General Information of Drug (ID: DMNFCXW)

Drug Name
THIOCTIC ACID Drug Info
Synonyms
dl-Thioctic acid; thioctic acid; 1077-28-7; 5-(1,2-Dithiolan-3-yl)pentanoic acid; DL-alpha-Lipoic acid; 1,2-dithiolane-3-pentanoic acid; Thioctacid; 6,8-Thioctic acid; 6-Thioctic acid; Lipothion; Biletan; dl-Lipoic acid; Tioctacid; Thioctsan; Liposan; Rac-lipoate; 1,2-Dithiolane-3-valeric acid; DL-6,8-Thioctic acid; alpha-Liponsaeure; DL-6-Thioctic acid; alpha-liponic acid; Thioktsaeure; Tioctidasi; (RS)-Lipoic acid; 6,8-Dithiooctanoic acid; espa-lipon; Thioctic acid dl-form; 62-46-4
Cross-matching ID
PubChem CID
864
ChEBI ID
CHEMBL33864
CAS Number
CAS 1077-28-7
TTD Drug ID
D0P6PQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.73 3.96e-1 52/108 (48.15%) NVL;LSG1;GTPBP4;...
Chemokine signaling pathway 1.69 2.85e-1 163/192 (84.9%) CXCL9;PXN;CCL2;...
Mineral absorption 1.69 1.99e-1 48/60 (80%) MT1F;FTH1;MT1X;...
Viral protein interaction with cytokine and cytokine re... 1.68 1.64e-1 84/100 (84%) ACKR3;CXCL9;CCL2;...
Homologous recombination 1.66 1.45e-1 35/41 (85.37%) RAD51C;BRCA1;RPA3;...
VEGF signaling pathway 1.63 1.67e-1 50/59 (84.75%) PXN;CDC42;BAD;...
Tryptophan metabolism 1.58 2.19e-1 35/42 (83.33%) KYNU;KMO;MAOA;...
African trypanosomiasis 1.58 1.93e-1 32/37 (86.49%) HBB;GNAQ;IL1B;...
Protein export 1.57 1.72e-1 17/23 (73.91%) SEC61G;SRP72;SPCS1;...
Small cell lung cancer 1.57 1.62e-1 90/92 (97.83%) COL4A5;ITGA6;BIRC3;...
Bacterial invasion of epithelial cells 1.53 2.04e-1 59/77 (76.62%) PXN;CDC42;CRKL;...
Proteasome 1.51 2.20e-1 44/46 (95.65%) PSMD6;PSMB9;PSMB1;...
Hematopoietic cell lineage 1.50 2.20e-1 90/99 (90.91%) IL7R;ITGA6;CD2;...
Folate biosynthesis 1.49 2.27e-1 23/26 (88.46%) MOCOS;AKR1C3;PAH;...
RNA degradation 1.48 2.29e-1 53/79 (67.09%) LSM5;PFKP;EXOSC4;...
Mannose type O-glycan biosynthesis 1.48 2.18e-1 14/23 (60.87%) FUT9;B4GALT3;RXYLT1;...
Fanconi anemia pathway 1.45 2.43e-1 36/54 (66.67%) FANCI;RMI1;RAD51C;...
Maturity onset diabetes of the young 1.45 2.29e-1 21/26 (80.77%) HHEX;PAX6;NKX2-2;...
Oocyte meiosis 1.44 2.30e-1 90/129 (69.77%) PRKACB;CCNB2;CDC20;...
Focal adhesion 1.42 2.76e-1 180/201 (89.55%) PXN;COL4A5;ITGA6;...
Human immunodeficiency virus 1 infection 1.36 4.06e-1 189/212 (89.15%) PXN;APOBEC3B;BAD;...
Toxoplasmosis 1.32 4.17e-1 103/112 (91.96%) ITGA6;BAD;ALOX5;...
Primary immunodeficiency 1.31 4.11e-1 33/38 (86.84%) IL7R;CD3D;TAP1;...
Pentose phosphate pathway 1.31 4.06e-1 25/30 (83.33%) PFKP;PRPS1;DERA;...
Protein digestion and absorption 1.31 4.06e-1 78/103 (75.73%) SLC3A1;COL4A5;COL15A1;...
DNA replication 1.29 4.18e-1 34/36 (94.44%) RPA3;FEN1;POLD3;...
Toll-like receptor signaling pathway 1.29 4.13e-1 94/104 (90.38%) CXCL9;CCL5;CXCL10;...
Cell cycle 1.28 4.18e-1 110/124 (88.71%) CCNB2;CDC20;ANAPC13;...
Serotonergic synapse 1.28 4.06e-1 97/114 (85.09%) PRKACB;MAOA;ALOX5;...
AGE-RAGE signaling pathway in diabetic complications 1.28 4.03e-1 97/100 (97%) COL4A5;CCL2;CDC42;...
Retinol metabolism -1.19 6.47e-1 41/68 (60.29%) CYP2C18;ALDH1A2;RDH11;...
Phosphonate and phosphinate metabolism -1.22 6.41e-1 5/6 (83.33%) CEPT1;CHPT1
Cardiac muscle contraction -1.23 6.21e-1 64/87 (73.56%) MYL2;SLC9A6;COX6B1;...
Breast cancer -1.23 6.24e-1 119/147 (80.95%) JAG2;ESR2;ESR1;...
Wnt signaling pathway -1.23 6.35e-1 124/166 (74.7%) CER1;NFATC1;MYC;...
Renin-angiotensin system -1.24 6.44e-1 20/23 (86.96%) CTSA;AGTR1;CTSG
Adherens junction -1.25 6.48e-1 63/71 (88.73%) ACTN4;PTPRJ;ERBB2;...
Glycerophospholipid metabolism -1.28 6.45e-1 71/98 (72.45%) MBOAT7;CDIPT;LPCAT1;...
Pantothenate and CoA biosynthesis -1.28 6.48e-1 14/21 (66.67%) BCAT1;PANK3;DPYD;...
Neuroactive ligand-receptor interaction -1.30 6.07e-1 294/341 (86.22%) TSHB;PTGER1;CSH1;...
Neutrophil extracellular trap formation -1.31 6.15e-1 101/189 (53.44%) PLCG1;FGG;CYBB;...
Steroid biosynthesis -1.31 6.17e-1 19/20 (95%) NSDHL;CYP51A1;MSMO1;...
Phospholipase D signaling pathway -1.33 5.86e-1 134/148 (90.54%) PLCB2;PDGFRA;DNM1;...
Fatty acid degradation -1.34 5.59e-1 40/43 (93.02%) CPT2;ACAA1;ACSL6;...
Ether lipid metabolism -1.35 5.50e-1 32/49 (65.31%) PLA2G10;ENPP2;PLA2G2F;...
Melanoma -1.35 5.59e-1 68/72 (94.44%) FGF1;BRAF;FGF6;...
Malaria -1.36 5.68e-1 44/50 (88%) SDC2;CSF3;CR1;...
Legionellosis -1.37 5.72e-1 51/57 (89.47%) TLR5;HSPD1;HSPA1A;...
Glioma -1.39 5.45e-1 67/75 (89.33%) BRAF;CDKN1A;KRAS;...
Sulfur metabolism -1.40 5.40e-1 9/10 (90%) MPST;PAPSS2
HIF-1 signaling pathway -1.42 5.09e-1 105/109 (96.33%) PLCG1;FLT1;HK3;...
Synaptic vesicle cycle -1.45 4.45e-1 63/78 (80.77%) CLTB;ATP6V1B2;SLC6A13;...
Glycerolipid metabolism -1.47 4.25e-1 44/61 (72.13%) PLPP3;LPL;ALDH3A2;...
Arginine biosynthesis -1.47 4.54e-1 17/22 (77.27%) GOT1;ASS1;GLUL;...
Epithelial cell signaling in Helicobacter pylori infect... -1.48 4.60e-1 62/70 (88.57%) PLCG1;NOD1;CSK;...
Lysosome -1.50 4.63e-1 115/128 (89.84%) CTSE;CD63;PLA2G15;...
Regulation of lipolysis in adipocytes -1.51 4.97e-1 52/55 (94.55%) PTGS2;NPR1;ADCY2;...
Phagosome -1.52 5.59e-1 118/152 (77.63%) MARCO;ACTB;HLA-DRB1;...
Taurine and hypotaurine metabolism -1.58 5.31e-1 8/11 (72.73%) GGT1;CSAD;GAD1;...
Cholesterol metabolism -1.64 4.76e-1 44/50 (88%) TSPO;LIPA;STAR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H