Details of the Drug

General Information of Drug (ID: DMN2FS3)

Drug Name
EPZ-5676
Synonyms
pinometostat; EPZ-5676; 1380288-87-8; EPZ5676; UNII-8V9YR09EF3; UNII-F66X4M38G5; 8V9YR09EF3; CHEMBL3087499; CHEMBL3414626; F66X4M38G5; 1380288-88-9; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol; Pinometostat, trans-; 5'-[{cis-3-[2-(5-Tert-Butyl-1h-Benzimidazol-2-Yl)ethyl]cyclobutyl}(Propan-2-Yl)amino]-5'-Deoxyadenosine
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1/2 [1]
Acute lymphoblastic leukaemia 2A85 Phase 1 [2]
Acute lymphocytic leukaemia 2B33.3 Phase 1 [3]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 562.7
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C30H42N8O3
IUPAC Name
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol
Canonical SMILES
CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
InChI
InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17?,19?,22-,25-,26-,29-/m1/s1
InChIKey
LXFOLMYKSYSZQS-XKHGBIBOSA-N
Cross-matching ID
PubChem CID
57345410
ChEBI ID
CHEBI:124919
CAS Number
1380288-87-8
UNII
8V9YR09EF3
DrugBank ID
DB12920
TTD ID
D0C6GK
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone-lysine N-methyltransferase (HLNM) TTSZ8T1 DOT1L_HUMAN Modulator [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute myeloid leukaemia
ICD Disease Classification 2A60
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histone-lysine N-methyltransferase (HLNM) DTT DOT1L 7.62E-02 0.08 0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.742 7.7808 2.6452 0.6619
TC-71 GDSC2 4.4319 6.234 2.6538 1.8914
CADO-ES1 GDSC2 4.5977 6.9362 2.4347 2.8148
EW-22 GDSC2 4.935 7.7922 2.245 3.3133
EW-24 GDSC2 4.9426 6.2464 2.8916 0.3758
ES1 GDSC2 5.1315 7.2497 2.5826 1.3776
EW-1 GDSC2 5.2755 7.669 2.4798 1.6824
CHSA0108 GDSC2 5.2824 9.4945 1.6762 5.8719
MG-63 GDSC2 5.318 7.3945 2.6114 1.0829
HOS GDSC2 5.3313 6.7111 2.874 0.2519
EW-3 GDSC2 5.3633 8.7861 2.0451 3.7258
ES8 GDSC2 5.3911 9.1148 1.9141 4.3817
SaOS-2 GDSC2 5.4649 8.5783 2.1916 2.8293
NOS-1 [Human HNSCC] GDSC2 5.6349 7.8633 2.5684 0.9905
CAL-72 GDSC2 5.6355 7.3028 2.7782 0.3528
SK-ES-1 GDSC2 5.6505 7.0401 2.8757 0.1578
CHSA0011 GDSC2 5.7028 8.5166 2.3382 1.86
CAL-78 GDSC2 5.7209 7.8101 2.6255 0.7362
EW-11 GDSC2 5.7306 13.4636 0.0909 13.389
A-673 GDSC2 5.7525 6.9058 2.9556 0.0511
EW-12 GDSC2 5.7676 7.8701 2.6222 0.7178
U-CH2 GDSC2 5.7701 7.4721 2.7688 0.3228
EW-13 GDSC2 5.833 8.8572 2.2612 2.0639
ES7 GDSC2 5.8991 8.3443 2.497 1.0509
SJSA-1 GDSC2 5.9486 7.9262 2.6741 0.4751
G-292 clone A141B1 GDSC2 5.9639 7.9519 2.6707 0.4769
ES4 GDSC2 5.9984 8.5504 2.4603 1.1087
EW-7 GDSC2 6.0059 7.7824 2.747 0.2882
CHSA8926 GDSC2 6.1246 7.7977 2.7846 0.1903
ES5 GDSC2 6.1667 8.9036 2.3966 1.2124
EW-16 GDSC2 6.2173 9.0214 2.373 1.2601
ES6 GDSC2 6.293 8.5225 2.5918 0.5307
SK-PN-DW GDSC2 6.3042 8.3435 2.6601 0.3672
EW-18 GDSC2 6.3068 8.36 2.6552 0.3768
MHH-ES-1 GDSC2 6.3197 8.1503 2.7331 0.2258
U2OS GDSC2 6.3426 8.548 2.6018 0.4848
HuO-3N1 GDSC2 6.5542 8.6319 2.6511 0.306
HuO9 GDSC2 6.5668 8.8469 2.5801 0.4469
H-EMC-SS GDSC2 6.7297 8.8434 2.6413 0.2754
NY GDSC2 6.7656 8.8496 2.652 0.2489
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 5.1929 8.5282 2.0632 3.8911
HT GDSC2 -1.3826 38.9114 -18.5309 49.6233
SU-DHL-1 GDSC2 -0.6242 1323.4013 -660.009 49.957
MC116 GDSC2 1.3967 32.2637 -12.783 44.636
MV4-11 GDSC2 1.7082 17.1226 -4.9654 38.6673
SUP-B8 GDSC2 3.3095 6.4719 1.7366 10.0592
OCI-AML-5 GDSC2 3.9033 5.8041 2.5256 3.5815
SU-DHL-16 GDSC2 4.0053 6.3027 2.3555 4.3941
RL GDSC2 4.0283 47.2528 -18.0577 42.8578
DEL GDSC2 4.1118 7.0668 2.06 5.9606
NU-DUL-1 GDSC2 4.1286 7.4605 1.8803 7.0201
JeKo-1 GDSC2 4.1484 6.7108 2.257 4.6836
KY821 GDSC2 4.1622 6.7602 2.2426 4.7409
Daudi GDSC2 4.2398 6.5063 2.4143 3.5615
OCI-Ly7 GDSC2 4.2441 5.8732 2.7082 1.8846
BC-3 GDSC2 4.2558 7.5585 1.9223 6.4758
Kasumi-1 GDSC2 4.2958 7.421 2.0162 5.8215
MY-M12 GDSC2 4.3448 7.8987 1.8198 6.8982
ME1 GDSC2 4.3719 5.9037 2.7654 1.4014
Mono-Mac-6 GDSC2 4.3789 8.459 1.5721 8.3081
OCI-M1 GDSC2 4.4021 5.9102 2.7785 1.2975
SU-DHL-4 GDSC2 4.4176 6.5088 2.5225 2.6242
TALL-1 [Human adult T-ALL] GDSC2 4.452 7.6354 2.0187 5.4797
Farage GDSC2 4.4568 10.9992 0.3832 14.8464
RPMI-6666 GDSC2 4.4598 6.916 2.3614 3.4601
SU-DHL-5 GDSC2 4.4618 5.9333 2.7993 1.1255
NCI-H929 GDSC2 4.4947 7.5321 2.0956 4.9392
L-363 GDSC2 4.4965 7.6913 2.0215 5.3727
SKM-1 GDSC2 4.5513 5.9417 2.8395 0.8503
MOLM-13 GDSC2 4.5578 9.8618 1.016 11.1423
NK-92MI GDSC2 4.5657 8.2238 1.814 6.4593
Namalwa GDSC2 4.6048 6.9665 2.4252 2.8557
Karpas-422 GDSC2 4.6118 6.6329 2.5776 2.0305
MOLP-8 GDSC2 4.6344 6.4854 2.6536 1.6156
QIMR-WIL GDSC2 4.6491 7.8871 2.0279 5.0357
697 GDSC2 4.6656 11.8138 0.1371 15.5842
MM1.S GDSC2 4.6738 6.4359 2.695 1.3683
EM-2 GDSC2 4.7046 6.3681 2.7385 1.1342
KMS-11 GDSC2 4.7222 10.5634 0.7914 12.012
MHH-CALL-4 GDSC2 4.7418 6.9849 2.4946 2.2767
SR GDSC2 4.7485 6.3682 2.7596 0.9976
U-698-M GDSC2 4.7602 6.9581 2.5163 2.1386
SIG-M5 GDSC2 4.7958 5.6825 3.037 0.1037
KMS-12-BM GDSC2 4.8015 6.8483 2.5856 1.7375
RPMI-8226 GDSC2 4.8157 10.1003 1.0825 10.175
MOLM-16 GDSC2 4.8514 6.7686 2.6446 1.3992
GA-10 GDSC2 4.8717 6.4432 2.7864 0.7782
ROS-50 GDSC2 4.8774 9.0959 1.6056 7.0416
BV-173 GDSC2 4.8846 7.3613 2.4079 2.5236
ST486 GDSC2 4.9299 7.1621 2.5184 1.9046
SU-DHL-10 GDSC2 4.9437 5.9442 2.9999 0.1279
NALM-6 GDSC2 4.9615 6.8 2.685 1.1071
ALL-PO GDSC2 4.9719 8.2435 2.0623 4.2571
EB2 GDSC2 4.9801 7.7028 2.3103 2.8957
ALL-SIL GDSC2 4.9976 6.7248 2.7318 0.8843
HL-60 GDSC2 4.9988 6.4146 2.8518 0.4622
AMO1 GDSC2 5.0221 6.4715 2.8401 0.4847
HEL GDSC2 5.0396 6.4105 2.8699 0.3868
WSU-DLCL2 GDSC2 5.0456 6.2818 2.919 0.2578
Karpas-45 GDSC2 5.0519 8.8906 1.8133 5.517
THP-1 GDSC2 5.0625 7.2466 2.5502 1.5967
KG-1 GDSC2 5.0634 7.1086 2.6077 1.3376
SUP-M2 GDSC2 5.0651 6.1148 2.9846 0.1231
P32/ISH GDSC2 5.0668 6.5235 2.839 0.4622
CML-T1 GDSC2 5.079 6.9381 2.684 1.0026
CESS GDSC2 5.0899 7.0789 2.6324 1.2048
BL-41 GDSC2 5.0912 6.3751 2.9029 0.2773
IM-9 GDSC2 5.1005 6.4426 2.8822 0.3246
SUP-B15 GDSC2 5.1008 6.9299 2.6972 0.9319
KE-37 GDSC2 5.1031 6.4766 2.8708 0.3529
GDM-1 GDSC2 5.1172 8.116 2.2041 3.2533
OCI-AML-2 GDSC2 5.1349 6.4494 2.893 0.2831
SU-DHL-8 GDSC2 5.1381 6.6195 2.8322 0.4427
Hs 445 GDSC2 5.139 6.7177 2.7958 0.5532
YT GDSC2 5.1404 6.6593 2.8183 0.4825
NB4 GDSC2 5.1567 13.7732 -0.4646 17.243
DG-75 GDSC2 5.1588 7.4376 2.5184 1.6353
Karpas-299 GDSC2 5.1612 6.6169 2.8424 0.4016
Karpas-231 GDSC2 5.168 6.7161 2.8084 0.4969
MOLT-13 GDSC2 5.1826 6.7077 2.8174 0.4616
Raji GDSC2 5.2098 6.6056 2.8656 0.3183
EoL-1 GDSC2 5.2103 6.835 2.7812 0.5558
ML-2 GDSC2 5.2199 7.4374 2.5482 1.4374
P31/FUJ GDSC2 5.2272 6.4318 2.9335 0.1677
A3/Kawakami GDSC2 5.2292 6.1894 3.0162 0.0555
BALL-1 GDSC2 5.2551 6.8529 2.7928 0.4942
WIL2 NS GDSC2 5.2588 6.8793 2.7845 0.5171
PF-382 GDSC2 5.2694 7.4264 2.5762 1.2694
MLMA GDSC2 5.2863 10.3257 1.2906 8.0193
SUP-T1 GDSC2 5.2996 7.0505 2.7369 0.642
OPM-2 GDSC2 5.305 7.0613 2.7351 0.6444
MOLT-16 GDSC2 5.312 6.791 2.8381 0.3424
MHH-CALL-2 GDSC2 5.3121 6.8913 2.8016 0.4388
SCC-3 GDSC2 5.3141 6.3575 2.9892 0.0713
NOMO-1 GDSC2 5.3326 6.7287 2.8682 0.2638
A4/Fukuda GDSC2 5.3633 7.1287 2.7339 0.6117
KM-H2 GDSC2 5.3818 7.0765 2.7611 0.5179
JVM-3 GDSC2 5.4062 7.1359 2.7489 0.5405
LP-1 GDSC2 5.413 6.9457 2.8212 0.3409
RPMI-8866 GDSC2 5.4165 7.033 2.7909 0.4164
SU-DHL-6 GDSC2 5.4194 7.1487 2.7495 0.5314
EJM GDSC2 5.4195 7.3187 2.6855 0.734
JSC-1 GDSC2 5.4328 8.0507 2.3989 1.8772
JURL-MK1 GDSC2 5.4462 7.1698 2.7525 0.508
Jiyoye GDSC2 5.4597 7.2282 2.7362 0.5483
ATN-1 GDSC2 5.4597 7.1438 2.7675 0.4588
CA46 GDSC2 5.4619 7.3922 2.6754 0.7396
Reh GDSC2 5.4655 6.8658 2.8693 0.2176
RPMI-8402 GDSC2 5.4824 7.0042 2.8267 0.3005
Ku812 GDSC2 5.4896 7.3367 2.7079 0.6171
MOLT-4 GDSC2 5.4898 7.3517 2.7024 0.6343
DoHH2 GDSC2 5.5004 6.9569 2.8502 0.2442
P12-Ichikawa GDSC2 5.5459 6.9082 2.8836 0.1699
HH [Human lymphoma] GDSC2 5.5532 7.6392 2.6197 0.8675
RC-K8 GDSC2 5.5572 7.0233 2.8478 0.2308
Karpas-620 GDSC2 5.5619 7.0886 2.8266 0.2721
ARH-77 GDSC2 5.565 7.2349 2.7756 0.3885
JJN-3 GDSC2 5.567 7.129 2.8142 0.297
K-562 GDSC2 5.5689 7.2916 2.7565 0.4357
VAL GDSC2 5.5978 7.4661 2.7038 0.5677
U266B1 GDSC2 5.5978 7.3542 2.745 0.4525
P30/OHK GDSC2 5.6033 7.4269 2.7205 0.5167
DB GDSC2 5.6176 7.4828 2.7056 0.5518
BE-13 GDSC2 5.6331 7.7642 2.6059 0.8591
KOPN-8 GDSC2 5.634 7.3236 2.7701 0.3725
OCI-AML-3 GDSC2 5.665 7.1323 2.8491 0.1977
Jurkat GDSC2 5.6766 7.0856 2.8693 0.1616
Ramos.2G6.4C10 GDSC2 5.6789 7.3563 2.7756 0.3418
L-428 GDSC2 5.6816 7.2981 2.7972 0.2929
RCH-ACV GDSC2 5.6954 7.6884 2.6607 0.6416
JVM-2 GDSC2 5.7179 9.0139 2.1375 2.7716
OCI-Ly19 GDSC2 5.7366 7.6022 2.709 0.482
WSU-NHL GDSC2 5.7367 7.8366 2.622 0.7374
L-540 GDSC2 5.7497 7.4053 2.7848 0.2957
HDLM-2 GDSC2 5.7534 7.5137 2.7476 0.3776
RS4;11 GDSC2 5.7571 7.6724 2.6914 0.5196
TK [Human B-cell lymphoma] GDSC2 5.7585 7.1049 2.8915 0.1143
BONNA-12 GDSC2 5.7598 8.0863 2.5363 1.0129
SUP-HD1 GDSC2 5.7871 7.788 2.6608 0.5903
MHH-PREB-1 GDSC2 5.8028 7.5091 2.7679 0.313
Loucy GDSC2 5.817 7.5583 2.7558 0.3342
MEG-01 GDSC2 5.8232 7.7538 2.6878 0.4974
Karpas-1106P GDSC2 5.8291 7.5198 2.7739 0.2914
KCL-22 GDSC2 5.8478 7.7768 2.689 0.4825
CTV-1 GDSC2 5.8494 7.5355 2.7759 0.2807
H9 GDSC2 5.8503 7.9491 2.6266 0.6563
CTB-1 GDSC2 5.888 32.7069 -9.2907 35.2004
CCRF-CEM GDSC2 5.8932 7.2917 2.8752 0.1115
KMOE-2 GDSC2 5.8958 7.5778 2.7782 0.2617
SK-MM-2 GDSC2 5.9111 8.0063 2.6299 0.6133
DND-41 GDSC2 5.9471 7.5363 2.8111 0.19
CRO-AP2 GDSC2 5.9678 8.2501 2.562 0.7857
BC-1 GDSC2 5.9683 8.0164 2.649 0.5316
L-1236 GDSC2 5.9777 8.4456 2.4918 1.0124
NKM-1 GDSC2 5.9781 8.0335 2.6465 0.5334
PL-21 GDSC2 6.0177 8.1814 2.608 0.6198
VL51 GDSC2 6.0762 8.39 2.5542 0.7457
LAMA-84 GDSC2 6.1093 8.0222 2.7009 0.3484
HAL-01 GDSC2 6.1182 7.6899 2.819 0.1425
Granta-519 GDSC2 6.1243 7.835 2.7717 0.2108
MN-60 GDSC2 6.3319 8.2433 2.7054 0.2701
TUR GDSC2 6.3786 7.8004 2.8705 0.0574
HC-1 GDSC2 6.4298 8.069 2.799 0.1153
GR-ST GDSC2 6.6808 9.1048 2.5313 0.5149
LC4-1 GDSC2 6.7145 8.4957 2.7539 0.1229
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC2 4.8962 7.3704 2.4103 2.4945
KYSE-220 GDSC2 5.5404 7.7413 2.5744 1.0416
HCE-4 GDSC2 5.5863 7.8139 2.5663 1.0356
KYSE-50 GDSC2 5.6772 7.5483 2.7053 0.5214
ESO-26 GDSC2 5.8927 7.3715 2.848 0.1466
FLO-1 GDSC2 5.9047 8.3259 2.5065 1.0131
KYAE-1 GDSC2 6.0483 7.6433 2.8103 0.1684
OACP4 C GDSC2 6.245 8.1416 2.7091 0.2882
OACM5.1 C GDSC2 6.3552 9.012 2.4356 0.9492
SK-GT-4 GDSC2 6.605 8.7146 2.6408 0.3103
TE-12 GDSC2 6.7817 9.4003 2.4636 0.6386
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 6.1802 8.1605 2.6785 0.3717
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC2 4.1262 9.8381 0.7074 13.9469
KP-N-RT-BM-1 GDSC2 4.1988 6.9803 2.1619 5.1502
SJNB-17 GDSC2 4.4067 21.5651 -4.9121 32.0225
CHP-126 GDSC2 4.5352 7.5675 2.105 4.8047
NB69 GDSC2 4.6024 6.974 2.4204 2.8858
SK-N-MC-IXC GDSC2 4.6045 5.9679 2.8537 0.7422
SK-N-AS GDSC2 4.6899 11.7603 0.1814 15.3028
SK-N-BE(2)-M17 GDSC2 5.0287 6.9986 2.6361 1.2497
SJNB-5 GDSC2 5.0404 7.6445 2.369 2.5058
SK-N-DZ GDSC2 5.1622 6.449 2.9035 0.2485
SK-N-FI GDSC2 5.2838 7.3563 2.611 1.1142
GOTO GDSC2 5.2898 7.4781 2.5648 1.2975
Kelly GDSC2 5.2909 6.7963 2.8279 0.3778
NB1 GDSC2 5.3795 6.6752 2.9043 0.1779
KP-N-YN GDSC2 5.5055 8.4912 2.2502 2.49
CHP-134 GDSC2 5.5127 6.9734 2.8489 0.2427
NB(TU)1 GDSC2 5.5651 7.0259 2.8498 0.2247
SJNB-13 GDSC2 5.5958 7.2127 2.7953 0.3286
SJNB-6 GDSC2 5.5968 7.3268 2.7546 0.4276
KP-N-YS GDSC2 5.6412 7.8664 2.57 0.9801
IMR-5 GDSC2 5.6553 7.3284 2.7765 0.3487
MHH-NB-11 GDSC2 5.7104 7.4291 2.7615 0.362
NH-12 GDSC2 5.7756 8.0266 2.5662 0.8969
SJNB-10 GDSC2 5.7975 7.5161 2.7635 0.3245
SJNB-14 GDSC2 5.8034 7.4175 2.8003 0.2473
SK-N-SH GDSC2 5.9058 7.4931 2.8112 0.2
SJNB-12 GDSC2 5.9124 8.0377 2.6188 0.6448
SiMa GDSC2 5.9426 8.4054 2.4922 1.0363
SJNB-7 GDSC2 5.9996 7.4488 2.8591 0.1132
TGW GDSC2 6.0042 7.2597 2.9232 0.0522
GI-ME-N GDSC2 6.1736 8.886 2.4065 1.1719
LA-N-6 GDSC2 6.1889 7.9161 2.7669 0.203
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.9342 6.9035 2.6294 1.3774
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC2 4.7717 6.8197 2.5823 1.7916
BT-474 GDSC2 4.8655 7.8155 2.1939 3.7046
CAL-120 GDSC2 4.8738 6.6368 2.7098 1.0872
HDQ-P1 GDSC2 4.902 8.3731 1.9602 4.9549
HCC2157 GDSC2 4.9277 6.7918 2.6723 1.1945
AU565 GDSC2 4.9331 8.1744 2.0707 4.2765
HCC1599 GDSC2 4.9492 6.7549 2.6974 1.0666
CAL-148 GDSC2 4.9791 6.4213 2.8412 0.5074
MDA-MB-453 GDSC2 5.0674 8.9979 1.7731 5.7159
MFM-223 GDSC2 5.1244 6.7142 2.7911 0.5777
DU4475 GDSC2 5.1428 6.7679 2.7784 0.6073
HCC1569 GDSC2 5.1662 8.451 2.0824 3.829
HCC1187 GDSC2 5.2532 6.8264 2.8019 0.4686
EFM-19 GDSC2 5.2697 7.151 2.6855 0.8408
UACC-812 GDSC2 5.2937 7.2171 2.6703 0.8781
HCC70 GDSC2 5.3037 6.6753 2.8763 0.2565
MDA-MB-361 GDSC2 5.311 7.3955 2.6077 1.1034
HCC1419 GDSC2 5.3518 6.8586 2.8291 0.3476
MRK-nu-1 GDSC2 5.4156 6.9065 2.8363 0.3043
BT-483 GDSC2 5.45 6.9651 2.8284 0.309
HCC38 GDSC2 5.4596 7.1985 2.7472 0.5161
COLO 824 GDSC2 5.4735 7.4956 2.6407 0.851
CAMA-1 GDSC2 5.5105 7.3522 2.7107 0.5964
HCC1954 GDSC2 5.513 7.2872 2.7359 0.5203
MDA-MB-175-VII GDSC2 5.534 7.0079 2.8447 0.2444
HCC1937 GDSC2 5.5377 7.6345 2.6148 0.8961
Evsa-T GDSC2 5.5729 6.9023 2.8953 0.1453
UACC-893 GDSC2 5.5817 11.0516 1.1389 8.2838
HCC2218 GDSC2 5.5983 7.339 2.7507 0.437
ZR-75-30 GDSC2 5.6274 7.8149 2.5839 0.9403
BT-549 GDSC2 5.6374 7.1714 2.8255 0.2497
Hs 578T GDSC2 5.6433 7.9391 2.5425 1.0793
HCC1500 GDSC2 5.6511 7.4588 2.7278 0.4729
MDA-MB-157 GDSC2 5.6734 7.7888 2.6136 0.8055
EFM-192A GDSC2 5.6756 7.2402 2.8154 0.2575
JIMT-1 GDSC2 5.7559 7.3024 2.8231 0.219
YMB-1-E GDSC2 5.7755 8.1008 2.5375 0.997
MDA-MB-231 GDSC2 5.7969 7.9209 2.6152 0.7222
MDA-MB-468 GDSC2 5.8382 7.5506 2.7665 0.3038
HCC1428 GDSC2 5.904 11.6409 1.0667 8.0729
MDA-MB-415 GDSC2 5.9164 7.6271 2.7685 0.2742
MCF-7 GDSC2 5.9299 7.8895 2.6801 0.4681
OCUB-M GDSC2 6.0269 7.6778 2.7909 0.2033
HCC1806 GDSC2 6.2407 8.2502 2.6694 0.3698
MDA-MB-436 GDSC2 6.2666 8.1164 2.7257 0.2519
HCC1395 GDSC2 6.2948 8.1305 2.731 0.2355
BT-20 GDSC2 6.4976 7.9676 2.8553 0.058
CAL-85-1 GDSC2 6.5203 8.4774 2.6923 0.2432
MDA-MB-330 GDSC2 6.5527 8.8616 2.5696 0.4763
T-47D GDSC2 6.6184 8.4534 2.735 0.1603
HCC1143 GDSC2 6.7378 9.2226 2.5108 0.5404
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC2 3.827 5.6686 2.5382 3.6716
U-251MG GDSC2 4.1425 6.1656 2.512 3.1756
U-87MG ATCC GDSC2 4.4602 7.4534 2.1104 4.9202
D-336MG GDSC2 4.5303 7.5773 2.0973 4.8596
SF126 GDSC2 4.6577 6.488 2.6647 1.5324
KINGS-1 GDSC2 4.7289 7.62 2.2015 3.8943
PFSK-1 GDSC2 4.7583 9.2745 1.4409 8.2439
AM-38 GDSC2 4.7857 8.2535 1.9431 5.2676
CAS-1 GDSC2 4.9321 6.4171 2.8229 0.599
D-263MG GDSC2 4.9434 6.2824 2.8786 0.4133
LN-229 GDSC2 5.0733 7.9658 2.246 3.0971
NMC-G1 GDSC2 5.0915 6.6272 2.8102 0.5366
LN-405 GDSC2 5.1743 6.7049 2.8151 0.4729
D-542MG GDSC2 5.2146 6.7029 2.832 0.4036
LN-18 GDSC2 5.2249 6.2996 2.978 0.0992
KNS-42 GDSC2 5.2619 6.7928 2.8178 0.4191
YKG-1 GDSC2 5.2811 6.7614 2.8368 0.3594
Onda 10 GDSC2 5.2883 7.084 2.7194 0.7081
A-172 GDSC2 5.2994 6.8255 2.8206 0.3931
Hs 683 GDSC2 5.3312 6.6687 2.8889 0.2211
SW1783 GDSC2 5.3895 7.3112 2.6755 0.7888
U-118MG GDSC2 5.3943 7.188 2.7244 0.6228
SF295 GDSC2 5.4305 7.0827 2.7783 0.4437
DK-MG GDSC2 5.4409 6.5744 2.9601 0.0845
D-247MG GDSC2 5.4834 7.7794 2.5336 1.2479
GI-1 GDSC2 5.525 7.7669 2.5574 1.1184
KNS-81-FD GDSC2 5.5541 7.8265 2.547 1.1344
YH-13 GDSC2 5.564 7.1317 2.8121 0.3028
D-245MG GDSC2 5.5646 9.2217 1.9649 3.8479
KALS-1 GDSC2 5.5658 11.959 0.6998 10.663
42-MG-BA GDSC2 5.5792 7.2272 2.7838 0.3622
D-566MG GDSC2 5.6392 7.3928 2.7471 0.4275
GaMG GDSC2 5.666 7.6166 2.6755 0.6138
KS-1 [Human Krukenberg tumour] GDSC2 5.6777 8.3695 2.3863 1.6769
8-MG-BA GDSC2 5.7469 7.2819 2.8269 0.2146
Daoy GDSC2 5.7663 7.7088 2.6817 0.5418
DBTRG-05MG GDSC2 5.7989 7.3443 2.8241 0.2055
ONS-76 GDSC2 5.849 7.3798 2.8298 0.1834
SW1088 GDSC2 5.8856 7.6838 2.737 0.3506
SK-MG-1 GDSC2 5.8951 7.4326 2.8281 0.1754
D-502MG GDSC2 5.9173 7.8613 2.6854 0.4603
Becker GDSC2 5.9407 8.4006 2.4932 1.0338
T98G GDSC2 6.0847 8.0333 2.6877 0.3864
M059J GDSC2 6.0953 8.0351 2.6911 0.3748
SNB-75 GDSC2 6.1056 8.4 2.5625 0.7044
GB-1 GDSC2 6.1604 7.5135 2.892 0.0613
SF539 GDSC2 6.1645 7.7126 2.8274 0.124
MOG-G-CCM GDSC2 6.2018 8.2156 2.6671 0.3889
D-392MG GDSC2 6.2073 8.3595 2.6176 0.5035
SF268 GDSC2 6.2588 8.7119 2.5086 0.7792
H4 GDSC2 6.2714 8.0521 2.7496 0.2109
MOG-G-UVW GDSC2 6.2764 8.1974 2.7011 0.294
D-423MG GDSC2 6.367 8.528 2.6182 0.4365
Onda 11 GDSC2 6.5194 8.4206 2.7115 0.2131
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 4.7846 8.9799 1.5995 7.2662
ETK-1 GDSC2 5.8344 8.9416 2.2269 2.2161
TGBC1TKB GDSC2 5.8749 7.4444 2.8168 0.1983
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 5.3253 7.2953 2.6537 0.915
MFE-319 GDSC2 5.4645 7.0656 2.7978 0.3766
AN3-CA GDSC2 5.4988 7.8131 2.5272 1.2597
RL95-2 GDSC2 5.5538 7.0355 2.8423 0.2429
EN GDSC2 5.6047 6.997 2.8741 0.171
MFE-280 GDSC2 5.7064 7.8654 2.5984 0.8347
KLE GDSC2 5.9439 7.8334 2.7057 0.3997
MFE-296 GDSC2 6.265 8.2229 2.688 0.323
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC2 4.262 9.7821 0.8379 12.8704
A-498 GDSC2 4.4663 8.7891 1.4734 8.6964
BFTC-909 GDSC2 4.9959 6.7456 2.7227 0.9213
RCC10RGB GDSC2 5.0861 7.4628 2.4712 1.9401
CAL-54 GDSC2 5.1908 8.0667 2.2664 2.8221
KMRC-1 GDSC2 5.207 6.6369 2.8531 0.3509
BB65-RCC GDSC2 5.3604 7.8434 2.4492 1.7284
786-O GDSC2 5.4037 7.551 2.5881 1.1012
A-704 GDSC2 5.4796 13.2901 0.0013 14.3589
KTCTL-1M GDSC2 5.4805 8.0949 2.4039 1.8026
KMRC-20 GDSC2 5.507 7.3894 2.6953 0.646
KTCTL-21 GDSC2 5.5264 11.132 1.0657 8.7871
SN12C GDSC2 5.5352 7.1428 2.7972 0.3482
KTCTL-195 GDSC2 5.5482 7.8201 2.5469 1.1399
VMRC-RCW GDSC2 5.5996 7.2678 2.777 0.3702
SW13 GDSC2 5.7079 7.4368 2.7578 0.3718
KTCTL-13 GDSC2 5.7669 7.4702 2.7682 0.3251
SW156 GDSC2 5.7804 8.0935 2.5425 0.9759
LB2241-RCC GDSC2 5.7859 7.8738 2.6284 0.6879
VMRC-RCZ GDSC2 5.8096 7.4809 2.7804 0.2846
UO-31 GDSC2 5.8686 7.7429 2.7094 0.4218
NCC010 GDSC2 5.9446 10.1224 1.7785 4.259
RXF 393L GDSC2 6.0121 9.8247 1.9442 3.3387
LB1047-RCC GDSC2 6.0208 8.4383 2.513 0.9112
NCC021 GDSC2 6.0768 7.9612 2.7104 0.3398
Caki-1 GDSC2 6.0835 8.7012 2.4389 1.1226
OS-RC-2 GDSC2 6.1038 7.8183 2.7701 0.2184
KTCTL-26A GDSC2 6.12 8.1488 2.6599 0.4371
HA7-RCC GDSC2 6.1309 8.5321 2.5234 0.8084
ACHN GDSC2 6.1993 8.124 2.6985 0.3232
LB996-RCC GDSC2 6.3977 8.6159 2.5984 0.4703
TK-10 GDSC2 6.4571 8.4731 2.671 0.2972
769-P GDSC2 6.5362 14.3794 0.1874 11.3341
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H508 GDSC2 4.4126 12.2573 -0.2725 18.1938
SW948 GDSC2 4.7275 6.2827 2.7843 0.9136
COLO 320HSR GDSC2 4.8368 6.883 2.5891 1.677
RKO GDSC2 4.9073 11.6147 0.4111 13.6117
HT-55 GDSC2 4.9515 6.4453 2.8204 0.5941
SW1116 GDSC2 4.9558 6.6174 2.7554 0.8278
T84 GDSC2 5.0315 7.2216 2.5452 1.6549
LS513 GDSC2 5.0473 7.3 2.5202 1.7535
LS411N GDSC2 5.0897 6.3073 2.9265 0.2243
SK-CO-1 GDSC2 5.1395 6.7281 2.7921 0.5648
HT-29 GDSC2 5.2015 6.5045 2.8986 0.2449
LS1034 GDSC2 5.2369 6.5164 2.9075 0.214
MDST8 GDSC2 5.2758 6.7894 2.8245 0.394
SW48 GDSC2 5.2908 7.3024 2.6355 1.0118
C2BBe1 GDSC2 5.348 7.3325 2.6492 0.9141
COLO205 GDSC2 5.3914 6.9573 2.8087 0.3817
SW626 GDSC2 5.422 7.8472 2.4775 1.5398
RCM-1 [Human ESC] GDSC2 5.4426 6.7405 2.9044 0.1613
SNU-61 GDSC2 5.4886 7.5959 2.6083 0.956
HCT 116 GDSC2 5.4889 7.2378 2.7445 0.5084
HT115 GDSC2 5.5299 6.8239 2.9068 0.1375
KM12 GDSC2 5.5626 7.4013 2.7136 0.5581
SW1417 GDSC2 5.568 7.2875 2.7576 0.4331
CW-2 GDSC2 5.5936 7.7727 2.5856 0.9594
SNU-81 GDSC2 5.6219 7.6912 2.629 0.7882
COLO 678 GDSC2 5.6301 8.0108 2.5084 1.2205
SNU-175 GDSC2 5.6437 7.4658 2.7223 0.4914
SNU-C5 GDSC2 5.6455 8.4185 2.3508 1.8641
SNU-1040 GDSC2 5.6519 6.9361 2.9114 0.1079
HCC2998 GDSC2 5.6956 7.5262 2.7207 0.4706
GP5d GDSC2 5.7032 7.4956 2.7347 0.4305
HCT 15 GDSC2 5.7472 7.1946 2.8571 0.1644
SNU-C1 GDSC2 5.757 7.8291 2.6333 0.6898
DiFi GDSC2 5.7816 8.2359 2.4875 1.1756
SNU-283 GDSC2 5.7892 7.5289 2.7558 0.3446
SW837 GDSC2 5.8065 7.6567 2.7165 0.4308
CaR-1 GDSC2 5.8221 7.4572 2.7933 0.255
NCI-H747 GDSC2 5.8304 8.4154 2.4387 1.3228
LoVo GDSC2 5.846 8.2862 2.4963 1.0927
LS123 GDSC2 5.8496 7.7346 2.705 0.4408
SW1463 GDSC2 5.9498 7.6262 2.781 0.2406
CL-11 GDSC2 6.0327 8.1838 2.6131 0.5978
CCK-81 GDSC2 6.098 7.7344 2.7968 0.1777
LS180 GDSC2 6.1091 7.7191 2.8059 0.1621
NCI-H716 GDSC2 6.133 8.007 2.7151 0.3112
SNU-407 GDSC2 6.3554 8.3011 2.6938 0.2845
SW620 GDSC2 6.5162 8.5166 2.6773 0.2695
SNU-C2B GDSC2 6.826 9.1804 2.559 0.401
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.7682 7.6046 2.7205 0.4376
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2/C3A GDSC2 4.3919 5.8922 2.7809 1.2984
JHH-1 GDSC2 4.8611 5.9118 2.981 0.1882
SK-HEP-1 GDSC2 4.8816 6.0595 2.9359 0.2855
HuH-1 GDSC2 5.1849 6.3403 2.9499 0.1505
SNU-387 GDSC2 5.246 7.3058 2.6138 1.1364
Hep 3B2.1-7 GDSC2 5.2529 6.8554 2.791 0.5008
Huh-7 GDSC2 5.4401 6.8677 2.8592 0.2456
JHH-4 GDSC2 5.459 7.6208 2.5854 1.0654
SNU-398 GDSC2 5.5165 7.79 2.5445 1.1759
SNU-423 GDSC2 5.619 7.5459 2.6827 0.6188
JHH-7 GDSC2 5.7026 7.6674 2.6715 0.6053
HLE GDSC2 5.9359 8.0495 2.6239 0.6175
JHH-2 GDSC2 5.9881 7.7797 2.7414 0.3053
SNU-449 GDSC2 6.4104 8.123 2.7743 0.1473
JHH-6 GDSC2 6.9269 21.0332 -2.7389 21.7282
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EMC-BAC-1 GDSC2 4.129 11.0505 0.1079 17.103
NCI-H345 GDSC2 4.3669 5.4652 2.9455 0.5848
NCI-H460 GDSC2 4.3843 7.6869 1.9487 6.0379
NCI-H2171 GDSC2 4.4578 6.0624 2.7425 1.4035
NCI-H1836 GDSC2 4.5082 6.9241 2.3871 3.2289
SBC-5 GDSC2 4.5741 5.6761 2.954 0.3983
NCI-H226 GDSC2 4.6169 7.2864 2.2868 3.6072
BEN GDSC2 4.6514 6.5223 2.6467 1.6278
COR-L279 GDSC2 4.6691 6.2619 2.765 1.0541
RERF-LC-KJ GDSC2 4.6919 8.2039 1.9064 5.6608
NCI-H1770 GDSC2 4.6997 6.7645 2.5679 1.9586
SHP-77 GDSC2 4.7136 6.821 2.5509 2.0262
DMS 273 GDSC2 4.756 7.2493 2.3854 2.8336
HCC827 GDSC2 4.7886 7.0439 2.4943 2.2119
LC-1/sq GDSC2 4.8403 8.4984 1.8632 5.6253
LCLC-103H GDSC2 4.8477 6.1384 2.8933 0.4234
SK-LU-1 GDSC2 4.8531 7.2805 2.426 2.4741
COR-L303 GDSC2 4.8544 6.3589 2.8118 0.6963
NCI-H1694 GDSC2 4.9112 6.535 2.7678 0.8168
NCI-H2291 GDSC2 4.9178 7.541 2.3471 2.7937
NCI-H835 GDSC2 4.9555 10.6026 0.9367 10.6807
NCI-H2444 GDSC2 4.974 6.2825 2.8908 0.3618
HCC33 GDSC2 4.9751 7.5852 2.3593 2.6467
COR-L321 GDSC2 4.978 6.5244 2.8014 0.6415
NCI-H720 GDSC2 4.9826 6.098 2.9605 0.1897
Lu-134-A GDSC2 4.9835 8.3095 2.0392 4.3663
HCC366 GDSC2 5.025 7.6073 2.3768 2.4868
LOU-NH91 GDSC2 5.0397 7.6233 2.3778 2.4615
NCI-H2228 GDSC2 5.0638 9.4697 1.5502 6.9905
NCI-H2135 GDSC2 5.0697 6.7554 2.7518 0.7512
NCI-H292 GDSC2 5.0987 6.9254 2.698 0.9305
COR-L23 GDSC2 5.1033 6.4882 2.8667 0.3639
NCI-H1435 GDSC2 5.1061 6.9444 2.6938 0.9406
NCI-H1793 GDSC2 5.1071 7.2219 2.5823 1.4041
NCI-H1105 GDSC2 5.1108 7.5802 2.434 2.0896
COR-L32 GDSC2 5.1122 7.5934 2.4291 2.1116
NCI-H2795 GDSC2 5.1218 8.319 2.1161 3.7169
DMS 79 GDSC2 5.1482 6.7132 2.8013 0.5301
NCI-H2369 GDSC2 5.1539 6.7412 2.7931 0.5526
COR-L88 GDSC2 5.1542 7.0784 2.6625 1.0227
NCI-H2081 GDSC2 5.1802 7.337 2.5703 1.3819
NCI-H522 GDSC2 5.2049 7.5554 2.4922 1.7038
NCI-H1436 GDSC2 5.208 6.8468 2.7758 0.5743
NCI-H2029 GDSC2 5.2157 6.5101 2.9019 0.2328
CPC-N GDSC2 5.22 7.5981 2.4819 1.7342
NCI-H596 GDSC2 5.2347 7.0467 2.7107 0.7762
VMRC-LCD GDSC2 5.2367 9.3109 1.7328 5.6372
NCI-H2172 GDSC2 5.2382 6.5414 2.8992 0.2307
NCI-H2141 GDSC2 5.2448 6.773 2.8183 0.4264
NCI-H146 GDSC2 5.2568 7.2902 2.6249 1.0824
IST-SL2 GDSC2 5.2583 8.6846 2.0307 3.9634
CAL-12T GDSC2 5.2728 7.4747 2.5582 1.3418
ChaGo-K-1 GDSC2 5.2754 9.8794 1.4931 6.9083
NCI-H524 GDSC2 5.2769 6.9609 2.7614 0.5777
NCI-H2227 GDSC2 5.2798 7.0436 2.7313 0.6738
NCI-H1092 GDSC2 5.3053 7.2361 2.668 0.8777
NCI-H2373 GDSC2 5.3092 7.7886 2.4468 1.7954
NCI-H2122 GDSC2 5.3132 6.7097 2.8677 0.2722
NCI-H1975 GDSC2 5.3145 7.5145 2.5617 1.2872
NCI-H1734 GDSC2 5.3147 7.0813 2.7316 0.6498
SBC-1 GDSC2 5.3151 6.9805 2.7697 0.5296
NCI-H2461 GDSC2 5.3279 10.5375 1.2176 8.3432
HCC78 GDSC2 5.3358 7.5812 2.5448 1.3378
NCI-H510A GDSC2 5.3413 6.9251 2.8007 0.4264
NCI-H847 GDSC2 5.35 6.8213 2.8418 0.3175
DMS 53 GDSC2 5.3541 7.2243 2.6937 0.7506
SBC-3 GDSC2 5.3573 7.0137 2.7745 0.4921
NCI-H2066 GDSC2 5.3583 7.07 2.7539 0.5525
LCLC-97TM1 GDSC2 5.359 9.9191 1.5269 6.5643
NCI-H526 GDSC2 5.3702 6.7918 2.86 0.2682
RERF-LC-MS GDSC2 5.3872 7.0069 2.7889 0.436
NCI-H82 GDSC2 5.4151 6.8345 2.8616 0.249
NCI-H1563 GDSC2 5.4166 6.9127 2.8344 0.3082
IST-SL1 GDSC2 5.4248 7.1274 2.7596 0.4991
NCI-H1838 GDSC2 5.4257 9.5148 1.7534 5.1974
NCI-H2009 GDSC2 5.4388 7.5395 2.6084 0.9947
NCI-H1568 GDSC2 5.4421 7.5657 2.5996 1.0253
IA-LM GDSC2 5.444 7.3419 2.687 0.7129
NCI-H23 GDSC2 5.4463 7.5293 2.6157 0.9616
EPLC-272H GDSC2 5.4491 8.0719 2.3981 1.8629
NCI-H2595 GDSC2 5.457 7.6759 2.5627 1.1551
NCI-H69 GDSC2 5.466 7.4683 2.6479 0.8308
NCI-H196 GDSC2 5.4737 7.0488 2.8075 0.3489
Lu-139 GDSC2 5.4809 7.4366 2.6665 0.7568
NCI-H1155 GDSC2 5.5148 7.1036 2.8035 0.3415
Lu-65 GDSC2 5.5175 7.4741 2.6676 0.7287
COLO 668 GDSC2 5.5207 7.3803 2.7043 0.6097
NCI-H64 GDSC2 5.5376 6.8296 2.9076 0.1347
NCI-H513 GDSC2 5.5463 7.255 2.7609 0.4345
NCI-H838 GDSC2 5.5489 7.0479 2.8362 0.2568
Ms-1 GDSC2 5.5496 7.0503 2.8355 0.2579
NCI-H209 GDSC2 5.5537 7.4872 2.6778 0.6728
NCI-H1048 GDSC2 5.5542 7.2924 2.7504 0.4588
LB647-SCLC GDSC2 5.558 7.4326 2.7001 0.6012
NCI-H810 GDSC2 5.5782 6.9969 2.8647 0.1938
NCI-H2170 GDSC2 5.5881 7.2938 2.7632 0.4095
EBC-1 GDSC2 5.5942 7.8897 2.54 1.1281
NCI-H1993 GDSC2 5.596 7.3932 2.73 0.494
HCC44 GDSC2 5.6084 7.4548 2.7123 0.5375
PC-14 GDSC2 5.617 7.5532 2.6791 0.6308
NCI-H1341 GDSC2 5.6343 7.1849 2.8196 0.2625
NCI-H2722 GDSC2 5.6347 7.2952 2.7806 0.3473
NCI-H1915 GDSC2 5.6361 7.8959 2.5563 1.0339
NCI-H740 GDSC2 5.641 8.2898 2.4013 1.6489
NCI-H727 GDSC2 5.6507 7.8222 2.5912 0.8978
UMC-11 GDSC2 5.6542 7.6688 2.651 0.696
NCI-H2196 GDSC2 5.6568 7.4203 2.744 0.4275
NCI-H1781 GDSC2 5.6585 7.1572 2.8381 0.2191
A-549 GDSC2 5.6667 7.5198 2.7116 0.5093
NCI-H2347 GDSC2 5.6828 8.3294 2.405 1.5924
Calu-3 GDSC2 5.6858 7.626 2.68 0.5894
NCI-H1581 GDSC2 5.6927 7.5155 2.7234 0.4647
NCI-H1792 GDSC2 5.6931 7.5161 2.7234 0.4646
NCI-H2818 GDSC2 5.6932 7.5368 2.7158 0.4846
DMS 114 GDSC2 5.696 7.2258 2.8279 0.2272
NCI-H290 GDSC2 5.7001 7.1091 2.8696 0.1558
Calu-6 GDSC2 5.7031 7.6369 2.6829 0.5714
NCI-H2030 GDSC2 5.7057 8.8412 2.2045 2.4663
LK-2 GDSC2 5.7264 7.6636 2.6824 0.5605
A-427 GDSC2 5.7382 9.8718 1.774 4.5874
NCI-H2810 GDSC2 5.7402 8.0469 2.5431 1.0032
NCI-H2803 GDSC2 5.7451 7.52 2.7422 0.3939
NCI-H358 GDSC2 5.7558 8.2587 2.467 1.2753
SK-MES-1 GDSC2 5.7674 8.0155 2.5669 0.9
RERF-LC-Sq1 GDSC2 5.7806 8.6691 2.3132 1.8894
KNS-62 GDSC2 5.794 7.5423 2.7528 0.3495
NCI-H1650 GDSC2 5.8066 7.5288 2.7624 0.3236
NCI-H1703 GDSC2 5.8071 7.6352 2.7245 0.4109
Lu-135 GDSC2 5.8088 7.5146 2.7682 0.3103
NCI-H3255 GDSC2 5.8126 8.0816 2.5608 0.8897
NCI-H2023 GDSC2 5.8263 7.3076 2.8465 0.1628
SW1271 GDSC2 5.8307 7.7072 2.7076 0.4425
NCI-H1876 GDSC2 5.8738 7.6215 2.7547 0.3163
HARA [Human squamous cell lung carcinoma] GDSC2 5.893 7.5749 2.7781 0.2626
NCI-H322M GDSC2 5.8945 8.9927 2.2352 2.114
HOP-92 GDSC2 5.9012 8.304 2.5134 0.9914
NCI-H1755 GDSC2 5.9122 7.8795 2.6768 0.4845
NCI-H2085 GDSC2 5.917 7.8327 2.6956 0.4351
NCI-H2087 GDSC2 5.9185 7.8632 2.6852 0.4603
NCI-H1648 GDSC2 5.9205 7.8576 2.688 0.4524
NCI-H1963 GDSC2 5.9403 7.6888 2.7556 0.292
Lu-165 GDSC2 5.9446 7.5396 2.809 0.1939
COR-L311 GDSC2 5.9471 7.4598 2.8372 0.1508
NCI-H446 GDSC2 5.9474 7.7638 2.7318 0.3393
NCI-H250 GDSC2 5.9515 7.5474 2.8088 0.1926
NCI-H1437 GDSC2 5.9534 7.796 2.7227 0.3573
NCI-H1573 GDSC2 5.9548 7.5077 2.8236 0.1689
HOP-62 GDSC2 5.9587 8.1652 2.5901 0.7043
LXF 289 GDSC2 5.969 7.9192 2.6845 0.4402
NCI-H647 GDSC2 5.9886 8.0208 2.6553 0.5054
ABC-1 GDSC2 5.9905 8.0952 2.6289 0.5752
NCI-H2731 GDSC2 5.9908 7.9044 2.6982 0.3987
NCI-H1688 GDSC2 6.0426 8.0486 2.6662 0.4539
NCI-H1869 GDSC2 6.0459 7.9048 2.7188 0.3327
NCI-H1651 GDSC2 6.0468 8.3254 2.5663 0.7259
LC-2/ad GDSC2 6.0623 7.9343 2.7145 0.3361
NCI-H1693 GDSC2 6.0667 7.7625 2.776 0.2179
NCI-H211 GDSC2 6.072 7.8312 2.7541 0.2549
NCI-H2342 GDSC2 6.0882 8.3242 2.5835 0.6526
HCC15 GDSC2 6.0912 8.2458 2.6135 0.5674
NCI-H2110 GDSC2 6.122 12.7405 0.6915 9.6231
EKVX GDSC2 6.1371 8.4208 2.5674 0.6728
NCI-H1355 GDSC2 6.1556 8.1123 2.6864 0.3633
NCI-H650 GDSC2 6.1562 7.9252 2.752 0.2356
NCI-H748 GDSC2 6.1612 8.0659 2.7048 0.3228
EMC-BAC-2 GDSC2 6.1613 8.342 2.606 0.5541
NCI-H1666 GDSC2 6.1718 8.0606 2.7106 0.3078
NCI-H2405 GDSC2 6.2012 8.3449 2.6205 0.4988
SW1573 GDSC2 6.2309 8.3826 2.6184 0.4913
PaCa-3 GDSC2 6.2755 8.2025 2.699 0.2983
NCI-H841 GDSC2 6.2924 7.9009 2.8082 0.1259
NCI-H441 GDSC2 6.3021 8.079 2.7513 0.2011
NCI-H2869 GDSC2 6.3083 8.5588 2.5846 0.5421
NCI-H520 GDSC2 6.3117 8.1222 2.7399 0.2167
NCI-H661 GDSC2 6.317 8.0608 2.7628 0.1808
NCI-H3122 GDSC2 6.3411 8.2499 2.7064 0.2657
NCI-H1944 GDSC2 6.4175 8.4111 2.6782 0.2955
NCI-H1623 GDSC2 6.4281 8.2532 2.7364 0.1958
NCI-H2591 GDSC2 6.4445 8.7472 2.5692 0.5213
COR-L105 GDSC2 6.451 13.6551 0.472 10.1169
NCI-H2804 GDSC2 6.6587 9.007 2.5578 0.4624
Lu-99A GDSC2 6.6818 9.005 2.5672 0.4332
NCI-H1299 GDSC2 8.7452 18.9782 -0.5815 11.0085
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 5.6892 7.6636 2.6674 0.6249
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC2 4.5095 10.768 0.5363 13.9066
OE33 GDSC2 4.7946 7.5411 2.2766 3.365
KYSE-150 GDSC2 4.8443 10.2167 1.046 10.3169
KYSE-520 GDSC2 4.9613 8.0215 2.1569 3.7513
TE-9 GDSC2 5.2028 6.563 2.8782 0.2908
COLO 680N GDSC2 5.2306 7.3896 2.5728 1.3208
TE-11 GDSC2 5.4354 7.3082 2.6961 0.6883
EC-GI-10 GDSC2 5.4522 7.5392 2.6144 0.9618
TE-5 GDSC2 5.5705 7.0536 2.8421 0.2379
TE-15 GDSC2 5.5882 8.9661 2.0897 3.1753
KYSE-70 GDSC2 5.6164 7.8442 2.5677 1.0071
T.T GDSC2 5.6687 7.3762 2.7645 0.3717
KYSE-510 GDSC2 5.697 7.9051 2.5791 0.9069
TE-1 GDSC2 5.7139 7.3957 2.7748 0.3302
TE-10 GDSC2 5.749 7.6918 2.6811 0.5525
KYSE-180 GDSC2 5.7798 7.4431 2.7826 0.2899
OE21 GDSC2 5.7991 7.4279 2.7951 0.2587
TE-4 GDSC2 5.9163 8.2226 2.551 0.8538
TE-6 GDSC2 5.9906 7.9844 2.6693 0.4686
KYSE-450 GDSC2 6.0385 7.2468 2.9388 0.0393
KYSE-270 GDSC2 6.0983 8.0349 2.6923 0.3711
KYSE-140 GDSC2 6.21 8.4623 2.5812 0.597
KYSE-410 GDSC2 6.2651 8.0505 2.7479 0.2151
TE-8 GDSC2 7.0091 9.001 2.6858 0.1545
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC2 4.621 8.5769 1.6823 7.122
TOV-21G GDSC2 4.7342 6.267 2.7938 0.8684
OAW42 GDSC2 4.8837 6.0744 2.9313 0.2965
ES-2 GDSC2 4.9432 6.4009 2.8339 0.5543
OV56 GDSC2 4.9771 6.101 2.9574 0.1979
OVISE GDSC2 5.0807 6.4944 2.8554 0.4065
JHOS-2 GDSC2 5.3406 7.1261 2.7254 0.6533
DOV13 GDSC2 5.3481 6.8951 2.8144 0.3867
A2780 GDSC2 5.4643 7.2096 2.745 0.5199
FU-OV-1 GDSC2 5.4915 7.5836 2.6144 0.9316
Caov-3 GDSC2 5.4951 7.143 2.7817 0.4041
TYK-nu GDSC2 5.5543 8.1936 2.3992 1.746
OV-90 GDSC2 5.5808 7.1817 2.8006 0.3222
EFO-21 GDSC2 5.6626 7.5868 2.6852 0.5868
OVCAR-3 GDSC2 5.6753 7.3435 2.7788 0.3357
OC 314 GDSC2 5.6995 7.1617 2.8514 0.185
SK-OV-3 GDSC2 5.7265 7.341 2.7988 0.2744
OVCAR-5 GDSC2 5.8137 7.6865 2.7085 0.4477
OVK18 GDSC2 5.833 7.3584 2.8315 0.1847
TOV-112D GDSC2 5.9386 8.1024 2.6054 0.67
OVCAR-4 GDSC2 6.1338 10.9392 1.5228 5.2936
JHOS-4 GDSC2 6.1718 8.3956 2.5905 0.5904
Caov-4 GDSC2 6.2318 8.3961 2.6138 0.5023
OVKATE GDSC2 6.233 7.9416 2.7738 0.1825
EFO-27 GDSC2 6.269 7.8972 2.8014 0.1381
OVTOKO GDSC2 6.2939 8.2276 2.697 0.2966
RMG-I GDSC2 6.37 8.421 2.6572 0.3511
Kuramochi GDSC2 6.4586 8.2864 2.7358 0.1901
OVCAR-8 GDSC2 6.4727 8.5341 2.6555 0.322
OAW28 GDSC2 6.5834 8.8419 2.5881 0.4232
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YAPC GDSC2 4.0223 6.1548 2.438 3.8577
DAN-G GDSC2 4.399 6.8096 2.373 3.5032
SU.86.86 GDSC2 4.9168 6.1595 2.9133 0.3286
PaTu 8988t GDSC2 4.9792 6.5379 2.7967 0.657
Panc 10.05 GDSC2 5.1229 7.2745 2.5683 1.4495
MIA PaCa-2 GDSC2 5.2145 6.7836 2.8021 0.4892
SUIT-2 GDSC2 5.2193 6.6472 2.8542 0.3427
HPAC GDSC2 5.2836 7.2286 2.6614 0.9192
KP-1N GDSC2 5.3066 7.6101 2.5191 1.4758
KP-4 GDSC2 5.3196 6.7454 2.8574 0.2931
CFPAC-1 GDSC2 5.3704 6.9723 2.7949 0.4279
HuP-T3 GDSC2 5.5223 7.3572 2.7137 0.5804
Panc 03.27 GDSC2 5.5662 7.0841 2.8298 0.2641
Hs 766T GDSC2 5.5843 7.5424 2.6697 0.6798
Panc 02.03 GDSC2 5.6151 7.2065 2.8048 0.3002
PL4 GDSC2 5.6293 7.6185 2.6597 0.6838
Panc 08.13 GDSC2 5.6339 7.3064 2.7763 0.3579
BxPC-3 GDSC2 5.6369 8.0069 2.513 1.1967
PaTu 8902 GDSC2 5.6678 7.3343 2.7792 0.3378
QGP-1 GDSC2 5.673 7.2663 2.8053 0.2789
PSN1 GDSC2 5.7102 7.358 2.7867 0.3053
Capan-1 GDSC2 5.7276 7.4808 2.7495 0.3834
AsPC-1 GDSC2 5.7971 8.0109 2.5812 0.8317
SW1990 GDSC2 5.8171 7.6462 2.7244 0.407
KP-2 GDSC2 5.913 7.5377 2.7984 0.2199
MZ-PC-1 GDSC2 5.9157 8.1642 2.5729 0.7834
HPAF-II GDSC2 5.9742 8.0323 2.6455 0.5381
HuP-T4 GDSC2 5.9835 7.6932 2.7699 0.2512
Capan-2 GDSC2 6.1145 8.2313 2.6279 0.5185
Panc 04.03 GDSC2 6.1582 8.0776 2.6996 0.3345
KP-3 GDSC2 6.4074 8.5321 2.632 0.3912
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 5.4497 8.0074 2.4251 1.741
MPP 89 GDSC2 5.7496 7.8918 2.6065 0.7792
IST-Mes1 GDSC2 5.959 7.6793 2.7658 0.2662
NCI-H2052 GDSC2 6.2911 8.2623 2.6839 0.323
NCI-H2452 GDSC2 6.4164 8.2878 2.7204 0.223
NCI-H28 GDSC2 6.7772 8.2845 2.8442 0.0446
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 4.9032 6.2933 2.8579 0.5012
VCaP GDSC2 5.1142 7.1312 2.6227 1.2227
LNCaP clone FGC GDSC2 5.4322 8.4357 2.2357 2.6533
DU145 GDSC2 5.584 7.3426 2.7438 0.4623
PC-3 GDSC2 6.1852 8.4349 2.5814 0.6087
22Rv1 GDSC2 6.2409 8.2648 2.6643 0.3807
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.0485 9.0986 1.7144 6.0843
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-3 GDSC2 0.1627 223.2756 -109.2986 49.5512
SK-MEL-28 GDSC2 4.0205 8.6871 1.1969 11.4149
M14 GDSC2 4.4767 7.3717 2.1595 4.5987
G-mel GDSC2 4.5155 6.6222 2.5284 2.4346
SK-MEL-30 GDSC2 4.5422 6.4993 2.598 2.0237
A101D GDSC2 4.6748 6.7413 2.5646 2.0096
CP50-MEL-B GDSC2 4.7117 9.4263 1.336 8.9538
WM35 GDSC2 4.7215 9.2043 1.4496 8.2722
G-361 GDSC2 4.7696 6.9048 2.5445 1.9825
Hs 938.T GDSC2 4.7989 6.8654 2.577 1.7832
WM793 GDSC2 4.9212 10.5052 0.9599 10.6274
MMAc-SF GDSC2 4.93 7.4989 2.3724 2.643
LB2518-MEL GDSC2 4.9477 6.6322 2.7459 0.8715
SK-MEL-31 GDSC2 4.9698 19.1451 -3.2619 27.23
UACC-62 GDSC2 4.9763 6.0621 2.9708 0.1713
WT2-iPS GDSC2 4.9956 6.2024 2.9283 0.2557
CP66-MEL GDSC2 4.9988 6.1778 2.9383 0.2315
VMRC-MELG GDSC2 5.0195 6.4169 2.8594 0.4277
IPC-298 GDSC2 5.0231 10.5512 1.008 10.1372
SK-MEL-2 GDSC2 5.0259 6.1348 2.9636 0.1702
Mel JuSo GDSC2 5.0563 9.5864 1.4903 7.3466
COLO 783 GDSC2 5.1107 6.8647 2.7272 0.8098
RPMI-7951 GDSC2 5.1123 7.2534 2.5718 1.4451
SK-MEL-1 GDSC2 5.1156 6.7859 2.7599 0.6886
DJM-1 GDSC2 5.1231 7.1858 2.6047 1.2905
A2058 GDSC2 5.1601 6.4899 2.8881 0.2846
GAK GDSC2 5.1602 6.5727 2.8582 0.3594
SK-MEL-5 GDSC2 5.186 6.261 2.9774 0.1076
RVH-421 GDSC2 5.2183 6.8047 2.7958 0.5061
A-431 GDSC2 5.2232 7.6259 2.4718 1.7766
UACC-257 GDSC2 5.249 6.5786 2.8901 0.2463
MZ-MEL-7 GDSC2 5.2816 7.1813 2.679 0.8557
WM115 GDSC2 5.2837 6.7272 2.8502 0.3247
LB373-MEL-D GDSC2 5.3021 6.621 2.8949 0.2184
MZ-MEL-2 GDSC2 5.3248 7.3198 2.6439 0.952
WM278 GDSC2 5.3282 9.4004 1.7473 5.3967
IGR-37 GDSC2 5.3392 6.7475 2.864 0.2706
Hs 940.T GDSC2 5.343 6.8736 2.8202 0.374
IGR-1 GDSC2 5.3461 7.1797 2.7074 0.7095
LOX-IMVI GDSC2 5.4829 6.8838 2.8693 0.2123
COLO 829 GDSC2 5.5315 8.9692 2.0577 3.4161
A-388 GDSC2 5.5673 7.7789 2.5716 1.0308
A-375 GDSC2 5.6195 7.2105 2.805 0.2982
MeWo GDSC2 5.6266 7.3611 2.7537 0.4164
WM1552C GDSC2 5.6762 7.4827 2.7289 0.4579
HT-144 GDSC2 5.7058 7.07 2.8849 0.1326
451Lu GDSC2 5.7069 7.2906 2.8093 0.2596
Mel Ho GDSC2 5.7448 7.6192 2.706 0.4861
SK-MEL-24 GDSC2 5.7462 7.4045 2.7838 0.299
COLO 800 GDSC2 5.7849 7.4058 2.7976 0.2582
COLO 792 GDSC2 5.7954 7.9447 2.6057 0.7533
COLO 679 GDSC2 5.8623 7.5998 2.7581 0.3131
CHL-1 GDSC2 5.9505 7.7497 2.738 0.325
HMV-II GDSC2 6.0958 12.8817 0.6087 10.0928
SH-4 GDSC2 6.1183 7.8737 2.7562 0.2385
IST-MEL1 GDSC2 6.3753 8.0589 2.7837 0.1417
EquiPSC Line K2 GDSC2 4.9971 10.5967 0.9682 10.4144
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 4.7847 14.5882 -1.1434 20.9643
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC2 4.7704 7.217 2.408 2.6907
VA-ES-BJ GDSC2 4.8613 8.1694 2.0293 4.6354
MES-SA GDSC2 4.9207 6.0089 2.9689 0.1932
GCT GDSC2 4.9692 8.5121 1.9374 4.9634
SW982 GDSC2 5.0248 6.5497 2.8117 0.5744
SW684 GDSC2 5.0996 6.2423 2.953 0.1683
TE 441.T GDSC2 5.2086 6.4007 2.9375 0.1656
RKN GDSC2 5.3127 6.485 2.9458 0.1267
Rh30 GDSC2 5.4184 7.4542 2.6327 0.9204
HT-1080 GDSC2 5.5001 6.9794 2.8421 0.2608
SK-LMS-1 GDSC2 5.5009 8.3062 2.3261 2.1355
KYM-1 GDSC2 5.5645 6.9577 2.8733 0.1826
EW-8 GDSC2 5.6272 7.4804 2.7103 0.5332
SK-UT-1 GDSC2 5.6417 7.1137 2.8472 0.2075
Hs 633.T GDSC2 5.7115 7.2494 2.8254 0.2274
MFH-ino GDSC2 5.9144 7.674 2.7513 0.3095
SW872 GDSC2 5.9664 7.6323 2.7849 0.2291
G-402 GDSC2 6.0741 8.5661 2.4868 0.9633
RD GDSC2 6.4012 8.6209 2.598 0.47
G-401 GDSC2 6.4612 8.3898 2.7013 0.243
A-204 GDSC2 6.6019 8.8808 2.5813 0.4315
STS-0421 GDSC2 7.1083 9.5503 2.5333 0.3636
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC2 4.4063 6.5749 2.4857 2.8489
MKN45 GDSC2 4.5381 5.855 2.8683 0.7428
TGBC11TKB GDSC2 4.5789 6.829 2.4721 2.6409
AGS GDSC2 4.9386 6.5501 2.7742 0.7703
SCH GDSC2 4.9797 6.4855 2.8171 0.5863
SNU-16 GDSC2 5.1213 6.3854 2.9107 0.2476
SNU-5 GDSC2 5.148 6.5852 2.8488 0.3906
OCUM-1 GDSC2 5.1888 8.3349 2.1472 3.4477
ECC12 GDSC2 5.2228 6.5309 2.8972 0.2404
NUGC-4 GDSC2 5.3584 6.9101 2.813 0.3856
TMK-1 GDSC2 5.3729 7.4432 2.6168 1.0159
ECC10 GDSC2 5.4522 7.93 2.4581 1.5932
NUGC-3 GDSC2 5.5331 7.9445 2.4904 1.3784
MKN1 GDSC2 5.5578 7.08 2.8281 0.2704
SK-GT-2 GDSC2 5.6459 8.5752 2.286 2.1558
HSC-39 GDSC2 5.7833 7.2491 2.8513 0.1652
HGC-27 GDSC2 5.8292 8.749 2.3038 1.8808
KATO III GDSC2 5.8471 7.6415 2.7375 0.3639
IM95 GDSC2 5.8901 8.176 2.5577 0.8487
Hs 746.T GDSC2 5.9189 7.6031 2.7778 0.2555
23132/87 GDSC2 5.997 7.7684 2.7487 0.2878
NCI-N87 GDSC2 6.0265 8.5928 2.4561 1.1031
MKN7 GDSC2 6.0361 7.7832 2.7578 0.2586
SNU-1 GDSC2 6.0783 7.7875 2.7716 0.2225
RERF-GC-1B GDSC2 6.0932 8.9445 2.3479 1.4539
GCIY GDSC2 6.136 8.0651 2.6957 0.3503
Fu97 GDSC2 6.2125 7.7845 2.8197 0.1252
MKN28 GDSC2 6.223 8.2123 2.6762 0.3615
SNG-M GDSC2 5.3402 7.0805 2.7426 0.5985
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC2 4.8896 6.495 2.774 0.8111
IHH-4 GDSC2 5.0117 6.3406 2.8845 0.3605
FTC-133 GDSC2 5.2128 6.7186 2.8255 0.4225
CGTH-W-1 GDSC2 5.2804 6.7399 2.8443 0.3405
8305C GDSC2 5.3541 6.9652 2.7911 0.4465
TT GDSC2 5.4365 6.9759 2.8194 0.3356
ASH-3 GDSC2 5.5261 7.2738 2.7461 0.4846
KMH-2 GDSC2 5.575 7.5747 2.6536 0.7376
WRO GDSC2 5.6308 7.5614 2.6817 0.615
HTC-C3 GDSC2 5.6365 7.5558 2.6861 0.5985
BHT-101 GDSC2 5.6708 7.358 2.7719 0.3534
B-CPAP GDSC2 5.7226 7.2241 2.8382 0.2014
ML-1 [Human leukemia] GDSC2 5.8948 7.6115 2.766 0.286
8505C GDSC2 6.0186 7.8499 2.728 0.3227
TT2609-C02 GDSC2 6.1358 8.0828 2.6894 0.3638
K5 GDSC2 6.2297 7.8969 2.7878 0.1632
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-15A GDSC2 4.0224 6.1271 2.4514 3.7768
PCI-04B GDSC2 4.4578 8.4053 1.6533 7.6462
FaDu GDSC2 4.6049 7.4912 2.1848 4.2107
CAL-27 GDSC2 4.6087 6.9612 2.4299 2.8238
KON GDSC2 4.85 7.7177 2.2291 3.5361
HSC-4 GDSC2 4.9814 9.1311 1.6565 6.5432
HSC-2 GDSC2 5.041 6.594 2.8016 0.5973
HO-1-N-1 GDSC2 5.0522 7.0768 2.6154 1.3157
JHU-011 GDSC2 5.1414 8.7681 1.9243 4.7364
HSC-3 GDSC2 5.2453 6.793 2.8111 0.4463
DOK GDSC2 5.2675 9.3247 1.7453 5.5133
OSC-19 GDSC2 5.2936 7.8517 2.4125 1.9717
JHU-022 GDSC2 5.4731 7.7305 2.5484 1.1978
HO-1-u-1 GDSC2 5.4795 7.6047 2.6009 0.9907
SKN-3 GDSC2 5.4931 8.3486 2.3043 2.2467
SAS GDSC2 5.5027 7.747 2.5553 1.1454
BICR 31 GDSC2 5.5545 8.0473 2.4589 1.4892
KOSC-2 GDSC2 5.558 11.5714 0.8787 9.7317
Detroit 562 GDSC2 5.5783 9.003 2.0683 3.2967
UPCI-SCC-090 GDSC2 5.6113 8.036 2.4898 1.31
JHU-029 GDSC2 5.6133 10.5435 1.3951 6.8311
BB49-HNC GDSC2 5.6442 13.3003 0.1104 13.4777
SCC-4 GDSC2 5.6915 7.636 2.6786 0.5902
BICR 10 GDSC2 5.7138 7.4293 2.7627 0.3578
NCI-H3118 GDSC2 5.7244 7.6489 2.6871 0.5484
PCI-30 GDSC2 5.7392 7.6257 2.7015 0.501
PE/CA-PJ15 GDSC2 5.7449 7.4671 2.761 0.3496
BB30-HNC GDSC2 5.7486 7.4437 2.7708 0.3263
BICR 22 GDSC2 5.8092 7.1838 2.8824 0.1167
Ca9-22 GDSC2 5.8884 7.6759 2.7409 0.3409
SCC-25 GDSC2 5.8886 7.5277 2.793 0.2362
CAL-33 GDSC2 5.9615 7.8565 2.7042 0.3963
SCC-9 GDSC2 6.0625 8.1498 2.6373 0.5182
OSC-20 GDSC2 6.0666 7.6872 2.8018 0.177
SCC-15 GDSC2 6.0919 7.6945 2.8082 0.1623
PCI-06A GDSC2 6.0932 7.8538 2.754 0.2492
BICR 78 GDSC2 6.1046 8.1864 2.6404 0.4912
BHY GDSC2 6.1274 7.9565 2.7307 0.2824
LB771-HNC GDSC2 6.3106 8.4678 2.6183 0.4585
SAT [Human HNSCC] GDSC2 6.4331 13.3101 0.6211 9.4119
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC2 4.0461 5.614 2.7084 2.2149
647V GDSC2 4.489 6.5578 2.542 2.4023
CAL-29 GDSC2 4.8896 6.4212 2.8029 0.7016
KU-19-19 GDSC2 4.9565 6.415 2.8341 0.5448
TCCSUP GDSC2 5.1559 6.7471 2.7918 0.5556
HT-1197 GDSC2 5.3745 7.1771 2.7203 0.6484
BFTC-905 GDSC2 5.4063 6.9004 2.8349 0.311
SW1710 GDSC2 5.5079 7.4028 2.6906 0.6603
SW780 GDSC2 5.6604 7.3432 2.7732 0.3545
J82 GDSC2 5.6687 7.7069 2.6427 0.7137
HT-1376 GDSC2 5.683 7.7165 2.645 0.6975
T24 GDSC2 5.6983 7.6051 2.6928 0.5459
RT-4 GDSC2 5.8219 7.7905 2.6738 0.5358
UM-UC-3 GDSC2 5.9533 7.4155 2.8543 0.1268
RT-112 GDSC2 6.0596 7.7865 2.7652 0.2385
5637 GDSC2 6.4971 8.4418 2.6963 0.2424
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa GDSC2 4.0338 5.5702 2.7212 2.1641
JEG-3 GDSC2 4.4667 10.2902 0.7397 12.9083
OVCA433 GDSC2 4.7562 14.9058 -1.3225 21.7189
NEC8 GDSC2 5.0371 6.6863 2.7644 0.7299
SW756 GDSC2 5.1573 7.2069 2.6123 1.2249
SiHa GDSC2 5.1587 6.3518 2.9364 0.182
NT2-D1 GDSC2 5.1634 6.985 2.7035 0.8569
SW954 GDSC2 5.1801 7.4029 2.5431 1.5009
ME-180 GDSC2 5.2625 9.0404 1.8724 4.8187
NCC-IT GDSC2 5.2998 6.8631 2.807 0.4298
SiSo GDSC2 5.3624 7.4673 2.6026 1.0795
LB831-BLC GDSC2 5.3688 7.0854 2.7525 0.551
HEC-1 GDSC2 5.374 7.0761 2.7581 0.5312
OVCA420 GDSC2 5.4134 7.3291 2.6789 0.7606
C-4-I GDSC2 5.4208 7.5937 2.579 1.1222
PWR-1E GDSC2 5.4496 7.2577 2.7211 0.5999
DSH1 GDSC2 5.5282 7.1801 2.7811 0.3907
SKG-IIIa GDSC2 5.5829 7.0897 2.834 0.25
SKN GDSC2 5.5961 7.7581 2.5923 0.9333
HT-3 GDSC2 5.6613 7.4889 2.7208 0.4868
DoTc2 4510 GDSC2 5.6701 7.6729 2.6561 0.6706
OMC-1 [Human cervical carcinoma] GDSC2 5.6738 7.5834 2.691 0.5638
JAR GDSC2 5.7069 6.9936 2.9111 0.0992
KGN GDSC2 5.7652 7.9063 2.6076 0.7659
PA-1 GDSC2 5.8344 7.5325 2.7714 0.2947
JHOS-3 GDSC2 5.8756 7.82 2.6842 0.4823
CAL-39 GDSC2 5.8822 7.7769 2.7024 0.4333
PEO1 GDSC2 5.934 7.9822 2.648 0.551
BPH-1 GDSC2 6.0755 8.5453 2.4953 0.9339
TC-YIK GDSC2 6.0987 7.8813 2.7465 0.2614
SW962 GDSC2 6.1264 7.6922 2.821 0.1384
C-33 A GDSC2 6.1304 8.0838 2.687 0.3711
HEY GDSC2 6.1522 8.2714 2.6281 0.5013
ACC-OV7 GDSC2 6.163 12.4854 0.8359 8.8091
MS751 GDSC2 6.2814 7.844 2.8235 0.1104
OVMIU GDSC2 6.3315 8.9815 2.4372 0.9588
Ca Ski GDSC2 6.4475 8.6567 2.6028 0.4408
UWB1.289 GDSC2 6.5394 8.6453 2.641 0.3294
OV17R GDSC2 6.7574 8.8673 2.643 0.2656
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT03701295) Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 August 8; 122(6): 1017-1025.