Details of the Drug

General Information of Drug (ID: DMM7ZXR)

Drug Name
GSK2126458
Synonyms
1086062-66-9; Omipalisib; GSK-2126458; GSK 2126458; UNII-1X8F5A3NA0; 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide; 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide; 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide; 1X8F5A3NA0; Omipalisib (GSK2126458, GSK458); C25H17F2N5O3S; Omipalisib [USAN:INN]
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 505.5
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C25H17F2N5O3S
IUPAC Name
2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide
Canonical SMILES
COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
InChI
InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
InChIKey
CGBJSGAELGCMKE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
25167777
ChEBI ID
CHEBI:95093
CAS Number
1086062-66-9
UNII
1X8F5A3NA0
DrugBank ID
DB12703
TTD ID
D03EZE
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Post-Translational Modifications [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [3]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Post-Translational Modifications [4]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lymphoma
ICD Disease Classification 2A80-2A86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -4.5322 2.2009 -6.9478 33.1518
ES5 GDSC1 -10.4395 -5.8829 -10.5494 79.2308
EW-1 GDSC1 -9.785 -6.2473 -9.8309 77.6351
EW-18 GDSC1 -9.1572 -5.123 -9.2791 70.8848
ES1 GDSC1 -9.1078 -3.3396 -9.5705 66.6477
EW-11 GDSC1 -8.8894 -4.6988 -9.053 68.1718
MHH-ES-1 GDSC1 -8.6879 -4.1629 -8.9291 65.7205
ES7 GDSC1 -8.201 -3.8161 -8.4715 61.6171
EW-7 GDSC1 -8.1035 -4.5907 -8.2271 61.9244
ES8 GDSC1 -7.7016 -3.3466 -8.0353 57.0064
EW-16 GDSC1 -7.3568 -2.1797 -7.9935 53.371
NOS-1 [Human HNSCC] GDSC1 -7.1923 4.0528 -10.4115 51.0535
G-292 clone A141B1 GDSC1 -7.1236 3.9275 -10.2852 50.7455
ES4 GDSC1 -7.0855 2.733 -9.7009 50.6283
SK-ES-1 GDSC1 -6.7564 -1.097 -7.7295 48.2972
TC-71 GDSC1 -6.5444 -4.1053 -6.6294 45.0183
SJSA-1 GDSC1 -6.2994 -0.0477 -7.6716 44.9652
CADO-ES1 GDSC1 -5.8174 -1.3726 -6.6219 39.2599
EW-3 GDSC1 -5.6996 0.2075 -7.1629 40.1145
ES6 GDSC1 -5.5569 1.8236 -7.7564 40.6972
HuO9 GDSC1 -5.4301 1.2319 -7.3558 39.0583
EW-13 GDSC1 -5.3224 6.6814 -9.8709 42.8457
SK-PN-DW GDSC1 -4.3864 0.3015 -5.8946 27.6222
H-EMC-SS GDSC1 -3.7449 4.5278 -7.3801 31.2912
A-673 GDSC1 -3.215 4.3469 -6.8318 27.1022
HuO-3N1 GDSC1 -2.0321 16.0515 -11.708 35.7035
CHSA0011 GDSC1 -1.344 6.2075 -6.2811 18.2897
CHSA8926 GDSC1 -0.5466 4.2941 -4.8327 7.6841
HOS GDSC1 -0.081 1.488 -3.467 0.1558
EW-24 GDSC1 0.0691 1.4251 -3.3958 0.0562
NY GDSC1 0.5137 5.5646 -4.7992 5.5225
CHSA0108 GDSC1 0.5142 7.9758 -5.8801 11.597
CAL-72 GDSC1 0.6827 2.2699 -3.4688 0.0576
MG-63 GDSC1 0.775 2.2217 -3.4233 0.028
SaOS-2 GDSC1 0.8274 8.4639 -5.9142 11.1407
CAL-78 GDSC1 0.836 2.8181 -3.5977 0.1654
U2OS GDSC1 0.8961 14.1927 -8.5788 22.1159
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -3.0331 10.9947 -10.0022 35.4998
GDM-1 GDSC1 -11.2733 -8.6979 -11.2752 91.6528
HAL-01 GDSC1 -11.2613 -7.0442 -11.3116 85.463
SU-DHL-16 GDSC1 -11.1898 -9.8703 -11.1899 96.067
SU-DHL-6 GDSC1 -11.1006 -9.4328 -11.1006 94.2289
NU-DUL-1 GDSC1 -10.7561 -8.4616 -10.7573 89.5834
RS4;11 GDSC1 -10.7046 -4.3233 -11.0833 75.6111
YT GDSC1 -10.4693 -2.1487 -11.3915 70.0983
Kasumi-1 GDSC1 -10.3474 -7.1957 -10.3641 83.3977
NALM-6 GDSC1 -10.347 -7.3713 -10.3586 84.0332
EB2 GDSC1 -10.2951 -2.7311 -11.0298 70.6137
SIG-M5 GDSC1 -10.2694 -7.6687 -10.2743 84.7921
697 GDSC1 -10.1763 -5.222 -10.3534 76.2282
Karpas-231 GDSC1 -10.0375 -6.1968 -10.0976 78.6705
P30/OHK GDSC1 -9.929 -3.5076 -10.4241 70.8523
MOLP-8 GDSC1 -9.8992 -6.6434 -9.9265 79.4918
NKM-1 GDSC1 -9.8521 -3.0363 -10.4619 69.5394
PL-21 GDSC1 -9.4825 -3.6901 -9.8938 69.2717
OCI-Ly19 GDSC1 -9.4481 -3.2386 -9.9675 68.1654
ML-2 GDSC1 -9.3862 -6.3951 -9.4103 75.7678
BL-41 GDSC1 -9.2821 -5.9533 -9.3282 73.8564
SUP-M2 GDSC1 -9.2746 -4.8651 -9.4406 70.9373
QIMR-WIL GDSC1 -9.2038 -1.843 -10.1102 64.577
MOLM-13 GDSC1 -9.1103 -2.7573 -9.7296 65.5993
MLMA GDSC1 -9.0777 -5.3503 -9.1677 70.9443
ARH-77 GDSC1 -8.9823 -1.5351 -9.9716 63.0806
SK-MM-2 GDSC1 -8.8596 -2.6966 -9.4733 64.1638
SU-DHL-5 GDSC1 -8.8464 -7.5684 -8.8465 73.3207
Namalwa GDSC1 -8.8155 -4.1843 -9.0631 66.603
Reh GDSC1 -8.784 -5.0868 -8.8868 68.2955
Ku812 GDSC1 -8.7363 -7.3336 -8.7365 71.8934
RPMI-6666 GDSC1 -8.7077 -2.4262 -9.3873 62.8993
ALL-PO GDSC1 -8.7066 -3.2883 -9.1459 64.2548
LC4-1 GDSC1 -8.6737 0.5475 -10.4123 59.364
CESS GDSC1 -8.6172 -4.2103 -8.8436 65.3265
Farage GDSC1 -8.5492 -5.5124 -8.597 67.3223
OCI-AML-5 GDSC1 -8.5243 -4.7349 -8.6565 65.638
HH [Human lymphoma] GDSC1 -8.4039 2.0248 -10.7402 57.1106
SU-DHL-10 GDSC1 -8.2129 -7.1346 -8.2129 65.5667
RPMI-8402 GDSC1 -8.1965 -5.4026 -8.2004 90.384
SUP-B15 GDSC1 -8.1944 -3.2198 -8.6046 60.7431
OCI-M1 GDSC1 -8.1646 -2.4616 -8.7847 59.5998
NB4 GDSC1 -8.0313 -3.0536 -8.4702 59.3415
HL-60 GDSC1 -7.906 -2.5839 -8.4661 57.9161
Mono-Mac-6 GDSC1 -7.831 -0.5245 -9.0964 55.7963
GR-ST GDSC1 -7.8239 -2.7425 -8.3302 57.4512
MN-60 GDSC1 -7.8188 -2.3537 -8.441 57.0664
KMOE-2 GDSC1 -7.7363 -3.5655 -8.0213 57.5034
SR GDSC1 -7.6133 -1.4367 -8.5245 54.9365
MC116 GDSC1 -7.5441 -6.5915 -7.5441 57.2265
CCRF-CEM GDSC1 -7.5328 -4.5514 -7.6235 56.3639
Karpas-422 GDSC1 -7.5037 -0.5972 -8.7192 53.7753
CA46 GDSC1 -7.4959 -2.1236 -8.1629 54.4569
WIL2 NS GDSC1 -7.4131 -3.1629 -7.7669 54.3285
NOMO-1 GDSC1 -7.3969 -2.618 -7.9009 53.9046
SU-DHL-8 GDSC1 -7.3896 8.9379 -12.9127 51.3919
TUR GDSC1 -7.381 -4.6064 -7.4553 54.7639
TK [Human B-cell lymphoma] GDSC1 -7.3777 2.7189 -9.9902 52.1083
LP-1 GDSC1 -7.3064 -1.7038 -8.0989 52.7872
KMS-12-BM GDSC1 -7.2999 -0.0583 -8.7163 52.2616
SUP-HD1 GDSC1 -7.241 -2.7414 -7.6946 52.5838
Hs 445 GDSC1 -7.2069 5.0267 -10.8785 51.0381
L-363 GDSC1 -7.1412 -2.3058 -7.7185 51.5798
AMO1 GDSC1 -7.1225 -0.5789 -8.3206 51.1475
MOLT-4 GDSC1 -7.1136 -3.1381 -7.1819 78.8068
MV4-11 GDSC1 -7.0818 -1.9485 -7.7716 51.0068
Ramos.2G6.4C10 GDSC1 -7.0745 -4.8233 -7.111 51.3048
ST486 GDSC1 -6.9608 -1.9665 -7.6344 49.9563
Daudi GDSC1 -6.9422 -3.467 -7.1795 49.7487
Karpas-45 GDSC1 -6.8422 -1.2917 -7.1542 72.3258
RL GDSC1 -6.7409 -3.5119 -6.9505 47.5373
ATN-1 GDSC1 -6.6998 6.703 -9.8027 60.6598
Karpas-620 GDSC1 -6.6877 6.442 -11.0434 48.8785
HC-1 GDSC1 -6.6854 10.6674 -13.0855 49.1311
P32/ISH GDSC1 -6.6409 -3.59 -6.825 46.374
BC-3 GDSC1 -6.6149 -3.5264 -6.8103 46.1003
THP-1 GDSC1 -6.5295 -1.9779 -7.1634 45.9345
KCL-22 GDSC1 -6.5269 -2.2613 -7.065 45.7608
HT GDSC1 -6.5017 -1.8284 -7.1857 45.7414
SU-DHL-1 GDSC1 -6.4739 -1.2359 -7.3746 45.7942
PF-382 GDSC1 -6.3786 -0.8638 -6.7411 69.1381
ALL-SIL GDSC1 -6.372 -0.8582 -6.7352 69.0924
Loucy GDSC1 -6.3206 -3.9486 -6.3265 76.8128
OCI-AML-3 GDSC1 -6.2365 -0.3684 -7.4711 44.2375
VL51 GDSC1 -6.1091 0.2394 -7.5974 43.6112
SU-DHL-4 GDSC1 -6.0987 -4.0641 -6.1595 39.487
KE-37 GDSC1 -6.0718 -2.6945 -6.1286 71.7663
A3/Kawakami GDSC1 -6.0601 -2.4161 -6.5074 40.6131
JJN-3 GDSC1 -6.0074 -0.7717 -7.0641 41.8472
RPMI-8226 GDSC1 -5.9461 -2.9005 -6.2364 38.7059
EJM GDSC1 -5.9191 -0.781 -6.9675 41.0009
KOPN-8 GDSC1 -5.7828 -0.358 -7.0026 40.2015
MOLT-16 GDSC1 -5.77 -1.9311 -5.8918 67.8577
KG-1 GDSC1 -5.7499 -0.4541 -6.9275 39.7763
OPM-2 GDSC1 -5.5907 0.4737 -7.1708 39.4813
Granta-519 GDSC1 -5.4975 2.2502 -7.8981 40.6781
MHH-PREB-1 GDSC1 -5.4777 -1.055 -6.391 36.1538
CTB-1 GDSC1 -5.3861 5.287 -9.2494 42.3571
BALL-1 GDSC1 -5.3138 -0.7242 -6.3597 35.0084
JSC-1 GDSC1 -5.2319 -0.1108 -6.5448 35.2844
K-562 GDSC1 -5.201 0.366 -6.729 35.8106
VAL GDSC1 -5.1399 2.5191 -7.6792 38.3697
Sc-1 GDSC1 -4.9626 0.1574 -6.3948 33.1307
BC-1 GDSC1 -4.9016 -0.731 -5.9324 30.5514
BV-173 GDSC1 -4.6767 -1.5602 -5.3421 25.8191
MY-M12 GDSC1 -4.5568 -0.7379 -5.5791 26.6661
WSU-DLCL2 GDSC1 -4.462 2.5581 -7.0559 33.2162
LAMA-84 GDSC1 -4.3566 3.0519 -7.2 33.2435
HEL GDSC1 -4.2527 -0.3707 -5.4465 24.2956
U266B1 GDSC1 -4.1352 0.4291 -5.7147 25.3715
P12-Ichikawa GDSC1 -4.0293 2.9341 -5.4282 50.4439
OCI-AML-2 GDSC1 -3.7885 -0.2272 -5.0693 19.5906
RPMI-8866 GDSC1 -3.6597 1.1403 -5.6223 22.6606
KM-H2 GDSC1 -3.6301 5.9863 -8.0068 32.8465
MEG-01 GDSC1 -3.5757 0.4201 -5.1904 19.499
EM-2 GDSC1 -3.5138 7.7443 -8.7841 34.4681
SCC-3 GDSC1 -3.4814 -1.0614 -4.3757 13.1241
DND-41 GDSC1 -3.4746 4.3752 -7.0685 29.0735
WSU-NHL GDSC1 -3.4511 5.5424 -7.6308 31.0174
ROS-50 GDSC1 -3.3043 3.4525 -6.4612 25.7606
Jiyoye GDSC1 -3.302 -0.1019 -4.6867 14.7472
Karpas-299 GDSC1 -3.1411 1.1868 -5.1899 17.7273
SUP-T1 GDSC1 -3.1046 10.7101 -8.1018 46.6915
KY821 GDSC1 -3.1002 0.1634 -4.6438 13.6355
DEL GDSC1 -3.0596 1.6985 -5.3765 18.6612
BE-13 GDSC1 -2.9727 2.2459 -5.5774 19.6134
L-428 GDSC1 -2.923 2.3608 -5.5935 19.5271
JURL-MK1 GDSC1 -2.8715 1.2441 -4.9927 15.3383
DG-75 GDSC1 -2.8348 -0.0295 -4.3263 10.2374
CTV-1 GDSC1 -2.7379 6.7175 -5.8274 43.376
MOLT-13 GDSC1 -2.6605 1.3349 -4.8673 13.6924
DB GDSC1 -2.6148 3.6288 -5.9753 20.6622
JVM-3 GDSC1 -2.5894 1.5727 -4.9295 13.894
ME1 GDSC1 -2.472 2.0354 -5.0678 14.4687
P31/FUJ GDSC1 -2.3726 0.7331 -4.3472 8.8855
EoL-1 GDSC1 -1.9963 4.0483 -5.7013 17.0131
U-698-M GDSC1 -1.9434 1.5199 -4.4244 8.2213
RC-K8 GDSC1 -1.9414 0.4473 -3.9129 4.4693
Raji GDSC1 -1.906 2.8155 -5.0278 12.4094
L-1236 GDSC1 -1.6183 6.1325 -6.4466 19.9307
H9 GDSC1 -1.5817 8.3266 -7.504 24.4525
KMS-11 GDSC1 -1.0259 6.7843 -6.334 17.6758
HDLM-2 GDSC1 -0.5907 3.9968 -4.7234 7.077
L-540 GDSC1 -0.0761 11.579 -7.9932 22.3216
A4/Fukuda GDSC1 0.5373 14.1665 -8.8171 23.6246
JVM-2 GDSC1 1.2234 15.4578 -8.9632 22.6255
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 -9.2776 -3.1478 -9.8052 67.1582
KYAE-1 GDSC1 -9.1319 -1.4127 -10.1752 63.6228
OACM5.1 C GDSC1 -8.7876 -2.4288 -9.4736 63.3496
KYSE-50 GDSC1 -7.8473 -2.1106 -8.549 57.0635
KYSE-220 GDSC1 -7.6035 0.1283 -9.1123 54.0904
SK-GT-4 GDSC1 -5.5926 0.8718 -7.3527 39.9674
ESO-26 GDSC1 -5.0974 0.87 -6.8582 35.7012
ESO-51 GDSC1 -4.9992 0.2774 -6.4864 33.726
FLO-1 GDSC1 -2.3326 9.1614 -8.5101 30.0031
TE-12 GDSC1 0.104 17.6832 -10.857 29.5937
HCE-4 GDSC1 0.4788 7.1131 -5.5062 9.6228
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -8.4605 -1.4831 -9.424 60.2931
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1 -8.9367 -3.1125 -9.4425 65.2939
NH-12 GDSC1 -8.5189 0.7586 -10.3334 58.4873
SJNB-7 GDSC1 -6.6353 -5.2446 -6.6391 45.8847
SJNB-6 GDSC1 -4.6318 4.3901 -8.1102 37.0922
SK-N-MC-IXC GDSC1 -4.5444 -2.8589 -4.7189 20.8825
TGW GDSC1 -4.1655 2.3149 -6.6622 30.306
SJNB-13 GDSC1 -4.1461 0.0614 -5.5483 24.4174
KP-N-YS GDSC1 -3.8606 2.0634 -6.2601 27.0811
Kelly GDSC1 -3.7426 0.0231 -5.1484 19.9354
SJNB-10 GDSC1 -3.2217 3.0261 -6.1776 24.0127
SJNB-5 GDSC1 -3.182 5.5133 -7.3868 29.1812
SJNB-12 GDSC1 -2.6768 7.5747 -7.9972 29.5295
GI-ME-N GDSC1 -2.5748 9.6722 -8.962 31.9287
IMR-5 GDSC1 -2.5672 2.8198 -5.5335 17.8718
SK-N-AS GDSC1 -2.2566 9.7039 -8.7197 30.3617
MHH-NB-11 GDSC1 -2.2218 7.4283 -7.5566 26.5722
SK-N-SH GDSC1 -2.2003 7.0404 -7.3461 25.708
GOTO GDSC1 -1.7072 2.4026 -4.6873 9.4736
NB(TU)1 GDSC1 -1.5592 5.2932 -5.9897 17.3484
SK-N-BE(2)-M17 GDSC1 -1.5583 5.5124 -6.0967 17.9334
LA-N-6 GDSC1 -1.2532 8.5146 -7.3487 22.9142
SJNB-17 GDSC1 -0.9324 12.9642 -9.3062 28.3869
CHP-134 GDSC1 -0.8989 9.7963 -7.7169 23.3743
SiMa GDSC1 -0.8503 10.6321 -8.0923 24.5793
CHP-126 GDSC1 -0.4293 8.3818 -6.69 17.8604
KP-N-YN GDSC1 -0.1775 9.487 -7.0494 18.8609
SK-N-FI GDSC1 -0.0807 12.6052 -8.4974 24.0238
CHP-212 GDSC1 -0.0493 9.4755 -6.9556 18.1405
SJNB-14 GDSC1 -0.0086 3.3978 -4.1514 2.6658
SK-N-DZ GDSC1 -0.0011 2.1669 -3.6738 0.5963
NB1 GDSC1 1.8512 13.1653 -7.4575 16.1756
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -5.8361 -0.216 -7.1188 40.853
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T-47D GDSC1 -10.2436 2.5786 -12.8932 63.2086
OCUB-M GDSC1 -8.1005 -5.8487 -8.1141 63.5097
MDA-MB-361 GDSC1 -7.687 -5.2777 -7.7162 58.5265
MDA-MB-453 GDSC1 -7.6331 -4.1312 -7.6588 84.1647
HCC1954 GDSC1 -7.5743 -3.0863 -7.9628 55.7074
BT-474 GDSC1 -7.3783 -3.6421 -7.6149 54.2542
HCC2218 GDSC1 -7.1742 2.8522 -8.7488 65.9871
HCC1569 GDSC1 -6.8373 -0.1029 -8.2111 49.0793
MDA-MB-175-VII GDSC1 -6.6378 -1.495 -7.4529 47.16
UACC-893 GDSC1 -6.5858 -4.2015 -6.6604 45.4873
ZR-75-30 GDSC1 -6.3723 -3.7326 -6.5057 43.1136
HCC1187 GDSC1 -5.8982 0.4789 -7.486 42.0856
YMB-1-E GDSC1 -5.8147 -1.6033 -6.53 38.919
Evsa-T GDSC1 -5.784 -3.3877 -5.9373 36.1023
MDA-MB-330 GDSC1 -5.6821 -2.794 -5.9788 35.6198
BT-20 GDSC1 -5.6746 -0.8164 -6.6963 38.5612
BT-549 GDSC1 -5.4505 0.821 -7.187 38.7124
MDA-MB-468 GDSC1 -5.4247 -0.9062 -6.3977 35.8494
HCC70 GDSC1 -5.3672 -1.7203 -6.0074 33.7026
HCC2157 GDSC1 -5.2725 -2.2689 -5.7028 31.471
HCC1599 GDSC1 -5.2535 0.0038 -5.7281 60.8635
CAL-120 GDSC1 -5.1924 5.1824 -9.0174 41.2213
HCC1419 GDSC1 -4.6848 3.7319 -7.8366 36.6373
CAL-85-1 GDSC1 -4.5026 2.0959 -6.8689 32.7133
DU4475 GDSC1 -4.2918 2.2417 -6.7431 31.2232
HCC1500 GDSC1 -4.2748 2.6647 -6.9346 31.9064
JIMT-1 GDSC1 -4.1967 4.0281 -7.5349 33.6527
CAMA-1 GDSC1 -4.0102 0.1464 -5.4596 23.2172
MRK-nu-1 GDSC1 -3.9989 -3.0382 -4.0743 13.4054
AU565 GDSC1 -3.8657 4.6815 -7.5631 32.3869
BT-483 GDSC1 -3.8307 12.0934 -9.4566 49.5457
CAL-148 GDSC1 -3.5633 0.6353 -5.2857 20.0907
EFM-19 GDSC1 -3.5199 9.2789 -9.5558 36.1249
HCC1937 GDSC1 -3.5168 2.5093 -6.1751 25.1837
HCC1806 GDSC1 -3.4347 0.2589 -4.9838 17.4627
HCC38 GDSC1 -3.3616 3.1647 -6.3669 25.5274
UACC-812 GDSC1 -2.9417 4.9222 -6.8897 26.342
CAL-51 GDSC1 -2.4178 3.8149 -5.911 19.6174
EFM-192A GDSC1 -2.1953 3.9151 -5.7871 18.159
MDA-MB-415 GDSC1 -1.709 3.9742 -5.4522 14.6105
MDA-MB-231 GDSC1 -1.5086 3.6107 -5.1331 11.9828
HDQ-P1 GDSC1 -1.1604 11.0362 -8.525 26.7752
MFM-223 GDSC1 -1.047 6.965 -6.4371 18.2536
COLO 824 GDSC1 -0.9513 7.9401 -6.8446 19.9338
MDA-MB-436 GDSC1 -0.3883 4.585 -4.8708 7.5964
MDA-MB-157 GDSC1 0.0434 7.0813 -5.7578 11.9419
HCC1428 GDSC1 0.1964 8.7557 -6.4471 15.1962
MCF-7 GDSC1 0.2864 2.6099 -3.7229 0.5963
Hs 578T GDSC1 0.6365 2.7005 -3.627 0.251
HCC1395 GDSC1 3.0647 10.895 -3.1259 13.8754
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-247MG GDSC1 -11.8307 -6.9227 -11.9136 86.0548
D-423MG GDSC1 -7.3407 1.8986 -9.5883 52.0737
KS-1 [Human Krukenberg tumour] GDSC1 -6.9666 0.6314 -8.6537 50.0052
GI-1 GDSC1 -6.8923 -3.2164 -7.1852 49.2358
D-566MG GDSC1 -6.8871 -3.2175 -7.1793 49.1813
GaMG GDSC1 -6.7699 -2.591 -7.2255 48.0851
D-336MG GDSC1 -6.759 -1.6124 -7.5405 48.2093
Daoy GDSC1 -6.6135 -2.1456 -7.1975 46.681
YKG-1 GDSC1 -6.422 -2.1693 -6.9817 44.7439
U-118MG GDSC1 -6.329 0.1105 -7.7696 45.2914
8-MG-BA GDSC1 -6.2514 -1.3045 -7.1108 43.681
Becker GDSC1 -5.9196 1.2946 -7.874 42.9347
MOG-G-CCM GDSC1 -5.8116 -0.3008 -7.057 40.5347
U-87MG ATCC GDSC1 -5.7841 1.3887 -7.7809 41.9963
SF295 GDSC1 -5.71 -0.944 -6.6806 38.739
Hs 683 GDSC1 -5.5516 -1.3674 -6.342 36.4239
LN-405 GDSC1 -5.37 0.5932 -7.0022 37.7025
GB-1 GDSC1 -5.3419 1.9344 -7.5972 39.1952
PFSK-1 GDSC1 -5.329 6.9889 -10.0277 43.0394
SF539 GDSC1 -5.3084 -0.1457 -6.6071 35.9758
MOG-G-UVW GDSC1 -5.2542 -0.9829 -6.1875 33.8778
AM-38 GDSC1 -5.2393 -0.5781 -6.346 34.5021
SF126 GDSC1 -5.0958 0.9687 -6.9026 35.8476
KALS-1 GDSC1 -5.0635 0.8333 -6.8076 35.335
NMC-G1 GDSC1 -5.026 1.8667 -7.258 36.6345
A-172 GDSC1 -4.7867 0.821 -6.5299 32.7674
D-502MG GDSC1 -4.7587 5.5853 -8.8142 39.1046
ONS-76 GDSC1 -4.6218 -0.9788 -5.537 26.7529
U-251MG GDSC1 -4.4758 -0.7756 -5.4804 25.6348
M059J GDSC1 -4.4282 0.5743 -6.0648 28.7419
DBTRG-05MG GDSC1 -4.1345 1.186 -6.0812 27.4074
T98G GDSC1 -4.1155 1.1389 -6.0404 27.1032
H4 GDSC1 -4.0924 1.9895 -6.4352 28.9612
Onda 11 GDSC1 -4.0789 1.2651 -6.0679 27.0785
YH-13 GDSC1 -4.0435 0.7497 -5.7835 25.3415
SW1783 GDSC1 -4.0328 1.1327 -5.9604 26.2877
SW1088 GDSC1 -3.9549 3.3342 -6.9738 30.6539
SF268 GDSC1 -3.9196 3.7229 -7.1349 31.1193
DK-MG GDSC1 -3.2629 6.2115 -7.8043 30.8991
Onda 10 GDSC1 -3.1496 2.6688 -5.9376 22.4261
D-392MG GDSC1 -3.1024 2.4201 -5.7734 21.296
KNS-81-FD GDSC1 -2.9419 -0.58 -4.1388 9.157
SNB-75 GDSC1 -2.8749 5.7817 -7.264 27.6277
KINGS-1 GDSC1 -2.7072 9.017 -8.743 31.771
LNZTA3WT4 GDSC1 -2.4469 4.355 -6.2033 21.3214
LN-18 GDSC1 -2.008 1.1164 -4.2744 7.2916
SK-MG-1 GDSC1 -1.3781 4.1076 -5.2827 12.597
D-542MG GDSC1 -0.891 5.9156 -5.8189 14.535
KNS-42 GDSC1 -0.4721 7.7657 -6.4224 16.6744
CAS-1 GDSC1 -0.3936 30.8197 -17.7657 38.7066
42-MG-BA GDSC1 -0.333 15.0241 -9.872 28.3831
D-263MG GDSC1 0.2891 2.3803 -3.6409 0.3828
D283 Med GDSC1 0.3843 1.869 -3.4365 0.0591
LN-229 GDSC1 0.922 8.7187 -5.9739 11.2642
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -4.7594 2.8637 -7.4833 36.0003
TGBC24TKB GDSC1 -3.6379 3.7248 -6.8865 28.9878
TGBC1TKB GDSC1 -2.1259 1.7267 -4.6542 10.4244
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 -6.3617 -2.5103 -6.8056 43.8684
MFE-319 GDSC1 -5.3961 -2.2676 -5.8369 32.9943
MFE-280 GDSC1 -4.7428 9.2744 -10.6233 41.6397
MFE-296 GDSC1 -3.2301 1.962 -5.6533 21.0744
EN GDSC1 -2.8491 2.9555 -5.8298 20.6734
RL95-2 GDSC1 -1.97 1.1416 -4.2606 7.0879
KLE GDSC1 -0.9401 13.0223 -9.3408 28.4946
ESS-1 GDSC1 -0.7925 9.3009 -7.3957 21.8595
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC1 -6.7893 -2.3513 -7.3212 48.3296
NCC021 GDSC1 -6.7335 -0.8429 -7.8036 48.1638
KTCTL-195 GDSC1 -6.3021 -1.0276 -7.2726 44.3598
KTCTL-140 GDSC1 -6.008 -1.4836 -6.7822 41.0999
LB1047-RCC GDSC1 -5.8655 -0.8283 -6.8916 40.43
KTCTL-1M GDSC1 -5.7114 -1.6918 -6.386 37.6643
OS-RC-2 GDSC1 -5.6044 -0.945 -6.5695 37.6598
TK-10 GDSC1 -4.7571 1.4873 -6.8176 33.767
786-O GDSC1 -4.5355 -0.9071 -5.4812 25.9509
SW156 GDSC1 -4.296 1.9019 -6.581 30.5574
UO-31 GDSC1 -4.2335 5.8969 -8.4934 36.3803
769-P GDSC1 -4.2303 1.3923 -6.2713 28.8198
KTCTL-26A GDSC1 -4.002 0.5053 -5.6258 24.2136
Caki-1 GDSC1 -3.5137 7.9847 -8.9041 34.7453
RXF 393L GDSC1 -3.4627 2.8283 -6.2866 25.5337
HA7-RCC GDSC1 -3.4076 1.6604 -5.6567 21.81
VMRC-RCZ GDSC1 -3.4066 2.4499 -6.0493 24.0641
VMRC-RCW GDSC1 -2.1663 4.6829 -6.146 20.0814
KTCTL-13 GDSC1 -2.1209 6.6143 -7.0712 24.3445
ACHN GDSC1 -2.0322 7.292 -7.3389 25.1557
BB65-RCC GDSC1 -1.6621 5.4575 -6.1465 18.5098
KMRC-20 GDSC1 -0.3622 3.7936 -4.5016 5.2351
A-704 GDSC1 -0.2899 4.5213 -4.7845 6.8599
A-498 GDSC1 -0.1568 4.6212 -4.7531 6.4116
SN12C GDSC1 -0.1115 6.3275 -5.5038 10.8426
SW13 GDSC1 -0.0716 2.718 -3.9092 1.5432
BFTC-909 GDSC1 -0.063 4.7164 -4.7425 6.1745
RCC10RGB GDSC1 0.0432 7.9204 -6.1519 14.0594
LB996-RCC GDSC1 0.3999 7.4674 -5.7157 10.945
LB2241-RCC GDSC1 0.6222 2.8313 -3.6768 0.3493
KMRC-1 GDSC1 0.9492 9.7614 -6.4379 13.5227
CAL-54 GDSC1 1.4732 14.4697 -8.3193 20.0756
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 GDSC1 -8.8813 5.4896 -11.5842 67.4787
SNU-81 GDSC1 -6.2078 -0.3418 -7.4522 44.011
C2BBe1 GDSC1 -6.1187 0.3068 -7.6366 43.738
HT-29 GDSC1 -5.7207 4.2599 -9.0703 43.5915
HCT 116 GDSC1 -5.3733 0.629 -7.0219 37.7835
SW626 GDSC1 -5.3595 2.0967 -7.691 39.5107
SNU-407 GDSC1 -5.3261 2.008 -7.6166 39.1603
LS411N GDSC1 -5.3177 -0.2373 -5.7346 61.6384
CCK-81 GDSC1 -4.8929 2.7814 -6.2809 55.9693
LS123 GDSC1 -4.7638 1.5449 -6.8517 33.9291
HCT 15 GDSC1 -4.7194 3.472 -7.7418 36.5414
SW620 GDSC1 -4.6623 2.1688 -5.7993 44.8379
MDST8 GDSC1 -4.6177 -0.0066 -5.976 29.2452
SW948 GDSC1 -4.6096 9.7919 -9.1026 52.3803
LS1034 GDSC1 -4.554 2.845 -7.2817 34.4178
RKO GDSC1 -4.4121 2.9072 -5.821 52.9944
SNU-1040 GDSC1 -4.0622 3.4478 -7.1266 31.6914
COLO205 GDSC1 -3.8826 1.4608 -5.9829 25.7291
T84 GDSC1 -3.7553 4.5057 -7.3782 31.3257
SW837 GDSC1 -3.5786 5.8192 -7.8789 32.277
SW1463 GDSC1 -3.4482 7.835 -8.7733 34.2219
GP5d GDSC1 -3.3831 6.7834 -8.1924 32.4916
SNU-175 GDSC1 -3.1882 8.5023 -8.8862 33.6374
SNU-C5 GDSC1 -2.7592 4.721 -6.6383 24.5667
CaR-1 GDSC1 -2.4641 3.2865 -5.6844 18.4449
LoVo GDSC1 -2.3422 1.9621 -4.9313 13.0865
LS180 GDSC1 -2.2436 5.8817 -6.803 23.571
RCM-1 [Human ESC] GDSC1 -2.1295 4.5809 -6.0669 19.5333
NCI-H716 GDSC1 -2.0763 7.9214 -5.7818 40.3539
KM12 GDSC1 -1.5715 7.0572 -4.8913 36.2831
HCC2998 GDSC1 -1.4222 6.811 -4.6332 34.9174
HT115 GDSC1 -0.7782 3.8779 -4.782 7.8551
LS513 GDSC1 -0.5608 33.0379 -16.9661 44.4871
SW48 GDSC1 -0.3826 12.6709 -6.6348 35.8491
SNU-61 GDSC1 -0.3726 12.0918 -8.4579 24.5905
HT-55 GDSC1 -0.1164 1.4115 -3.4535 0.1432
CL-11 GDSC1 0.0487 5.702 -5.1198 8.2394
COLO 678 GDSC1 0.1714 8.2961 -6.246 14.2505
SW1116 GDSC1 0.5602 2.1985 -3.4859 0.082
SW1417 GDSC1 0.615 14.0588 -8.7101 23.129
SNU-C2B GDSC1 0.8958 12.5165 -5.5043 29.3137
COLO 320HSR GDSC1 1.4621 16.5572 -7.0696 27.6621
SNU-C1 GDSC1 2.0323 16.997 -6.845 29.7842
CW-2 GDSC1 2.6033 16.0213 -5.9324 26.0803
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -3.8953 10.4838 -10.4801 38.8091
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 -8.4494 -0.8749 -9.6279 59.5877
SNU-423 GDSC1 -6.1921 2.1694 -8.547 45.3513
SNU-387 GDSC1 -4.9768 1.9299 -7.2406 36.331
JHH-2 GDSC1 -4.5888 -0.5246 -5.7083 27.6033
SNU-449 GDSC1 -4.5824 -0.2318 -5.8365 28.3008
Huh-7 GDSC1 -2.9573 3.7872 -6.3352 23.8178
SK-HEP-1 GDSC1 -2.8467 -0.6992 -4.0015 7.744
SNU-398 GDSC1 -2.6813 5.4572 -6.9426 25.6498
Hep 3B2.1-7 GDSC1 -2.5535 1.4453 -4.8378 13.1146
JHH-4 GDSC1 -1.6516 1.0485 -4.0122 4.5248
JHH-7 GDSC1 -1.3311 6.0802 -6.2093 17.878
SNU-475 GDSC1 -0.7008 7.5929 -6.4974 17.6293
JHH-6 GDSC1 0.0478 1.6188 -3.4667 0.1311
Hep-G2/C3A GDSC1 0.2714 1.9297 -3.4941 0.1285
HuH-1 GDSC1 0.4252 2.6174 -3.6739 0.4098
HLE GDSC1 0.5491 2.5156 -3.5949 0.2181
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1048 GDSC1 -9.2639 -4.6216 -9.4681 70.2779
SBC-3 GDSC1 -9.1597 -5.0323 -9.2938 70.6746
NCI-H1648 GDSC1 -7.5559 -2.8584 -7.6753 79.5485
NCI-H2085 GDSC1 -7.4898 -1.3945 -8.4064 54.0376
COR-L311 GDSC1 -7.457 -3.6875 -7.6907 55.0417
DMS 273 GDSC1 -7.4472 -2.1194 -8.1113 54.0709
Calu-3 GDSC1 -7.393 -1.9925 -8.0942 53.5814
EPLC-272H GDSC1 -7.3485 -3.0247 -7.7328 53.671
NCI-H446 GDSC1 -7.3272 -2.2065 -7.9526 53.1381
NCI-H64 GDSC1 -7.2686 -5.9811 -7.2694 53.777
CAL-12T GDSC1 -7.1717 -2.5836 -7.6656 51.9123
NCI-H520 GDSC1 -7.1175 -0.7714 -8.2402 51.1369
HARA [Human squamous cell lung carcinoma] GDSC1 -7.0006 0.0066 -8.4277 50.2419
NCI-H647 GDSC1 -6.8455 -2.7712 -7.2546 48.8084
Lu-65 GDSC1 -6.7172 -1.3403 -7.5955 47.9078
LCLC-97TM1 GDSC1 -6.637 1.5618 -8.7203 47.9872
LC-2/ad GDSC1 -6.619 0.0001 -8.025 47.4834
LC-1/sq GDSC1 -6.5845 5.2153 -10.359 48.3033
NCI-H1304 GDSC1 -6.5738 0.5101 -8.1944 47.3006
COR-L23 GDSC1 -6.5669 -2.1268 -7.1532 46.2296
DMS 114 GDSC1 -6.5643 0.7825 -8.3025 47.3135
NCI-H2171 GDSC1 -6.4473 -3.1309 -6.7215 44.3879
COR-L303 GDSC1 -6.4346 -2.1815 -6.9913 44.8658
ABC-1 GDSC1 -6.4311 3.9926 -9.6317 47.3407
COR-L105 GDSC1 -6.4024 -2.3336 -6.9062 44.4302
HCC78 GDSC1 -6.3134 -0.8281 -7.3639 44.5968
NCI-H1876 GDSC1 -6.251 -1.5174 -7.0295 43.5074
NCI-H1703 GDSC1 -6.1872 3.1361 -8.9906 45.7347
NCI-H847 GDSC1 -6.1344 -0.1471 -7.4577 43.5301
Ms-1 GDSC1 -6.1163 0.2966 -7.6297 43.7112
NCI-H358 GDSC1 -6.0902 0.169 -7.5475 43.4039
IST-SL2 GDSC1 -5.8893 -0.9535 -6.8655 40.5157
NCI-H1792 GDSC1 -5.7806 1.4451 -7.8033 42.0193
NCI-H596 GDSC1 -5.6683 1.1825 -7.5705 40.9112
NCI-H1944 GDSC1 -5.6359 1.6467 -7.7522 41.1166
NCI-H3122 GDSC1 -5.4301 1.8571 -7.6473 39.7792
SBC-1 GDSC1 -5.161 0.2595 -6.6403 35.2506
NCI-H2869 GDSC1 -4.9359 0.0138 -6.3023 32.5691
NCI-H2227 GDSC1 -4.854 3.1073 -7.6906 37.0234
NCI-H1781 GDSC1 -4.8512 -1.6121 -5.5036 27.8038
COLO 668 GDSC1 -4.846 3.0479 -7.6542 36.8881
NCI-H1975 GDSC1 -4.771 6.4802 -7.7308 53.7361
NCI-H1437 GDSC1 -4.7483 3.1233 -7.599 36.2808
HCC44 GDSC1 -4.7466 0.1139 -6.1597 30.8645
EMC-BAC-2 GDSC1 -4.5692 2.0914 -6.9295 33.2604
NCI-H1694 GDSC1 -4.5342 7.3154 -9.4656 39.3752
NCI-H524 GDSC1 -4.5048 2.06 -6.8535 32.6639
NCI-H1793 GDSC1 -4.4897 -0.0159 -5.8455 27.8713
NCI-H810 GDSC1 -4.3995 1.3384 -6.4046 30.2623
NCI-H650 GDSC1 -4.3548 3.0315 -7.1883 33.1952
NCI-H211 GDSC1 -4.2785 1.3833 -6.3122 29.2464
LCLC-103H GDSC1 -4.2432 10.1849 -10.6338 40.0731
NCI-H69 GDSC1 -4.1487 6.9587 -8.9453 37.0396
SK-MES-1 GDSC1 -4.0829 3.4496 -7.1462 31.8513
IA-LM GDSC1 -4.0726 -0.2033 -5.3511 22.8103
EBC-1 GDSC1 -4.0061 2.4291 -6.5727 29.2004
Lu-139 GDSC1 -3.9745 2.589 -6.6229 29.2834
NCI-H2081 GDSC1 -3.9387 8.1375 -9.3477 37.0941
NCI-H209 GDSC1 -3.9366 2.7783 -6.6822 29.3766
NCI-H2030 GDSC1 -3.905 3.7702 -7.1453 31.0974
NCI-H841 GDSC1 -3.894 4.2461 -7.3717 31.861
NCI-H727 GDSC1 -3.8806 2.0262 -6.2599 27.1678
NCI-H196 GDSC1 -3.8745 0.5869 -5.5466 23.142
BEN GDSC1 -3.8351 0.0874 -5.266 21.1486
COR-L321 GDSC1 -3.8186 3.2239 -6.7973 29.3625
NCI-H2196 GDSC1 -3.7849 2.1796 -6.2494 26.6976
SBC-5 GDSC1 -3.7299 1.7533 -5.9889 25.09
SHP-77 GDSC1 -3.7142 -0.6788 -4.7803 17.1832
NCI-H526 GDSC1 -3.7098 3.1439 -6.6609 28.3198
PC-14 GDSC1 -3.6077 2.8014 -6.4004 26.691
CPC-N GDSC1 -3.5702 3.9159 -6.9224 28.863
UMC-11 GDSC1 -3.5331 -0.4857 -4.7054 15.841
NCI-H1568 GDSC1 -3.4738 6.2325 -7.9948 32.2416
NCI-H2347 GDSC1 -3.4735 3.089 -6.4261 26.265
EMC-BAC-1 GDSC1 -3.4103 3.3471 -6.4999 26.3633
NCI-H1581 GDSC1 -3.2639 0.97 -5.1873 18.1922
NCI-H1573 GDSC1 -3.2552 4.9737 -7.1792 28.6709
NCI-H2110 GDSC1 -3.2376 1.7987 -5.5781 20.6413
PaCa-3 GDSC1 -3.2133 7.2917 -8.3023 32.2153
NCI-H2135 GDSC1 -3.2115 5.2087 -7.2595 28.8159
IST-SL1 GDSC1 -3.1972 2.4578 -5.8728 22.243
NCI-H1836 GDSC1 -2.9975 3.4649 -6.2076 23.3121
NCI-H226 GDSC1 -2.9604 3.6111 -6.2498 23.3928
HOP-62 GDSC1 -2.9395 2.0214 -5.4376 18.6037
NCI-H2804 GDSC1 -2.923 4.4834 -6.6547 25.2308
HCC827 GDSC1 -2.902 1.4849 -5.1382 16.4674
NCI-H1838 GDSC1 -2.8247 1.1423 -4.9035 14.5318
RERF-LC-MS GDSC1 -2.7881 4.8191 -6.7111 25.0039
Lu-134-A GDSC1 -2.7556 5.3648 -6.9572 25.9698
NCI-H187 GDSC1 -2.6424 7.2309 -7.7972 28.7637
RERF-LC-KJ GDSC1 -2.5643 3.8037 -6.022 20.7457
NCI-H1869 GDSC1 -2.537 7.4635 -7.8276 28.5248
LXF 289 GDSC1 -2.4385 2.9768 -5.5099 17.2811
NCI-H661 GDSC1 -2.4171 6.1297 -7.0648 25.2737
NCI-H1092 GDSC1 -2.3557 4.2472 -6.0773 20.3357
Lu-165 GDSC1 -2.3467 5.581 -6.7349 23.5997
NCI-H510A GDSC1 -2.3461 0.9752 -4.4467 9.5548
NCI-H3255 GDSC1 -2.1695 5.3672 -6.4887 21.852
NCI-H1155 GDSC1 -2.1598 2.426 -5.023 13.1482
DMS 79 GDSC1 -2.1561 5.8069 -6.697 22.803
COR-L95 GDSC1 -2.0528 5.8688 -6.6472 22.2403
NCI-H1435 GDSC1 -2.015 1.2651 -4.3508 7.876
LK-2 GDSC1 -1.9843 4.8912 -6.1093 19.3004
NCI-H2141 GDSC1 -1.9779 14.7592 -11.0191 34.5103
NCI-H2405 GDSC1 -1.9733 5.058 -6.1835 19.6641
NCI-H1436 GDSC1 -1.9546 14.2377 -10.74 33.9763
NCI-H2795 GDSC1 -1.698 6.4157 -6.6464 21.1402
NCI-H2087 GDSC1 -1.685 4.0757 -3.5518 32.3345
Lu-135 GDSC1 -1.6028 9.4092 -8.0573 26.4875
NCI-H2591 GDSC1 -1.5959 4.7431 -5.7468 16.0671
NCI-H2803 GDSC1 -1.3528 3.06 -4.7637 9.083
NCI-H1563 GDSC1 -1.3296 24.8155 -15.5175 38.4774
EKVX GDSC1 -1.3106 8.1307 -5.1829 35.9408
Calu-6 GDSC1 -1.291 5.447 -3.8429 31.6224
NCI-H2444 GDSC1 -1.2885 4.2919 -5.3098 12.5274
HCC33 GDSC1 -1.2609 11.9201 -9.0401 28.5081
NCI-H345 GDSC1 -1.2347 2.1694 -4.2744 5.4451
NCI-H2461 GDSC1 -1.1077 2.9477 -4.5548 7.0756
SK-LU-1 GDSC1 -1.1011 6.1595 -6.0832 16.563
LOU-NH91 GDSC1 -1.0494 3.0933 -4.5862 7.1572
NCI-H1693 GDSC1 -0.9861 6.3703 -4.0197 30.9645
NCI-H322M GDSC1 -0.7734 11.7244 -8.5734 25.934
NCI-H2029 GDSC1 -0.6201 6.7664 -6.043 15.0808
NCI-H2731 GDSC1 -0.5695 16.8468 -10.9528 31.1942
NCI-H2373 GDSC1 -0.4846 12.8095 -8.8933 26.1771
NCI-H2122 GDSC1 -0.4657 8.3561 -4.5503 30.8013
NCI-H2170 GDSC1 -0.4638 5.3546 -5.2716 10.2487
NCI-H2595 GDSC1 -0.4285 6.1155 -5.606 12.1604
NCI-H290 GDSC1 -0.3877 4.0491 -4.6291 6.0765
NCI-H82 GDSC1 -0.3761 3.6174 -4.432 4.8303
NCI-H748 GDSC1 -0.299 13.8629 -9.2743 26.7999
NCI-H2228 GDSC1 -0.2609 17.253 -10.919 30.4734
NCI-H1915 GDSC1 -0.2049 6.3853 -5.5895 11.5469
RERF-LC-Sq1 GDSC1 -0.1772 16.5986 -10.5324 29.515
NCI-H1770 GDSC1 -0.1705 4.8504 -4.8634 7.1154
A-427 GDSC1 -0.1508 4.0929 -4.5172 4.9641
DMS 53 GDSC1 -0.1248 3.238 -4.1418 2.7616
NCI-H1993 GDSC1 -0.095 13.8148 -9.1004 25.8562
NCI-H2722 GDSC1 -0.0914 5.9374 -5.311 9.6669
NCI-H292 GDSC1 -0.0701 5.1306 -4.9313 7.3359
NCI-H23 GDSC1 -0.0576 5.5608 -5.1185 8.4447
NCI-H2369 GDSC1 -0.0314 4.943 -4.8253 6.6185
SW1271 GDSC1 0.0368 9.4816 -6.8999 17.6878
NCI-H2342 GDSC1 0.1036 7.3494 -5.8449 12.2882
NCI-H2818 GDSC1 0.109 5.0192 -4.7806 6.0953
NCI-H2009 GDSC1 0.1238 6.6368 -5.5018 10.3234
NCI-H460 GDSC1 0.192 2.4692 -3.7085 0.601
ChaGo-K-1 GDSC1 0.2114 8.132 -6.143 13.6325
NCI-H2291 GDSC1 0.2401 2.8896 -3.8431 1.0189
NCI-H720 GDSC1 0.2621 2.6395 -3.7428 0.6676
HCC15 GDSC1 0.3717 9.883 -6.8669 16.7658
COR-L88 GDSC1 0.3924 10.3399 -7.0709 17.6165
Lu-99A GDSC1 0.4814 9.6925 -6.7042 15.7783
NCI-H838 GDSC1 0.4851 2.9403 -3.7655 0.6221
NCI-H1651 GDSC1 0.5079 6.0764 -5.0254 6.8282
NCI-H1688 GDSC1 0.5216 7.1808 -5.5117 9.5688
NCI-H441 GDSC1 0.5305 3.3551 -3.8985 1.0234
NCI-H1355 GDSC1 0.5395 6.9541 -5.3987 8.9
A-549 GDSC1 0.5543 4.9782 -4.5294 3.9564
NCI-H513 GDSC1 0.6385 11.7624 -7.5858 19.1736
NCI-H522 GDSC1 0.6626 8.8119 -6.1754 12.8223
NCI-H1623 GDSC1 0.7935 9.3377 -6.3381 13.36
HOP-92 GDSC1 0.7976 3.0028 -3.6732 0.2916
NCI-H2023 GDSC1 0.8207 11.6949 -7.4313 18.1673
NCI-H1734 GDSC1 0.8446 12.7948 -5.684 29.9702
NCI-H1650 GDSC1 1.0166 13.8401 -8.3261 21.0344
NCI-H1755 GDSC1 1.031 12.92 -7.8754 19.4212
NCI-H2172 GDSC1 1.4004 11.1941 -6.8223 14.3906
NCI-H1666 GDSC1 1.7222 21.7312 -9.4416 35.0908
SW1573 GDSC1 1.7791 17.2697 -9.4544 22.9427
NCI-H1299 GDSC1 2.1432 18.7269 -9.9063 23.4662
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -6.9091 -0.3686 -8.1784 49.5847
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 -7.7248 -2.9877 -8.1535 56.888
TE-4 GDSC1 -5.9903 -3.2452 -6.1947 38.8476
KYSE-410 GDSC1 -5.2662 -0.1276 -6.5722 35.5925
KYSE-140 GDSC1 -5.0023 -1.3023 -5.7903 30.3516
TE-15 GDSC1 -4.9417 2.4129 -7.4384 36.7456
KYSE-520 GDSC1 -4.6946 9.3314 -10.6085 41.4668
KYSE-270 GDSC1 -3.8716 -2.1453 -4.2562 14.0164
TE-10 GDSC1 -3.6233 3.396 -6.71 28.1789
TE-5 GDSC1 -3.4741 3.5024 -6.6327 27.2318
T.T GDSC1 -3.38 1.3016 -5.4538 20.4289
OE21 GDSC1 -2.7488 3.1559 -5.8478 20.4128
KYSE-150 GDSC1 -2.4005 6.5593 -7.2658 26.0348
OE33 GDSC1 -1.9086 6.7372 -6.9668 23.2363
KYSE-180 GDSC1 -1.5634 7.2883 -6.9762 22.241
TE-11 GDSC1 -0.5242 5.2357 -5.2542 10.2802
KYSE-70 GDSC1 -0.303 8.9619 -6.8827 18.4322
OE19 GDSC1 -0.1318 3.0186 -4.0557 2.3162
TE-9 GDSC1 0.1662 2.273 -3.6485 0.4486
EC-GI-10 GDSC1 0.1681 2.6404 -3.7799 0.8417
COLO 680N GDSC1 0.198 11.3925 -7.7098 20.6431
TE-1 GDSC1 0.7725 8.7967 -6.1005 12.2142
TE-8 GDSC1 0.8682 7.2695 -5.3518 8.0312
TE-6 GDSC1 1.2465 12.809 -7.6794 18.2393
KYSE-510 GDSC1 1.2639 19.6955 -10.994 27.6047
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 -9.6426 -2.6891 -10.3298 67.9799
IGROV-1 GDSC1 -8.2953 0.4005 -9.953 57.6931
FU-OV-1 GDSC1 -7.8348 0.4548 -9.4887 55.2556
OVISE GDSC1 -7.8299 4.6264 -11.3114 53.6538
SK-OV-3 GDSC1 -6.97 -1.0052 -7.9928 50.0333
OC 314 GDSC1 -6.8302 -1.658 -7.6008 48.8292
OAW42 GDSC1 -6.5571 1.5935 -8.6532 47.4866
TOV-112D GDSC1 -6.4092 -2.0581 -7.0056 44.6871
RMG-I GDSC1 -6.3053 1.2815 -8.2579 45.699
OVCAR-8 GDSC1 -5.9336 -0.7083 -7.0127 41.218
Kuramochi GDSC1 -5.5922 2.8411 -8.2696 41.8507
OAW28 GDSC1 -5.2194 1.5872 -7.3139 37.8037
OVTOKO GDSC1 -5.0864 2.4029 -7.5721 37.8286
EFO-27 GDSC1 -4.9191 -0.638 -5.9915 30.9599
EFO-21 GDSC1 -4.0069 6.184 -8.4348 35.384
OV56 GDSC1 -3.8168 -0.2839 -5.0685 19.7118
OVCAR-5 GDSC1 -3.7665 6.374 -8.3187 34.2047
Caov-3 GDSC1 -3.5791 1.5981 -5.777 23.2433
OVCAR-4 GDSC1 -3.4264 4.7863 -7.232 29.5165
OVK18 GDSC1 -3.4222 3.3577 -6.5155 26.4844
OV-90 GDSC1 -3.2031 4.6647 -6.9805 27.6837
ES-2 GDSC1 -2.5828 0.2273 -4.2555 8.8436
TYK-nu GDSC1 -2.4529 -0.6006 -3.753 4.5782
JHOS-2 GDSC1 -0.7638 4.6994 -5.1555 10.224
OVKATE GDSC1 -0.6246 10.9156 -8.0652 23.912
Caov-4 GDSC1 -0.3692 5.7284 -5.3864 10.7274
TOV-21G GDSC1 -0.2202 10.2208 -7.4347 20.5688
DOV13 GDSC1 0.4617 3.8041 -4.0981 1.8894
OVCAR-3 GDSC1 0.4696 2.2615 -3.5371 0.1499
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 -8.0942 -3.7847 -8.3622 60.7361
HPAC GDSC1 -7.9968 -2.0368 -8.7354 58.0286
Panc 08.13 GDSC1 -7.8547 -1.8295 -8.6497 56.8819
PaTu 8902 GDSC1 -7.3984 -3.4129 -7.6889 54.3266
Panc 10.05 GDSC1 -7.3117 -1.9818 -8.0096 52.9264
SUIT-2 GDSC1 -7.0798 2.5 -9.59 50.6113
HPAF-II GDSC1 -7.0397 3.2166 -9.8748 50.3735
KP-2 GDSC1 -6.5257 -0.8172 -7.5931 46.4466
Panc 03.27 GDSC1 -6.4649 -1.2519 -7.3589 45.7046
DAN-G GDSC1 -5.3433 -0.646 -6.4239 35.4572
HuP-T4 GDSC1 -5.3013 0.5903 -6.932 37.0857
Panc 02.03 GDSC1 -4.8184 3.0827 -7.6451 36.7347
Capan-1 GDSC1 -4.7494 5.4115 -8.7201 38.8905
HuP-T3 GDSC1 -4.4773 5.858 -8.693 37.7564
PaTu 8988t GDSC1 -4.1166 1.8922 -6.4098 28.953
PSN1 GDSC1 -3.9003 4.2528 -7.3807 31.9172
KP-3 GDSC1 -3.7994 3.5454 -6.9397 29.8659
KP-4 GDSC1 -3.7822 7.6721 -8.9795 35.8205
QGP-1 GDSC1 -3.4875 7.9382 -8.8584 34.553
CFPAC-1 GDSC1 -2.9504 2.2469 -5.5593 19.4173
SU.86.86 GDSC1 -2.5694 3.6179 -5.9334 20.2668
BxPC-3 GDSC1 -2.4974 7.0593 -7.5935 27.584
SW1990 GDSC1 -2.3614 1.5611 -4.7474 11.8294
Hs 766T GDSC1 -0.9443 5.5116 -5.6611 13.762
PL4 GDSC1 -0.6484 8.9055 -7.0985 20.2536
AsPC-1 GDSC1 -0.4518 15.8239 -10.3566 29.7381
Capan-2 GDSC1 0.0987 16.8092 -10.4301 28.7129
MIA PaCa-2 GDSC1 0.2451 4.7866 -4.6062 4.8435
YAPC GDSC1 0.9923 14.8761 -8.8423 22.7351
Panc 04.03 GDSC1 1.323 10.8727 -6.7212 14.0901
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 -1.1518 1.8369 -4.077 3.9648
MPP 89 GDSC1 -0.2038 7.0515 -5.902 13.3008
NCI-H28 GDSC1 -0.1643 5.7477 -5.2682 9.5675
IST-Mes1 GDSC1 0.4466 9.5534 -6.6611 15.6551
NCI-H2452 GDSC1 0.4603 2.6412 -3.6694 0.387
NCI-H2052 GDSC1 1.0056 9.5543 -6.3071 12.7736
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -7.806 0.9841 -9.6774 54.8389
LNCaP clone FGC GDSC1 -5.9201 -1.952 -6.5143 39.6061
22Rv1 GDSC1 -5.8346 1.224 -7.7564 42.238
PC-3 GDSC1 -5.0856 0.4186 -6.6376 34.8169
DU145 GDSC1 -0.4275 3.8464 -4.5614 5.7269
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -3.4869 -0.2238 -4.792 16.288
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM35 GDSC1 -8.578 -3.4885 -8.9561 63.7797
WM115 GDSC1 -7.8516 0.2134 -9.4087 55.4795
MZ-MEL-2 GDSC1 -7.2876 -1.4101 -8.1829 52.5478
CHL-1 GDSC1 -6.8099 -1.0141 -7.8185 48.7535
A-431 GDSC1 -6.6222 -2.0065 -7.254 46.8224
WM1552C GDSC1 -6.5119 -1.4471 -7.3355 46.0343
RPMI-7951 GDSC1 -6.3943 -0.9364 -7.4065 45.2473
G-mel GDSC1 -5.9241 -2.2722 -6.4071 39.2393
COLO 792 GDSC1 -5.8482 -1.0481 -6.7838 39.9941
A-388 GDSC1 -5.7873 -1.9615 -6.3677 38.1131
MZ-MEL-7 GDSC1 -5.7413 -1.5899 -6.4568 38.1443
SK-MEL-2 GDSC1 -5.6326 0.1214 -7.0564 39.4143
G-361 GDSC1 -5.6326 -3.9702 -5.6759 33.6011
COLO 800 GDSC1 -5.5818 1.0197 -7.4094 40.0457
IST-MEL1 GDSC1 -5.5609 1.9828 -7.8347 40.8817
WM793 GDSC1 -5.4989 1.5954 -7.5928 40.0216
Mel JuSo GDSC1 -5.3659 2.1369 -7.7162 39.6021
SK-MEL-3 GDSC1 -5.0785 3.0813 -7.8905 38.5821
COLO 829 GDSC1 -4.9212 -0.2652 -6.1606 31.8204
SK-MEL-30 GDSC1 -4.8785 -0.3943 -6.0592 31.0809
UACC-62 GDSC1 -4.6031 0.7204 -6.3036 30.807
SK-MEL-5 GDSC1 -4.2221 0.7578 -5.9559 27.154
LOX-IMVI GDSC1 -4.1563 0.5758 -5.8056 25.9997
IGR-37 GDSC1 -4.1148 -3.1614 -4.1722 14.7333
IPC-298 GDSC1 -4.0812 3.0771 -6.9606 31.1464
COLO 679 GDSC1 -3.5993 2.3582 -6.1725 25.5135
WM278 GDSC1 -3.4386 -0.8822 -4.4238 13.3117
RVH-421 GDSC1 -3.3988 -0.7138 -4.4703 13.5013
LB2518-MEL GDSC1 -3.1472 -1.2729 -3.9678 8.5842
CP50-MEL-B GDSC1 -3.14 1.0895 -5.1403 17.382
A2058 GDSC1 -3.0383 1.5108 -5.2648 17.8394
451Lu GDSC1 -2.837 0.7954 -4.7402 13.384
Mel Ho GDSC1 -2.829 1.8904 -5.2809 17.1679
UACC-257 GDSC1 -2.7646 5.5658 -7.0651 26.4517
Hs 940.T GDSC1 -2.7344 5.9668 -7.2408 27.0518
GAK GDSC1 -2.6611 1.1186 -4.7599 12.9128
DJM-1 GDSC1 -2.6416 2.3177 -5.3425 16.9057
IGR-1 GDSC1 -2.5565 1.6198 -4.927 13.7645
HMV-II GDSC1 -2.0867 7.9196 -7.6944 26.6542
SK-MEL-28 GDSC1 -2.0466 4.8581 -6.1406 19.6669
SH-4 GDSC1 -1.9813 9.4897 -8.3933 28.6301
SK-MEL-1 GDSC1 -1.4587 2.0134 -4.3395 6.3896
WT2-iPS GDSC1 -1.2032 3.4255 -4.8389 9.2216
CP66-MEL GDSC1 -1.1982 5.7496 -5.9527 16.1133
Hs 938.T GDSC1 -0.5725 5.7753 -5.5389 12.1106
MMAc-SF GDSC1 -0.3787 6.7701 -5.8832 13.6125
COLO 783 GDSC1 -0.3367 8.1353 -6.5075 16.7569
A101D GDSC1 -0.0042 1.455 -3.43 0.0955
A-375 GDSC1 0.3555 2.1169 -3.5278 0.1578
VMRC-MELG GDSC1 0.4543 7.7364 -5.8064 11.3261
HT-144 GDSC1 0.5358 6.4012 -5.1534 7.5127
LB373-MEL-D GDSC1 0.5604 7.5891 -5.6745 10.3919
M14 GDSC1 1.0006 3.0299 -3.6122 0.1564
SK-MEL-24 GDSC1 1.0147 2.4606 -3.4227 0.0194
MeWo GDSC1 1.1324 12.1969 -7.4641 17.6375
EquiPSC Line K2 GDSC1 -3.0054 2.5605 -5.762 20.8584
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -7.8349 -3.9226 -8.0523 58.7256
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN GDSC1 -7.2711 1.9923 -9.5584 51.6854
SK-LMS-1 GDSC1 -6.0065 -1.5191 -6.7671 41.045
A-204 GDSC1 -5.637 0.3438 -7.1596 39.7268
SW982 GDSC1 -5.5416 -1.7184 -6.1942 35.7144
Rh30 GDSC1 -5.1156 -0.1082 -6.428 34.1334
G-401 GDSC1 -4.9233 5.2372 -8.7945 39.7376
Hs 633.T GDSC1 -4.7844 -2.1066 -5.237 25.7273
RD GDSC1 -4.7151 1.2087 -6.6443 32.8724
MES-SA GDSC1 -4.7104 0.7195 -6.4076 31.8369
EW-8 GDSC1 -4.4262 -3.5886 -4.4424 18.3578
VA-ES-BJ GDSC1 -4.0214 0.1082 -5.4517 23.2191
G-402 GDSC1 -3.5927 7.3659 -8.6629 34.4486
Rh41 GDSC1 -3.1846 1.7233 -5.4951 19.9102
KYM-1 GDSC1 -3.0116 0.7379 -4.8559 14.8727
MFH-ino GDSC1 -2.9382 2.7162 -5.7838 20.7343
SW872 GDSC1 -2.8171 1.9433 -5.2976 17.2359
SK-UT-1 GDSC1 -2.5851 2.1383 -5.208 15.8128
HT-1080 GDSC1 -1.806 2.8357 -4.966 11.6943
TE 441.T GDSC1 -1.2596 9.8002 -7.9886 25.3068
SW684 GDSC1 -0.3015 7.0196 -5.9509 13.7983
GCT GDSC1 0.1971 2.5906 -3.7503 0.7263
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GCIY GDSC1 -7.9498 -1.8374 -8.7503 57.5316
HGC-27 GDSC1 -7.9261 -1.7372 -8.7582 57.2863
IM95 GDSC1 -7.0764 1.5601 -9.1687 50.6486
RF-48 GDSC1 -6.5163 0.6556 -8.1979 46.9356
23132/87 GDSC1 -5.697 -0.294 -6.9413 39.48
Hs 746.T GDSC1 -4.4998 0.7171 -6.2021 29.7948
MKN1 GDSC1 -4.0911 5.1259 -7.9839 34.5431
HSC-39 GDSC1 -3.7684 3.1755 -6.7285 28.8593
SNU-1 GDSC1 -3.5332 3.6634 -6.7644 28.0506
RERF-GC-1B GDSC1 -3.5065 4.3598 -7.0884 29.2755
NCI-N87 GDSC1 -2.301 5.5694 -6.6928 23.2548
AGS GDSC1 -2.1977 6.3113 -6.9808 24.2047
NUGC-3 GDSC1 -2.0719 4.7797 -6.1212 19.6432
TMK-1 GDSC1 -2.0362 1.9755 -4.7111 10.5705
Fu97 GDSC1 -1.8691 9.1639 -8.1427 27.5268
MKN45 GDSC1 -1.3777 11.1093 -8.7276 27.9444
ECC10 GDSC1 -0.7474 7.9147 -6.6864 18.6598
OCUM-1 GDSC1 -0.6535 7.0279 -6.1916 15.956
MKN7 GDSC1 -0.5098 3.8153 -4.5943 6.0906
SCH GDSC1 -0.3343 4.5978 -4.8448 7.324
NUGC-4 GDSC1 -0.3241 2.9111 -4.104 2.8176
SNU-5 GDSC1 -0.3189 2.0311 -3.7512 1.0798
SNU-16 GDSC1 0.1387 1.578 -3.4227 0.0713
MKN28 GDSC1 0.3343 9.1955 -6.5651 15.4533
TGBC11TKB GDSC1 0.4414 2.3511 -3.5768 0.2134
SNG-M GDSC1 -6.3235 -2.1745 -6.8731 43.718
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 -6.2385 1.2911 -8.1945 45.2377
KMH-2 GDSC1 -5.9809 -0.6796 -7.0742 41.6922
K5 GDSC1 -5.9465 -0.6609 -7.0458 41.3899
B-CPAP GDSC1 -4.2394 1.887 -6.521 30.0289
HTC-C3 GDSC1 -3.6068 2.4827 -6.2411 25.8976
8505C GDSC1 -3.3396 2.5225 -6.0273 23.674
TT2609-C02 GDSC1 -2.8882 2.6715 -5.72 20.1692
CAL-62 GDSC1 -2.718 3.0254 -5.7575 19.7723
IHH-4 GDSC1 -2.6618 3.3271 -5.8627 20.1877
BHT-101 GDSC1 -2.2486 5.9297 -6.8309 23.7121
ML-1 [Human leukemia] GDSC1 -1.738 7.7555 -7.3407 24.2736
FTC-133 GDSC1 -1.5492 2.5925 -4.6715 8.9455
ASH-3 GDSC1 -0.9486 7.556 -6.655 19.0467
8305C GDSC1 -0.0055 7.0043 -5.7526 12.022
TT GDSC1 0.3278 4.0239 -4.2465 2.7508
WRO GDSC1 0.6428 4.6358 -4.3461 2.8843
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 GDSC1 -8.1267 -1.7317 -8.9776 58.5777
CAL-33 GDSC1 -7.6606 -3.3235 -7.9963 56.6343
NCI-H3118 GDSC1 -7.319 -1.4897 -8.1882 52.8123
BICR 22 GDSC1 -7.1645 -3.1863 -7.4896 51.9914
BB30-HNC GDSC1 -6.7745 -1.701 -7.5254 48.3282
PCI-04B GDSC1 -6.501 -0.4448 -7.7172 46.4012
SCC-15 GDSC1 -6.0421 -1.1075 -6.9651 41.84
BHY GDSC1 -5.5943 -0.0788 -6.9291 38.8046
KOSC-2 GDSC1 -5.5442 -0.1444 -6.8489 38.2447
JHU-011 GDSC1 -5.401 3.2232 -8.2669 40.9084
SCC-25 GDSC1 -5.3178 1.1219 -7.1935 37.9886
LB771-HNC GDSC1 -5.2597 -0.4022 -6.444 35.0389
OSC-19 GDSC1 -4.6442 3.6099 -7.7393 36.1964
PCI-06A GDSC1 -4.2916 1.8248 -6.5393 30.3544
PCI-15A GDSC1 -4.2796 0.7383 -6.0011 27.6754
HSC-4 GDSC1 -4.1702 1.3287 -6.184 28.1036
Ca9-22 GDSC1 -4.1161 2.9972 -6.9529 31.2689
SAS GDSC1 -3.6535 5.7053 -7.887 32.5797
BICR 31 GDSC1 -3.521 4.5431 -7.1924 29.731
CAL-27 GDSC1 -3.1382 4.5734 -6.88 27.0206
OSC-20 GDSC1 -3.1307 6.0983 -7.6359 29.8748
HSC-2 GDSC1 -3.115 3.7524 -6.4501 24.9774
HO-1-u-1 GDSC1 -2.9728 0.4197 -4.6644 13.3135
SAT [Human HNSCC] GDSC1 -2.9049 8.3423 -8.5692 31.9306
BICR 10 GDSC1 -2.7653 1.5779 -5.0728 15.5185
SCC-4 GDSC1 -2.6852 2.6732 -5.555 18.4214
JHU-022 GDSC1 -2.4509 10.0661 -9.0578 31.8016
HSC-3 GDSC1 -2.2205 2.1689 -4.9416 12.7714
Detroit 562 GDSC1 -1.7395 6.1714 -6.557 20.8374
PE/CA-PJ15 GDSC1 -1.6311 8.126 -7.4424 24.3586
DOK GDSC1 -0.9991 29.5216 -17.601 39.4927
PCI-38 GDSC1 -0.9968 5.628 -5.7531 14.4356
HO-1-N-1 GDSC1 -0.4184 6.8689 -5.9565 14.1106
SKN-3 GDSC1 -0.2916 9.408 -7.0906 19.3186
KON GDSC1 0.099 5.5142 -5.006 7.4617
BICR 78 GDSC1 0.235 11.3687 -7.6726 20.4164
PCI-30 GDSC1 0.5458 7.2112 -5.5112 9.5189
BB49-HNC GDSC1 0.6777 6.2277 -4.9987 6.3859
FaDu GDSC1 1.065 12.5747 -7.688 18.6493
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 -7.2037 -2.1648 -7.8319 52.0884
CAL-29 GDSC1 -5.9169 -0.2859 -7.1727 41.5078
5637 GDSC1 -5.8769 -1.2919 -6.7169 39.9812
BFTC-905 GDSC1 -5.3669 -1.1914 -6.2184 34.7106
RT-112 GDSC1 -5.3117 0.8552 -7.0641 37.5662
SW1710 GDSC1 -4.9646 0.6894 -6.6429 34.1749
647V GDSC1 -3.2328 2.3111 -5.83 22.1365
J82 GDSC1 -1.6789 5.4227 -6.1418 18.5352
SW780 GDSC1 -1.1563 2.5993 -4.424 6.2946
RT-4 GDSC1 -0.9758 6.4494 -6.1358 16.5057
KU-19-19 GDSC1 -0.9622 2.8734 -4.4328 5.9432
HT-1197 GDSC1 -0.9578 6.1969 -6.0008 15.7275
T24 GDSC1 -0.6326 8.2874 -6.7864 18.8266
TCCSUP GDSC1 -0.5708 8.1139 -6.6589 18.0724
639V GDSC1 -0.2277 3.8351 -4.4466 4.6676
HT-1376 GDSC1 0.3527 3.0113 -3.8428 0.9428
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVMIU GDSC1 -9.1635 -3.4329 -9.6079 67.1256
PA-1 GDSC1 -8.8035 -5.7258 -8.8462 69.8512
SW954 GDSC1 -8.0106 -2.0865 -8.7344 58.1694
Ca Ski GDSC1 -8.0022 -1.7755 -8.8278 57.8216
BPH-1 GDSC1 -7.8322 -3.0552 -8.2525 57.8124
KGN GDSC1 -7.6037 -1.6117 -8.4525 54.9709
ME-180 GDSC1 -7.3599 -1.6772 -8.1661 53.193
NCC-IT GDSC1 -6.6118 0.2087 -8.1053 47.4896
ACC-OV7 GDSC1 -5.2425 -0.3469 -6.4506 34.9645
OMC-1 [Human cervical carcinoma] GDSC1 -5.1024 -0.279 -6.338 33.6671
C-33 A GDSC1 -4.382 1.2085 -6.3252 29.8064
DSH1 GDSC1 -4.2967 -0.5796 -5.3921 24.1653
NT2-D1 GDSC1 -4.0978 3.255 -7.0635 31.6104
HEY GDSC1 -2.6603 3.6443 -6.0198 21.0712
JAR GDSC1 -2.6058 3.9178 -6.1123 21.3848
SKN GDSC1 -2.3649 4.505 -6.213 21.0951
CAL-39 GDSC1 -2.2354 2.4791 -5.1061 13.9576
LB831-BLC GDSC1 -2.0606 6.4004 -6.9175 23.4943
OV17R GDSC1 -1.6565 14.085 -10.4262 32.6696
SiSo GDSC1 -1.5334 11.0747 -8.8309 28.6497
DoTc2 4510 GDSC1 -1.3911 6.1862 -6.305 18.548
HEC-1 GDSC1 -1.0029 4.7687 -5.3449 12.0002
UWB1.289 GDSC1 -0.928 10.0218 -7.8494 23.9332
JHOS-3 GDSC1 -0.8991 13.4974 -9.5448 28.907
SiHa GDSC1 -0.7773 2.9614 -4.3654 5.1361
NEC8 GDSC1 -0.6072 6.4278 -5.8721 14.1106
OVCA420 GDSC1 -0.5556 7.5655 -6.3833 16.6898
HT-3 GDSC1 -0.481 9.1544 -7.1007 19.835
OVCA433 GDSC1 -0.2552 7.9276 -6.3527 15.7904
SKG-IIIa GDSC1 -0.2271 2.9855 -4.0875 2.6004
SW962 GDSC1 -0.1557 9.0357 -6.8168 17.7732
C-4-I GDSC1 -0.0777 3.6943 -4.3083 3.6216
MS751 GDSC1 0.0089 4.4357 -4.5802 5.0735
JEG-3 GDSC1 0.0483 1.8536 -3.5457 0.2587
HeLa GDSC1 0.0557 9.3609 -6.8292 17.3247
PEO1 GDSC1 0.4788 2.3362 -3.5589 0.1781
SW756 GDSC1 1.2152 9.6223 -6.211 11.8879
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma. Mol Cancer Ther. 2015 Feb;14(2):429-39.
2 Company report (GSK)
3 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
4 Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells. Cancer Biol Ther. 2011 Jun 1;11(11):938-46. doi: 10.4161/cbt.11.11.15527. Epub 2011 Jun 1.