Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNE56X)

Drug Name
ABT-263 Drug Info
Synonyms
Navitoclax; ABT 263; S1001_Selleck; ABT263, Navitoclax; 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-({(1R)-3-morpholin-4-yl-1-[(phenylsulfanyl)methyl]propyl}amino)-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)benzamide
Cross-matching ID
PubChem CID
24978538
ChEBI ID
CHEMBL443684
CAS Number
CAS 923564-51-6
TTD Drug ID
D06ETI
VARIDT Drug ID
DR01365
INTEDE Drug ID
DR1839

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.48 0.00e+0 52/108 (48.15%) NVL;HEATR1;NOP56;...
Ribosome 2.24 0.00e+0 113/158 (71.52%) MRPL3;RPL10;RPS4Y1;...
DNA replication 2.24 0.00e+0 34/36 (94.44%) PCNA;POLE2;MCM6;...
Spliceosome 2.23 0.00e+0 101/150 (67.33%) LSM5;SRSF1;LSM6;...
Pyrimidine metabolism 2.22 0.00e+0 40/56 (71.43%) RRM2;NT5E;UCK2;...
RNA transport 1.98 3.13e-3 128/186 (68.82%) EIF4G1;EIF5B;NUP93;...
One carbon pool by folate 1.92 2.69e-3 15/20 (75%) TYMS;MTR;GART;...
Fanconi anemia pathway 1.90 2.35e-3 36/54 (66.67%) REV1;BRCA1;REV3L;...
RNA polymerase 1.78 1.78e-2 23/31 (74.19%) POLR3G;POLR3B;POLR3K;...
Cell cycle 1.73 2.16e-2 110/124 (88.71%) PLK1;TFDP1;MYC;...
Protein export 1.71 2.56e-2 17/23 (73.91%) SRP72;SEC61A1;OXA1L;...
Oocyte meiosis 1.71 2.51e-2 90/129 (69.77%) PLK1;IGF1;CDC20;...
Complement and coagulation cascades 1.70 2.39e-2 76/85 (89.41%) PLAT;C3;A2M;...
Progesterone-mediated oocyte maturation 1.67 3.16e-2 75/100 (75%) PLK1;IGF1;CDC25A;...
Regulation of lipolysis in adipocytes 1.66 3.20e-2 52/55 (94.55%) MGLL;NPY1R;FABP4;...
Mismatch repair 1.62 4.17e-2 22/23 (95.65%) PCNA;EXO1;MSH6;...
Natural killer cell mediated cytotoxicity -1.60 4.71e-2 99/131 (75.57%) PIK3CA;TNF;CD244;...
Tryptophan metabolism -1.62 4.32e-2 35/42 (83.33%) CYP1B1;MAOA;AOC1;...
Primary immunodeficiency -1.62 4.37e-2 33/38 (86.84%) ICOS;CD4;TNFRSF13B;...
Antigen processing and presentation -1.63 4.28e-2 60/78 (76.92%) TAPBP;HLA-G;IFNG;...
Glycolysis / Gluconeogenesis -1.65 3.54e-2 56/67 (83.58%) ENO3;AKR1A1;GPI;...
Fructose and mannose metabolism -1.67 3.00e-2 30/33 (90.91%) PMM1;PFKM;ALDOA;...
Metabolism of xenobiotics by cytochrome P450 -1.68 2.76e-2 49/77 (63.64%) GSTK1;GSTM2;CBR3;...
Synthesis and degradation of ketone bodies -1.68 2.86e-2 9/10 (90%) OXCT1;ACAT2;OXCT2;...
Cell adhesion molecules -1.71 2.38e-2 118/148 (79.73%) ICAM2;NRCAM;HLA-G;...
Butanoate metabolism -1.72 2.33e-2 23/28 (82.14%) HADHA;ACAT1;ABAT;...
Oxidative phosphorylation -1.72 2.19e-2 93/133 (69.92%) NDUFA1;COX7A1;COX7A2;...
Type I diabetes mellitus -1.75 1.95e-2 38/43 (88.37%) HLA-G;IFNG;HLA-DOB;...
Glycosaminoglycan degradation -1.82 7.93e-3 19/19 (100%) SGSH;IDUA;HGSNAT;...
Pentose phosphate pathway -1.84 6.73e-3 25/30 (83.33%) RGN;GPI;TKTL1;...
Graft-versus-host disease -1.84 7.40e-3 32/42 (76.19%) HLA-DRB1;TNF;CD80;...
Valine, leucine and isoleucine degradation -1.87 4.70e-3 42/48 (87.5%) OXCT1;ACAT2;OXCT2;...
Autoimmune thyroid disease -1.87 5.29e-3 46/53 (86.79%) HLA-DOB;HLA-DOA;HLA-DPB1;...
Autophagy -1.89 4.53e-3 113/169 (66.86%) BCL2;MTMR4;ATG4B;...
Galactose metabolism -1.91 3.52e-3 26/31 (83.87%) PFKM;GLB1;GLA;...
Mitophagy -1.98 2.11e-3 56/68 (82.35%) TBC1D17;GABARAPL2;TFE3;...
Allograft rejection -2.01 2.64e-3 32/38 (84.21%) HLA-DRB1;TNF;CD80;...
Other glycan degradation -2.05 3.52e-3 13/18 (72.22%) MANBA;MAN2B1;HEXA;...
Lysosome -2.16 0.00e+0 115/128 (89.84%) LAMP2;IDUA;HGSNAT;...
Steroid biosynthesis -2.28 0.00e+0 19/20 (95%) HSD17B7;NSDHL;LIPA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 3.33uM 24H