Details of the Drug

General Information of Drug (ID: DMLN4V5)

Drug Name
EPZ-004777
Synonyms DOT1L inhibitors (mixed lineage leukemia); DOT1L inhibitors (leukemia), Epizyme/GSK; DOT1L inhibitors (mixed lineage leukemia), Epizyme/GlaxoSmithKline
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 539.7
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C28H41N7O4
IUPAC Name
1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
Canonical SMILES
CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O
InChI
InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1
InChIKey
WXRGFPHDRFQODR-ICLZECGLSA-N
Cross-matching ID
PubChem CID
56962336
ChEBI ID
CHEBI:124920
CAS Number
1338466-77-5
TTD ID
D09ENZ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone-lysine N-methyltransferase (HLNM) TTSZ8T1 DOT1L_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [3]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) OTHODA1F MYCB2_HUMAN Gene/Protein Processing [3]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Gene/Protein Processing [3]
Homeobox protein Hox-A9 (HOXA9) OTKNK5H0 HXA9_HUMAN Gene/Protein Processing [5]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Gene/Protein Processing [5]
Homeobox protein Hox-B8 (HOXB8) OTKHOD17 HXB8_HUMAN Gene/Protein Processing [5]
Homeobox protein Meis1 (MEIS1) OTH9DKAD MEIS1_HUMAN Gene/Protein Processing [5]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease leukaemia
ICD Disease Classification 2A60-2B33
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histone-lysine N-methyltransferase (HLNM) DTT DOT1L 7.62E-02 0.08 0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.8364 7.9753 2.6111 0.7113
EW-24 GDSC2 3.8189 6.39 2.1798 5.9069
CADO-ES1 GDSC2 4.2432 7.5105 1.9369 6.4156
SJSA-1 GDSC2 4.4482 8.6969 1.5054 8.5479
A-673 GDSC2 4.4538 6.1875 2.6862 1.6919
CHSA0011 GDSC2 4.529 7.5791 2.0956 4.8718
ES1 GDSC2 4.6021 7.9176 1.9833 5.3875
SK-PN-DW GDSC2 4.6512 7.1683 2.3611 3.1334
EW-1 GDSC2 4.7165 7.5176 2.2409 3.6938
EW-13 GDSC2 4.7314 9.3095 1.4057 8.5061
ES8 GDSC2 4.7774 8.0086 2.0519 4.6577
HOS GDSC2 4.7886 10.467 0.8856 11.3386
EW-3 GDSC2 4.8114 7.8421 2.1495 4.0439
CHSA8926 GDSC2 4.8672 7.5384 2.3197 3.0156
EW-12 GDSC2 4.9536 7.02 2.5905 1.5333
SaOS-2 GDSC2 4.9594 8.9741 1.7161 6.2435
EW-18 GDSC2 4.9657 7.3922 2.4384 2.2551
TC-71 GDSC2 5.0469 7.6264 2.3804 2.4389
EW-22 GDSC2 5.1016 9.0556 1.7676 5.6845
MHH-ES-1 GDSC2 5.2123 8.0715 2.276 2.7434
SK-ES-1 GDSC2 5.2639 7.1842 2.67 0.9026
ES4 GDSC2 5.2914 7.8461 2.4138 1.9685
EW-11 GDSC2 5.3023 9.7677 1.5619 6.4733
EW-7 GDSC2 5.438 7.6187 2.5769 1.116
CAL-78 GDSC2 5.6293 7.4411 2.7256 0.4894
U2OS GDSC2 5.634 7.9732 2.525 1.1532
ES5 GDSC2 5.7195 8.8109 2.2242 2.3579
U-CH2 GDSC2 5.755 7.6153 2.7115 0.4668
EW-16 GDSC2 5.8683 9.2953 2.0954 2.7887
CHSA0108 GDSC2 5.9251 8.8001 2.3284 1.6822
NOS-1 [Human HNSCC] GDSC2 5.9524 8.7143 2.3754 1.4667
G-292 clone A141B1 GDSC2 6.0365 12.1568 0.9097 8.6563
CAL-72 GDSC2 6.0466 14.8144 -0.3427 14.7434
HuO9 GDSC2 6.0671 8.9912 2.3175 1.597
H-EMC-SS GDSC2 6.1428 8.6811 2.472 0.967
ES6 GDSC2 6.1453 8.4315 2.5668 0.6702
ES7 GDSC2 6.1543 8.3765 2.5906 0.5987
HuO-3N1 GDSC2 6.2258 8.4973 2.5747 0.6071
NY GDSC2 6.3513 9.2578 2.3397 1.2796
MG-63 GDSC2 7.2344 17.6467 -0.9012 14.7958
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 4.5348 10.7977 0.5404 13.8225
SUP-B8 GDSC2 2.8778 10.5841 -0.6856 24.4375
BONNA-12 GDSC2 3.0403 16.3571 -3.4318 32.3788
OCI-Ly19 GDSC2 3.6375 5.4523 2.5069 4.3122
JeKo-1 GDSC2 3.7032 6.2176 2.1783 6.2041
OCI-Ly7 GDSC2 3.7171 5.1928 2.6919 2.9761
SIG-M5 GDSC2 3.8085 8.004 1.373 10.9151
H9 GDSC2 3.862 7.0311 1.896 7.5647
SU-DHL-4 GDSC2 3.8911 5.8997 2.4711 3.9401
Jiyoye GDSC2 3.9129 8.4835 1.2156 11.5841
Karpas-422 GDSC2 3.9335 5.9791 2.462 3.9023
DB GDSC2 3.9654 6.1753 2.3894 4.2748
SUP-HD1 GDSC2 3.9807 5.9368 2.5144 3.4852
QIMR-WIL GDSC2 4.0286 12.0816 -0.4838 20.1708
NU-DUL-1 GDSC2 4.058 5.8945 2.5851 2.9087
Farage GDSC2 4.0733 6.7258 2.1982 5.2025
RPMI-8226 GDSC2 4.1084 7.0157 2.0823 5.8315
Loucy GDSC2 4.1381 5.9836 2.5942 2.7053
WSU-NHL GDSC2 4.1439 5.8171 2.6746 2.2353
Karpas-620 GDSC2 4.1554 9.6019 0.8466 13.0931
MHH-PREB-1 GDSC2 4.1564 6.1994 2.5049 3.1901
MC116 GDSC2 4.1614 10.5535 0.3797 15.6231
KE-37 GDSC2 4.1621 5.8108 2.6884 2.1266
DEL GDSC2 4.1659 9.0608 1.1219 11.4859
MOLM-16 GDSC2 4.1735 8.8575 1.2278 10.846
L-428 GDSC2 4.2137 6.4153 2.4403 3.4591
Namalwa GDSC2 4.2563 9.6688 0.8896 12.5934
OCI-AML-5 GDSC2 4.2621 8.8727 1.2858 10.286
L-1236 GDSC2 4.2702 7.6194 1.9029 6.5615
ML-2 GDSC2 4.3299 6.593 2.4307 3.2973
Karpas-1106P GDSC2 4.3303 6.4995 2.4742 3.0468
SUP-M2 GDSC2 4.3434 5.9671 2.7223 1.6607
SR GDSC2 4.3458 6.659 2.4099 3.3879
SKM-1 GDSC2 4.3498 8.466 1.5481 8.5186
MM1.S GDSC2 4.3528 6.038 2.6963 1.7834
WSU-DLCL2 GDSC2 4.3609 6.606 2.4438 3.1656
NOMO-1 GDSC2 4.4012 6.0002 2.7393 1.4937
MV4-11 GDSC2 4.4065 13.6074 -0.9473 21.1368
Daudi GDSC2 4.4171 5.9351 2.7756 1.2925
ALL-PO GDSC2 4.4307 8.0184 1.8211 6.7029
THP-1 GDSC2 4.4389 7.2437 2.1955 4.4612
KMS-11 GDSC2 4.4389 11.7831 -0.0177 16.9148
SU-DHL-6 GDSC2 4.4454 6.5674 2.5123 2.6349
Raji GDSC2 4.4525 6.4772 2.5572 2.3773
MOLT-16 GDSC2 4.4575 7.3969 2.1353 4.7784
MOLT-13 GDSC2 4.4876 7.099 2.2939 3.7971
BC-3 GDSC2 4.5026 13.6251 -0.8818 20.6241
CML-T1 GDSC2 4.5128 6.3959 2.6272 1.9138
GA-10 GDSC2 4.5218 6.1486 2.7389 1.3411
JURL-MK1 GDSC2 4.5248 6.9126 2.4024 3.1145
MY-M12 GDSC2 4.5461 9.1016 1.3778 9.0791
ME1 GDSC2 4.5539 6.3475 2.6705 1.6361
MOLM-13 GDSC2 4.5876 7.0074 2.3966 3.0413
Reh GDSC2 4.5922 6.064 2.8092 0.9401
NK-92MI GDSC2 4.6031 7.5276 2.1668 4.3176
Karpas-299 GDSC2 4.6065 8.7276 1.6002 7.6366
A3/Kawakami GDSC2 4.6068 5.8216 2.9123 0.5182
HEL GDSC2 4.6127 6.0507 2.8243 0.8556
EoL-1 GDSC2 4.6162 6.296 2.7247 1.2956
DG-75 GDSC2 4.6193 7.0564 2.3931 3.0089
OPM-2 GDSC2 4.6382 6.4843 2.6562 1.5983
JSC-1 GDSC2 4.6509 7.6779 2.1267 4.4598
KOPN-8 GDSC2 4.6733 10.4208 0.826 11.9355
GDM-1 GDSC2 4.6815 10.7601 0.666 12.792
Granta-519 GDSC2 4.6855 6.6164 2.6243 1.6947
LC4-1 GDSC2 4.7032 6.9431 2.4917 2.3475
RL GDSC2 4.7033 9.7755 1.1613 9.9784
ATN-1 GDSC2 4.7228 6.1588 2.8317 0.7271
AMO1 GDSC2 4.7318 7.7353 2.1502 4.1791
MHH-CALL-4 GDSC2 4.7551 16.786 -2.2562 24.9065
Mono-Mac-6 GDSC2 4.7553 8.4264 1.8426 5.9087
RCH-ACV GDSC2 4.7853 8.2315 1.9532 5.21
CTB-1 GDSC2 4.7873 9.3445 1.427 8.2625
U-698-M GDSC2 4.7914 7.1976 2.4284 2.5514
BV-173 GDSC2 4.792 6.7839 2.6081 1.6403
RPMI-6666 GDSC2 4.7935 7.0746 2.4836 2.2602
697 GDSC2 4.8059 6.2793 2.8214 0.6986
JVM-3 GDSC2 4.8192 6.7917 2.6187 1.557
SU-DHL-10 GDSC2 4.8232 5.7494 3.0238 0.1184
IM-9 GDSC2 4.8246 6.55 2.7217 1.0846
K-562 GDSC2 4.8418 6.6235 2.6999 1.1618
ARH-77 GDSC2 4.8583 6.7923 2.6381 1.4213
SCC-3 GDSC2 4.8595 6.059 2.9274 0.3183
BALL-1 GDSC2 4.8646 6.4524 2.7795 0.8108
SUP-T1 GDSC2 4.8657 6.7498 2.6595 1.3159
HT GDSC2 4.8767 14.5132 -1.0367 20.3202
ST486 GDSC2 4.8903 6.7851 2.6569 1.301
CTV-1 GDSC2 4.9018 6.5933 2.7404 0.9335
GR-ST GDSC2 4.9458 7.1345 2.5384 1.7882
P30/OHK GDSC2 4.9657 7.0525 2.583 1.5545
OCI-AML-3 GDSC2 4.9657 6.3183 2.8743 0.4136
TALL-1 [Human adult T-ALL] GDSC2 4.9878 10.2861 1.1113 9.6362
HDLM-2 GDSC2 5.0152 7.3357 2.4886 1.943
NCI-H929 GDSC2 5.0309 7.1252 2.5851 1.4727
HL-60 GDSC2 5.0822 6.5395 2.8393 0.4526
VL51 GDSC2 5.1025 7.1996 2.5892 1.3783
JVM-2 GDSC2 5.1208 7.4106 2.5107 1.7129
WIL2 NS GDSC2 5.1504 6.4652 2.8932 0.2763
RC-K8 GDSC2 5.1551 6.7242 2.8 0.5301
Ramos.2G6.4C10 GDSC2 5.1625 6.484 2.8911 0.2765
EM-2 GDSC2 5.1641 6.6167 2.8436 0.3969
YT GDSC2 5.1664 7.0103 2.6949 0.8866
ROS-50 GDSC2 5.1759 7.855 2.3503 2.4182
MOLT-4 GDSC2 5.1764 6.728 2.8074 0.495
CA46 GDSC2 5.1811 7.515 2.4972 1.7072
L-540 GDSC2 5.1815 6.7166 2.8137 0.4731
KM-H2 GDSC2 5.1993 7.2074 2.6316 1.1064
P31/FUJ GDSC2 5.2248 6.4885 2.9129 0.2073
CRO-AP2 GDSC2 5.245 8.3529 2.1707 3.2407
HH [Human lymphoma] GDSC2 5.2501 7.7007 2.454 1.8283
SU-DHL-5 GDSC2 5.2512 6.3523 2.9693 0.1059
VAL GDSC2 5.2514 7.6622 2.4707 1.7502
MOLP-8 GDSC2 5.2582 7.4355 2.5672 1.3177
KMOE-2 GDSC2 5.2671 7.2455 2.6473 0.986
SK-MM-2 GDSC2 5.3006 6.948 2.7759 0.5191
A4/Fukuda GDSC2 5.3061 7.0269 2.7486 0.6004
OCI-AML-2 GDSC2 5.3082 6.8038 2.832 0.3594
OCI-M1 GDSC2 5.309 6.4663 2.9508 0.1202
MHH-CALL-2 GDSC2 5.3394 6.8349 2.8328 0.3437
NB4 GDSC2 5.3634 18.8416 -2.8092 25.1409
DoHH2 GDSC2 5.3691 6.6725 2.9014 0.1859
LAMA-84 GDSC2 5.3752 7.3549 2.6524 0.8814
EJM GDSC2 5.3867 7.0948 2.7562 0.5296
ALL-SIL GDSC2 5.3938 6.8257 2.8568 0.2667
SU-DHL-8 GDSC2 5.4004 6.7012 2.9028 0.1749
BL-41 GDSC2 5.4048 6.791 2.8731 0.229
CESS GDSC2 5.422 7.2693 2.7053 0.6669
Hs 445 GDSC2 5.4234 7.1159 2.7633 0.4892
Karpas-231 GDSC2 5.4333 7.017 2.8033 0.3765
RPMI-8402 GDSC2 5.4393 6.8745 2.8565 0.2514
BE-13 GDSC2 5.474 7.4664 2.6521 0.8107
KCL-22 GDSC2 5.476 7.1347 2.7772 0.4246
P32/ISH GDSC2 5.4832 6.948 2.8469 0.2565
SUP-B15 GDSC2 5.4902 7.3262 2.7121 0.6037
MN-60 GDSC2 5.5018 7.4176 2.6825 0.6901
TK [Human B-cell lymphoma] GDSC2 5.5078 7.0075 2.8351 0.273
P12-Ichikawa GDSC2 5.5861 6.8182 2.9283 0.0984
KMS-12-BM GDSC2 5.5957 7.4617 2.7045 0.5667
HC-1 GDSC2 5.645 7.2271 2.8087 0.2813
HAL-01 GDSC2 5.6536 7.6974 2.64 0.7316
Jurkat GDSC2 5.6631 6.9321 2.9166 0.0997
LP-1 GDSC2 5.6859 7.4686 2.7378 0.4303
L-363 GDSC2 5.6932 13.4611 0.0665 13.5854
Ku812 GDSC2 5.7218 7.5443 2.7243 0.4488
SU-DHL-16 GDSC2 5.7265 17.1064 -1.6835 20.7845
SU-DHL-1 GDSC2 5.7353 24.0206 -5.0913 29.6387
RS4;11 GDSC2 5.7367 7.6921 2.676 0.5734
JJN-3 GDSC2 5.7468 7.2974 2.8215 0.2244
KG-1 GDSC2 5.7883 7.6458 2.7134 0.4468
TUR GDSC2 5.8133 7.2451 2.8631 0.1414
KY821 GDSC2 5.8149 7.2302 2.8687 0.1334
BC-1 GDSC2 5.8409 7.5466 2.7689 0.2978
EB2 GDSC2 5.8416 7.7506 2.6961 0.467
RPMI-8866 GDSC2 5.9259 7.6361 2.7688 0.2705
Karpas-45 GDSC2 5.9297 7.6609 2.7615 0.2837
U266B1 GDSC2 5.9637 7.4829 2.8351 0.1504
PF-382 GDSC2 6.0826 7.7693 2.7794 0.2084
Kasumi-1 GDSC2 6.1376 15.1056 -0.4206 14.9019
CCRF-CEM GDSC2 6.1436 7.6191 2.8515 0.1001
MEG-01 GDSC2 6.2655 8.1768 2.7044 0.2911
DND-41 GDSC2 6.3379 8.149 2.74 0.2104
MLMA GDSC2 6.3562 15.1022 -0.2718 13.8004
PL-21 GDSC2 6.5305 8.7813 2.5898 0.4388
NALM-6 GDSC2 6.6979 18.0951 -1.4756 18.0185
NKM-1 GDSC2 6.7061 8.6156 2.7108 0.1758
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 4.5897 7.3478 2.2419 3.9106
FLO-1 GDSC2 4.9354 9.0577 1.6614 6.6046
KYSE-50 GDSC2 4.9474 6.72 2.7106 1.0134
KYAE-1 GDSC2 5.0864 7.1189 2.6145 1.2847
ESO-51 GDSC2 5.1243 7.5627 2.4484 2.0029
ESO-26 GDSC2 5.4402 7.3978 2.664 0.7933
KYSE-220 GDSC2 5.4981 7.4098 2.6839 0.6881
SK-GT-4 GDSC2 5.7557 8.1913 2.4936 1.1736
OACP4 C GDSC2 6.3835 8.6505 2.5806 0.5192
HCE-4 GDSC2 6.5425 8.5194 2.6858 0.2484
TE-12 GDSC2 6.9776 9.9274 2.348 0.8565
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 5.2991 8.5901 2.0959 3.5535
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-6 GDSC2 3.5968 11.9821 -0.7813 22.6596
KP-N-RT-BM-1 GDSC2 3.637 10.0073 0.238 17.8013
SK-N-FI GDSC2 4.1782 7.1728 2.055 5.8427
CHP-126 GDSC2 4.5501 6.5704 2.571 2.154
IMR-5 GDSC2 4.5652 9.2493 1.3196 9.3759
Kelly GDSC2 4.5792 6.5556 2.5936 1.9936
CHP-134 GDSC2 4.6241 7.1856 2.3372 3.3114
NB1 GDSC2 4.6695 9.5906 1.2272 9.6759
SJNB-17 GDSC2 4.6749 8.1695 1.9116 5.664
SK-N-DZ GDSC2 4.7109 6.3796 2.7369 1.1349
MHH-NB-11 GDSC2 4.8073 7.0088 2.5197 2.0575
SJNB-12 GDSC2 4.8101 8.6822 1.7574 6.296
SiMa GDSC2 4.8667 9.0039 1.6422 6.8515
SK-N-MC-IXC GDSC2 4.8825 6.155 2.9013 0.38
GOTO GDSC2 4.9662 7.8081 2.2557 3.2071
SK-N-BE(2)-M17 GDSC2 5.0083 6.8866 2.6719 1.1171
CHP-212 GDSC2 5.0119 9.2434 1.6233 6.6742
SJNB-14 GDSC2 5.0357 6.7783 2.7278 0.868
SJNB-5 GDSC2 5.3103 7.4438 2.5882 1.1823
KP-N-YN GDSC2 5.319 10.2994 1.324 7.7695
SJNB-10 GDSC2 5.3264 7.4119 2.6083 1.0879
SJNB-13 GDSC2 5.3922 7.1262 2.7468 0.5548
KP-N-YS GDSC2 5.4502 7.2009 2.7426 0.5348
SJNB-7 GDSC2 5.493 7.0339 2.8201 0.3114
TGW GDSC2 5.528 7.0958 2.8113 0.3181
NH-12 GDSC2 5.541 7.3684 2.7171 0.5598
SK-N-SH GDSC2 5.6628 8.1326 2.4749 1.3244
LA-N-6 GDSC2 5.8908 7.4533 2.8195 0.1901
NB(TU)1 GDSC2 5.9145 7.5963 2.7785 0.2554
GI-ME-N GDSC2 5.9872 10.0196 1.8467 3.8541
NB69 GDSC2 5.9984 7.8026 2.7371 0.3106
SK-N-AS GDSC2 6.4551 14.9693 -0.1433 13.0259
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 5.1965 7.0313 2.7 0.8437
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-148 GDSC2 4.0414 8.0153 1.5445 9.2781
Hs 578T GDSC2 4.2316 10.3676 0.5255 14.6659
HDQ-P1 GDSC2 4.2899 8.3022 1.5851 8.4355
DU4475 GDSC2 4.5042 6.4062 2.618 1.9742
BT-474 GDSC2 4.5508 7.3635 2.2104 4.1625
HCC2157 GDSC2 4.656 6.8722 2.4967 2.3906
UACC-893 GDSC2 4.6629 8.2888 1.8474 6.0634
CAL-120 GDSC2 4.6854 6.1476 2.8191 0.8096
COLO 824 GDSC2 4.7948 7.2255 2.4179 2.6015
HCC2218 GDSC2 4.8236 9.6934 1.2842 9.0083
CAL-51 GDSC2 4.9057 8.9349 1.7001 6.4398
HCC1569 GDSC2 4.9615 7.758 2.2753 3.1092
BT-483 GDSC2 4.9925 9.5373 1.4719 7.5794
HCC1419 GDSC2 5.0365 6.9403 2.6634 1.1257
MDA-MB-361 GDSC2 5.0858 7.2 2.581 1.4323
HCC1806 GDSC2 5.0998 6.7306 2.7744 0.6496
HCC1599 GDSC2 5.1229 7.179 2.6074 1.2791
MFM-223 GDSC2 5.1313 7.6412 2.4186 2.1389
HCC1187 GDSC2 5.1638 7.5444 2.4762 1.824
CAMA-1 GDSC2 5.1664 12.2497 0.2862 13.6556
MDA-MB-453 GDSC2 5.19 9.0164 1.8399 5.1221
OCUB-M GDSC2 5.1916 7.1624 2.6461 1.0552
HCC1428 GDSC2 5.2922 6.9862 2.7582 0.5786
MDA-MB-468 GDSC2 5.2959 7.9067 2.3905 2.0727
HCC1500 GDSC2 5.3029 6.9413 2.7793 0.5077
JIMT-1 GDSC2 5.3649 7.0211 2.7748 0.487
AU565 GDSC2 5.3651 11.344 0.8593 10.228
MDA-MB-175-VII GDSC2 5.3924 7.6842 2.5296 1.3474
BT-549 GDSC2 5.4113 7.5924 2.5751 1.1455
HCC70 GDSC2 5.4272 8.1159 2.3689 2.0212
MCF-7 GDSC2 5.4437 7.3359 2.6891 0.7058
MDA-MB-231 GDSC2 5.4628 7.6082 2.5921 1.0368
BT-20 GDSC2 5.4813 7.3802 2.6881 0.6852
UACC-812 GDSC2 5.484 7.0583 2.808 0.3434
MDA-MB-436 GDSC2 5.4855 7.2839 2.726 0.5644
ZR-75-30 GDSC2 5.4924 7.3759 2.6943 0.6582
YMB-1-E GDSC2 5.5256 11.1692 1.0477 8.8867
HCC1395 GDSC2 5.5347 7.8852 2.5149 1.2773
HCC38 GDSC2 5.5858 7.3351 2.7472 0.4521
HCC1937 GDSC2 5.6018 7.5713 2.6661 0.6804
EFM-19 GDSC2 5.6144 9.8554 1.7101 5.1214
EFM-192A GDSC2 5.6422 7.4156 2.74 0.4445
MRK-nu-1 GDSC2 5.66 6.9208 2.9193 0.0971
MDA-MB-415 GDSC2 5.7158 7.5328 2.7261 0.4468
MDA-MB-157 GDSC2 5.7991 7.8102 2.6574 0.5937
T-47D GDSC2 5.8263 8.0412 2.582 0.8101
Evsa-T GDSC2 5.8375 7.3 2.853 0.1508
HCC1954 GDSC2 6.1511 7.8021 2.7925 0.1727
HCC1143 GDSC2 6.2033 8.868 2.4262 1.0811
CAL-85-1 GDSC2 6.3726 8.202 2.7342 0.2114
MDA-MB-330 GDSC2 6.524 8.4865 2.6905 0.2452
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC2 3.8773 8.02 1.4182 10.4612
AM-38 GDSC2 4.168 9.0448 1.1313 11.4257
A-172 GDSC2 4.4463 7.7239 1.9727 5.7646
SW1783 GDSC2 4.4697 9.8757 0.9454 11.7523
DK-MG GDSC2 4.582 6.7096 2.5272 2.3392
GI-1 GDSC2 4.6711 6.7262 2.5691 1.9914
LN-18 GDSC2 4.7238 6.5498 2.6723 1.4162
SF539 GDSC2 4.7709 7.7345 2.1744 3.9738
Becker GDSC2 4.8 6.7761 2.6156 1.595
D-336MG GDSC2 4.8106 7.1969 2.4393 2.4658
GaMG GDSC2 4.8601 9.0371 1.6221 6.9811
NMC-G1 GDSC2 4.8835 6.3613 2.8235 0.6315
SF126 GDSC2 4.9916 6.9128 2.6534 1.2121
MOG-G-CCM GDSC2 5.0279 8.1039 2.1586 3.6352
CAS-1 GDSC2 5.0348 6.459 2.85 0.4472
D-245MG GDSC2 5.0491 10.7879 0.9119 10.6119
KINGS-1 GDSC2 5.0654 10.198 1.2058 8.9409
YKG-1 GDSC2 5.1043 6.5099 2.8591 0.3841
D-392MG GDSC2 5.1201 8.4573 2.0529 4.0635
MOG-G-UVW GDSC2 5.1207 7.5354 2.4581 1.9609
SF295 GDSC2 5.1723 7.1417 2.6455 1.0745
U-87MG ATCC GDSC2 5.1945 8.5761 2.0426 3.9998
D-263MG GDSC2 5.2271 7.0498 2.7062 0.798
KNS-42 GDSC2 5.25 6.9468 2.7555 0.6133
SK-MG-1 GDSC2 5.2545 7.3259 2.6097 1.1457
M059J GDSC2 5.2593 7.0624 2.7153 0.7424
8-MG-BA GDSC2 5.2632 6.8715 2.7892 0.5003
KALS-1 GDSC2 5.2855 8.5663 2.0988 3.5585
GB-1 GDSC2 5.3594 14.2794 -0.5656 17.2196
U-251MG GDSC2 5.3703 7.0135 2.7798 0.47
D-247MG GDSC2 5.4268 8.2376 2.3174 2.2636
SW1088 GDSC2 5.4556 7.3358 2.6941 0.6818
LN-229 GDSC2 5.4569 9.9128 1.5901 6.0395
ONS-76 GDSC2 5.4735 7.575 2.6098 0.9621
T98G GDSC2 5.4833 7.2038 2.7548 0.4821
YH-13 GDSC2 5.5608 7.4803 2.6834 0.6509
DBTRG-05MG GDSC2 5.5707 8.5884 2.2425 2.4477
H4 GDSC2 5.5721 7.4152 2.7123 0.5568
Hs 683 GDSC2 5.5835 6.7995 2.9337 0.0925
D-542MG GDSC2 5.6006 7.0969 2.838 0.2366
Daoy GDSC2 5.6469 7.4719 2.7213 0.4924
LN-405 GDSC2 5.6929 7.438 2.7516 0.3929
42-MG-BA GDSC2 5.7291 7.5683 2.7185 0.4607
KNS-81-FD GDSC2 5.7542 7.7353 2.6671 0.5898
SNB-75 GDSC2 5.7814 8.4079 2.4193 1.4422
PFSK-1 GDSC2 5.8035 14.8519 -0.5288 16.0771
D-502MG GDSC2 5.8482 8.0839 2.575 0.819
SF268 GDSC2 5.8544 8.216 2.5272 0.9766
Onda 11 GDSC2 5.9937 8.1914 2.5947 0.6712
U-118MG GDSC2 6.0037 7.9406 2.6901 0.4125
D-566MG GDSC2 6.0238 7.576 2.8246 0.153
Onda 10 GDSC2 6.1105 7.9696 2.7199 0.3088
KS-1 [Human Krukenberg tumour] GDSC2 6.117 8.5777 2.5004 0.8901
D-423MG GDSC2 6.4276 8.6293 2.605 0.4434
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC2 4.5295 6.694 2.5042 2.5443
TGBC24TKB GDSC2 5.0955 7.621 2.4085 2.2338
ETK-1 GDSC2 5.6205 8.1357 2.4541 1.4469
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC2 4.8473 7.8252 2.1788 3.819
MFE-280 GDSC2 5.2941 8.7478 2.0229 3.9495
EN GDSC2 5.3382 6.832 2.8334 0.3428
RL95-2 GDSC2 5.449 7.2956 2.7066 0.6458
MFE-296 GDSC2 5.8488 7.4664 2.7998 0.2349
AN3-CA GDSC2 5.8832 9.24 2.1264 2.6245
KLE GDSC2 5.896 8.6642 2.3695 1.5404
ESS-1 GDSC2 5.9685 7.3901 2.8681 0.1077
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB GDSC2 4.4731 6.2694 2.6609 1.7953
SW156 GDSC2 4.6142 7.6541 2.1148 4.5974
A-498 GDSC2 4.6166 13.4244 -0.6951 19.5549
KMRC-20 GDSC2 4.6766 6.6018 2.6259 1.6982
BFTC-909 GDSC2 4.7366 6.4468 2.7216 1.1756
786-O GDSC2 4.7419 7.0653 2.4592 2.4615
NCC010 GDSC2 4.7575 9.5493 1.3082 9.0137
BB65-RCC GDSC2 4.9284 8.5466 1.8961 5.2717
A-704 GDSC2 5.0261 9.219 1.6438 6.5294
OS-RC-2 GDSC2 5.0356 7.4636 2.4446 2.1327
HA7-RCC GDSC2 5.1259 7.3261 2.5485 1.5349
Caki-1 GDSC2 5.1701 10.9964 0.8943 10.4479
KTCTL-195 GDSC2 5.1893 9.1032 1.7995 5.3485
KMRC-1 GDSC2 5.3059 7.0442 2.7419 0.6218
KTCTL-26A GDSC2 5.3439 7.3985 2.6214 1.0221
ACHN GDSC2 5.3727 7.5872 2.5595 1.2423
RXF 393L GDSC2 5.4681 10.9934 1.0934 8.7503
VMRC-RCW GDSC2 5.4876 7.2247 2.7488 0.4969
KTCTL-140 GDSC2 5.5514 9.5454 1.8132 4.6695
SW13 GDSC2 5.5627 7.5458 2.6594 0.7264
SN12C GDSC2 5.614 7.4177 2.7281 0.4901
LB996-RCC GDSC2 5.6547 7.5617 2.6913 0.5732
VMRC-RCZ GDSC2 5.7142 7.5474 2.7202 0.463
KTCTL-21 GDSC2 5.7832 8.5909 2.3463 1.7435
CAL-54 GDSC2 5.7895 13.6353 0.0486 13.4687
KTCTL-13 GDSC2 5.82 7.5999 2.7421 0.3638
769-P GDSC2 5.8692 8.7055 2.3404 1.6851
UO-31 GDSC2 5.9671 7.8488 2.709 0.3828
KTCTL-1M GDSC2 6.0314 8.0657 2.6557 0.485
LB2241-RCC GDSC2 6.1869 8.2749 2.6402 0.4566
LB1047-RCC GDSC2 6.1927 8.5441 2.5442 0.7103
NCC021 GDSC2 6.3173 8.0214 2.7762 0.1619
TK-10 GDSC2 6.6651 9.2077 2.4881 0.6285
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKO GDSC2 4.1256 7.2193 1.9956 6.3227
HCT 116 GDSC2 4.4505 6.3855 2.597 2.1654
SW48 GDSC2 4.6096 8.8265 1.5548 7.8981
SW1463 GDSC2 4.6605 6.7052 2.5726 1.9883
SNU-C1 GDSC2 4.7998 7.1928 2.4351 2.5035
KM12 GDSC2 4.8758 6.6707 2.6969 1.1402
T84 GDSC2 4.8866 7.4412 2.3738 2.6988
SW1116 GDSC2 4.9403 6.7076 2.7124 1.013
HT-55 GDSC2 4.9454 6.2724 2.8831 0.3987
COLO 320HSR GDSC2 4.9782 6.926 2.6416 1.2769
LoVo GDSC2 4.9812 8.1275 2.1206 3.9183
SW626 GDSC2 4.9841 8.4434 1.9781 4.7076
LS411N GDSC2 5.0016 6.228 2.9215 0.2697
SW948 GDSC2 5.0379 7.4297 2.4604 2.0522
SNU-81 GDSC2 5.091 7.0533 2.6433 1.1582
HCT 15 GDSC2 5.1007 6.6995 2.7867 0.6075
COLO205 GDSC2 5.1069 6.5174 2.8574 0.3876
RCM-1 [Human ESC] GDSC2 5.161 6.7658 2.7868 0.5684
SK-CO-1 GDSC2 5.1641 6.9392 2.7217 0.7893
HT-29 GDSC2 5.1853 7.1914 2.6316 1.1189
HCC2998 GDSC2 5.2029 7.0814 2.6832 0.9016
SW1417 GDSC2 5.2368 7.2029 2.6506 0.9988
SW620 GDSC2 5.2474 8.4425 2.1324 3.4381
NCI-H716 GDSC2 5.2672 7.3763 2.5953 1.1926
SNU-1040 GDSC2 5.2738 6.7433 2.8405 0.353
HT115 GDSC2 5.2903 6.475 2.9412 0.1388
CCK-81 GDSC2 5.318 7.3495 2.6292 1.0138
MDST8 GDSC2 5.3977 6.6155 2.9312 0.1299
LS513 GDSC2 5.433 6.8539 2.8614 0.2434
GP5d GDSC2 5.4714 7.2024 2.7505 0.5003
SNU-283 GDSC2 5.4919 7.112 2.7916 0.3801
SNU-175 GDSC2 5.5043 7.4242 2.6811 0.6932
LS1034 GDSC2 5.5401 6.8871 2.8888 0.1629
SNU-61 GDSC2 5.5667 7.4928 2.6811 0.6546
C2BBe1 GDSC2 5.5688 7.7582 2.5804 0.9971
COLO 678 GDSC2 5.5758 7.6216 2.6361 0.7954
LS180 GDSC2 5.5776 7.0385 2.85 0.2207
LS123 GDSC2 5.6506 7.1211 2.8478 0.2038
NCI-H508 GDSC2 5.6597 22.7096 -4.4992 28.6138
CaR-1 GDSC2 5.7138 7.6582 2.6794 0.5759
DiFi GDSC2 5.7297 8.1028 2.5167 1.1075
CL-11 GDSC2 5.8393 8.0476 2.585 0.792
CW-2 GDSC2 5.8681 7.7809 2.6954 0.4568
NCI-H747 GDSC2 5.8952 8.3828 2.4803 1.1137
SNU-C5 GDSC2 5.9672 8 2.6545 0.5174
SW837 GDSC2 6.0582 7.9378 2.7117 0.3435
SNU-407 GDSC2 6.1758 7.9495 2.7507 0.2328
SNU-C2B GDSC2 6.3559 9.4782 2.2553 1.5921
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.2097 7.0551 2.1333 5.2993
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 GDSC2 4.0077 6.0505 2.4782 3.6464
Hep 3B2.1-7 GDSC2 4.0242 7.338 1.8649 7.3605
SK-HEP-1 GDSC2 4.2226 6.0403 2.6198 2.409
SNU-398 GDSC2 4.5802 7.2537 2.2795 3.713
HuH-1 GDSC2 4.7496 6.834 2.5645 1.9087
JHH-7 GDSC2 5 6.8807 2.6704 1.1315
JHH-1 GDSC2 5.2197 9.7703 1.5088 6.9254
Hep-G2/C3A GDSC2 5.2754 6.8197 2.8133 0.4247
SNU-387 GDSC2 5.3451 8.2686 2.2617 2.6379
SNU-423 GDSC2 5.4315 11.4285 0.8632 10.0699
SNU-449 GDSC2 5.5095 9.0617 2.0049 3.7203
JHH-4 GDSC2 5.5556 7.6246 2.6263 0.8429
HLE GDSC2 5.7875 7.6693 2.7045 0.47
Huh-7 GDSC2 5.805 7.4902 2.7754 0.2964
JHH-2 GDSC2 5.9267 7.827 2.7014 0.4168
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Lu-134-A GDSC2 2.1018 9.7213 -0.9439 28.0903
NCI-H526 GDSC2 4.031 6.8533 2.1066 5.8588
COR-L279 GDSC2 4.0639 7.5681 1.781 7.7803
NCI-H2444 GDSC2 4.0869 7.1672 1.9935 6.4235
NCI-H2171 GDSC2 4.1265 6.3388 2.4198 3.7524
BEN GDSC2 4.1994 5.6974 2.7612 1.668
NCI-H510A GDSC2 4.2045 6.5029 2.3931 3.7553
SHP-77 GDSC2 4.2112 8.5715 1.3963 9.7535
Lu-165 GDSC2 4.2236 6.0329 2.6238 2.3846
NCI-H1155 GDSC2 4.2675 6.3167 2.52 2.8972
NCI-H146 GDSC2 4.2897 7.2146 2.111 5.264
NCI-H847 GDSC2 4.2997 6.4394 2.4831 3.0504
NCI-H1836 GDSC2 4.3247 8.8225 1.356 9.7206
COR-L321 GDSC2 4.3708 6.0712 2.6917 1.7815
NCI-H740 GDSC2 4.3846 6.7044 2.4129 3.3004
SBC-5 GDSC2 4.4042 5.3738 2.9974 0.3657
NCI-H835 GDSC2 4.4439 11.5306 0.111 16.268
NCI-H647 GDSC2 4.4463 8.7714 1.4679 8.7746
HCC366 GDSC2 4.4491 7.9068 1.8872 6.2686
NCI-H1770 GDSC2 4.5119 6.2564 2.6875 1.6067
HCC33 GDSC2 4.5125 11.6941 0.0819 16.239
NCI-H1688 GDSC2 4.5132 6.4753 2.5924 2.0955
NCI-H2227 GDSC2 4.5355 6.7361 2.4887 2.619
NCI-H720 GDSC2 4.5418 6.194 2.7299 1.3598
IST-SL2 GDSC2 4.5515 7.8538 1.9805 5.5041
NCI-H1581 GDSC2 4.562 6.3791 2.6612 1.6721
COR-L105 GDSC2 4.5669 8.3286 1.7647 6.7488
COR-L88 GDSC2 4.63 6.7539 2.5345 2.2293
NCI-H226 GDSC2 4.6632 13.5447 -0.7192 19.5407
HCC78 GDSC2 4.6645 8.8397 1.5858 7.5976
NCI-H1435 GDSC2 4.6804 6.6374 2.6126 1.7596
NCI-H810 GDSC2 4.7041 7.4952 2.2437 3.6991
LCLC-103H GDSC2 4.7057 6.0842 2.8534 0.658
NCI-H596 GDSC2 4.7587 6.918 2.533 2.0555
NCI-H345 GDSC2 4.7591 5.8371 2.9689 0.2564
DMS 273 GDSC2 4.7623 8.1819 1.9618 5.2037
NCI-H2023 GDSC2 4.7684 7.3352 2.3541 2.9834
COR-L303 GDSC2 4.7694 6.2948 2.7989 0.8162
NCI-H1437 GDSC2 4.7724 7.3125 2.3665 2.9099
NCI-H2029 GDSC2 4.7978 6.5215 2.7205 1.1167
NCI-H69 GDSC2 4.8107 7.9087 2.1185 4.2201
NCI-H2795 GDSC2 4.8293 11.7772 0.2753 14.4924
NCI-H1703 GDSC2 4.8306 8.3364 1.9328 5.2427
NCI-H838 GDSC2 4.8401 6.4909 2.7529 0.9386
COR-L23 GDSC2 4.859 6.5634 2.7326 1.0053
NCI-H1105 GDSC2 4.8739 9.9182 1.2104 9.3214
NCI-H524 GDSC2 4.8772 6.9372 2.5868 1.6396
COR-L32 GDSC2 4.887 7.6144 2.297 3.107
NCI-H1648 GDSC2 4.8964 7.1848 2.4911 2.0826
LC-1/sq GDSC2 4.8978 7.306 2.4393 2.3428
NCI-H1876 GDSC2 4.9044 8.5012 1.9023 5.2809
LCLC-97TM1 GDSC2 4.9083 7.0277 2.5645 1.7086
LB647-SCLC GDSC2 4.9105 7.8456 2.2067 3.5607
NCI-H1563 GDSC2 4.9184 6.9823 2.5887 1.5821
NCI-H1993 GDSC2 4.9291 7.5909 2.3313 2.8603
NCI-H1915 GDSC2 4.9402 8.2489 2.0408 4.4315
LXF 289 GDSC2 4.9493 7.4626 2.3989 2.4783
NCI-H1793 GDSC2 4.9502 10.0508 1.1987 9.2242
IA-LM GDSC2 4.984 6.6546 2.7534 0.8125
DMS 79 GDSC2 5.0213 7.1427 2.573 1.538
NCI-H1975 GDSC2 5.0354 9.7416 1.4032 7.8845
NCI-H2141 GDSC2 5.064 6.8644 2.7065 0.9267
NCI-H2122 GDSC2 5.0832 6.8027 2.7393 0.7866
Ms-1 GDSC2 5.0914 7.2027 2.5826 1.4192
NCI-H1568 GDSC2 5.0957 7.2868 2.5499 1.5612
NCI-H1341 GDSC2 5.0976 6.8495 2.7274 0.8196
NCI-H2196 GDSC2 5.1041 6.6485 2.8074 0.5377
VMRC-LCD GDSC2 5.1309 8.0382 2.2461 3.0124
NCI-H1781 GDSC2 5.1416 6.7869 2.7706 0.634
NCI-H2081 GDSC2 5.16 7.806 2.363 2.3758
RERF-LC-KJ GDSC2 5.1605 7.0871 2.6619 1.0194
NCI-H1092 GDSC2 5.1758 7.0154 2.6971 0.871
NCI-H522 GDSC2 5.1818 10.5267 1.1267 9.1422
ABC-1 GDSC2 5.1942 7.3498 2.5717 1.3614
NCI-H2009 GDSC2 5.1993 8.7589 1.9629 4.4265
NCI-H1623 GDSC2 5.2009 7.8824 2.3517 2.3789
NCI-H2087 GDSC2 5.2034 8.02 2.2936 2.6663
SK-LU-1 GDSC2 5.2064 7.0234 2.7074 0.8091
NCI-H446 GDSC2 5.2076 6.9642 2.7309 0.7246
NCI-H2869 GDSC2 5.21 8.3989 2.1307 3.5032
HCC827 GDSC2 5.2225 7.8011 2.3977 2.1271
NCI-H2810 GDSC2 5.2358 7.4167 2.5643 1.3523
NCI-H2110 GDSC2 5.2425 10.0105 1.4107 7.433
LK-2 GDSC2 5.2511 11.7869 0.5693 12.0112
NCI-H82 GDSC2 5.2566 7.0328 2.7255 0.709
SW1271 GDSC2 5.2589 7.8232 2.407 2.0387
NCI-H290 GDSC2 5.278 6.8196 2.8144 0.4204
NCI-H196 GDSC2 5.2787 6.7257 2.8488 0.3302
A-427 GDSC2 5.2802 8.35 2.1913 3.0832
Calu-6 GDSC2 5.2815 7.3252 2.6223 1.0713
NCI-H2066 GDSC2 5.2854 7.1903 2.6771 0.8596
NCI-H2804 GDSC2 5.2886 14.2203 -0.5879 17.4785
NCI-H2030 GDSC2 5.2893 9.1884 1.8209 5.0569
NCI-H2373 GDSC2 5.3005 7.0274 2.7461 0.6118
CPC-N GDSC2 5.3025 7.2312 2.6687 0.8775
SBC-3 GDSC2 5.3087 7.4574 2.582 1.2091
NCI-H1355 GDSC2 5.3143 9.6258 1.6352 6.0431
NCI-H64 GDSC2 5.3411 7.1137 2.7304 0.6368
DMS 53 GDSC2 5.3461 7.3379 2.6462 0.9266
NCI-H2342 GDSC2 5.3576 8.1638 2.3132 2.3689
NCI-H1299 GDSC2 5.3577 11.5257 0.7675 10.7352
NCI-H211 GDSC2 5.3615 7.5599 2.5653 1.2289
ChaGo-K-1 GDSC2 5.3656 10.6373 1.195 8.3944
NCI-H3255 GDSC2 5.3731 7.1128 2.744 0.5744
NCI-H2595 GDSC2 5.3774 7.9183 2.4265 1.8124
NCI-H2135 GDSC2 5.3989 6.7695 2.8785 0.2203
NCI-H2085 GDSC2 5.4003 7.3566 2.6626 0.8262
SW1573 GDSC2 5.4031 8.795 2.0634 3.5704
LOU-NH91 GDSC2 5.4178 7.6114 2.5705 1.1581
EPLC-272H GDSC2 5.4295 8.0829 2.3838 1.9497
Calu-3 GDSC2 5.4306 7.7364 2.5264 1.3249
NCI-H460 GDSC2 5.4377 11.8625 0.6603 11.1352
NCI-H292 GDSC2 5.4468 7.383 2.6725 0.7596
NCI-H2461 GDSC2 5.4528 9.2146 1.9049 4.3341
NCI-H2731 GDSC2 5.4563 7.7639 2.5273 1.2978
UMC-11 GDSC2 5.4644 7.1251 2.7762 0.4329
A-549 GDSC2 5.4672 7.807 2.515 1.3379
NCI-H650 GDSC2 5.469 7.3134 2.7082 0.6286
NCI-H1792 GDSC2 5.4757 9.6435 1.7245 5.2714
NCI-H1436 GDSC2 5.4782 7.1532 2.7714 0.4391
KNS-62 GDSC2 5.4816 11.7584 0.7394 10.6273
NCI-H1694 GDSC2 5.4885 7.2273 2.7482 0.4981
NCI-H513 GDSC2 5.493 7.661 2.5848 1.0402
RERF-LC-Sq1 GDSC2 5.4943 8.5684 2.2114 2.6933
NCI-H250 GDSC2 5.5107 7.2426 2.7514 0.4776
NCI-H661 GDSC2 5.5193 7.6698 2.593 0.9888
NCI-H1755 GDSC2 5.5407 11.54 0.8823 9.7469
NCI-H358 GDSC2 5.5475 15.2049 -0.8823 18.133
NCI-H1693 GDSC2 5.5526 7.7794 2.5649 1.0676
EBC-1 GDSC2 5.5586 7.8119 2.5548 1.101
Lu-65 GDSC2 5.563 7.71 2.5965 0.9427
NCI-H209 GDSC2 5.5639 7.542 2.6614 0.7193
PC-14 GDSC2 5.5748 7.5008 2.6814 0.6486
NCI-H1869 GDSC2 5.5959 7.6877 2.6193 0.8387
NCI-H2803 GDSC2 5.5963 7.4 2.7276 0.5004
SBC-1 GDSC2 5.6013 7.207 2.7994 0.3172
NCI-H2818 GDSC2 5.6171 7.8455 2.5675 1.0073
NCI-H2170 GDSC2 5.6439 7.5834 2.6788 0.6162
NCI-H2172 GDSC2 5.6636 7.173 2.8345 0.2243
PaCa-3 GDSC2 5.6916 10.0688 1.6589 5.271
NCI-H1963 GDSC2 5.7047 7.395 2.7715 0.3411
NCI-H2722 GDSC2 5.7197 7.3582 2.7902 0.2945
NCI-H727 GDSC2 5.7281 7.9373 2.5801 0.8818
DMS 114 GDSC2 5.7303 7.2434 2.8343 0.2061
HOP-92 GDSC2 5.7601 8.0576 2.5476 0.9725
NCI-H1048 GDSC2 5.7623 7.8249 2.637 0.6751
NCI-H2228 GDSC2 5.7758 8.8869 2.2206 2.3101
IST-SL1 GDSC2 5.8156 8.3985 2.4387 1.3351
EMC-BAC-1 GDSC2 5.8268 8.8802 2.2486 2.1267
NCI-H520 GDSC2 5.8317 13.7103 0.0413 13.4156
NCI-H2369 GDSC2 5.8416 7.2891 2.8581 0.1427
NCI-H1944 GDSC2 5.8532 8.2524 2.5126 1.0289
NCI-H1666 GDSC2 5.8629 13.7667 0.0353 13.3791
HCC44 GDSC2 5.8735 8.3614 2.4791 1.1347
NCI-H1651 GDSC2 5.8966 8.2592 2.5287 0.9419
HOP-62 GDSC2 5.9006 7.8137 2.6962 0.4407
NCI-H1734 GDSC2 5.9023 7.9321 2.6537 0.5509
NCI-H2291 GDSC2 5.906 7.9543 2.647 0.5675
Lu-139 GDSC2 5.9585 7.6585 2.7729 0.253
NCI-H23 GDSC2 5.9821 8.1371 2.6101 0.6326
NCI-H1573 GDSC2 5.9825 7.7799 2.7392 0.3116
EKVX GDSC2 5.985 8.557 2.4519 1.149
COLO 668 GDSC2 5.996 7.937 2.6885 0.4195
SK-MES-1 GDSC2 6.0075 7.8501 2.7238 0.3354
CAL-12T GDSC2 6.0514 20.9739 -3.3455 25.1353
NCI-H748 GDSC2 6.0583 8.1993 2.6176 0.5727
HCC15 GDSC2 6.1095 8.4957 2.5282 0.8062
HARA [Human squamous cell lung carcinoma] GDSC2 6.1306 12.4106 0.8505 8.7927
LC-2/ad GDSC2 6.142 8.202 2.6492 0.4535
COR-L311 GDSC2 6.1496 8.2004 2.6527 0.4421
NCI-H322M GDSC2 6.161 8.1095 2.6894 0.3551
RERF-LC-MS GDSC2 6.1979 7.9278 2.7661 0.2021
EMC-BAC-2 GDSC2 6.2409 8.0482 2.7401 0.234
NCI-H1838 GDSC2 6.242 7.9976 2.7578 0.2048
NCI-H2347 GDSC2 6.2771 8.4717 2.604 0.507
Lu-99A GDSC2 6.313 8.6303 2.5604 0.6032
NCI-H2591 GDSC2 6.3254 8.3423 2.6684 0.3429
NCI-H3122 GDSC2 6.3537 8.5246 2.6144 0.4505
NCI-H1650 GDSC2 6.379 8.298 2.7035 0.2607
NCI-H441 GDSC2 6.3851 14.4348 0.064 12.2017
NCI-H2405 GDSC2 6.4268 8.7716 2.5535 0.5684
NCI-H841 GDSC2 6.462 8.27 2.7425 0.1798
Lu-135 GDSC2 6.5261 8.109 2.8184 0.0841
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.6198 6.7615 2.5254 2.2924
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-6 GDSC2 4.0457 6.849 2.1191 5.7486
TE-11 GDSC2 4.212 5.9187 2.669 2.1517
TE-9 GDSC2 4.2973 6.1875 2.5973 2.4085
OE19 GDSC2 4.501 13.281 -0.7124 19.921
KYSE-510 GDSC2 4.5783 10.6459 0.6469 13.143
TE-5 GDSC2 4.751 6.6985 2.6233 1.6175
TE-1 GDSC2 4.8255 6.8927 2.5791 1.7392
KYSE-180 GDSC2 4.9487 6.8712 2.6498 1.2712
T.T GDSC2 4.9628 7.2682 2.4902 2.0009
OE21 GDSC2 5.0397 7.7687 2.3143 2.7884
KYSE-450 GDSC2 5.2585 7.1876 2.6663 0.9208
TE-10 GDSC2 5.3709 7.4711 2.6049 1.0633
EC-GI-10 GDSC2 5.3752 7.6267 2.5448 1.3006
KYSE-150 GDSC2 5.3781 6.9768 2.7964 0.4202
OE33 GDSC2 5.4068 9.3188 1.8312 4.8047
KYSE-410 GDSC2 5.5126 7.5723 2.6279 0.8677
COLO 680N GDSC2 5.5276 11.1286 1.0681 8.7719
TE-4 GDSC2 5.6245 7.5363 2.6885 0.5982
TE-15 GDSC2 5.7128 9.3813 1.9763 3.5779
KYSE-270 GDSC2 5.7631 8.1344 2.5191 1.073
KYSE-140 GDSC2 5.9663 8.1551 2.597 0.6793
TE-8 GDSC2 6.0145 8.488 2.4913 0.9885
KYSE-70 GDSC2 6.554 15.5953 -0.3753 13.8727
KYSE-520 GDSC2 6.5883 8.7426 2.6249 0.3455
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Caov-3 GDSC2 4.61 6.5555 2.6104 1.8644
TYK-nu GDSC2 4.694 8.9119 1.5712 7.6207
OVK18 GDSC2 4.7093 6.8132 2.5519 2.0265
OAW42 GDSC2 4.7777 5.9209 2.9457 0.3087
OVISE GDSC2 4.8748 6.1832 2.8876 0.4249
OV56 GDSC2 4.8868 6.1353 2.9103 0.3519
OVKATE GDSC2 4.9337 7.8254 2.2293 3.4002
OAW28 GDSC2 4.9627 7.3209 2.4675 2.1133
IGROV-1 GDSC2 4.9705 9.2289 1.6034 6.8693
OVCAR-8 GDSC2 5.1559 7.7828 2.3708 2.3426
A2780 GDSC2 5.1828 7.878 2.344 2.4404
ES-2 GDSC2 5.1938 6.5484 2.88 0.29
TOV-21G GDSC2 5.206 7.1388 2.662 0.9801
OVCAR-3 GDSC2 5.2647 9.7227 1.5594 6.5569
Kuramochi GDSC2 5.3178 7.6709 2.4996 1.5495
OC 314 GDSC2 5.3317 7.2598 2.6704 0.8491
EFO-27 GDSC2 5.3836 7.1818 2.7224 0.636
DOV13 GDSC2 5.4025 7.213 2.7184 0.6369
OVCAR-4 GDSC2 5.4054 8.0151 2.4001 1.9018
Caov-4 GDSC2 5.4229 7.8559 2.4743 1.5525
JHOS-4 GDSC2 5.5203 7.714 2.5762 1.0509
EFO-21 GDSC2 5.5332 10.7677 1.241 7.8195
OVCAR-5 GDSC2 5.5872 12.0722 0.6601 10.827
RMG-I GDSC2 5.6148 7.8451 2.5667 1.012
SK-OV-3 GDSC2 5.6182 7.4636 2.7129 0.5304
FU-OV-1 GDSC2 5.7393 7.4712 2.7574 0.3601
TOV-112D GDSC2 5.7915 8.3841 2.4335 1.3765
JHOS-2 GDSC2 5.9066 7.5224 2.8014 0.2164
OV-90 GDSC2 5.9462 7.5822 2.7949 0.217
OVTOKO GDSC2 6.3866 8.7286 2.5535 0.5868
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 766T GDSC2 4.209 6.8774 2.218 4.7904
Panc 04.03 GDSC2 4.5661 6.6812 2.5308 2.3438
YAPC GDSC2 4.7833 6.4204 2.7549 0.9839
PSN1 GDSC2 4.8415 6.8508 2.6052 1.5948
HuP-T4 GDSC2 4.8575 7.2071 2.4605 2.2898
BxPC-3 GDSC2 4.8615 7.3471 2.4013 2.591
DAN-G GDSC2 4.8792 6.7557 2.6637 1.2827
MIA PaCa-2 GDSC2 4.9466 7.5562 2.3564 2.7029
PL4 GDSC2 5.0345 12.0399 0.2946 13.9138
Panc 08.13 GDSC2 5.1149 7.0979 2.6365 1.1642
KP-2 GDSC2 5.1183 6.9666 2.6906 0.9429
HPAC GDSC2 5.1716 9.8526 1.4394 7.4086
PaTu 8988t GDSC2 5.2577 6.3993 2.9556 0.1242
KP-4 GDSC2 5.2811 6.7431 2.8434 0.3425
Panc 03.27 GDSC2 5.2918 7.6786 2.4838 1.6468
PaTu 8902 GDSC2 5.3401 6.6435 2.9009 0.195
Panc 02.03 GDSC2 5.3981 7.6218 2.5574 1.228
SUIT-2 GDSC2 5.4038 6.9779 2.806 0.3828
KP-3 GDSC2 5.4101 7.842 2.4739 1.5673
SW1990 GDSC2 5.4159 8.4308 2.2293 2.7064
AsPC-1 GDSC2 5.5401 8.919 2.0842 3.2687
QGP-1 GDSC2 5.5479 7.2638 2.7584 0.4405
Panc 10.05 GDSC2 5.626 9.8376 1.7249 5.0232
HuP-T3 GDSC2 5.7955 7.8602 2.6374 0.6549
SU.86.86 GDSC2 5.8133 7.3766 2.8181 0.212
Capan-1 GDSC2 5.878 7.8901 2.6595 0.5471
MZ-PC-1 GDSC2 5.9076 8.216 2.5498 0.8633
KP-1N GDSC2 5.9227 8.2503 2.5431 0.8756
Capan-2 GDSC2 6.0618 13.2274 0.4241 11.0847
CFPAC-1 GDSC2 6.1319 7.519 2.8807 0.0735
HPAF-II GDSC2 6.2481 8.6768 2.5173 0.7592
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 4.8516 7.3131 2.4108 2.5557
IST-Mes1 GDSC2 5.0426 8.2294 2.1106 3.8734
NCI-H2452 GDSC2 5.1454 8.6051 2.0008 4.307
MSTO-211H GDSC2 5.2421 8.3082 2.1887 3.1507
NCI-H2052 GDSC2 5.3855 7.5009 2.5997 1.0712
NCI-H28 GDSC2 5.6969 7.4334 2.7548 0.3834
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2 4.4799 7.3142 2.1886 4.4227
LNCaP clone FGC GDSC2 4.5362 8.5167 1.6536 7.4727
NCI-H660 GDSC2 5.0047 6.6108 2.7796 0.6995
DU145 GDSC2 5.6527 7.557 2.6922 0.5716
PC-3 GDSC2 6.054 8.1101 2.6484 0.4934
22Rv1 GDSC2 6.2396 8.4027 2.6145 0.4972
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 6.0441 7.6833 2.7952 0.1923
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A101D GDSC2 3.9995 6.4295 2.2902 4.8051
WM115 GDSC2 4.3823 6.6054 2.4572 3.0518
A-431 GDSC2 4.4352 7.6317 2.0093 5.5698
WT2-iPS GDSC2 4.4469 6.1065 2.7177 1.5415
IGR-37 GDSC2 4.488 7.458 2.1262 4.7724
CP50-MEL-B GDSC2 4.5367 12.7205 -0.4073 18.494
RVH-421 GDSC2 4.6383 6.2675 2.7477 1.1645
LOX-IMVI GDSC2 4.6731 6.5314 2.6542 1.5642
SK-MEL-28 GDSC2 4.6862 5.8357 2.9404 0.3734
RPMI-7951 GDSC2 4.6885 6.5991 2.6333 1.6467
WM278 GDSC2 4.7551 9.3787 1.3887 8.5538
SK-MEL-2 GDSC2 4.7886 5.7421 3.0138 0.1459
WM35 GDSC2 4.7934 9.0623 1.566 7.4427
A-388 GDSC2 4.8053 7.0744 2.4901 2.2106
UACC-257 GDSC2 4.8098 6.9366 2.5522 1.8916
WM793 GDSC2 4.8289 7.8878 2.1391 4.072
SK-MEL-24 GDSC2 4.8367 7.2073 2.4491 2.3779
COLO 792 GDSC2 4.9266 8.8373 1.7593 6.0586
A2058 GDSC2 4.9371 6.2244 2.8975 0.362
IST-MEL1 GDSC2 4.9418 7.5427 2.3597 2.6925
COLO 829 GDSC2 4.9694 9.6565 1.4 8.0377
MeWo GDSC2 5.0026 6.6225 2.7741 0.7208
WM1552C GDSC2 5.0058 7.3421 2.481 1.9917
451Lu GDSC2 5.0427 10.2733 1.1546 9.2762
G-361 GDSC2 5.0801 12.1157 0.2902 13.8315
UACC-62 GDSC2 5.0808 6.3103 2.9221 0.2372
LB2518-MEL GDSC2 5.1071 6.7657 2.764 0.6804
SK-MEL-30 GDSC2 5.1075 6.2117 2.9664 0.1424
A-375 GDSC2 5.1218 7.119 2.6312 1.1796
COLO 800 GDSC2 5.1392 13.121 -0.158 15.8826
LB373-MEL-D GDSC2 5.1415 6.1576 2.9969 0.0898
GAK GDSC2 5.1477 6.4594 2.8943 0.275
IGR-1 GDSC2 5.1621 6.7906 2.7779 0.5965
SH-4 GDSC2 5.1955 8.052 2.2754 2.7696
COLO 679 GDSC2 5.2403 6.9935 2.7336 0.6925
CHL-1 GDSC2 5.2897 7.8036 2.4308 1.891
SK-MEL-1 GDSC2 5.2963 6.6115 2.8961 0.2178
M14 GDSC2 5.3022 7.1563 2.6976 0.7737
IPC-298 GDSC2 5.347 17.466 -2.1415 23.1694
Mel JuSo GDSC2 5.3697 7.1285 2.7367 0.5991
SK-MEL-3 GDSC2 5.3718 6.9857 2.7906 0.439
HMV-II GDSC2 5.3722 11.798 0.6469 11.3436
Mel Ho GDSC2 5.3813 6.9135 2.8206 0.3559
SK-MEL-5 GDSC2 5.4444 6.6034 2.9516 0.0938
Hs 940.T GDSC2 5.4477 7.2444 2.7253 0.588
Hs 938.T GDSC2 5.5252 7.2697 2.7472 0.4819
VMRC-MELG GDSC2 5.5354 6.8065 2.9147 0.1251
G-mel GDSC2 5.5681 7.3893 2.7203 0.5359
COLO 783 GDSC2 5.5697 6.9652 2.8725 0.1824
CP66-MEL GDSC2 5.6567 7.0114 2.8876 0.1387
HT-144 GDSC2 5.672 7.0536 2.8787 0.1485
DJM-1 GDSC2 5.9394 8.1075 2.6038 0.6742
MZ-MEL-2 GDSC2 5.9656 8.0151 2.6484 0.5345
MZ-MEL-7 GDSC2 6.0595 7.7465 2.779 0.2149
SK-MEL-31 GDSC2 6.0764 17.3822 -1.5658 19.6136
MMAc-SF GDSC2 6.2028 20.6997 -3.0986 24.1716
EquiPSC Line K2 GDSC2 4.8982 13.4126 -0.4775 17.914
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 5.0431 8.2529 2.1002 3.9295
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MES-SA GDSC2 4.332 6.7119 2.3766 3.6067
EW-8 GDSC2 4.4098 6.1494 2.6788 1.7926
MFH-ino GDSC2 4.566 7.5965 2.1111 4.7098
Rh41 GDSC2 4.7281 6.6159 2.6466 1.5333
Hs 633.T GDSC2 4.7703 7.579 2.245 3.5795
TE 441.T GDSC2 4.792 6.3617 2.7825 0.8619
RKN GDSC2 4.8042 8.8869 1.6566 6.8938
SW982 GDSC2 4.8165 6.8254 2.6031 1.6345
VA-ES-BJ GDSC2 4.8909 9.0979 1.6135 6.9692
SW872 GDSC2 4.9597 6.8235 2.6746 1.1529
G-401 GDSC2 4.965 7.3727 2.4464 2.2158
Rh30 GDSC2 4.9733 8.1011 2.128 3.8909
KYM-1 GDSC2 5.0256 9.4088 1.5542 7.0425
HT-1080 GDSC2 5.1918 6.6346 2.848 0.3713
SW684 GDSC2 5.3295 6.9261 2.7957 0.4463
GCT GDSC2 5.3333 7.9089 2.4085 1.9448
SK-LMS-1 GDSC2 5.4095 11.2324 0.9419 9.6909
RD GDSC2 5.8144 8.4985 2.3983 1.4976
SK-UT-1 GDSC2 5.9011 7.7219 2.7293 0.3619
G-402 GDSC2 5.9335 8.5501 2.4318 1.2639
STS-0421 GDSC2 6.3102 8.7684 2.5084 0.751
A-204 GDSC2 6.5223 8.7925 2.5827 0.458
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC2 4.2649 5.547 2.8622 1.0609
ECC12 GDSC2 4.4268 6.9825 2.31 3.8159
Fu97 GDSC2 4.4912 7.3857 2.1623 4.5546
MKN7 GDSC2 4.5112 6.7224 2.4808 2.7016
SNU-16 GDSC2 4.5143 8.8499 1.4775 8.5638
OCUM-1 GDSC2 4.6026 7.6749 2.0977 4.7185
TGBC11TKB GDSC2 4.622 8.2443 1.8417 6.1799
MKN1 GDSC2 4.7436 7.1144 2.4385 2.5686
23132/87 GDSC2 4.8362 6.5927 2.7098 1.1242
SCH GDSC2 4.8534 6.5584 2.7319 1.0132
SK-GT-2 GDSC2 4.8567 7.0998 2.5067 2.0571
HSC-39 GDSC2 4.8891 7.2037 2.479 2.1527
ECC10 GDSC2 4.9811 7.6239 2.3456 2.7091
NUGC-3 GDSC2 5.0871 6.6614 2.7955 0.5873
SNU-5 GDSC2 5.3371 6.5703 2.9252 0.1532
NUGC-4 GDSC2 5.4967 7.5459 2.6312 0.8675
GCIY GDSC2 5.5553 7.7339 2.5839 0.9946
IM95 GDSC2 5.5622 8.4712 2.2877 2.2439
NCI-N87 GDSC2 5.5806 9.3447 1.9194 4.0619
Hs 746.T GDSC2 5.6192 7.4834 2.706 0.5496
SNU-1 GDSC2 5.6792 7.3609 2.774 0.3451
KATO III GDSC2 5.7076 7.8466 2.6061 0.808
RF-48 GDSC2 5.725 7.9379 2.5786 0.8894
MKN28 GDSC2 5.7319 8.4451 2.3813 1.6453
HGC-27 GDSC2 5.815 7.4139 2.8058 0.2337
AGS GDSC2 5.8476 7.289 2.8602 0.1387
RERF-GC-1B GDSC2 6.0651 8.8189 2.3849 1.3352
TMK-1 GDSC2 6.1831 8.3804 2.6006 0.5582
SNG-M GDSC2 5.8995 7.7257 2.7273 0.367
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC2 4.5348 6.8106 2.4547 2.8068
8305C GDSC2 4.6061 6.5073 2.6293 1.7742
FTC-133 GDSC2 4.7659 6.4736 2.7248 1.1308
IHH-4 GDSC2 4.7664 6.6843 2.6372 1.532
CAL-62 GDSC2 5.1231 6.6488 2.8152 0.5021
B-CPAP GDSC2 5.2006 6.9766 2.723 0.7574
K5 GDSC2 5.2581 7.6319 2.4866 1.6704
ASH-3 GDSC2 5.3558 6.736 2.8743 0.2427
TT GDSC2 5.3998 6.9869 2.8012 0.3972
BHT-101 GDSC2 5.4629 6.9176 2.8501 0.2567
WRO GDSC2 5.5112 7.7875 2.543 1.1861
ML-1 [Human leukemia] GDSC2 5.5393 7.4582 2.6828 0.6659
HTC-C3 GDSC2 5.6748 8.3511 2.3925 1.6534
KMH-2 GDSC2 5.706 7.2552 2.8213 0.2366
8505C GDSC2 5.8026 7.6453 2.7191 0.426
TT2609-C02 GDSC2 6.2299 7.9179 2.7807 0.1731
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-15A GDSC2 3.7822 5.8947 2.396 4.6522
HO-1-u-1 GDSC2 3.9402 6.8839 2.0262 6.5669
HSC-3 GDSC2 4.3092 7.5478 1.9644 6.1045
HO-1-N-1 GDSC2 4.3501 6.9347 2.2837 4.1154
HSC-2 GDSC2 4.5235 6.553 2.5638 2.2321
Detroit 562 GDSC2 4.5714 7.9237 1.9605 5.5825
BICR 22 GDSC2 4.5867 6.2889 2.7127 1.3878
SCC-4 GDSC2 4.6493 7.0474 2.4146 2.8423
SCC-9 GDSC2 4.6998 13.7445 -0.7903 19.7493
CAL-27 GDSC2 4.7268 6.7577 2.5853 1.8347
SCC-25 GDSC2 4.7513 7.8875 2.0918 4.477
FaDu GDSC2 4.8237 6.4759 2.7513 0.9604
KOSC-2 GDSC2 4.8514 10.5218 0.9033 11.0976
CAL-33 GDSC2 4.9039 7.2824 2.4528 2.2655
OSC-19 GDSC2 4.9231 7.3197 2.447 2.2691
SAS GDSC2 4.9924 7.268 2.5057 1.8888
BB30-HNC GDSC2 5.0425 6.926 2.672 1.0846
JHU-011 GDSC2 5.0655 10.584 1.0211 9.9736
BICR 78 GDSC2 5.0746 7.6507 2.3847 2.3801
HSC-4 GDSC2 5.1185 6.8911 2.7204 0.8293
PE/CA-PJ15 GDSC2 5.1662 7.6526 2.4318 2.032
PCI-30 GDSC2 5.3345 7.1831 2.7012 0.7387
JHU-029 GDSC2 5.3564 7.9089 2.42 1.8651
KON GDSC2 5.3724 9.6903 1.641 5.9074
PCI-04B GDSC2 5.4345 8.7549 2.0984 3.3437
LB771-HNC GDSC2 5.4357 7.9156 2.456 1.6191
BICR 31 GDSC2 5.4898 7.2347 2.746 0.5036
SCC-15 GDSC2 5.509 7.5959 2.6172 0.9084
BICR 10 GDSC2 5.535 7.7983 2.5496 1.1405
BB49-HNC GDSC2 5.565 8.3423 2.3429 1.986
NCI-H3118 GDSC2 5.6023 7.7417 2.6013 0.8968
UPCI-SCC-090 GDSC2 5.6221 7.8933 2.5511 1.064
Ca9-22 GDSC2 5.6724 7.4999 2.7211 0.4804
DOK GDSC2 5.8594 12.9798 0.4087 11.5612
BHY GDSC2 5.8682 7.4613 2.8086 0.2139
OSC-20 GDSC2 5.9077 7.7502 2.7217 0.3768
SKN-3 GDSC2 5.949 8.3077 2.5323 0.8941
JHU-022 GDSC2 5.9633 8.9234 2.2965 1.7795
SAT [Human HNSCC] GDSC2 5.9943 9.2827 2.1641 2.3249
PCI-06A GDSC2 6.5461 8.6831 2.6302 0.3484
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC2 4.2725 5.9949 2.6699 2.0481
BFTC-905 GDSC2 4.6652 6.3723 2.7173 1.2738
KU-19-19 GDSC2 4.7348 6.1226 2.8513 0.6432
RT-4 GDSC2 4.9317 11.7431 0.3658 13.7883
HT-1197 GDSC2 5.1033 6.6218 2.8171 0.5079
647V GDSC2 5.1327 6.569 2.8487 0.3987
CAL-29 GDSC2 5.2943 6.8186 2.8211 0.3942
SW1710 GDSC2 5.3497 7.4335 2.6103 1.0603
HT-1376 GDSC2 5.4695 10.8939 1.1411 8.4871
RT-112 GDSC2 5.4831 9.3318 1.8697 4.4747
J82 GDSC2 5.4951 7.497 2.6494 0.8052
TCCSUP GDSC2 5.5104 8.015 2.4512 1.5649
T24 GDSC2 5.6327 7.41 2.7384 0.4534
SW780 GDSC2 5.7454 7.4572 2.7648 0.3409
UM-UC-3 GDSC2 5.8782 7.6941 2.7305 0.3679
5637 GDSC2 6.7381 8.4561 2.775 0.0987
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-IT GDSC2 3.8927 6.1103 2.3701 4.5555
PA-1 GDSC2 4.3084 6.8985 2.2738 4.2553
NT2-D1 GDSC2 4.3687 6.6031 2.4499 3.117
TC-YIK GDSC2 4.4449 8.4677 1.6142 7.9084
OMC-1 [Human cervical carcinoma] GDSC2 4.459 6.5212 2.5412 2.4544
OVCA433 GDSC2 4.6239 6.9717 2.434 2.7772
PWR-1E GDSC2 4.7049 6.8534 2.532 2.1352
OVCA420 GDSC2 4.7253 6.9055 2.5203 2.1666
DoTc2 4510 GDSC2 4.7915 7.507 2.2901 3.2957
HEC-1 GDSC2 4.8372 6.9651 2.5543 1.8456
MS751 GDSC2 4.8465 8.3969 1.9145 5.318
SiHa GDSC2 4.9084 6.1737 2.9047 0.3564
KGN GDSC2 4.9596 11.6007 0.4553 13.2603
SW756 GDSC2 4.9868 7.3569 2.4648 2.0957
SKG-IIIa GDSC2 5.0553 6.8698 2.7004 0.9583
C-4-I GDSC2 5.0572 6.7282 2.7569 0.7419
UWB1.289 GDSC2 5.0605 7.6561 2.3747 2.4492
NEC8 GDSC2 5.1007 6.9781 2.678 1.0077
JAR GDSC2 5.1107 6.7345 2.7776 0.6314
HeLa GDSC2 5.1897 6.4189 2.9243 0.1958
PEO1 GDSC2 5.2182 7.9731 2.3218 2.5048
C-33 A GDSC2 5.2437 7.9099 2.3623 2.2722
SW954 GDSC2 5.2586 7.1176 2.6936 0.8199
SKN GDSC2 5.3222 8.0246 2.3541 2.2149
LB831-BLC GDSC2 5.4188 7.5378 2.6001 1.0422
HEY GDSC2 5.4394 7.4421 2.6465 0.8549
JHOS-3 GDSC2 5.4569 7.9005 2.4724 1.5268
SiSo GDSC2 5.4731 7.6209 2.5917 1.0302
CAL-39 GDSC2 5.6147 7.6572 2.639 0.7599
HT-3 GDSC2 5.811 7.7207 2.6951 0.4838
SW962 GDSC2 5.8595 7.7207 2.7138 0.4148
DSH1 GDSC2 6.0072 8.1723 2.6071 0.6277
ACC-OV7 GDSC2 6.0797 10.2852 1.7811 4.0561
BPH-1 GDSC2 6.1613 8.8989 2.3961 1.2185
OVMIU GDSC2 6.1868 9.4921 2.1712 2.0925
ME-180 GDSC2 6.3002 14.7501 -0.1413 13.3194
OV17R GDSC2 6.3985 8.7422 2.5532 0.582
JEG-3 GDSC2 6.6586 19.2706 -2.0718 20.1708
Ca Ski GDSC2 6.8462 9.2653 2.5366 0.4409
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
3 Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer. Nat Commun. 2020 Aug 19;11(1):4153. doi: 10.1038/s41467-020-18013-7.
4 Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer. Clin Epigenetics. 2019 Dec 30;11(1):199. doi: 10.1186/s13148-019-0778-y.
5 DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22.