Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM7ZXR)

Drug Name
GSK2126458 Drug Info
Synonyms
1086062-66-9; Omipalisib; GSK-2126458; GSK 2126458; UNII-1X8F5A3NA0; 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide; 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide; 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide; 1X8F5A3NA0; Omipalisib (GSK2126458, GSK458); C25H17F2N5O3S; Omipalisib [USAN:INN]
Cross-matching ID
PubChem CID
25167777
ChEBI ID
CHEMBL1236962
CAS Number
CAS 1086062-66-9
TTD Drug ID
D03EZE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mitophagy 2.18 0.00e+0 56/68 (82.35%) SQSTM1;ATF4;TBC1D15;...
beta-Alanine metabolism -1.58 3.72e-2 25/30 (83.33%) ACOX3;CNDP2;ACOX1;...
Carbohydrate digestion and absorption -1.58 3.66e-2 37/47 (78.72%) HKDC1;PLCB2;SLC37A4;...
Alanine, aspartate and glutamate metabolism -1.60 3.31e-2 27/37 (72.97%) PPAT;GAD1;GLS2;...
Parkinson disease -1.63 2.66e-2 176/249 (70.68%) PSMD8;BAX;COX6C;...
Arginine and proline metabolism -1.63 2.59e-2 39/50 (78%) P4HA1;AMD1;ALDH1B1;...
Pyruvate metabolism -1.64 2.63e-2 41/47 (87.23%) DLAT;ADH1B;MDH2;...
Propanoate metabolism -1.67 1.76e-2 30/34 (88.24%) SUCLA2;DLD;ACAT2;...
Glyoxylate and dicarboxylate metabolism -1.68 1.68e-2 23/30 (76.67%) MDH2;ACO2;GLDC;...
Drug metabolism -1.69 1.55e-2 78/151 (51.66%) UGT2B28;CYP2C8;UCK2;...
Valine, leucine and isoleucine degradation -1.72 1.28e-2 42/48 (87.5%) ALDH1B1;DLD;IVD;...
Oxidative phosphorylation -1.72 1.30e-2 93/133 (69.92%) COX11;ATP5MG;ATP5ME;...
Nucleotide excision repair -1.73 1.23e-2 40/47 (85.11%) RPA1;RAD23A;CETN2;...
Protein processing in endoplasmic reticulum -1.74 1.15e-2 127/171 (74.27%) LMAN2;BAX;SEC23A;...
Prion disease -1.75 1.22e-2 209/273 (76.56%) PSMD8;BAX;COX6C;...
Spliceosome -1.80 5.06e-3 101/150 (67.33%) DDX46;THOC1;PPIH;...
Pentose phosphate pathway -1.83 4.20e-3 25/30 (83.33%) RBKS;PFKL;ALDOA;...
Fructose and mannose metabolism -1.85 4.49e-3 30/33 (90.91%) PFKL;ALDOA;ALDOB;...
Ribosome biogenesis in eukaryotes -1.85 4.84e-3 52/108 (48.15%) SNU13;RCL1;RPP40;...
Base excision repair -1.86 5.24e-3 29/33 (87.88%) POLD1;POLE3;TDG;...
Glycine, serine and threonine metabolism -1.90 5.72e-3 31/40 (77.5%) BHMT;GLDC;PSPH;...
Biosynthesis of unsaturated fatty acids -1.91 6.29e-3 21/27 (77.78%) HACD2;ACAA1;HSD17B12;...
Cysteine and methionine metabolism -1.93 4.00e-3 43/50 (86%) GSS;MDH2;DNMT1;...
Glutathione metabolism -1.95 4.49e-3 43/57 (75.44%) RRM1;GGCT;GSTA3;...
Terpenoid backbone biosynthesis -1.96 5.14e-3 18/22 (81.82%) MVK;HMGCR;ACAT2;...
Glycolysis / Gluconeogenesis -1.97 4.49e-3 56/67 (83.58%) FBP1;DLAT;ADH1B;...
Proteasome -2.03 0.00e+0 44/46 (95.65%) PSMA7;PSMD13;POMP;...
Mismatch repair -2.13 0.00e+0 22/23 (95.65%) SSBP1;RPA1;MLH1;...
Citrate cycle (TCA cycle) -2.16 0.00e+0 30/30 (100%) DLAT;SDHB;MDH2;...
DNA replication -2.35 0.00e+0 34/36 (94.44%) RNASEH2B;RNASEH2A;SSBP1;...
Steroid biosynthesis -2.42 0.00e+0 19/20 (95%) HSD17B7;SC5D;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H