General Information of Drug (ID: DMODA2X)

Drug Name
Bardoxolone methyl Drug Info
Synonyms BARD; WPTTVJLTNAWYAO-OYWPANLISA-N; 218600-53-4
Cross-matching ID
PubChem CID
400769
ChEBI ID
CHEMBL1762621
CAS Number
CAS 218600-53-4
TTD Drug ID
D0JU5X
VARIDT Drug ID
DR00793

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis 2.45 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;GCLM;...
Protein processing in endoplasmic reticulum 2.27 0.00e+0 127/171 (74.27%) DDIT3;HERPUD1;ATF4;...
Glutathione metabolism 2.18 0.00e+0 43/57 (75.44%) GCLM;GPX2;G6PD;...
Metabolism of xenobiotics by cytochrome P450 2.17 0.00e+0 49/77 (63.64%) AKR1C1;ALDH3A1;GSTA4;...
IL-17 signaling pathway 2.12 0.00e+0 84/94 (89.36%) CXCL8;MMP3;CEBPB;...
Steroid hormone biosynthesis 2.06 2.12e-3 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Pentose and glucuronate interconversions 2.03 1.81e-3 17/34 (50%) AKR1B10;UGDH;UGT2B15;...
Collecting duct acid secretion 1.99 3.17e-3 22/27 (81.48%) CA2;ATP6V1B2;ATP6V1G1;...
Amino sugar and nucleotide sugar metabolism 1.95 5.64e-3 38/48 (79.17%) UGDH;GFPT1;GNPDA1;...
Folate biosynthesis 1.92 7.62e-3 23/26 (88.46%) AKR1B10;AKR1C3;GGH;...
Galactose metabolism 1.91 8.08e-3 26/31 (83.87%) AKR1B10;GALE;HKDC1;...
Fluid shear stress and atherosclerosis 1.91 7.41e-3 123/139 (88.49%) HMOX1;NQO1;FOS;...
Parathyroid hormone synthesis, secretion and action 1.83 1.95e-2 98/106 (92.45%) EGR1;FOS;NR4A2;...
Protein export 1.81 2.27e-2 17/23 (73.91%) HSPA5;SEC61G;SRP54;...
Chemical carcinogenesis 1.81 2.12e-2 186/281 (66.19%) AKR1C2;KLF4;FOS;...
Arachidonic acid metabolism 1.80 2.30e-2 48/61 (78.69%) AKR1C3;GPX2;CYP4F3;...
Apelin signaling pathway 1.79 2.39e-2 117/137 (85.4%) EGR1;SPP1;PRKACB;...
Amphetamine addiction 1.78 2.33e-2 57/69 (82.61%) FOS;FOSB;ATF4;...
Porphyrin and chlorophyll metabolism 1.77 2.47e-2 23/43 (53.49%) HMOX1;BLVRB;UGT2B15;...
Mitophagy 1.77 2.41e-2 56/68 (82.35%) SQSTM1;ATF4;EIF2AK3;...
Autophagy 1.74 3.32e-2 113/169 (66.86%) SQSTM1;EIF2AK3;DDIT4;...
Oxytocin signaling pathway 1.73 3.35e-2 128/154 (83.12%) FOS;CDKN1A;PRKACB;...
beta-Alanine metabolism 1.72 3.53e-2 25/30 (83.33%) ALDH3A1;ALDH6A1;ALDH3B1;...
Glycine, serine and threonine metabolism 1.70 3.81e-2 31/40 (77.5%) CTH;CBS;SHMT2;...
Rheumatoid arthritis 1.70 3.71e-2 78/93 (83.87%) CXCL8;MMP3;FOS;...
Fructose and mannose metabolism 1.69 4.10e-2 30/33 (90.91%) AKR1B10;ALDOB;GMPPA;...
Glycerolipid metabolism 1.69 4.04e-2 44/61 (72.13%) AKR1B10;PLPP3;MGLL;...
Epithelial cell signaling in Helicobacter pylori infect... 1.68 3.94e-2 62/70 (88.57%) CXCL8;CXCL3;CXCL2;...
Bladder cancer 1.66 4.86e-2 40/41 (97.56%) CXCL8;CDKN1A;MMP1;...
Cysteine and methionine metabolism 1.65 4.96e-2 43/50 (86%) GCLM;CTH;GCLC;...
Influenza A -1.62 4.94e-2 156/172 (90.7%) IRF7;IFNGR2;RAB11A;...
Cytosolic DNA-sensing pathway -1.65 3.74e-2 52/63 (82.54%) IRF7;POLR3G;IL33;...
Aminoacyl-tRNA biosynthesis -1.66 3.44e-2 15/66 (22.73%) GATB;SARS2;GATC;...
Systemic lupus erythematosus -1.72 1.87e-2 45/135 (33.33%) ACTN4;FCGR3B;C8B;...
Primary immunodeficiency -1.73 1.77e-2 33/38 (86.84%) DCLRE1C;TNFRSF13B;CD3D;...
Asthma -1.77 1.44e-2 25/31 (80.65%) HLA-DPB1;HLA-DRA;RNASE3;...
Type I diabetes mellitus -1.80 1.12e-2 38/43 (88.37%) CD80;TNF;PRF1;...
Herpes simplex virus 1 infection -1.80 1.35e-2 165/498 (33.13%) IRF7;IFNGR2;DAXX;...
Graft-versus-host disease -2.01 0.00e+0 32/42 (76.19%) CD80;TNF;PRF1;...
DNA replication -2.02 0.00e+0 34/36 (94.44%) PRIM1;POLA2;RNASEH1;...
Autoimmune thyroid disease -2.05 0.00e+0 46/53 (86.79%) CD80;PRF1;FAS;...
Allograft rejection -2.12 0.00e+0 32/38 (84.21%) CD80;TNF;PRF1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 3.33uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H