Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNQ3HV)

Drug Name
AZ20 Drug Info
Synonyms AZ-20; AZ 20; compound 6 [PMID: 46244454]
Cross-matching ID
PubChem CID
46244454
ChEBI ID
CHEMBL2325697
TTD Drug ID
D02TSN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Transcriptional misregulation in cancer 1.96 2.44e-2 158/192 (82.29%) DUSP6;DDB2;PLAT;...
Chronic myeloid leukemia 1.84 3.25e-2 72/76 (94.74%) DDB2;CDKN1A;BCL2L1;...
Small cell lung cancer 1.82 2.98e-2 90/92 (97.83%) DDB2;CDKN1A;ITGA3;...
ECM-receptor interaction 1.77 4.27e-2 80/88 (90.91%) ITGB4;ITGA3;LAMA2;...
p53 signaling pathway 1.76 3.58e-2 63/73 (86.3%) DDB2;TNFRSF10B;CDKN1A;...
Ribosome 1.72 3.80e-2 113/158 (71.52%) RPS27L;RPL36;RPL26;...
NF-kappa B signaling pathway 1.72 3.25e-2 90/104 (86.54%) RELB;BCL2L1;CXCL12;...
Galactose metabolism -1.77 4.98e-3 26/31 (83.87%) PFKM;HK3;GLA;...
Glycine, serine and threonine metabolism -1.77 5.15e-3 31/40 (77.5%) BPGM;DLD;PSAT1;...
Butanoate metabolism -1.77 4.93e-3 23/28 (82.14%) GAD2;ACSM3;ACAT1;...
Prion disease -1.78 4.68e-3 209/273 (76.56%) SDHA;NDUFA9;PSMA1;...
Propanoate metabolism -1.79 4.42e-3 30/34 (88.24%) HADHA;SUCLG2;BCKDHB;...
Steroid hormone biosynthesis -1.80 3.68e-3 43/61 (70.49%) HSD11B2;STS;SRD5A1;...
Aldosterone-regulated sodium reabsorption -1.81 2.87e-3 34/37 (91.89%) ATP1A3;ATP1A1;PDPK1;...
Proteasome -1.82 2.00e-3 44/46 (95.65%) PSMC4;PSMD13;PSMC6;...
Ferroptosis -1.83 2.09e-3 36/41 (87.8%) TF;ACSL3;SLC11A2;...
Vibrio cholerae infection -1.84 2.19e-3 44/50 (88%) SEC61A1;ACTB;PRKACA;...
Fat digestion and absorption -1.90 5.75e-4 35/43 (81.4%) APOA1;PLPP3;PLA2G12A;...
Valine, leucine and isoleucine degradation -1.92 6.05e-4 42/48 (87.5%) PCCA;DBT;ACAT1;...
Thyroid hormone synthesis -1.92 6.38e-4 66/75 (88%) ATP1A3;CGA;ATP1A1;...
PPAR signaling pathway -1.92 6.76e-4 66/74 (89.19%) PCK2;SLC27A6;PLIN2;...
Tryptophan metabolism -1.97 0.00e+0 35/42 (83.33%) ACAT1;DLD;AOC1;...
Terpenoid backbone biosynthesis -1.98 0.00e+0 18/22 (81.82%) DHDDS;PDSS2;GGPS1;...
Thiamine metabolism -1.98 0.00e+0 12/15 (80%) NFS1;ALPI;AK4;...
Fructose and mannose metabolism -2.01 0.00e+0 30/33 (90.91%) GMDS;TPI1;HK1;...
Folate biosynthesis -2.01 0.00e+0 23/26 (88.46%) PCBD1;ALPI;ALPG;...
Glyoxylate and dicarboxylate metabolism -2.04 0.00e+0 23/30 (76.67%) PCCA;ACO2;MDH2;...
Protein processing in endoplasmic reticulum -2.05 0.00e+0 127/171 (74.27%) DERL2;SKP1;CRYAB;...
Biosynthesis of unsaturated fatty acids -2.08 0.00e+0 21/27 (77.78%) TECR;HACD2;HSD17B12;...
Cysteine and methionine metabolism -2.08 0.00e+0 43/50 (86%) ENOPH1;AHCYL2;CBS;...
Oxidative phosphorylation -2.09 0.00e+0 93/133 (69.92%) ATP6V1E1;NDUFS4;NDUFA4;...
Pyruvate metabolism -2.13 0.00e+0 41/47 (87.23%) PDHB;LDHB;PKM;...
Glutathione metabolism -2.19 0.00e+0 43/57 (75.44%) MGST3;IDH2;GSTO1;...
Amino sugar and nucleotide sugar metabolism -2.22 0.00e+0 38/48 (79.17%) HK3;CYB5R4;GMDS;...
Citrate cycle (TCA cycle) -2.22 0.00e+0 30/30 (100%) SDHA;PCK2;SDHB;...
Glycolysis / Gluconeogenesis -2.23 0.00e+0 56/67 (83.58%) PDHB;LDHB;G6PC3;...
Steroid biosynthesis -2.43 0.00e+0 19/20 (95%) SOAT1;HSD17B7;LBR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 3.33uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H