General Information of Drug (ID: DMLE7IO)

Drug Name
Tigecycline Drug Info
Synonyms
Tigilcycline; Tygacil; Tigecycline [USAN]; GAR 936; GAR-936; TBG-MINO; Tygacil (TN); Tygacil(TM); GAR-936,Tigecycline; Tigecycline (JAN/USAN); WAY-GAR-936; Tygacil, GAR-936, WAY-GAR-936, TBG-MINO, Tigecycline; N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide; (4S,12aS)-4,7-Bis(dimethylamino)-9-{2-[(tert-butyl)amino]acetylamino}-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide; (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; (4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 9-t-Butylglycylamido minocycline
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
54686904
ChEBI ID
CHEMBL149836
CAS Number
CAS 220620-09-7
TTD Drug ID
D0G4OD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Arginine biosynthesis 2.04 1.17e-2 17/22 (77.27%) ASS1;GOT1;ARG2;...
Cytosolic DNA-sensing pathway 1.97 1.17e-2 52/63 (82.54%) CXCL10;CCL4;POLR1D;...
Mineral absorption 1.89 1.57e-2 48/60 (80%) MT1X;MT1G;MT2A;...
Alanine, aspartate and glutamate metabolism 1.84 3.23e-2 27/37 (72.97%) ASNS;ASS1;GOT1;...
Fluid shear stress and atherosclerosis 1.84 2.58e-2 123/139 (88.49%) VEGFA;ASS1;ARHGEF2;...
Insulin resistance 1.76 4.89e-2 96/108 (88.89%) PCK2;TRIB3;RPS6KA2;...
B cell receptor signaling pathway 1.76 4.53e-2 71/81 (87.65%) PIK3CA;GSK3B;RASGRP3;...
Endometrial cancer 1.75 4.26e-2 56/58 (96.55%) PIK3CA;GSK3B;GADD45A;...
FoxO signaling pathway 1.68 4.79e-2 118/131 (90.08%) PCK2;KLF2;PIK3CA;...
RIG-I-like receptor signaling pathway 1.67 4.53e-2 64/70 (91.43%) ISG15;CXCL10;IRF7;...
Prostate cancer 1.65 4.99e-2 93/97 (95.88%) TGFA;ATF4;PDGFA;...
Parkinson disease -1.75 4.48e-2 176/249 (70.68%) MAPK8;KIF5C;NDUFA4L2;...
Proteasome -1.82 2.98e-2 44/46 (95.65%) PSMA7;PSMD2;PSMA6;...
DNA replication -1.86 2.85e-2 34/36 (94.44%) RNASEH2B;PRIM2;MCM4;...
Oxidative phosphorylation -2.33 0.00e+0 93/133 (69.92%) ATP12A;COX5B;ATP6AP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U266 CVCL_0566 Homo sapiens 0.125uM - 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.125uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.125uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.125uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.125uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.125uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.125uM - 10uM 6H, 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.125uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.125uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.125uM - 10uM 6H, 24H