Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN2FS3)

Drug Name
EPZ-5676 Drug Info
Synonyms
pinometostat; EPZ-5676; 1380288-87-8; EPZ5676; UNII-8V9YR09EF3; UNII-F66X4M38G5; 8V9YR09EF3; CHEMBL3087499; CHEMBL3414626; F66X4M38G5; 1380288-88-9; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol; Pinometostat, trans-; 5'-[{cis-3-[2-(5-Tert-Butyl-1h-Benzimidazol-2-Yl)ethyl]cyclobutyl}(Propan-2-Yl)amino]-5'-Deoxyadenosine
Cross-matching ID
PubChem CID
57345410
ChEBI ID
CHEMBL124919
CAS Number
CAS 1380288-87-8
TTD Drug ID
D0C6GK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 2.17 0.00e+0 45/135 (33.33%) FCGR3B;ACTN1;FCGR2A;...
Spliceosome 2.10 0.00e+0 101/150 (67.33%) MAGOH;HSPA1A;SNRPD2;...
Ribosome biogenesis in eukaryotes 1.98 0.00e+0 52/108 (48.15%) NOP56;FBL;NOL6;...
Neutrophil extracellular trap formation 1.94 2.20e-3 101/189 (53.44%) PRKCA;TLR4;C5AR1;...
Glutathione metabolism -2.09 0.00e+0 43/57 (75.44%) GSTM1;PRDX6;LAP3;...
Steroid biosynthesis -2.23 0.00e+0 19/20 (95%) CYP24A1;CYP51A1;DHCR7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H