Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLB81S)

Drug Name
Paclitaxel Drug Info
Synonyms
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-b; 7-epi-Paclitaxel; ABI-007; Abraxane; Capxol; Ebetaxel; EmPAC; Genaxol; Genetaxyl; Genexol; Intaxel; LipoPac; OncoGel; Onxol; Paclitaxel (Taxol); Paxceed; Paxene; Plaxicel; TAXOL; TaxAlbin; Taxol A; Xorane; Yewtaxan; Zisu; nab-paclitaxel; paclitaxel
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
36314
ChEBI ID
CHEMBL428647
CAS Number
CAS 33069-62-4
VARIDT Drug ID
DR00342

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 1.92 3.62e-2 48/60 (80%) MT1E;MT1H;MT1F;...
Focal adhesion 1.87 3.62e-2 180/201 (89.55%) CAV1;ITGA6;CAV2;...
Amoebiasis 1.85 3.22e-2 99/102 (97.06%) CXCL3;ACTN1;CXCL1;...
Chagas disease 1.84 2.41e-2 93/102 (91.18%) CXCL8;TGFB1;GNA11;...
Bacterial invasion of epithelial cells 1.75 4.59e-2 59/77 (76.62%) CAV1;CAV2;PXN;...
Sulfur metabolism -1.58 4.98e-2 9/10 (90%) MPST;SELENBP1;SUOX;...
Fructose and mannose metabolism -1.59 4.97e-2 30/33 (90.91%) FBP2;ALDOA;FBP1;...
Citrate cycle (TCA cycle) -1.61 4.53e-2 30/30 (100%) IDH3A;SDHA;SUCLG1;...
Cell cycle -1.62 4.03e-2 110/124 (88.71%) PRKDC;TP53;CDC7;...
Fanconi anemia pathway -1.62 4.17e-2 36/54 (66.67%) RAD51;FANCA;BRCA1;...
Nucleotide excision repair -1.64 3.64e-2 40/47 (85.11%) RFC3;POLE2;DDB1;...
Glycerolipid metabolism -1.65 3.66e-2 44/61 (72.13%) LIPG;DGKD;PNPLA2;...
Histidine metabolism -1.68 3.09e-2 16/22 (72.73%) ASPA;FTCD;ALDH9A1;...
Arachidonic acid metabolism -1.70 2.29e-2 48/61 (78.69%) CYP4F2;GPX3;GPX7;...
Galactose metabolism -1.74 1.23e-2 26/31 (83.87%) HK2;GAA;MGAM;...
Ascorbate and aldarate metabolism -1.75 1.21e-2 15/30 (50%) ALDH9A1;UGT2B15;UGT2B4;...
Base excision repair -1.77 1.14e-2 29/33 (87.88%) APEX1;NEIL1;MUTYH;...
Fatty acid degradation -1.78 1.11e-2 40/43 (93.02%) ADH1B;ADH6;ACSL6;...
Glyoxylate and dicarboxylate metabolism -1.78 1.13e-2 23/30 (76.67%) GLUL;ACO2;SHMT2;...
One carbon pool by folate -1.78 1.10e-2 15/20 (75%) SHMT2;MTHFD1;ALDH1L1;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.79 1.06e-2 20/26 (76.92%) GPAA1;PIGT;PIGZ;...
Steroid hormone biosynthesis -1.80 1.15e-2 43/61 (70.49%) SULT1E1;UGT2A3;HSD17B12;...
Glycine, serine and threonine metabolism -1.88 6.34e-3 31/40 (77.5%) BHMT;SHMT2;CTH;...
Pentose and glucuronate interconversions -1.91 6.16e-3 17/34 (50%) UGT2B15;UGT2B4;UGP2;...
Pyruvate metabolism -1.92 6.94e-3 41/47 (87.23%) LDHB;ADH1B;PDHA1;...
Glutathione metabolism -2.00 4.53e-3 43/57 (75.44%) GSTM1;GCLC;GSTM2;...
Drug metabolism -2.02 3.96e-3 78/151 (51.66%) CMPK1;UGT2B15;TYMP;...
Folate biosynthesis -2.04 4.76e-3 23/26 (88.46%) PAH;GGH;ALPL;...
Mismatch repair -2.13 1.98e-3 22/23 (95.65%) RPA3;MSH2;RFC5;...
Glycolysis / Gluconeogenesis -2.20 2.64e-3 56/67 (83.58%) PDHB;PKLR;ADPGK;...
Metabolism of xenobiotics by cytochrome P450 -2.28 0.00e+0 49/77 (63.64%) ADH1B;UGT2A3;GSTM4;...
DNA replication -2.39 0.00e+0 34/36 (94.44%) RFC3;POLE2;DNA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 2.22uM - 10uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Normal (Stromal)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HS-27a CVCL_0313 Homo sapiens 1.11uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 4uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SKM-1 CVCL_0010 Homo sapiens 1.11uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 1.11uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H