Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLVHAJ)

Drug Name
PX-12 Drug Info
Synonyms PX12, PX 12, IV-2
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
219104
ChEBI ID
CHEMBL406050
CAS Number
CAS 141400-58-0
TTD Drug ID
D04JTD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
C-type lectin receptor signaling pathway 2.12 0.00e+0 93/104 (89.42%) RELB;CLEC7A;CALML5;...
Viral protein interaction with cytokine and cytokine re... 2.05 0.00e+0 84/100 (84%) CCR1;PPBP;IL10RA;...
Tuberculosis 2.04 0.00e+0 159/180 (88.33%) TGFB1;SPHK1;HLA-DQA1;...
Mineral absorption 2.02 0.00e+0 48/60 (80%) HMOX1;MT1F;MT1H;...
Hematopoietic cell lineage 1.99 0.00e+0 90/99 (90.91%) ANPEP;IL7R;HLA-DQA1;...
Intestinal immune network for IgA production 1.96 0.00e+0 38/48 (79.17%) TGFB1;HLA-DQA1;CD86;...
Chemokine signaling pathway 1.96 0.00e+0 163/192 (84.9%) GNG11;CCR1;PPBP;...
Cytokine-cytokine receptor interaction 1.91 0.00e+0 246/295 (83.39%) TNFRSF12A;IL7R;TGFB1;...
Bacterial invasion of epithelial cells 1.90 5.83e-3 59/77 (76.62%) CDC42;PXN;PIK3CD;...
Leishmaniasis 1.87 5.25e-3 67/77 (87.01%) TGFB1;HLA-DQA1;IRAK1;...
Lipid and atherosclerosis 1.84 9.54e-3 190/215 (88.37%) IRAK1;CD36;CCL5;...
NF-kappa B signaling pathway 1.83 8.75e-3 90/104 (86.54%) RELB;LTB;IRAK1;...
Renal cell carcinoma 1.82 9.08e-3 68/69 (98.55%) TGFB1;TGFA;CDC42;...
Salmonella infection 1.76 1.87e-2 198/249 (79.52%) TUBB2A;DYNLT1;IRAK1;...
Yersinia infection 1.75 1.92e-2 120/137 (87.59%) IRAK1;FCGR2A;TICAM1;...
TNF signaling pathway 1.75 1.80e-2 103/112 (91.96%) CCL5;TRAF3;PTGS2;...
Proteasome 1.74 1.70e-2 44/46 (95.65%) POMP;ADRM1;PSMB10;...
Toxoplasmosis 1.73 1.97e-2 103/112 (91.96%) PPIF;TGFB1;HLA-DQA1;...
Kaposi sarcoma-associated herpesvirus infection 1.72 2.07e-2 172/193 (89.12%) CCND1;GNG11;CCR1;...
Chagas disease 1.72 2.10e-2 93/102 (91.18%) TGFB1;IRAK1;CCL5;...
VEGF signaling pathway 1.70 2.44e-2 50/59 (84.75%) SPHK1;PTGS2;CDC42;...
Caffeine metabolism 1.69 2.80e-2 5/6 (83.33%) CYP2A6;NAT2;NAT1
Fc gamma R-mediated phagocytosis 1.69 2.80e-2 79/97 (81.44%) SPHK1;FCGR2A;CDC42;...
Human cytomegalovirus infection 1.68 2.73e-2 201/225 (89.33%) CCND1;GNG11;CCR1;...
Herpes simplex virus 1 infection 1.67 2.89e-2 165/498 (33.13%) HLA-DQA1;IRAK1;CCL5;...
Ribosome biogenesis in eukaryotes 1.66 3.33e-2 52/108 (48.15%) NOP10;DKC1;NXT1;...
Asthma 1.66 3.26e-2 25/31 (80.65%) HLA-DQA1;FCER1G;HLA-DRA;...
Rheumatoid arthritis 1.65 3.37e-2 78/93 (83.87%) TGFB1;HLA-DQA1;LTB;...
Osteoclast differentiation 1.65 3.35e-2 117/127 (92.13%) FOSL1;RELB;TGFB1;...
Inflammatory bowel disease 1.65 3.41e-2 58/65 (89.23%) TGFB1;HLA-DQA1;IFNGR2;...
Steroid biosynthesis -1.94 1.39e-2 19/20 (95%) NSDHL;CYP24A1;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 30uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 30uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 30uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 30uM 6H, 24H
MDST8 CVCL_1400 Homo sapiens 30uM 6H
NCI-H508 CVCL_1561 Homo sapiens 30uM 6H
SNU-1040 CVCL_5001 Homo sapiens 30uM 6H
SNU-C4 CVCL_5008 Homo sapiens 30uM 6H
SNU-C5 CVCL_5009 Homo sapiens 30uM 6H
SW480 CVCL_0546 Homo sapiens 30uM 6H
SW620 CVCL_0547 Homo sapiens 30uM 6H
SW948 CVCL_0550 Homo sapiens 30uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 30uM 6H
HT115 CVCL_1294 Homo sapiens 30uM 6H
RKO CVCL_0504 Homo sapiens 30uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 30uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 30uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 30uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 30uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 30uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 30uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 30uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 30uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 30uM 6H
T3M-10 CVCL_1729 Homo sapiens 30uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 30uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 30uM 6H
HCC515 CVCL_5134 Homo sapiens 30uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 30uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 30uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 30uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 30uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OV7 CVCL_1623 Homo sapiens 30uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 30uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 30uM 6H
RMUG-S CVCL_1666 Homo sapiens 30uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 30uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 30uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 30uM 6H
PL-21 CVCL_2161 Homo sapiens 30uM 6H
SKM-1 CVCL_0010 Homo sapiens 30uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 30uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 30uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 30uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 30uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 30uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 30uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 30uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H