General Information of Drug (ID: DMMG26Z)

Drug Name
Dolasetron Drug Info
Synonyms Dolasetronum; Dolasteron; Anzemet (TN); Dolasetron (INN); Dolasetron [INN:BAN]; Dolasetronum [INN-Latin]; 3-oxooctahydro-2h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate
Therapeutic ClassAntiemetics
Cross-matching ID
PubChem CID
3033818
ChEBI ID
CHEMBL94561
CAS Number
CAS 115956-12-2
TTD Drug ID
D00YLW
INTEDE Drug ID
DR0524
ACDINA Drug ID
D00209

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 1.82 1.87e-1 84/94 (89.36%) CXCL2;LCN2;S100A7;...
Pyrimidine metabolism 1.80 9.94e-2 40/56 (71.43%) NME4;DCK;NME1;...
Aminoacyl-tRNA biosynthesis 1.79 7.01e-2 15/66 (22.73%) NARS2;LARS2;QRSL1;...
TNF signaling pathway 1.75 7.60e-2 103/112 (91.96%) CXCL2;CASP10;CXCL3;...
Renin secretion 1.71 8.18e-2 61/69 (88.41%) ADRB2;GNAI1;AGTR1;...
Phosphonate and phosphinate metabolism 1.71 6.82e-2 5/6 (83.33%) CHPT1;CEPT1
Tyrosine metabolism 1.68 7.85e-2 30/36 (83.33%) ADH1B;ALDH3A1;TYR;...
Viral protein interaction with cytokine and cytokine re... 1.67 8.47e-2 84/100 (84%) CXCL2;CXCL3;CXCL1;...
DNA replication 1.67 7.79e-2 34/36 (94.44%) MCM2;PCNA;MCM5;...
Amoebiasis 1.66 7.60e-2 99/102 (97.06%) CXCL2;CXCL3;CXCL1;...
Mineral absorption 1.65 7.33e-2 48/60 (80%) MT1X;MT1HL1;CYBRD1;...
Metabolism of xenobiotics by cytochrome P450 1.65 7.11e-2 49/77 (63.64%) ADH1B;ALDH3A1;AKR7A2;...
Cell cycle 1.63 7.73e-2 110/124 (88.71%) E2F2;CCNB2;MCM2;...
Carbohydrate digestion and absorption 1.59 1.18e-1 37/47 (78.72%) SLC5A1;PRKCB;ATP1B3;...
Base excision repair 1.54 1.70e-1 29/33 (87.88%) PCNA;HMGB1;LIG3;...
NOD-like receptor signaling pathway 1.51 1.88e-1 145/181 (80.11%) CXCL2;CXCL3;CXCL1;...
Drug metabolism 1.51 1.88e-1 78/151 (51.66%) NME4;ADH1B;ALDH3A1;...
Chemokine signaling pathway 1.50 1.86e-1 163/192 (84.9%) CXCL2;GNAI1;CXCL3;...
Fat digestion and absorption 1.49 1.91e-1 35/43 (81.4%) PLA2G2A;PLA2G5;PLA2G10;...
Lipid and atherosclerosis 1.48 1.97e-1 190/215 (88.37%) CXCL2;CXCL3;CXCL1;...
Purine metabolism 1.47 2.13e-1 102/129 (79.07%) NME4;GMPR;PRPS2;...
Mucin type O-glycan biosynthesis 1.47 2.05e-1 20/36 (55.56%) GALNT7;GALNT12;GALNT6;...
Pentose and glucuronate interconversions 1.47 1.97e-1 17/34 (50%) AKR1B10;DCXR;UGT2B15;...
Fanconi anemia pathway 1.47 1.89e-1 36/54 (66.67%) ATR;RMI1;PALB2;...
Melanogenesis 1.45 2.07e-1 74/101 (73.27%) GNAI1;PRKACB;CTNNB1;...
Salivary secretion 1.41 2.64e-1 76/93 (81.72%) ADRB2;PRKACB;DMBT1;...
Retinol metabolism 1.41 2.54e-1 41/68 (60.29%) ALDH1A1;ADH1B;ALDH1A2;...
Gap junction 1.41 2.47e-1 72/88 (81.82%) GNAI1;PRKACB;SRC;...
Neomycin, kanamycin and gentamicin biosynthesis 1.40 2.60e-1 5/5 (100%) HK2;HKDC1
Intestinal immune network for IgA production 1.39 2.61e-1 38/48 (79.17%) HLA-DQA1;PIGR;HLA-DRA;...
Measles -1.25 5.10e-1 133/139 (95.68%) JAK1;AKT2;IRF9;...
Mannose type O-glycan biosynthesis -1.25 5.14e-1 14/23 (60.87%) FKRP;B4GALT3;CHST10;...
Protein processing in endoplasmic reticulum -1.30 4.52e-1 127/171 (74.27%) EIF2AK1;HSPA6;DERL1;...
Sulfur relay system -1.32 4.25e-1 5/8 (62.5%) TST;MOCS2
Cysteine and methionine metabolism -1.32 4.23e-1 43/50 (86%) GOT1;TST;BHMT;...
Circadian rhythm -1.33 4.18e-1 26/31 (83.87%) CLOCK;RBX1;BHLHE40;...
Toll-like receptor signaling pathway -1.33 4.27e-1 94/104 (90.38%) TBK1;PIK3CA;TLR3;...
Glycosphingolipid biosynthesis -1.35 4.00e-1 37/57 (64.91%) B3GNT2;ST6GALNAC4;ST3GAL6;...
Synaptic vesicle cycle -1.35 4.07e-1 63/78 (80.77%) ATP6V0D1;DNM1;UNC13B;...
Viral myocarditis -1.40 3.06e-1 53/60 (88.33%) CAV1;CD86;MYH7;...
Cell adhesion molecules -1.40 3.17e-1 118/148 (79.73%) CD22;NECTIN3;HLA-G;...
Nicotinate and nicotinamide metabolism -1.42 2.77e-1 25/35 (71.43%) SIRT7;NNT;SIRT2;...
Thyroid cancer -1.43 2.88e-1 36/37 (97.3%) CDH1;PPARG;MAP2K1;...
Phagosome -1.44 2.66e-1 118/152 (77.63%) ATP6V1A;ATP6V1C1;FCGR2C;...
MAPK signaling pathway -1.45 2.73e-1 272/294 (92.52%) KIT;MAPK9;EGFR;...
Ferroptosis -1.48 2.20e-1 36/41 (87.8%) SLC39A14;PRNP;ATG5;...
Glycine, serine and threonine metabolism -1.50 2.03e-1 31/40 (77.5%) PSPH;GRHPR;ALDH7A1;...
Osteoclast differentiation -1.51 2.12e-1 117/127 (92.13%) PIK3CA;PIK3CB;MAPK11;...
Leishmaniasis -1.51 2.27e-1 67/77 (87.01%) MAPK13;ITGB2;TGFB2;...
Citrate cycle (TCA cycle) -1.54 1.84e-1 30/30 (100%) SDHB;SUCLA2;SUCLG2;...
RNA degradation -1.55 1.81e-1 53/79 (67.09%) C1D;CNOT4;DCP2;...
Proteoglycans in cancer -1.55 1.93e-1 172/205 (83.9%) HCLS1;NANOG;SOS1;...
Propanoate metabolism -1.56 2.13e-1 30/34 (88.24%) LDHA;PCCA;PCCB;...
Valine, leucine and isoleucine degradation -1.57 2.28e-1 42/48 (87.5%) ABAT;ACAA2;HMGCS1;...
Fluid shear stress and atherosclerosis -1.59 2.09e-1 123/139 (88.49%) CAV2;KDR;PIK3CA;...
Collecting duct acid secretion -1.59 2.45e-1 22/27 (81.48%) ATP6V1A;ATP6V1C1;ATP6V1E1;...
Cardiac muscle contraction -1.68 1.09e-1 64/87 (73.56%) TNNT2;MYH7;CASQ2;...
Hypertrophic cardiomyopathy -1.75 8.29e-2 81/90 (90%) CACNG4;PRKAB1;IGF1;...
Malaria -1.79 7.29e-2 44/50 (88%) COMP;HGF;THBS1;...
Dilated cardiomyopathy -1.81 1.37e-1 86/96 (89.58%) ADCY9;CACNG4;IGF1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H