General Information of Drug (ID: DMM0LRE)

Drug Name
TGX-221 Drug Info
Synonyms TGX 221
Cross-matching ID
PubChem CID
9907093
ChEBI ID
CHEMBL1972466
CAS Number
CAS 663619-89-4
TTD Drug ID
D06DNH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.01 0.00e+0 76/85 (89.41%) SERPINA1;TFPI;F5;...
Fanconi anemia pathway 1.90 2.13e-2 36/54 (66.67%) BRCA1;RMI1;USP1;...
DNA replication 1.87 1.42e-2 34/36 (94.44%) MCM3;FEN1;RFC4;...
Mismatch repair 1.84 1.42e-2 22/23 (95.65%) MSH6;RFC4;MSH2;...
Butanoate metabolism 1.81 1.70e-2 23/28 (82.14%) ACAT1;ACSM3;HMGCS1;...
Glyoxylate and dicarboxylate metabolism 1.80 1.42e-2 23/30 (76.67%) GRHPR;ACAT1;SHMT1;...
Ascorbate and aldarate metabolism 1.80 1.22e-2 15/30 (50%) UGDH;UGT2B28;UGT2B4;...
Homologous recombination 1.75 2.22e-2 35/41 (85.37%) BRCA1;MRE11;POLD4;...
Wnt signaling pathway 1.73 2.68e-2 124/166 (74.7%) LEF1;LGR5;BAMBI;...
Pantothenate and CoA biosynthesis 1.71 3.12e-2 14/21 (66.67%) DPYS;AASDHPPT;DPYD;...
NF-kappa B signaling pathway -1.63 4.06e-2 90/104 (86.54%) TRIM25;BCL2A1;CCL4;...
Leishmaniasis -1.63 4.10e-2 67/77 (87.01%) NOS2;ELK1;JUN;...
Caffeine metabolism -1.64 3.91e-2 5/6 (83.33%) NAT1;XDH;CYP2A6;...
Human cytomegalovirus infection -1.66 3.19e-2 201/225 (89.33%) RAC2;BAK1;GNG4;...
Chagas disease -1.66 3.31e-2 93/102 (91.18%) FOS;MAPK1;AKT3;...
RIG-I-like receptor signaling pathway -1.67 3.34e-2 64/70 (91.43%) CYLD;ISG15;MAP3K1;...
Chemokine signaling pathway -1.67 3.47e-2 163/192 (84.9%) GNG10;CCL7;STAT5B;...
Lipid and atherosclerosis -1.67 3.33e-2 190/215 (88.37%) CYP2A6;SELE;APOA4;...
Kaposi sarcoma-associated herpesvirus infection -1.67 3.36e-2 172/193 (89.12%) MICA;BAK1;GNG4;...
Morphine addiction -1.68 3.39e-2 80/91 (87.91%) GNAI2;GNG3;PDE4C;...
Tuberculosis -1.68 3.49e-2 159/180 (88.33%) RAB7A;CTSS;NOS2;...
Antigen processing and presentation -1.70 3.24e-2 60/78 (76.92%) TAPBP;KIR2DL1;HLA-DRB1;...
Measles -1.70 3.42e-2 133/139 (95.68%) APAF1;AKT2;CD46;...
Autoimmune thyroid disease -1.74 2.25e-2 46/53 (86.79%) IFNA21;GZMB;HLA-DOA;...
Pertussis -1.74 2.31e-2 64/76 (84.21%) CXCL6;NOS2;JUN;...
Pathogenic Escherichia coli infection -1.76 2.00e-2 152/197 (77.16%) MYO1F;JUN;TUBB;...
Toll-like receptor signaling pathway -1.77 2.15e-2 94/104 (90.38%) IFNAR2;TLR1;JUN;...
NOD-like receptor signaling pathway -1.77 2.21e-2 145/181 (80.11%) MFN2;TXN;DEFA6;...
Toxoplasmosis -1.79 1.82e-2 103/112 (91.96%) HLA-DOA;GNAI2;CD40LG;...
Amoebiasis -1.82 1.49e-2 99/102 (97.06%) LAMA2;LAMC3;IL1R2;...
Thyroid hormone synthesis -1.82 1.50e-2 66/75 (88%) CREB3L1;ATP1A1;SLC26A4;...
Endocytosis -1.83 1.37e-2 198/252 (78.57%) ARPC3;CLTC;GRK3;...
Legionellosis -1.86 1.03e-2 51/57 (89.47%) ARF1;CASP7;BNIP3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.88 7.81e-3 62/70 (88.57%) JUN;MAPK8;ATP6V0D1;...
TNF signaling pathway -1.90 6.84e-3 103/112 (91.96%) JUNB;CREB3L2;CX3CL1;...
Salmonella infection -1.91 8.20e-3 198/249 (79.52%) HRAS;FLNC;TXN;...
Cytokine-cytokine receptor interaction -1.94 3.42e-3 246/295 (83.39%) LTBR;TNFRSF11A;IL17A;...
Rheumatoid arthritis -1.96 4.56e-3 78/93 (83.87%) CTLA4;TNFRSF11A;IL17A;...
Protein processing in endoplasmic reticulum -1.96 6.84e-3 127/171 (74.27%) OS9;SSR2;DNAJB2;...
Viral protein interaction with cytokine and cytokine re... -2.11 0.00e+0 84/100 (84%) CX3CL1;CCR3;CXCL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H