Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNG35S)

Drug Name
ABT-751 Drug Info
Synonyms
ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; ABT-751 (E7010); UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; N-[2-[(4-HYDROXYPHENYL)AMINO]-3-PYRIDYL]-4-METHOXYBENZENESULFONAMIDE; CHEMBL20684; N-(2-((4-Hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl}-4-methoxybenzenesulfonamide; Benzenesulfonamide,N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-; N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide
Cross-matching ID
PubChem CID
3035714
ChEBI ID
CHEMBL20684
CAS Number
CAS 141430-65-1
TTD Drug ID
D09EHO
INTEDE Drug ID
DR1853

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 2.05 0.00e+0 86/96 (89.58%) ITGA6;TPM1;TPM4;...
Hypertrophic cardiomyopathy 2.00 0.00e+0 81/90 (90%) ITGA6;TPM1;TPM4;...
Focal adhesion 1.98 3.36e-3 180/201 (89.55%) ITGA6;CAV1;LAMC2;...
Salmonella infection 1.97 2.52e-3 198/249 (79.52%) PODXL;TUBB2A;FLNA;...
Proteasome 1.96 6.04e-3 44/46 (95.65%) PSMD9;PSMD2;PSMB6;...
Oocyte meiosis 1.79 3.02e-2 90/129 (69.77%) PLK1;AURKA;CDC20;...
Amoebiasis 1.78 2.73e-2 99/102 (97.06%) LAMC2;ACTN1;CXCL3;...
Bacterial invasion of epithelial cells 1.77 2.52e-2 59/77 (76.62%) CAV1;CAV2;ILK;...
Arrhythmogenic right ventricular cardiomyopathy 1.76 2.24e-2 70/77 (90.91%) ITGA6;ITGA3;DES;...
Mineral absorption 1.76 2.01e-2 48/60 (80%) MT1E;MT1H;MT1F;...
Shigellosis 1.71 4.12e-2 180/246 (73.17%) ACTN1;ILK;ACTN4;...
Regulation of actin cytoskeleton 1.70 4.03e-2 185/218 (84.86%) ITGA6;ACTN1;ACTN4;...
VEGF signaling pathway 1.66 4.80e-2 50/59 (84.75%) PRKCA;PPP3CA;MAPKAPK2;...
Pentose and glucuronate interconversions -1.65 4.37e-2 17/34 (50%) AKR1B1;DCXR;UGT2B28;...
Steroid hormone biosynthesis -1.74 1.98e-2 43/61 (70.49%) UGT2B4;CYP3A4;HSD17B8;...
Glycine, serine and threonine metabolism -1.76 1.68e-2 31/40 (77.5%) GCAT;MAOA;GLDC;...
Alanine, aspartate and glutamate metabolism -1.77 1.82e-2 27/37 (72.97%) ASRGL1;GFPT1;GLUD2;...
Folate biosynthesis -1.77 1.80e-2 23/26 (88.46%) DHFR;GCH1;AKR1B10;...
Primary bile acid biosynthesis -1.78 1.69e-2 15/17 (88.24%) CH25H;CYP7B1;AKR1D1;...
Butanoate metabolism -1.80 1.10e-2 23/28 (82.14%) ACSM5;BDH1;ECHS1;...
Mismatch repair -1.80 1.12e-2 22/23 (95.65%) RFC3;RFC4;POLD3;...
Fatty acid degradation -1.80 9.92e-3 40/43 (93.02%) GCDH;ECHS1;ACSBG1;...
One carbon pool by folate -1.87 0.00e+0 15/20 (75%) MTHFD1;SHMT1;ALDH1L1;...
Glyoxylate and dicarboxylate metabolism -1.92 0.00e+0 23/30 (76.67%) GLUL;GLDC;DLD;...
Metabolism of xenobiotics by cytochrome P450 -1.96 0.00e+0 49/77 (63.64%) UGT2B4;SULT2A1;CYP3A4;...
Glycolysis / Gluconeogenesis -2.00 0.00e+0 56/67 (83.58%) PFKL;ADH6;ADH1B;...
Valine, leucine and isoleucine degradation -2.02 0.00e+0 42/48 (87.5%) ECHS1;MCCC2;BCAT2;...
DNA replication -2.28 0.00e+0 34/36 (94.44%) DNA2;PRIM1;RFC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.08uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.08uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.08uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.08uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.08uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.08uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.08uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.08uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.08uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
GP2d CVCL_1234 Homo sapiens 0.08uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.08uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.08uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.08uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM - 10uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.08uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.08uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.08uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.08uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.08uM - 1.11uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.08uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.08uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.08uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.08uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 0.08uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.08uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.08uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.08uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 10uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.08uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.08uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.08uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.08uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.08uM - 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.08uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.08uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
OVK18 CVCL_1629 Homo sapiens 0.08uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.08uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.08uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.08uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.08uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.08uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.08uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.08uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.08uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.08uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.08uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.08uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.08uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.08uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.08uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.08uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM - 10uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.08uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.08uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.08uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.08uM - 1.11uM 24H