General Information of Drug (ID: DMLN4V5)

Drug Name
EPZ-004777 Drug Info
Synonyms DOT1L inhibitors (mixed lineage leukemia); DOT1L inhibitors (leukemia), Epizyme/GSK; DOT1L inhibitors (mixed lineage leukemia), Epizyme/GlaxoSmithKline
Cross-matching ID
PubChem CID
56962336
ChEBI ID
CHEMBL2169919
CAS Number
CAS 1338466-77-5
TTD Drug ID
D09ENZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Graft-versus-host disease 2.05 0.00e+0 32/42 (76.19%) HLA-F;HLA-C;HLA-DPB1;...
Complement and coagulation cascades 2.04 5.27e-3 76/85 (89.41%) C1QA;C1QB;C3;...
Antigen processing and presentation 2.00 1.41e-2 60/78 (76.92%) CALR;HLA-F;IFI30;...
Pertussis 1.99 1.05e-2 64/76 (84.21%) C1QA;C1QB;C3;...
Allograft rejection 1.89 1.69e-2 32/38 (84.21%) HLA-F;HLA-C;HLA-DPB1;...
Systemic lupus erythematosus 1.89 1.41e-2 45/135 (33.33%) C1QA;C1QB;C3;...
Epstein-Barr virus infection 1.88 1.21e-2 189/202 (93.56%) CXCL10;CALR;HLA-F;...
Viral carcinogenesis 1.87 1.05e-2 149/203 (73.4%) C3;HLA-F;PKM;...
Autoimmune thyroid disease 1.85 1.29e-2 46/53 (86.79%) HLA-F;HLA-C;HLA-DPB1;...
Toll-like receptor signaling pathway 1.84 1.16e-2 94/104 (90.38%) CXCL9;CXCL10;TLR2;...
Viral myocarditis 1.83 1.15e-2 53/60 (88.33%) HLA-F;DMD;HLA-C;...
JAK-STAT signaling pathway 1.82 1.14e-2 146/162 (90.12%) IL6R;IL7R;SOCS5;...
Herpes simplex virus 1 infection 1.78 2.19e-2 165/498 (33.13%) C3;CALR;HLA-F;...
Type I diabetes mellitus 1.78 2.11e-2 38/43 (88.37%) HLA-F;HLA-C;HLA-DPB1;...
Staphylococcus aureus infection 1.72 3.30e-2 72/95 (75.79%) C1QA;C1QB;KRT18;...
Hepatitis C 1.68 4.48e-2 139/157 (88.54%) CXCL10;MX2;TNFRSF1A;...
Tuberculosis 1.68 4.41e-2 159/180 (88.33%) C3;TLR2;ITGB2;...
Proteasome 1.66 4.75e-2 44/46 (95.65%) PSMB9;PSMB3;PSMC4;...
AMPK signaling pathway 1.65 4.66e-2 106/120 (88.33%) EIF4EBP1;FASN;CD36;...
Oxidative phosphorylation -1.75 4.17e-2 93/133 (69.92%) NDUFS8;NDUFA4;COX5B;...
Valine, leucine and isoleucine degradation -1.78 4.51e-2 42/48 (87.5%) ACAA1;HADHB;BCAT1;...
Propanoate metabolism -1.81 4.74e-2 30/34 (88.24%) LDHC;EHHADH;SUCLG2;...
Endocrine and other factor-regulated calcium reabsorpti... -1.88 4.74e-2 49/53 (92.45%) ESR1;ADCY9;GNAS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H