JHH-4 CTRP2 8.0003 11.4792 4.732 2.6919
SNU-475 CTRP2 8.1201 9.5222 5.5899 0.1613
HuH-1 CTRP2 8.1918 9.6893 5.5576 0.1903
JHH-5 CTRP2 8.2759 11.2579 4.9786 1.5967
SNU-423 CTRP2 8.2921 9.6652 5.6027 0.1126
SNU-398 CTRP2 8.3028 10.7514 5.2009 0.919
SNU-878 CTRP2 8.3371 10.0535 5.4825 0.2694
SNU-182 CTRP2 8.5381 13.58 4.0962 4.4359
SNU-449 CTRP2 8.8138 11.4826 5.1419 0.7881
Li-7 CTRP2 10.6675 22.5471 1.2545 11.8221
JHH-2 CTRP2 11.8061 29.5198 -1.3082 17.4583
JHH-6 CTRP2 12.5599 25.1079 1.2395 9.6817
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 141 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1693 CTRP2 6.3721 16.1869 1.2436 18.6107
NCI-H2141 CTRP2 6.5156 11.8492 3.5247 9.6888
NCI-H2126 CTRP2 6.5436 11.539 2.9456 6.7466
LK2 CTRP2 6.7276 8.9309 5.1232 2.7351
NCI-H23 CTRP2 6.8259 8.6988 5.2983 1.9097
NCI-H889 CTRP2 7.0924 10.7296 4.5072 4.6964
LUDLU-1 CTRP2 7.1267 9.614 5.0607 2.453
DMS 79 CTRP2 7.1332 10.9732 4.4178 4.9983
NCI-H1105 CTRP2 7.1887 10.2952 4.7803 3.4682
NCI-H1915 CTRP2 7.2707 9.2609 5.3066 1.3861
NCI-H2029 CTRP2 7.3005 11.307 4.3721 4.9412
RERF-LC-Ad1 CTRP2 7.3046 13.7871 3.1665 9.7921
SBC-5 CTRP2 7.3191 8.3681 5.6972 0.2129
NCI-H2023 CTRP2 7.3202 10.8437 3.7497 2.4794
NCI-H322 CTRP2 7.3678 9.6079 5.2072 1.6398
LC-1/sq-SF CTRP2 7.3958 9.7027 5.1809 1.7051
NCI-H2106 CTRP2 7.4189 12.7535 3.7549 7.2536
NCI-H2291 CTRP2 7.4412 11.2622 4.4876 4.2867
BEN CTRP2 7.4747 8.9931 5.5231 0.5472
Sq-1 CTRP2 7.4883 8.9733 5.5371 0.5026
NCI-H226 CTRP2 7.5592 8.999 5.5585 0.4125
NCI-H2081 CTRP2 7.6044 14.5102 3.0307 9.8484
NCI-H1341 CTRP2 7.6114 10.3373 5.0204 2.0582
NCI-H810 CTRP2 7.6351 13.5758 3.5079 7.9163
NCI-H2444 CTRP2 7.6569 8.6568 5.7224 0.0864
LCLC-97TM1 CTRP2 7.6576 10.0368 5.1782 1.4665
NCI-H1694 CTRP2 7.6707 15.0342 2.8223 10.5537
LCLC-103H CTRP2 7.6719 8.6919 5.7157 0.0915
NCI-H1435 CTRP2 7.6757 9.0966 5.5707 0.3325
RERF-LC-Ad2 CTRP2 7.6771 14.9171 2.8842 10.3042
IA-LM CTRP2 7.6838 9.1222 5.5644 0.3426
NCI-H520 CTRP2 7.6853 10.3812 5.0426 1.9055
NCI-H69 CTRP2 7.692 11.7593 4.4157 4.2411
NCI-H1975 CTRP2 7.6922 13.5714 3.5499 7.6642
DMS 53 CTRP2 7.7169 9.3856 5.4772 0.5304
NCI-H522 CTRP2 7.7256 14.4283 3.1575 9.1637
NCI-H460 CTRP2 7.7583 9.1743 5.5755 0.2904
HCC78 CTRP2 7.794 11.2044 4.7355 2.9015
EPLC-272H CTRP2 7.8167 20.1392 0.414 18.6301
NCI-H1666 CTRP2 7.8276 12.2923 4.2521 4.7032
NCI-H196 CTRP2 7.8282 15.6361 2.6417 10.9969
NCI-H2342 CTRP2 7.8438 9.906 5.3272 0.8578
HCC1438 CTRP2 7.8463 9.3281 5.554 0.3003
NCI-H1568 CTRP2 7.8469 10.8704 4.9164 2.1901
COR-L95 CTRP2 7.8664 9.3569 5.5514 0.2981
NCI-H2122 CTRP2 7.8704 9.4305 5.5256 0.3483
Calu-1 CTRP2 7.9145 9.4387 5.5406 0.3018
Lu-99 CTRP2 7.9238 14.7429 3.1444 8.9155
NCI-H526 CTRP2 7.9273 17.2529 1.9214 13.4941
PC-14 CTRP2 7.9298 11.7972 4.5461 3.4539
NCI-H1092 CTRP2 7.9412 9.5954 5.4928 0.3884
COR-L47 CTRP2 7.9452 26.0087 -2.4013 25.4084
NCI-H2172 CTRP2 7.9539 9.3284 5.5962 0.1924
DMS 273 CTRP2 8.0019 9.584 5.5219 0.3065
NCI-H2286 CTRP2 8.0256 13.0557 4.0204 5.3483
NCI-H2171 CTRP2 8.0611 14.9098 3.159 8.6564
NCI-H1581 CTRP2 8.0635 14.9451 3.1437 8.7122
HCC4006 CTRP2 8.0773 10.0797 5.365 0.6196
NCI-H2196 CTRP2 8.0783 9.4375 5.6042 0.1511
NCI-H1155 CTRP2 8.0809 9.4862 5.588 0.1729
VMRC-LCD CTRP2 8.0813 11.3093 4.8531 2.1836
NCI-H1395 CTRP2 8.0851 11.2587 4.8773 2.0966
NCI-H1355 CTRP2 8.1038 11.8885 4.6078 3.0325
LOU-NH91 CTRP2 8.1322 12.6103 4.2953 4.1618
EBC-1 CTRP2 8.1545 14.631 3.3568 7.7557
NCI-H1838 CTRP2 8.1683 12.5101 4.3633 3.8642
HOP-62 CTRP2 8.1766 10.1238 5.3911 0.5097
NCI-H1184 CTRP2 8.1785 10.5517 5.2233 0.9343
Calu-6 CTRP2 8.195 12.4786 4.3938 3.7199
NCI-H2110 CTRP2 8.2032 12.6791 4.3069 4.0351
NCI-H838 CTRP2 8.211 9.5285 5.6207 0.1063
RERF-LC-MS CTRP2 8.2281 9.7642 5.5446 0.2005
COLO 668 CTRP2 8.2411 14.6316 3.4147 7.4112
CAL-12T CTRP2 8.2496 14.3109 3.5729 6.7879
NCI-H841 CTRP2 8.2576 9.8744 5.5164 0.2363
HCC1195 CTRP2 8.2621 11.9056 4.6905 2.5749
HARA [Human squamous cell lung carcinoma] CTRP2 8.2662 15.9544 2.7966 9.7438
SHP-77 CTRP2 8.2743 9.4142 5.6813 0.0467
DMS 114 CTRP2 8.2902 9.6462 5.6086 0.1067
SW1271 CTRP2 8.3143 14.382 3.5816 6.6678
NCI-H2030 CTRP2 8.3145 10.6711 5.2383 0.8125
NCI-H1755 CTRP2 8.3181 12.3292 4.5336 3.0752
NCI-H1573 CTRP2 8.3317 9.9765 5.5081 0.2295
NCI-H1299 CTRP2 8.3378 10.2244 5.42 0.3827
DMS 454 CTRP2 8.3526 10.4196 5.3527 0.517
NCI-H727 CTRP2 8.3726 10.1048 5.4777 0.2671
Calu-3 CTRP2 8.3916 10.0331 5.5106 0.2105
NCI-H1339 CTRP2 8.4197 9.7224 5.6281 0.0712
HCC366 CTRP2 8.4301 16.5841 2.6059 10.2192
RERF-LC-A1 CTRP2 8.4318 9.779 5.6132 0.0824
NCI-H1623 CTRP2 8.4418 11.873 4.8022 2.0294
NCI-H446 CTRP2 8.4778 14.7626 3.5081 6.7344
KNS-62 CTRP2 8.5037 9.8956 5.5988 0.0861
NCI-H661 CTRP2 8.5288 10.1847 5.5082 0.1825
NCI-H1563 CTRP2 8.5363 10.2212 5.4982 0.1944
COR-L88 CTRP2 8.6011 20.1125 1.0106 15.5055
NCI-H1944 CTRP2 8.6026 10.5736 5.3971 0.3355
NCI-H1793 CTRP2 8.6121 10.8972 5.2804 0.5631
SK-LU-1 CTRP2 8.613 15.4029 3.2936 7.3732
HCC2935 CTRP2 8.664 10.2275 5.5423 0.1179
HCC95 CTRP2 8.6818 17.9409 2.1249 11.6039
SK-MES-1 CTRP2 8.7052 10.5418 5.4479 0.2262
NCI-H1651 CTRP2 8.7518 10.2655 5.5601 0.0893
NCI-H2170 CTRP2 8.7746 15.5416 3.3327 7.0157
LXF 289 CTRP2 8.7851 10.8715 5.3601 0.3434
HCC15 CTRP2 8.8313 10.9294 5.3571 0.3346
NCI-H1734 CTRP2 8.8956 24.2205 -0.7908 20.2174
HOP-92 CTRP2 8.9439 11.1522 5.3201 0.3639
NCI-H2087 CTRP2 8.9783 10.8946 5.4249 0.1976
EKVX CTRP2 8.9869 10.9642 5.4037 0.2237
HCC44 CTRP2 9.0113 21.8101 0.4766 16.5276
NCI-H2228 CTRP2 9.02 17.0243 2.7922 8.7072
NCI-H2405 CTRP2 9.0645 15.0557 3.7375 5.1608
DV-90 CTRP2 9.3115 20.785 1.1873 13.8709
NCI-H647 CTRP2 9.4276 18.6487 2.2897 9.9754
NCI-H1869 CTRP2 9.5149 16.5592 3.3206 6.164
A-549 CTRP2 9.707 19.0444 2.2846 9.6272
NCI-H1650 CTRP2 9.9334 19.0819 2.4114 8.8989
NCI-H650 CTRP2 10.1089 18.3403 2.8628 7.1127
NCI-H211 CTRP2 10.1692 19.886 2.1848 9.3891
NCI-H358 CTRP2 10.274 20.733 1.8548 10.3722
NCI-H2085 CTRP2 10.2961 26.0767 -0.6877 17.9019
NCI-H2009 CTRP2 10.4249 23.4585 0.6619 13.9595
HCC2279 CTRP2 10.5654 22.6897 1.1207 12.3716
T3M-10 CTRP2 10.7795 20.7796 2.1493 8.7804
HCC1833 CTRP2 10.8414 22.0389 1.6038 10.494
Lu-65 CTRP2 10.9332 22.7103 1.3481 11.1967
HCC827 CTRP2 11.1562 23.5121 1.1145 11.6517
ChaGo-K-1 CTRP2 11.2666 22.088 1.844 9.2228
HCC1588 CTRP2 11.4959 21.4648 2.264 7.6167
NCI-H292 CTRP2 11.6171 25.055 0.685 12.385
NCI-H441 CTRP2 11.6974 23.7676 1.3336 10.3406
HCC1171 CTRP2 11.7698 22.2349 2.0762 7.9333
COLO 699 CTRP2 12.0499 28.5744 -0.6947 15.6422
MOR/CPR CTRP2 12.0555 22.7171 2.0246 7.803
HCC2108 CTRP2 12.7066 25.16 1.3023 9.3419
NCI-H1703 CTRP2 12.8061 28.3425 -0.0996 13.2013
NCI-H1792 CTRP2 13.1872 28.9027 -0.1225 12.8391
NCI-H1373 CTRP2 14.2142 30.116 -0.0568 11.5892
COR-L105 CTRP2 14.5357 37.7101 -3.3941 18.777
Hs 888.Lu CTRP2 8.5879 10.9715 5.2416 0.6618
⏷ Show the Full List of 141 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 5.9018 6.6614 5.6103 2.1198
Yamato-SS CTRP2 5.9199 6.5576 5.6779 1.7989
Tm87-16 CTRP2 6.1021 7.207 5.5105 2.1353
BT-16 CTRP2 6.3685 7.7075 5.465 1.8766
SW982 CTRP2 6.4478 8.113 5.324 2.3328
BT-12 CTRP2 6.5662 7.5963 5.6481 0.8873
TTC-709 CTRP2 6.9447 9.0306 5.2183 2.0706
TE 441.T CTRP2 7.0771 8.9693 5.3266 1.5116
HT-1080 CTRP2 7.5057 12.52 3.9287 6.4259
SK-UT-1 CTRP2 7.586 9.8453 5.2228 1.3807
RKN CTRP2 7.764 9.0039 5.64 0.1744
TE 617.T CTRP2 7.8843 13.5105 3.711 6.7499
Hs 729.T CTRP2 8.0185 10.5235 5.1574 1.2379
MES-SA CTRP2 8.1482 9.2085 5.7068 0.0408
KYM-1 CTRP2 8.2062 9.4608 5.6422 0.0853
Rh41 CTRP2 8.3617 9.9201 5.5394 0.1767
GCT CTRP2 8.3865 10.0457 5.5042 0.2214
Rh18 CTRP2 8.4035 9.9095 5.5584 0.1438
A-204 CTRP2 8.527 11.5753 4.9714 1.4279
SK-LMS-1 CTRP2 8.5788 10.6202 5.3705 0.3918
G-401 CTRP2 9.0901 16.9361 2.8795 8.294
G-402 CTRP2 10.1144 18.2251 2.9188 6.9108
RD CTRP2 10.3188 18.0213 3.1315 5.9501
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.6559 18.7012 0.2181 21.2806
ES2 CTRP2 7.0234 9.9786 4.8212 3.5306
FU-OV-1 CTRP2 7.5061 10.5939 4.8416 2.8333
OAW42 CTRP2 7.6344 8.8326 5.6518 0.1917
COV362 CTRP2 7.692 12.5769 4.0282 5.7644
JHOS-2 CTRP2 7.7705 9.2429 5.5549 0.3274
SNU-8 CTRP2 7.8339 9.5033 5.4825 0.4588
OV56 CTRP2 7.9253 8.9667 5.7114 0.0591
TYK-nu CTRP2 8.0878 10.6875 5.1235 1.29
EFO-27 CTRP2 8.1187 12.3722 4.3966 3.7965
OVCAR-5 CTRP2 8.1418 10.1075 5.3824 0.5459
COV434 CTRP2 8.1516 12.9084 4.1692 4.6171
OC 314 CTRP2 8.1866 9.4171 5.6501 0.0805
OVK18 CTRP2 8.1925 11.2041 4.9584 1.7301
DOV13 CTRP2 8.2096 10.0075 5.4487 0.3736
JHOM-1 CTRP2 8.218 10.671 5.1936 0.9921
OV-90 CTRP2 8.2229 11.248 4.9554 1.7143
EFO-21 CTRP2 8.283 10.2021 5.406 0.432
IGROV-1 CTRP2 8.3969 11.0658 5.1179 1.0898
HEY A8 CTRP2 8.4174 14.1677 3.7491 5.8913
TOV-112D CTRP2 8.4231 10.2951 5.4281 0.3377
COV644 CTRP2 8.4422 16.0618 2.8657 9.2285
MCAS CTRP2 8.5418 10.2311 5.4967 0.1952
A2780 CTRP2 8.6321 10.7802 5.3327 0.4461
OVCAR-8 CTRP2 8.6693 10.4721 5.4591 0.2186
OAW28 CTRP2 8.7452 18.3077 1.9916 11.9833
SNU-119 CTRP2 8.8405 10.435 5.5337 0.1015
SK-OV-3 CTRP2 9.0583 16.6177 3.0089 7.8585
OVCAR-4 CTRP2 9.1791 13.6448 4.4291 2.6228
ONCO-DG-1 CTRP2 9.63 17.2469 3.0744 6.9164
RMG-I CTRP2 9.6679 21.9932 0.8506 14.4248
OV7 CTRP2 10.0965 21.0653 1.5831 11.4994
OVISE CTRP2 10.2301 19.9828 2.1781 9.3372
OVSAHO CTRP2 10.4628 18.0189 3.2151 5.516
Kuramochi CTRP2 10.5778 22.1789 1.37 11.5695
Caov-3 CTRP2 11.1574 24.6209 0.5935 13.2167
SNU-840 CTRP2 11.4478 19.6366 3.0478 5.1291
OVTOKO CTRP2 11.4681 22.5529 1.7527 9.2881
JHOC-5 CTRP2 14.1097 25.7453 1.8258 6.5101
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.112 8.1223 5.7036 0.2867
SYO-1 CTRP2 8.1361 9.6321 5.5569 0.2053
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.4178 10.7362 4.7204 3.4053
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 CTRP2 7.3206 9.4355 5.2572 1.5105
ACC-MESO-1 CTRP2 7.4458 11.7425 4.2617 5.1782
JL-1 CTRP2 7.7992 17.1497 1.8777 13.8583
NCI-H2452 CTRP2 8.1393 10.0997 5.3843 0.5424
NCI-H28 CTRP2 8.2501 10.5435 5.2597 0.7933
MPP 89 CTRP2 8.3065 10.0103 5.4862 0.272
NCI-H2052 CTRP2 8.397 14.7288 3.4715 6.9813
MSTO-211H CTRP2 8.4847 10.2781 5.4584 0.2668
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 6.972 10.0851 4.7351 3.9494
PaCa-3 CTRP2 7.4144 8.7894 5.5765 0.4426
VCaP CTRP2 7.8864 9.6984 5.4297 0.5592
DU145 CTRP2 8.6771 14.6776 3.6748 5.8495
22Rv1 CTRP2 10.8378 23.3175 1.0014 12.3939
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 8.0462 10.0447 5.3649 0.6363
YD-15 CTRP2 12.8149 24.7725 1.5396 8.5253
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-3 CTRP2 6.6359 8.7869 4.274 1.255
GSU CTRP2 7.0019 7.6345 5.8397 0.0678
ECC12 CTRP2 7.3257 12.7889 3.6712 7.7339
MKN45 CTRP2 7.3973 8.3613 5.7304 0.1309
SNU-620 CTRP2 7.5106 8.6756 5.6605 0.2156
MKN1 CTRP2 7.6432 13.9094 3.3515 8.5247
GSS CTRP2 7.669 13.1235 3.7502 6.9017
Fu97 CTRP2 7.909 9.7958 5.4016 0.6177
NUGC-4 CTRP2 7.9865 9.5981 5.5105 0.3343
AGS CTRP2 8.0112 9.9865 5.3722 0.6367
SNU-16 CTRP2 8.0222 9.38 5.6036 0.1644
SNU-5 CTRP2 8.0513 9.5435 5.5562 0.2297
23132/87 CTRP2 8.1404 9.6072 5.5674 0.1885
OCUM-1 CTRP2 8.1555 9.7386 5.526 0.5363
SNU-1 CTRP2 8.2822 14.2878 3.6052 6.6195
SNU-601 CTRP2 8.3164 9.8951 5.5313 0.1985
SNU-216 CTRP2 8.3442 9.733 5.598 0.1093
HGC-27 CTRP2 8.3737 12.6042 4.4422 3.3467
MKN74 CTRP2 8.3787 11.3606 4.9874 1.4892
IM95 CTRP2 8.4567 11.8071 4.8383 1.8989
KATO III CTRP2 8.6261 10.5316 5.4215 0.2871
NCI-N87 CTRP2 8.6688 11.8217 4.939 1.4235
LMSU CTRP2 8.7531 10.7963 5.3749 0.3277
KE-39 CTRP2 9.3075 11.9499 5.1716 0.5144
SNU-719 CTRP2 9.4044 15.7159 3.6388 5.1422
ECC10 CTRP2 9.5562 19.8896 1.7845 11.5497
HuG1-N CTRP2 10.5125 25.1877 -0.1081 16.0573
MKN7 CTRP2 11.2839 25.0963 0.4511 13.4733
SNU-668 CTRP2 12.0316 22.1256 2.275 7.0396
SH-10-TC CTRP2 12.3564 23.3036 1.9344 7.7818
Hs 746.T CTRP2 12.788 24.8587 1.4854 8.714
SNG-M CTRP2 8.0122 9.5813 5.527 0.2933
SNU-685 CTRP2 11.3295 20.2512 2.712 6.3283
SNU-1077 CTRP2 12.1496 23.8764 1.5561 9.1593
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 7.5126 9.4312 5.3615 0.9928
CGTH-W-1 CTRP2 7.7131 9.644 5.3718 0.817
FTC-133 CTRP2 7.7282 9.5629 5.4118 0.6952
B-CPAP CTRP2 7.823 13.9863 3.4402 7.9054
CAL-62 CTRP2 7.9041 9.3373 5.5737 0.2441
8305C CTRP2 8.1364 10.2693 5.3169 0.7091
ML-1 [Human leukemia] CTRP2 8.3573 13.3167 4.1074 4.6045
8505C CTRP2 8.543 10.148 5.5262 0.1566
TT2609-C02 CTRP2 9.1605 14.0048 4.263 3.195
BHT-101 CTRP2 9.3928 16.8622 3.1061 7.0847
TT CTRP2 12.2139 27.4575 -0.0609 13.7792
SW579 CTRP2 14.0164 25.7606 1.7696 6.7475
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ49 CTRP2 7.3879 10.7499 4.6949 3.5426
BICR 56 CTRP2 7.4048 9.5201 5.2665 1.3973
SCC-25 CTRP2 7.516 15.8878 2.2888 12.83
HSC-3 CTRP2 7.6688 9.1362 5.5528 0.3746
BHY CTRP2 7.8236 9.558 5.4569 0.525
SCC-9 CTRP2 7.9611 10.1706 5.2753 0.9285
HSC-2 CTRP2 7.9638 9.2456 5.6293 0.1421
BICR 22 CTRP2 7.9648 9.3715 5.5849 0.2074
Detroit 562 CTRP2 7.9826 12.0631 4.456 3.7313
CAL-27 CTRP2 8.0292 9.3207 5.627 0.1316
PE/CA-PJ34 (clone C12) CTRP2 8.1211 10.293 5.3006 0.7601
BICR 18 CTRP2 8.1282 10.0491 5.399 0.5138
HSC-4 CTRP2 8.2337 9.7963 5.5353 0.2132
SNU-899 CTRP2 8.2632 18.5948 1.5086 14.3938
PE/CA-PJ15 CTRP2 8.2998 9.8433 5.5435 0.185
FaDu CTRP2 8.3168 9.7569 5.5799 0.1342
BICR 16 CTRP2 8.3923 10.0592 5.5016 0.2238
CAL-33 CTRP2 8.4121 10.1839 5.4643 0.2778
SNU-46 CTRP2 8.6523 16.1014 2.988 8.4749
SNU-1066 CTRP2 9.5427 17.5149 2.8963 7.6617
YD-10B CTRP2 9.6071 24.2251 -0.275 17.787
BICR 31 CTRP2 9.6687 18.3767 2.5736 8.6588
SNU-1214 CTRP2 9.6986 20.651 1.5162 12.2521
SNU-1041 CTRP2 9.9207 20.3515 1.806 10.9894
SCC-4 CTRP2 10.362 21.5504 1.5267 11.34
BICR 6 CTRP2 10.8497 19.3009 2.8631 6.3114
YD-8 CTRP2 11.9524 25.0202 0.9116 11.3241
PE/CA-PJ41 (clone D2) CTRP2 12.9388 25.8614 1.1211 9.6363
SNU-1076 CTRP2 14.5146 29.1841 0.5384 9.7204
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 CTRP2 7.5898 9.333 5.4398 0.7045
253J-BV CTRP2 7.6016 11.1959 4.6218 3.557
639V CTRP2 7.6171 8.8862 5.6254 0.2448
HT-1197 CTRP2 7.6517 9.4081 5.4385 1.4372
JMSU-1 CTRP2 7.6833 11.2784 4.6344 3.4094
253J CTRP2 7.7144 9.1731 5.5579 0.3438
BC-3C CTRP2 7.804 10.0852 5.2336 1.1661
HT-1376 CTRP2 7.937 10.4235 5.1584 1.2976
CAL-29 CTRP2 8.0349 9.6048 5.5275 0.2848
SCaBER CTRP2 8.0362 9.6035 5.5284 0.2826
SW1710 CTRP2 8.0636 10.4445 5.2124 1.0411
TCCSUP CTRP2 8.1481 9.9558 5.4428 0.4094
647V CTRP2 8.2377 9.7219 5.5632 0.1717
U-BLC1 CTRP2 8.3528 9.7427 5.5978 0.1082
UM-UC-3 CTRP2 8.6562 10.1724 5.5583 0.1032
UM-UC-1 CTRP2 8.9135 18.067 2.2234 10.9175
T24 CTRP2 8.9194 10.3212 5.5987 0.0467
J82 CTRP2 10.0653 17.6494 3.1516 6.151
5637 CTRP2 10.3344 27.5373 -1.3706 19.5429
KU-19-19 CTRP2 10.5528 22.2717 1.3101 11.7917
VM-CUB-1 CTRP2 10.6834 20.9204 2.0252 9.3052
RT-4 CTRP2 11.0235 24.5191 0.5541 13.5009
RT-112 CTRP2 11.2448 20.8184 2.4093 7.4066
KMBC-2 CTRP2 11.4525 27.9999 -0.819 16.7013
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.9088 8.9699 5.7046 0.067

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6978).
2 A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med. 2013 Jul 25;369(4):341-50.
3 Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.