Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNLQHK)

Drug Name
Tanespimycin Drug Info
Synonyms
CNF-101; [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; 17AAG, Tanespimycin, Geldanamycin, NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin, CP 127374
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
6505803
ChEBI ID
CHEMBL64153
CAS Number
CAS 75747-14-7
TTD Drug ID
D0SC2J

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.69 0.00e+0 127/171 (74.27%) HSPA1A;HSPA8;HSPH1;...
Antigen processing and presentation 2.05 0.00e+0 60/78 (76.92%) HSPA1A;HSPA8;HSPA6;...
Spliceosome 1.82 3.25e-2 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Longevity regulating pathway 1.80 2.61e-2 90/151 (59.6%) HSPA1A;HSPA8;HSPA6;...
Malaria -1.68 4.39e-2 44/50 (88%) TGFB2;CSF3;HBB;...
Fructose and mannose metabolism -1.70 4.04e-2 30/33 (90.91%) HK2;AKR1B10;HKDC1;...
IL-17 signaling pathway -1.70 4.37e-2 84/94 (89.36%) CXCL10;MAPK1;IL13;...
Leishmaniasis -1.71 4.42e-2 67/77 (87.01%) MAPK1;HLA-DRB1;IL1B;...
NF-kappa B signaling pathway -1.71 4.86e-2 90/104 (86.54%) ICAM1;TICAM1;IL1B;...
Cytosolic DNA-sensing pathway -1.74 3.70e-2 52/63 (82.54%) CXCL10;PYCARD;IL33;...
C-type lectin receptor signaling pathway -1.75 3.84e-2 93/104 (89.42%) CLEC7A;PPP3CB;IRF9;...
Homologous recombination -1.75 4.39e-2 35/41 (85.37%) BRIP1;ATM;TOPBP1;...
Pantothenate and CoA biosynthesis -1.83 1.71e-2 14/21 (66.67%) ALDH2;PPCS;AASDHPPT;...
Pyrimidine metabolism -1.85 1.02e-2 40/56 (71.43%) NT5E;TK2;NT5C;...
Fanconi anemia pathway -2.05 0.00e+0 36/54 (66.67%) ATR;POLI;FANCL;...
Base excision repair -2.08 0.00e+0 29/33 (87.88%) APEX2;MPG;POLD3;...
Mismatch repair -2.14 0.00e+0 22/23 (95.65%) RPA2;POLD3;MSH2;...
DNA replication -2.73 0.00e+0 34/36 (94.44%) LIG1;POLA1;RFC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.37uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 20uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.66uM - 10uM XH
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 1.11uM - 10uM 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.37uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 20uM 2H, 6H, 24H, XH
LoVo CVCL_0399 Homo sapiens 0.37uM 6H
MDST8 CVCL_1400 Homo sapiens 0.37uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.37uM - 10uM 6H, XH
SNU-1040 CVCL_5001 Homo sapiens 0.37uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.37uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.37uM 6H
SW480 CVCL_0546 Homo sapiens 0.37uM 6H
SW620 CVCL_0547 Homo sapiens 0.37uM 6H
SW948 CVCL_0550 Homo sapiens 0.37uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.37uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 0.37uM 6H
RKO CVCL_0504 Homo sapiens 0.37uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.37uM 6H
SNG-M CVCL_1707 Homo sapiens 0.37uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.37uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 6H, 24H, 48H, XH
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 20uM 6H, 24H, XH
A549/Asc-1 CVCL_YA87 Homo sapiens 10uM 24H
DV-90 CVCL_1184 Homo sapiens 0.37uM 6H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
SK-LU-1 CVCL_0624 Homo sapiens 0.37uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.37uM - 10uM 6H, XH
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.37uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.37uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.37uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.37uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.37uM - 10uM 6H, XH
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.37uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.37uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 0.37uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.37uM 6H
OV7 CVCL_1623 Homo sapiens 0.37uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.37uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.37uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.37uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.37uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HL-60 CVCL_0002 Homo sapiens 0.08uM - 10uM 2H, 24H
NOMO-1 CVCL_1609 Homo sapiens 0.37uM 6H
PL-21 CVCL_2161 Homo sapiens 0.37uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.37uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.37uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 20uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 0.37uM - 20uM 6H, 24H, 48H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 20uM 6H, 24H, XH
SK-L CVCL_1699 Homo sapiens 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.37uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.37uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.37uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 10uM 24H