Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMO8PT9)

Drug Name
MLN8237 Drug Info
Synonyms Alisertib
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
24771867
ChEBI ID
CHEMBL483158
CAS Number
CAS 1028486-01-2
TTD Drug ID
D0S4JK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.15 0.00e+0 80/88 (90.91%) ITGA3;COL4A5;COL9A2;...
Focal adhesion 1.98 1.32e-2 180/201 (89.55%) ITGA3;COL4A5;COL9A2;...
Endocrine and other factor-regulated calcium reabsorpti... 1.92 1.76e-2 49/53 (92.45%) PLCB1;PLCB4;AP2B1;...
Amoebiasis 1.85 2.31e-2 99/102 (97.06%) COL4A5;COL4A6;ACTN4;...
Terpenoid backbone biosynthesis -1.58 4.77e-2 18/22 (81.82%) HMGCR;MVK;MVD;...
Amyotrophic lateral sclerosis -1.60 4.36e-2 267/364 (73.35%) ANG;PSMC4;PSMA7;...
Folate biosynthesis -1.65 2.42e-2 23/26 (88.46%) CBR1;AKR1B10;PTS;...
Parkinson disease -1.67 1.98e-2 176/249 (70.68%) PSMC4;PSMA7;NDUFA4;...
Ribosome biogenesis in eukaryotes -1.67 1.75e-2 52/108 (48.15%) RPP38;DKC1;CSNK2A2;...
RNA polymerase -1.73 1.08e-2 23/31 (74.19%) POLR1E;POLR2J;POLR3B;...
Ribosome -1.78 6.52e-3 113/158 (71.52%) RPS29;RPS10;RPS14;...
Biosynthesis of unsaturated fatty acids -1.90 1.08e-3 21/27 (77.78%) TECR;ELOVL6;ELOVL2;...
Base excision repair -1.90 1.17e-3 29/33 (87.88%) PARP1;HMGB1;POLD2;...
Nucleotide excision repair -1.91 1.28e-3 40/47 (85.11%) CETN2;RPA3;POLD2;...
Homologous recombination -1.95 7.02e-4 35/41 (85.37%) SEM1;TOP3B;BRCA2;...
RNA transport -2.00 0.00e+0 128/186 (68.82%) THOC2;NUP98;POP5;...
Steroid biosynthesis -2.03 0.00e+0 19/20 (95%) LIPA;LBR;FDFT1;...
Spliceosome -2.06 0.00e+0 101/150 (67.33%) HNRNPA1;CRNKL1;CTNNBL1;...
Cysteine and methionine metabolism -2.09 0.00e+0 43/50 (86%) KYAT1;GOT1;MAT2B;...
Cell cycle -2.12 0.00e+0 110/124 (88.71%) SKP1;ORC3;RBX1;...
Proteasome -2.15 0.00e+0 44/46 (95.65%) PSMC4;PSMA7;POMP;...
Fanconi anemia pathway -2.20 0.00e+0 36/54 (66.67%) BRCA2;RPA1;FANCC;...
Mismatch repair -2.21 0.00e+0 22/23 (95.65%) RPA1;MLH1;RPA3;...
DNA replication -2.71 0.00e+0 34/36 (94.44%) RPA3;POLD2;RPA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 20uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 20uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 20uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 20uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H