Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNHU4M)

• Drug Name: TRIM Drug Info
• Synonyms: Trim; 25371-96-4; 1-[2-(trifluoromethyl)phenyl]imidazole; 1-(2-Trifluoromethylphenyl)imidazole; 1-(2-(Trifluoromethyl)phenyl)-1H-imidazole; 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole; CHEMBL277525; WZBWBNCQUTXYEL-UHFFFAOYSA-N; NCGC00016047-03; 1H-Imidazole,1-[2-(trifluoromethyl)phenyl]-; DSSTox_RID_80756; DSSTox_CID_25217; DSSTox_GSID_45217; [2-(trifluoromethyl)phenyl]imidazole; 1-TRIM; CAS-25371-96-4; SR-01000076173; PubChem6489; Tocris-0919; ACMC-1CKKY; AC1L1BAW; AC1Q4JVD; Lopac-T-7313; Lopac0_001200; KBioSS_000064
• Cross-matching ID:
  PubChem CID: 1359
  ChEBI ID: CHEMBL109530
  CAS Number: CAS 25371-96-4
  TTD Drug ID: D0B3AR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Viral protein interaction with cytokine and cytokine re...	1.96	7.50e-3	84/100 (84%)	CCL4;CCL5;CXCL13;...
Oxidative phosphorylation	1.94	7.50e-3	93/133 (69.92%)	LHPP;ATP6V1D;COX11;...
Legionellosis	1.84	3.00e-2	51/57 (89.47%)	HSPA1A;CASP3;RAB1B;...
IL-17 signaling pathway	1.83	2.81e-2	84/94 (89.36%)	S100A8;MMP9;CASP3;...
DNA replication	1.82	2.25e-2	34/36 (94.44%)	MCM5;MCM2;RPA3;...
Valine, leucine and isoleucine degradation	1.78	2.12e-2	42/48 (87.5%)	HADHB;ABAT;ALDH3A2;...
TNF signaling pathway	1.76	2.03e-2	103/112 (91.96%)	MMP9;CCL5;CASP3;...
Thyroid hormone synthesis	-1.79	3.59e-2	66/75 (88%)	GSR;CREB3L1;ADCY7;...
Autoimmune thyroid disease	-1.80	3.29e-2	46/53 (86.79%)	FAS;HLA-DOA;CD86;...
Intestinal immune network for IgA production	-1.81	4.12e-2	38/48 (79.17%)	CD86;HLA-DOB;HLA-DPB1;...
Basal cell carcinoma	-1.83	4.64e-2	41/63 (65.08%)	TCF7;CTNNB1;WNT5A;...
Melanogenesis	-1.88	3.80e-2	74/101 (73.27%)	TCF7;CTNNB1;WNT5A;...
Viral myocarditis	-1.94	2.53e-2	53/60 (88.33%)	CD86;HLA-DOB;EIF4G1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	25uM	6H	Hide ▲