Details of the Drug

General Information of Drug (ID: DMLE7IO)

Drug Name
Tigecycline
Synonyms
Tigilcycline; Tygacil; Tigecycline [USAN]; GAR 936; GAR-936; TBG-MINO; Tygacil (TN); Tygacil(TM); GAR-936,Tigecycline; Tigecycline (JAN/USAN); WAY-GAR-936; Tygacil, GAR-936, WAY-GAR-936, TBG-MINO, Tigecycline; N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide; (4S,12aS)-4,7-Bis(dimethylamino)-9-{2-[(tert-butyl)amino]acetylamino}-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide; (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; (4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 9-t-Butylglycylamido minocycline
Indication
Disease Entry ICD 11 Status REF
Skin infection 1F28-1G0Z Approved [1]
Therapeutic Class
Antibiotics
Affected Organisms
Enteric bacteria and other eubacteria
ATC Code
J01AA12: Tigecycline
J01AA: Tetracyclines
J01A: TETRACYCLINES
J01: ANTIBACTERIALS FOR SYSTEMIC USE
J: ANTIINFECTIVES FOR SYSTEMIC USE
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 585.6
Logarithm of the Partition Coefficient (xlogp) 1.1
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 7
Hydrogen Bond Acceptor Count (hbondacc) 11
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [2]
Clearance
The drug present in the plasma can be removed from the body at the rate of 3.8 mL/min/kg [3]
Elimination
22% of drug is excreted from urine in the unchanged form [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 27 - 43 hours [3]
Metabolism
The drug is metabolized via the liver []
Unbound Fraction
The unbound fraction of drug in plasma is 0.2% [3]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 12 L/kg [3]
Water Solubility
The ability of drug to dissolve in water is measured as 295 mg/mL [2]
Chemical Identifiers
Formula
C29H39N5O8
IUPAC Name
(4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
Canonical SMILES
CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
InChI
InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,40,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1
InChIKey
SOVUOXKZCCAWOJ-HJYUBDRYSA-N
Cross-matching ID
PubChem CID
54686904
ChEBI ID
CHEBI:149836
CAS Number
220620-09-7
UNII
70JE2N95KR
DrugBank ID
DB00560
TTD ID
D0G4OD
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 87 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 3.5701 6.3968 3.2403 17.6523
KMS-12-BM CTRP2 0.8305 2.7097 0.8266 34.7488
RS4;11 CTRP2 1.1184 2.6666 1.1171 32.8223
THP-1 CTRP2 1.389 4.0252 1.3405 31.1768
NU-DUL-1 CTRP2 1.4446 3.3749 1.4353 30.6754
L-540 CTRP2 1.5737 3.8709 1.545 29.8802
OCI-AML-2 CTRP2 1.5831 2.7557 1.5829 29.7226
NB4 CTRP2 1.5989 2.4415 1.5989 29.6165
NOMO-1 CTRP2 1.7228 3.7087 1.7078 28.8414
RCH-ACV CTRP2 1.7375 3.4736 1.7307 28.716
SU-DHL-6 CTRP2 1.8059 5.4367 1.5694 29.0373
SUP-T11 CTRP2 1.8463 4.1229 1.8109 28.087
MOLT-16 CTRP2 1.9178 3.4637 1.9138 27.5052
GDM-1 CTRP2 2.0155 3.953 1.9974 26.9016
Mono-Mac-1 CTRP2 2.1256 3.918 2.1123 26.1518
HPB-ALL CTRP2 2.1709 4.1527 2.1466 25.8875
MOLT-13 CTRP2 2.2645 4.3558 2.2293 25.3007
Karpas-299 CTRP2 2.2805 4.9011 2.1829 25.4067
REC-1 CTRP2 2.3326 3.9823 2.322 24.7639
SR CTRP2 2.3811 5.1312 2.2537 24.8399
U-937 CTRP2 2.3895 4.9409 2.2938 24.6745
Mono-Mac-6 CTRP2 2.6641 8.8804 1.3247 27.1983
SU-DHL-8 CTRP2 2.6762 5.7063 2.4551 23.2034
SU-DHL-4 CTRP2 2.6828 5.9243 2.4079 23.3499
MM1.S CTRP2 2.9372 5.8691 2.6997 21.5256
BV-173 CTRP2 2.982 5.6766 2.7951 21.0479
AMO1 CTRP2 3.0137 5.7554 2.8111 20.8924
KMS-26 CTRP2 3.0187 4.3323 3.0112 20.1826
KMS-34 CTRP2 3.1283 6.7067 2.6593 21.0953
MOLM-16 CTRP2 3.135 6.0263 2.8742 20.2937
KMS-28BM CTRP2 3.1733 8.0536 2.2012 22.6547
Ri-1 CTRP2 3.2314 7.3131 2.5541 21.184
MC116 CTRP2 3.2963 6.5922 2.8797 19.7891
MHH-CALL-4 CTRP2 3.317 6.0999 3.0525 19.0969
L-363 CTRP2 3.4351 6.3289 3.1143 18.5163
MOLM-6 CTRP2 3.4917 5.859 3.3069 17.6484
KYO-1 CTRP2 3.499 6.4347 3.1509 18.1921
MHH-CALL-3 CTRP2 3.5834 6.6179 3.1827 17.8259
SK-MM-2 CTRP2 3.6226 7.3505 2.9576 18.5585
KMS-11 CTRP2 3.735 6.9014 3.2472 17.1458
NCI-H929 CTRP2 3.7974 5.8546 3.6413 15.5116
KMS-18 CTRP2 3.8122 7.3122 3.1743 17.2041
PF-382 CTRP2 3.9503 5.2191 3.9204 14.0519
SUP-T1 CTRP2 4.1815 8.441 3.0801 16.5795
TALL-1 [Human adult T-ALL] CTRP2 4.499 9.7329 2.7944 16.9132
Peer CTRP2 4.5505 6.0958 4.3997 10.4819
HT CTRP2 4.6639 5.9355 4.5662 9.5362
P3HR-1 CTRP2 4.8176 8.4083 3.7312 12.3805
Karpas-620 CTRP2 4.893 7.7759 4.0989 10.7098
WSU-DLCL2 CTRP2 4.9138 5.8105 4.8657 7.6971
SU-DHL-10 CTRP2 5.0059 8.5523 3.8466 11.4576
SU-DHL-1 CTRP2 5.0675 5.7943 5.0347 6.6204
MOLP-2 CTRP2 5.1481 7.2618 4.5892 8.0998
KHM-1B CTRP2 5.167 7.1531 4.6572 7.7798
EM-2 CTRP2 5.3619 6.2308 5.2415 4.9784
CML-T1 CTRP2 5.3934 6.2647 5.2636 4.8045
DEL CTRP2 5.4047 5.9332 5.3732 4.3702
Ki-JK CTRP2 5.4724 7.3862 4.8527 6.2347
KE-37 CTRP2 5.5748 6.3223 5.4362 3.6367
NCO2 CTRP2 5.6353 7.5661 4.9205 5.5777
JURL-MK1 CTRP2 5.6679 6.6585 5.3863 3.5906
JVM-3 CTRP2 5.7294 6.844 5.3591 3.5522
NALM-6 CTRP2 5.949 6.8291 5.5699 2.1865
L-1236 CTRP2 5.949 11.9181 3.0277 12.7911
P12-Ichikawa CTRP2 5.9646 7.09 5.4537 2.6411
KMS-21-BM CTRP2 6.2507 8.586 4.9412 4.254
KE-97 CTRP2 6.2914 8.2659 5.1322 3.3833
MOLM-13 CTRP2 6.3424 8.1852 5.2111 2.9679
Raji CTRP2 6.5289 8.3867 5.2483 2.5187
KMS-27 CTRP2 6.6834 8.5447 5.2783 2.1757
ME1 CTRP2 6.686 9.713 4.7134 4.4712
RPMI-8402 CTRP2 6.7359 8.7077 5.2356 2.2739
MV4-11 CTRP2 6.858 9.9884 4.7024 4.2507
Ku812 CTRP2 6.8667 8.8613 5.2481 2.0529
P31/FUJ CTRP2 6.8881 10.8208 4.3176 5.7815
Reh CTRP2 6.9349 9.0925 5.1832 2.2187
SKM-1 CTRP2 6.9752 8.3678 5.536 0.8751
KM-H2 CTRP2 7.0745 9.8096 4.9355 3.0075
Jurkat CTRP2 7.0774 9.7268 4.9765 2.8427
KCL-22 CTRP2 7.1933 10.1159 4.868 3.1172
PL21 CTRP2 7.3498 12.0826 4.0318 6.2402
KMM-1 CTRP2 7.4105 13.5127 3.3785 8.7776
RPMI-8226 CTRP2 7.7575 9.4369 5.475 0.5146
HDLM-2 CTRP2 7.8312 10.1902 5.2031 1.2401
HEL CTRP2 8.2274 9.5562 5.6171 0.1076
LAMA-84 CTRP2 8.2396 10.0031 5.4624 0.3362
EHEB CTRP2 8.2532 15.3943 3.0575 8.7695
⏷ Show the Full List of 87 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 4.8543 8.358 3.7908 12.0494
TE-6 CTRP2 4.0498 7.1839 3.4772 15.3848
KYSE-410 CTRP2 4.8711 8.4827 3.7487 12.1795
TE-4 CTRP2 6.1359 8.967 4.6587 5.6503
TE-10 CTRP2 7.3536 9.0253 5.4519 0.8343
TE-9 CTRP2 7.6193 8.8209 5.6502 0.199
COLO 680N CTRP2 7.6553 9.7842 5.285 1.121
TE-1 CTRP2 8.2663 13.1343 4.1357 4.606
KYSE-140 CTRP2 8.553 10.7869 5.2975 0.5512
KYSE-180 CTRP2 8.5999 10.1095 5.5599 0.1097
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-SI9s CTRP2 3.4447 5.8451 3.2591 17.9639
CHP-126 CTRP2 5.0931 8.5287 3.9416 10.8629
Kelly CTRP2 7.0697 11.7006 4.0186 6.7217
NB1 CTRP2 7.5359 13.1237 3.6576 7.4678
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 6.301 9.6435 4.454 6.2055
SNU-1196 CTRP2 6.384 7.5729 5.5413 1.542
SNU-478 CTRP2 6.604 8.4149 5.2869 2.2522
HuCC-T1 CTRP2 7.811 9.46 5.4894 0.4537
HuH-28 CTRP2 7.9286 9.1493 5.65 0.1225
SNU-308 CTRP2 8.1531 9.5113 5.6058 0.1337
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJSA-1 CTRP2 4.2975 7.4139 3.6455 14.0568
MHH-ES-1 CTRP2 6.4876 7.9398 5.4358 1.8184
SW1353 CTRP2 7.8417 9.2936 5.565 0.2808
CAL-78 CTRP2 7.9361 9.6414 5.4732 0.4332
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-148 CTRP2 5.2822 11.3968 2.7092 15.4525
CAL-51 CTRP2 5.9872 8.3557 4.8408 5.1706
KPL-1 CTRP2 6.0063 8.1171 4.9761 4.5644
HDQ-P1 CTRP2 7.0803 8.8498 5.382 1.3089
CAMA-1 CTRP2 7.1398 30.0103 -5.0384 31.1334
CAL-120 CTRP2 7.1633 8.4637 5.5911 0.5545
HCC1937 CTRP2 7.6149 11.7793 4.3564 4.5728
HCC1143 CTRP2 7.8479 12.3008 4.2611 4.6424
ZR-75-1 CTRP2 7.8872 9.6427 5.4518 0.5054
MDA-MB-231 CTRP2 8.1064 11.5987 4.7391 2.5579
HMC-1-8 CTRP2 8.1705 9.1169 5.7443 0.0205
MCF-7 CTRP2 8.3002 10.1126 5.4463 0.3456
HCC1395 CTRP2 8.3197 9.9419 5.5159 0.2206
HCC1806 CTRP2 8.4719 9.8249 5.6116 0.0788
JIMT-1 CTRP2 8.5757 9.7501 5.6716 0.0311
HCC1954 CTRP2 8.6698 10.3907 5.4879 0.1795
HCC1569 CTRP2 8.9239 11.1277 5.3212 0.3682
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 8.0412 9.1123 5.7024 0.0536
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 CTRP2 0.012 10.031 -1.9352 43.3922
SW1088 CTRP2 4.8955 9.8011 3.1398 14.594
KALS-1 CTRP2 5.7191 9.9031 3.8377 9.9175
CAS-1 CTRP2 6.0233 7.9489 5.0746 4.1174
SNU-738 CTRP2 6.1186 7.0693 5.5924 1.7614
SNU-626 CTRP2 6.2651 7.438 5.5219 1.8054
SNU-489 CTRP2 6.6876 8.0367 5.5196 1.2298
SNU-466 CTRP2 6.7338 7.8941 5.6112 0.8437
SNU-1105 CTRP2 6.7467 7.963 5.5879 0.9139
Daoy CTRP2 6.9054 8.2218 5.5618 0.851
KNS-60 CTRP2 7.2215 8.292 5.6854 0.2775
KNS-81 CTRP2 7.3569 8.4386 5.6863 0.2205
LN-229 CTRP2 7.4365 9.2377 5.4044 0.9179
GB-1 CTRP2 7.4403 9.0514 5.4835 0.6785
GaMG CTRP2 7.5138 12.0051 4.1818 5.4016
NMC-G1 CTRP2 7.5301 9.428 5.3716 0.9479
LN-18 CTRP2 7.6125 8.7485 5.6737 0.162
SF295 CTRP2 7.6695 9.9532 5.2205 1.3164
U-87MG ATCC CTRP2 7.69 9.6983 5.3383 0.9312
DBTRG-05MG CTRP2 7.7486 9.5594 5.4227 0.6536
SF126 CTRP2 7.9158 9.1637 5.6403 0.1377
SNU-201 CTRP2 8.0131 9.6359 5.5072 0.3309
ONS-76 CTRP2 8.2202 9.3876 5.6717 0.0585
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-50B CTRP2 3.2832 5.9415 3.0584 19.1787
HEC-151 CTRP2 3.4664 6.4713 3.1037 18.462
EFE-184 CTRP2 4.6141 7.6274 3.8826 12.2863
HEC-265 CTRP2 6.9715 8.8358 5.3248 1.6346
JHUEM-2 CTRP2 6.9768 9.5268 5.0055 2.8611
KLE CTRP2 7.1854 9.5115 5.1442 2.0659
RL95-2 CTRP2 7.5108 8.865 5.5893 0.3636
HEC-6 CTRP2 7.6368 10.0383 5.1664 1.5247
HEC-108 CTRP2 7.8645 9.1105 5.64 0.1495
HEC-59 CTRP2 7.9866 9.9023 5.3943 0.5946
HEC-251 CTRP2 8.2569 9.6448 5.5971 0.1249
HEC-1-B CTRP2 11.0032 23.8828 0.8418 12.6709
Ishikawa (Heraklio) 02 ER- CTRP2 7.6719 8.5883 5.7511 0.0556
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR10TKB CTRP2 2.4449 4.5154 2.4044 24.1167
VMRC-RCW CTRP2 7.3162 14.332 2.9069 10.7981
OS-RC-2 CTRP2 7.8249 13.2778 3.7823 6.5521
769-P CTRP2 7.9817 9.5805 5.515 0.3271
BFTC-909 CTRP2 8.1638 9.4774 5.6214 0.1133
SNU-1272 CTRP2 8.2559 9.623 5.6043 0.1169
TUHR4TKB CTRP2 8.2865 9.6356 5.6109 0.1048
KMRC-20 CTRP2 8.7892 10.1676 5.6056 0.0523
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 CTRP2 2.2011 5.3005 2.0272 26.1983
LoVo CTRP2 2.398 6.8014 1.8352 26.253
SW620 CTRP2 2.5484 4.8668 2.4743 23.542
SNU-407 CTRP2 2.6473 5.8159 2.3969 23.4992
SNU-C5 CTRP2 2.7768 7.3231 2.0625 24.3057
CW-2 CTRP2 3.1473 9.3252 1.6327 24.7673
SNU-61 CTRP2 6.2332 19.4352 -0.4944 24.0531
KM12 CTRP2 6.2663 10.3373 4.08 7.8355
RKO CTRP2 6.3156 8.7892 4.891 4.3494
CL-11 CTRP2 6.5148 9.4653 4.7084 4.7707
HT-55 CTRP2 6.529 10.9261 3.9947 7.7189
SNU-C2A CTRP2 6.6537 8.9041 5.085 2.9974
SW1116 CTRP2 6.7511 9.6788 4.7772 4.1075
HT115 CTRP2 7.1705 8.7501 5.4747 0.9082
SW48 CTRP2 7.3499 8.9807 5.4686 0.7857
COLO201 CTRP2 7.4623 9.2035 5.4315 0.8158
MDST8 CTRP2 7.6577 9.3982 5.4453 0.6471
HCT 116 CTRP2 7.661 8.8843 5.6434 0.198
DLD-1 CTRP2 7.6844 8.6974 5.7183 0.0864
COLO205 CTRP2 7.7556 9.0909 5.6052 0.2353
LS123 CTRP2 7.795 14.6488 3.0994 9.2846
LS411N CTRP2 7.7996 9.2181 5.576 0.2747
NCI-H508 CTRP2 7.99 9.5249 5.539 0.2787
LS513 CTRP2 8.1521 9.5341 5.5975 0.1443
HT-29 CTRP2 8.1676 9.3712 5.659 0.0749
LS180 CTRP2 8.2079 9.7806 5.531 0.2267
OUMS-23 CTRP2 8.3517 9.4708 5.6886 0.0364
SK-CO-1 CTRP2 8.5586 10.3705 5.4535 0.2545
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP2 3.6379 11.5768 1.0841 25.2875
SNU-761 CTRP2 5.4647 10.2523 3.4398 12.1016
HuH-6 CTRP2 6.0111 8.7894 4.6441 5.9505
SNU-878 CTRP2 6.4996 7.965 5.4318 1.8175
Li-7 CTRP2 6.6287 8.6529 5.1891 2.6115
Hep-G2 CTRP2 7.8006 9.1765 5.5917 0.2452
Hep 3B2.1-7 CTRP2 11.1423 26.8935 -0.4986 16.2741
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 81 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2228 CTRP2 3.1903 6.7991 2.6951 20.7811
NCI-H1755 CTRP2 3.3087 7.7133 2.4814 21.2344
NCI-H520 CTRP2 3.5532 6.8871 3.0565 18.3833
NCI-H2087 CTRP2 3.7718 6.7951 3.3252 16.7475
SW1573 CTRP2 3.8515 8.2667 2.8192 18.4622
NCI-H1355 CTRP2 3.9129 7.179 3.3335 16.3156
NCI-H446 CTRP2 4.1052 8.0441 3.1773 16.3976
NCI-H211 CTRP2 4.3162 6.0161 4.166 12.0381
DMS 79 CTRP2 4.5097 5.2987 4.4999 10.2572
Sq-1 CTRP2 4.543 8.0173 3.6367 13.4462
NCI-H889 CTRP2 4.6091 7.945 3.7362 12.8808
EPLC-272H CTRP2 4.7141 15.1832 0.324 24.9933
NCI-H1666 CTRP2 4.7322 8.8205 3.4537 13.7105
LOU-NH91 CTRP2 4.7747 7.6702 4.0274 11.2962
LCLC-97TM1 CTRP2 4.9677 8.9832 3.6034 12.541
PC-14 CTRP2 4.9974 7.3525 4.3957 9.2571
NCI-H1734 CTRP2 5.0743 7.5381 4.3893 9.0879
NCI-H1573 CTRP2 5.0899 7.5545 4.3974 9.0162
NCI-H226 CTRP2 5.1947 6.646 4.9042 6.734
NCI-H1155 CTRP2 5.2107 8.8234 3.9109 10.7161
NCI-H661 CTRP2 5.2475 9.3749 3.6759 11.6021
Calu-6 CTRP2 5.2907 9.6831 3.5642 11.9668
NCI-H2444 CTRP2 5.3162 6.9142 4.9155 6.3677
SW1271 CTRP2 5.3921 8.4766 4.2495 8.9054
NCI-H2106 CTRP2 5.6043 8.6336 4.3669 7.9488
NCI-H69 CTRP2 5.803 10.3097 3.7074 10.289
COLO 699 CTRP2 6.2145 7.764 5.3219 2.7241
Lu-99 CTRP2 6.364 7.5759 5.5259 1.6346
NCI-H2286 CTRP2 6.3873 14.535 2.0814 15.6176
NCI-H1184 CTRP2 6.3923 11.5551 3.5733 9.7118
NCI-H1581 CTRP2 6.4488 8.5063 5.1321 3.1214
NCI-H526 CTRP2 6.4975 8.2404 5.2973 2.3664
CAL-12T CTRP2 6.8737 8.483 5.4273 1.3632
HCC1588 CTRP2 6.9534 8.3853 5.5166 0.9614
BEN CTRP2 7.098 8.2679 5.6398 0.4592
NCI-H2291 CTRP2 7.2152 11.1805 4.3745 5.0538
SHP-77 CTRP2 7.2579 9.0024 5.4123 1.0384
RERF-LC-Ad1 CTRP2 7.2865 8.1226 5.7734 0.0952
NCI-H1975 CTRP2 7.3371 8.994 5.4567 0.832
RERF-LC-A1 CTRP2 7.3687 8.931 5.4984 0.6837
HCC1833 CTRP2 7.3923 9.3759 5.3225 1.2191
NCI-H460 CTRP2 7.4584 8.8675 5.5654 0.4469
HCC366 CTRP2 7.4594 9.6975 5.2187 1.5103
HCC1195 CTRP2 7.4703 12.2534 4.0329 6.0594
NCI-H2405 CTRP2 7.4715 9.3875 5.359 1.0332
LCLC-103H CTRP2 7.4894 8.7215 5.6348 0.2737
MOR/CPR CTRP2 7.5044 8.3261 5.7814 0.0497
NCI-H2172 CTRP2 7.5409 9.255 5.4484 0.7122
SBC-5 CTRP2 7.5962 8.3957 5.7896 0.0338
HCC2279 CTRP2 7.6039 9.4425 5.4019 0.8038
NCI-H650 CTRP2 7.6111 9.5632 5.3555 0.9366
NCI-H2023 CTRP2 7.6472 9.5266 5.3882 0.814
HCC95 CTRP2 7.7075 9.5147 5.4216 0.6812
NCI-H1650 CTRP2 7.7345 13.3891 3.6673 7.1365
NCI-H1435 CTRP2 7.7354 13.1395 3.788 6.6562
NCI-H727 CTRP2 7.7472 9.4637 5.4599 0.5576
HARA [Human squamous cell lung carcinoma] CTRP2 7.774 9.8111 5.3327 0.889
LXF 289 CTRP2 7.8354 9.9945 5.2869 0.9806
HCC2108 CTRP2 7.8378 9.7058 5.405 0.6485
NCI-H1792 CTRP2 7.8835 10.1295 5.2546 1.0426
NCI-H1838 CTRP2 7.9072 10.0868 5.2837 0.9404
NCI-H2085 CTRP2 7.9172 16.8651 2.1044 12.8518
NCI-H2009 CTRP2 7.9218 9.8412 5.3894 0.6419
NCI-H2126 CTRP2 7.9824 12.1703 4.4064 3.9191
HCC78 CTRP2 8.0017 9.604 5.5145 0.3209
HCC44 CTRP2 8.0734 9.9407 5.4172 0.4976
A-549 CTRP2 8.0996 14.2427 3.5056 7.254
NCI-H2122 CTRP2 8.1607 9.6403 5.5632 0.1896
HCC827 CTRP2 8.1723 9.7755 5.5192 0.2563
NCI-H196 CTRP2 8.1729 9.7209 5.5391 0.2234
HCC1171 CTRP2 8.1967 10.0204 5.4386 0.3988
NCI-H1373 CTRP2 8.2151 10.2483 5.3597 0.5638
Calu-3 CTRP2 8.2176 10.0317 5.4429 0.3821
SK-LU-1 CTRP2 8.2677 10.1138 5.4328 0.3835
EBC-1 CTRP2 8.3641 10.186 5.4448 0.3268
NCI-H1299 CTRP2 8.538 10.258 5.4858 0.2113
NCI-H358 CTRP2 8.6784 10.7967 5.3453 0.4049
HCC15 CTRP2 8.7277 10.4933 5.4733 0.1865
NCI-H2030 CTRP2 8.8177 10.4492 5.5209 0.1167
NCI-H292 CTRP2 8.8287 10.2745 5.5835 0.0633
NCI-H441 CTRP2 10.5065 20.2147 2.2426 8.7864
⏷ Show the Full List of 81 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 CTRP2 3.2023 5.7512 3.0176 19.5739
TYK-nu CTRP2 4.6667 8.7254 3.4343 13.9485
SNU-840 CTRP2 5.9441 14.0374 1.964 16.9211
FU-OV-1 CTRP2 6.0143 12.9912 2.5459 14.5753
HEY A8 CTRP2 6.3062 10.3564 4.1025 7.6678
IGROV-1 CTRP2 6.4587 10.5597 4.122 7.3123
MCAS CTRP2 6.6914 11.5289 3.8209 8.1573
OVK18 CTRP2 6.749 11.4087 3.9244 7.6317
OVCAR-4 CTRP2 6.7866 9.2175 5.0257 3.0436
ONCO-DG-1 CTRP2 6.894 8.8108 5.2889 1.8617
OVCAR-8 CTRP2 6.9063 8.3752 5.4948 1.0836
DOV13 CTRP2 6.9734 9.7245 4.9091 3.2486
ES2 CTRP2 6.9942 8.8645 5.3252 1.6072
SNU-119 CTRP2 7.1033 9.6663 5.0215 2.6339
SNU-8 CTRP2 7.2321 8.3603 5.6637 0.3228
OAW28 CTRP2 7.4209 15.1252 2.5939 11.8364
OVISE CTRP2 7.6223 8.7308 5.6838 0.1441
Caov-3 CTRP2 7.787 13.219 3.7849 6.5952
OVSAHO CTRP2 7.9074 9.4268 5.5421 0.3013
JHOC-5 CTRP2 8.2591 9.4242 5.6728 0.0538
Kuramochi CTRP2 8.5853 10.1757 5.532 0.142
SK-OV-3 CTRP2 8.5878 15.6624 3.1541 7.9358
RMG-I CTRP2 8.6261 15.857 3.0869 8.1379
OVTOKO CTRP2 8.7247 10.3922 5.5073 0.1458
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SU.86.86 CTRP2 4.2812 6.1499 4.0903 12.4181
KP-3 CTRP2 4.6605 10.7392 2.4631 17.8227
L3.3 CTRP2 4.8908 8.7754 3.629 12.6182
YAPC CTRP2 6.3678 11.4094 3.6264 9.5372
HuP-T4 CTRP2 6.873 12.8475 3.3063 9.9525
KP-4 CTRP2 6.9428 8.4378 5.4875 1.0728
PaTu 8902 CTRP2 7.2596 9.7219 5.0926 2.1746
CFPAC-1 CTRP2 7.6223 9.2998 5.4683 0.6063
SUIT-2 CTRP2 7.8196 9.488 5.4823 0.4662
Panc 05.04 CTRP2 7.8421 10.2678 5.1759 1.3178
SNU-410 CTRP2 7.9186 14.2166 3.3951 7.9432
SNU-213 CTRP2 7.9585 9.0734 5.6869 0.0769
HPAC CTRP2 8.0597 9.6013 5.5385 0.2572
TCC-Pan2 CTRP2 8.1461 10.0917 5.3903 0.5254
QGP-1 CTRP2 8.2545 9.7161 5.5714 0.157
HPAF-II CTRP2 8.5078 10.2354 5.4825 0.2235
PK-59 CTRP2 8.5167 10.2353 5.4858 0.2163
BxPC-3 CTRP2 8.5953 10.4689 5.4322 0.2783
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 3.8758 8.3938 2.7888 18.5147
NCI-H28 CTRP2 6.2431 7.9354 5.259 2.9371
NCI-H2452 CTRP2 6.3329 8.8534 4.8725 4.3965
NCI-H2052 CTRP2 6.7264 12.4775 3.377 9.9194
ACC-MESO-1 CTRP2 6.827 8.7556 5.2723 2.0091
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 7.8666 9.9155 5.3342 0.8233
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.8382 9.0275 5.6595 0.1288
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-5 CTRP2 2.4838 4.2316 2.4659 23.781
Hs 944.T CTRP2 2.89 5.7607 2.675 21.7595
WM793 CTRP2 3.6634 6.2725 3.3802 16.8616
Hs 852.T CTRP2 5.8304 12.8224 2.4755 15.2178
RPMI-7951 CTRP2 5.8498 6.7806 5.5038 2.6782
COLO 741 CTRP2 6.3656 10.0351 4.31 6.6924
IPC-298 CTRP2 6.8588 11.7182 3.8543 7.7372
SK-MEL-1 CTRP2 6.9853 8.8295 5.3359 1.5776
SK-MEL-30 CTRP2 6.9965 9.972 4.8063 3.6281
SK-MEL-28 CTRP2 7.1514 7.9182 5.7953 0.0955
Hs 936.T CTRP2 7.2658 9.7708 5.0739 2.2373
WM1799 CTRP2 7.3886 8.8523 5.5398 0.554
SK-MEL-31 CTRP2 7.4843 11.7624 4.2781 5.0592
Mel Ho CTRP2 7.6025 8.8392 5.6369 0.2283
Mel JuSo CTRP2 8.1623 10.0966 5.3953 0.5065
MDA-MB-435S CTRP2 8.4511 14.9781 3.3888 7.2259
A-375 CTRP2 9.2405 18.5233 2.2255 10.4545
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 CTRP2 5.1661 6.374 4.9792 6.5265
RKN CTRP2 7.3896 9.2975 5.3549 1.1142
Rh18 CTRP2 7.9443 9.2879 5.607 0.1783
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 CTRP2 1.4239 3.5637 1.4071 30.8381
NCI-N87 CTRP2 6.1519 9.165 4.5727 5.9815
GSS CTRP2 6.1589 7.3039 5.5073 2.0461
MKN1 CTRP2 6.2477 8.6965 4.8837 4.5004
GSU CTRP2 7.2901 7.9379 5.8379 0.0285
MKN45 CTRP2 7.3025 8.2774 5.724 0.1686
OCUM-1 CTRP2 7.3106 9.1578 5.3733 1.1218
SNU-620 CTRP2 7.3483 8.3774 5.7055 0.187
SNU-5 CTRP2 7.6393 9.0515 5.5726 0.3438
SNU-668 CTRP2 7.7215 9.1084 5.5851 0.2851
23132/87 CTRP2 7.8074 9.3063 5.5463 0.3306
ECC12 CTRP2 7.8618 9.0251 5.6689 0.1122
KE-39 CTRP2 8.0857 10.691 5.121 1.2992
Fu97 CTRP2 8.1182 10.0879 5.3797 0.5634
MKN74 CTRP2 8.2365 13.3833 4.0012 5.1544
NUGC-4 CTRP2 8.243 10.0076 5.4622 0.3355
SNU-719 CTRP2 8.2493 10.2898 5.3584 0.5508
AGS CTRP2 8.8328 10.0856 5.6471 0.0284
SNU-1077 CTRP2 7.4182 8.9095 5.5305 0.5612
SNG-M CTRP2 8.2056 10.0027 5.4489 0.3747
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 CTRP2 6.1888 7.4934 5.4364 2.29
8305C CTRP2 6.4107 7.7359 5.481 1.7476
ML-1 [Human leukemia] CTRP2 7.0784 10.7545 4.4855 4.8046
CGTH-W-1 CTRP2 7.5683 12.8306 3.8221 6.7616
B-CPAP CTRP2 7.631 13.1 3.7354 7.0159
BHT-101 CTRP2 7.745 9.4111 5.4795 0.5098
TT CTRP2 7.7796 9.6773 5.3897 0.7242
8505C CTRP2 8.1428 9.8368 5.4851 0.3271
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-8 CTRP2 4.7902 9.6318 3.122 14.9116
HSC-4 CTRP2 5.3807 9.4359 3.7681 10.9258
SCC-25 CTRP2 6.3855 11.0374 3.8261 8.6763
SNU-46 CTRP2 6.5501 10.9799 3.9844 7.7249
HSC-3 CTRP2 7.3262 9.9167 5.0435 2.282
YD-10B CTRP2 7.5548 8.968 5.5686 0.3909
SNU-899 CTRP2 7.6364 9.0414 5.5752 0.3395
SNU-1041 CTRP2 7.6892 9.1961 5.5385 0.3974
SNU-1076 CTRP2 7.8089 9.1201 5.6154 0.2015
SNU-1214 CTRP2 7.8999 9.8421 5.3791 0.6808
Detroit 562 CTRP2 7.9528 16.7796 2.1722 12.5483
SNU-1066 CTRP2 8.3134 9.7018 5.5977 0.1145
BHY CTRP2 8.7084 10.2978 5.534 0.1197
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP2 3.345 6.0535 3.096 18.8544
CAL-29 CTRP2 6.2446 7.4774 5.4871 1.9835
SW1710 CTRP2 6.3765 8.7138 4.9753 3.8921
JMSU-1 CTRP2 6.6222 7.9335 5.5269 1.2802
639V CTRP2 7.0256 8.0339 5.7001 0.3406
TCCSUP CTRP2 7.1271 8.5993 5.5165 0.8089
253J CTRP2 7.219 8.5044 5.6009 0.4911
BFTC-905 CTRP2 7.7565 8.8709 5.6842 0.1136
KU-19-19 CTRP2 7.8167 8.9304 5.6854 0.1008
253J-BV CTRP2 7.8927 9.4723 5.5191 0.3529
5637 CTRP2 8.1546 10.0872 5.3957 0.5092
RT-112 CTRP2 8.2155 9.558 5.6122 0.1149
HT-1376 CTRP2 8.2674 10.0779 5.446 0.3578
VM-CUB-1 CTRP2 8.3506 9.8486 5.5603 0.1517
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4513 8.187 5.8098 0.0331

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Tigecycline (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Mycophenolic acid DMRBMAU Moderate Altered absorption of Tigecycline due to GI flora changes caused by Mycophenolic acid. Crohn disease [DD70] [4]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Tigecycline and Porfimer Sodium. Lung cancer [2C25] [5]
Mycophenolate mofetil DMPQAGE Moderate Altered absorption of Tigecycline due to GI flora changes caused by Mycophenolate mofetil. Transplant rejection [NE84] [4]

References

1 Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110.
2 BDDCS applied to over 900 drugs
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
5 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]