Details of the Drug

General Information of Drug (ID: DMODA2X)

Drug Name
Bardoxolone methyl
Synonyms BARD; WPTTVJLTNAWYAO-OYWPANLISA-N; 218600-53-4
Indication
Disease Entry ICD 11 Status REF
Mixed connective tissue disease 4A43.3 Phase 3 [1]
Pulmonary arterial hypertension BB01.0 Phase 2 [2]
Pulmonary hypertension BB01 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 505.7
Logarithm of the Partition Coefficient (xlogp) 6.7
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C32H43NO4
IUPAC Name
methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate
Canonical SMILES
C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
InChI
InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChIKey
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Cross-matching ID
PubChem CID
400769
CAS Number
218600-53-4
UNII
CEG1Q6OGU1
DrugBank ID
DB05983
TTD ID
D0JU5X
VARIDT ID
DR00793
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PPAR-gamma messenger RNA (PPARG mRNA) TTT2SVW PPARG_HUMAN Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Gene/Protein Processing [4]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) OTHTAM54 AAKG2_HUMAN Gene/Protein Processing [5]
5-hydroxytryptamine receptor 2A (HTR2A) OTWXJX0M 5HT2A_HUMAN Gene/Protein Processing [4]
5-hydroxytryptamine receptor 2C (HTR2C) OT6H8DE0 5HT2C_HUMAN Gene/Protein Processing [4]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Gene/Protein Processing [4]
Alpha-2C adrenergic receptor (ADRA2C) OT5B9RKP ADA2C_HUMAN Gene/Protein Processing [4]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Gene/Protein Processing [5]
AN1-type zinc finger protein 2A OTTG7P8R ZFN2A_HUMAN Gene/Protein Processing [5]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Gene/Protein Processing [6]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 126 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -2.9817 1.7868 -3.0485 59.4676
MEC1 CTRP2 -2.8376 -0.6113 -2.8379 59.1582
JM1 CTRP2 -2.3319 0.4162 -2.335 55.773
KMS-11 CTRP2 -6.3545 -1.465 -6.3713 78.6641
SKM-1 CTRP2 -5.1857 -3.2231 -5.1857 74.7305
Mino CTRP2 -4.6963 -2.2555 -4.6964 71.3996
RPMI-8226 CTRP2 -4.4748 -0.4462 -4.4866 69.1082
EB1 CTRP2 -4.2597 -2.0443 -4.2598 73.5483
697 CTRP2 -4.1458 -2.2712 -4.1458 72.8477
GA-10 CTRP2 -3.9734 -1.9638 -3.9734 71.5999
EoL-1 CTRP2 -3.8988 -1.5176 -3.8991 70.9675
RS4;11 CTRP2 -3.7832 -1.4991 -3.7834 65.4264
BV-173 CTRP2 -3.6839 -0.3211 -3.6892 64.5108
NB4 CTRP2 -3.6833 -2.3969 -3.6833 64.807
Reh CTRP2 -3.6442 -1.508 -3.6443 64.5198
OPM-2 CTRP2 -3.4792 -1.604 -3.4792 68.1165
MOLT-16 CTRP2 -3.4163 -1.413 -3.4163 63.0148
SUP-M2 CTRP2 -3.3266 -1.2086 -3.3267 66.9999
MOLM-16 CTRP2 -3.319 1.1691 -3.3604 61.6873
AMO1 CTRP2 -3.2992 0.6929 -3.3203 61.7952
SU-DHL-10 CTRP2 -3.2975 -0.1516 -3.3017 62.0706
KMS-34 CTRP2 -3.2971 -1.8209 -3.2971 62.2336
SU-DHL-6 CTRP2 -3.2786 0.7715 -3.3019 61.6399
MV4-11 CTRP2 -3.2442 -1.1652 -3.2443 61.8675
Hs 611.T CTRP2 -3.2206 -0.5623 -3.2217 66.1281
NU-DUL-1 CTRP2 -3.1224 -1.0544 -3.1225 61.0582
KMS-20 CTRP2 -3.0592 0.3194 -3.0674 60.4592
OCI-AML-2 CTRP2 -3.0578 -2.3859 -3.0578 60.6401
NCI-H929 CTRP2 -2.9525 -1.1029 -2.9525 59.9341
Ri-1 CTRP2 -2.944 0.3875 -2.952 59.7202
OCI-AML-3 CTRP2 -2.915 0.1011 -2.919 59.5914
Pfeiffer CTRP2 -2.8498 -1.327 -2.8498 63.6427
Karpas-299 CTRP2 -2.7967 -1.4152 -2.7967 58.9004
KMS-12-BM CTRP2 -2.7542 0.1415 -2.7575 58.55
PL21 CTRP2 -2.7157 -0.3651 -2.7163 58.3424
A3/Kawakami CTRP2 -2.7121 -2.0275 -2.7121 62.6604
ST486 CTRP2 -2.6415 -0.2533 -2.6422 57.8477
Raji CTRP2 -2.6382 -1.5855 -2.6382 57.8445
OCI-Ly3 CTRP2 -2.612 -1.0122 -2.612 61.9403
Granta-519 CTRP2 -2.5969 -0.843 -2.5969 61.8286
MOLT-13 CTRP2 -2.586 -0.5929 -2.5861 57.4917
JJN-3 CTRP2 -2.4497 0.8495 -2.4602 56.4943
L-363 CTRP2 -2.4229 -0.3947 -2.4231 56.4058
RCH-ACV CTRP2 -2.4145 0.2508 -2.4168 56.3257
Namalwa CTRP2 -2.405 -0.9753 -2.405 60.4621
MOLM-6 CTRP2 -2.3386 -0.4023 -2.3387 55.846
KE-37 CTRP2 -2.2786 -1.6019 -2.2786 55.4491
KE-97 CTRP2 -2.2543 -0.657 -2.2543 55.2867
L-540 CTRP2 -2.2515 -0.6666 -2.2515 55.268
MOLM-13 CTRP2 -2.2402 -1.0885 -2.2402 55.193
P12-Ichikawa CTRP2 -2.1995 -1.5291 -2.1995 54.9221
A4/Fukuda CTRP2 -2.1905 -0.8549 -2.1905 54.8622
JVM-3 CTRP2 -2.1785 -0.2976 -2.1786 54.7801
NCO2 CTRP2 -2.1779 -1.0211 -2.1779 54.778
SEM CTRP2 -2.1345 -0.5669 -2.1346 54.489
HT CTRP2 -2.1237 -1.4795 -2.1237 54.417
Jurkat CTRP2 -2.1088 -0.7575 -2.1088 54.3175
SUP-T1 CTRP2 -2.1042 0.152 -2.105 54.2812
Kasumi-2 CTRP2 -2.0936 -0.4106 -2.0937 54.2163
KM-H2 CTRP2 -2.0619 -0.4991 -2.0619 54.0048
KMS-27 CTRP2 -2.0532 -0.8377 -2.0532 53.9471
DB CTRP2 -2.0473 0.3408 -2.0486 53.8999
KCL-22 CTRP2 -2.0468 -0.6164 -2.0468 53.9044
KMS-26 CTRP2 -2.042 -1.0361 -2.042 53.8728
PF-382 CTRP2 -1.9863 -0.826 -1.9863 53.5018
NALM-6 CTRP2 -1.9777 -0.4569 -1.9777 53.4441
Daudi CTRP2 -1.9739 -0.371 -1.9739 53.4187
WSU-DLCL2 CTRP2 -1.9657 -0.856 -1.9657 53.3646
SU-DHL-1 CTRP2 -1.9559 -1.2542 -1.9559 53.2995
JURL-MK1 CTRP2 -1.9145 -0.4678 -1.9146 53.0236
Ku812 CTRP2 -1.9083 0.0425 -1.9086 52.9808
HPB-ALL CTRP2 -1.8497 0.0281 -1.8499 52.5908
JVM-2 CTRP2 -1.8425 0.592 -1.8443 52.5378
SET-2 CTRP2 -1.8319 0.1074 -1.8321 52.472
BL-70 CTRP2 -1.8298 -0.6125 -1.8298 52.4589
HH [Human lymphoma] CTRP2 -1.8254 -0.2897 -1.8254 52.4297
EM-2 CTRP2 -1.808 -0.6957 -1.808 52.3137
CA46 CTRP2 -1.7765 0.2633 -1.7769 55.9581
CML-T1 CTRP2 -1.7656 -0.81 -1.7656 52.031
LP-1 CTRP2 -1.7634 0.1641 -1.7636 55.8665
SIG-M5 CTRP2 -1.7558 0.3458 -1.7564 51.9648
SUP-B15 CTRP2 -1.7085 0.5301 -1.7095 51.6489
AML-193 CTRP2 -1.6852 0.8482 -1.688 51.4911
DEL CTRP2 -1.6627 -1.0062 -1.6627 51.346
KO52 CTRP2 -1.636 -0.2601 -1.636 51.168
JeKo-1 CTRP2 -1.6182 -0.6853 -1.6182 51.0491
MC116 CTRP2 -1.5666 1.3323 -1.5748 50.7007
DND-41 CTRP2 -1.5291 -0.7533 -1.5291 50.4556
MOTN-1 CTRP2 -1.5015 0.6621 -1.5024 50.2716
NU-DHL-1 CTRP2 -1.4876 -0.3609 -1.4876 50.1793
MHH-CALL-4 CTRP2 -1.4843 2.1404 -1.5184 50.1543
F-36P CTRP2 -1.4817 -0.1575 -1.4817 50.1398
HD-MY-Z CTRP2 -1.4793 0.132 -1.4793 50.1238
U266B1 CTRP2 -1.4732 -0.0518 -1.4732 50.0831
EHEB CTRP2 -1.4655 -0.0521 -1.4656 50.0323
KMS-28BM CTRP2 -1.4339 3.2273 -1.5553 49.8318
L-428 CTRP2 -1.3987 -0.2942 -1.3987 49.5868
TF-1 CTRP2 -1.3761 -0.7805 -1.3761 49.4364
HDLM-2 CTRP2 -1.3749 0.0242 -1.3749 49.4282
HEL CTRP2 -1.3693 -0.3229 -1.3693 49.391
SUP-HD1 CTRP2 -1.3396 0.6015 -1.34 52.8364
HEL 92.1.7 CTRP2 -1.2772 0.1482 -1.2772 48.7775
MOLP-2 CTRP2 -1.2546 2.0321 -1.2772 48.6453
OCI-M1 CTRP2 -1.228 -0.2309 -1.228 48.4495
K-562 CTRP2 -1.2034 0.3182 -1.2034 48.2858
LAMA-84 CTRP2 -1.1844 -0.1858 -1.1844 48.1595
RL CTRP2 -1.1816 0.5213 -1.1817 48.1407
ALL-SIL CTRP2 -1.0452 0.1135 -1.0452 47.2317
HuT 78 CTRP2 -1.0343 0.2257 -1.0343 47.1591
TALL-1 [Human adult T-ALL] CTRP2 -0.899 1.9134 -0.9102 46.2795
P3HR-1 CTRP2 -0.8909 2.7186 -0.9385 46.2837
KHM-1B CTRP2 -0.7841 2.2067 -0.802 45.5301
OCI-AML-5 CTRP2 -0.7451 0.0149 -0.7451 45.2325
KMS-18 CTRP2 -0.6821 1.2297 -0.6829 44.8152
KYO-1 CTRP2 -0.5728 0.7805 -0.5728 44.0849
SUP-T11 CTRP2 -0.3246 2.9624 -0.3663 42.5402
ME1 CTRP2 -0.2822 2.4991 -0.2992 42.1965
MJ CTRP2 -0.0869 1.586 -0.0874 40.8494
HL-60 CTRP2 0.023 1.1589 0.023 40.1152
Mono-Mac-1 CTRP2 1.0672 8.552 -0.2311 36.73
BL-41 CTRP2 1.1775 4.1378 1.1067 35.0724
GDM-1 CTRP2 1.1793 5.1906 0.9413 33.1838
KMM-1 CTRP2 7.8819 10.4416 5.1224 1.4572
REC-1 CTRP2 8.3114 10.0849 5.4609 0.3148
MHH-CALL-3 CTRP2 8.5685 23.5002 -0.6797 20.4438
Mono-Mac-6 CTRP2 11.4312 32.0027 -2.7655 21.1479
⏷ Show the Full List of 126 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 -1.9566 0.6829 -1.9597 53.2906
TE15 CTRP2 -0.2832 2.2298 -0.2922 42.1817
TE-6 CTRP2 -2.5764 -0.0227 -2.5778 61.6115
TE-14 CTRP2 -1.9682 0.8464 -1.9731 53.3615
KYSE-150 CTRP2 -1.7753 2.3926 -1.8358 52.0167
KYSE-410 CTRP2 -1.5417 1.6241 -1.5565 50.5337
KYSE-30 CTRP2 -1.4718 1.8835 -1.4939 50.0727
OE21 CTRP2 -1.4689 -0.2441 -1.4689 50.0544
KYSE-520 CTRP2 -1.4303 0.1934 -1.4303 49.7974
TE-4 CTRP2 -1.4153 1.7654 -1.4319 49.7008
TE-5 CTRP2 -1.2569 0.9402 -1.2582 48.6436
KYSE-510 CTRP2 -1.1116 -0.4483 -1.1116 47.6745
TE-10 CTRP2 -0.8818 0.3587 -0.8818 46.1433
TE-9 CTRP2 -0.7375 0.1504 -0.7375 45.1817
COLO 680N CTRP2 -0.7196 1.2503 -0.7205 45.0651
KYSE-180 CTRP2 -0.6414 0.9597 -0.6416 44.5422
KYSE-70 CTRP2 -0.5791 0.9821 -0.5793 44.1274
OE33 CTRP2 -0.573 1.6509 -0.576 44.0944
TE-11 CTRP2 -0.5193 0.8687 -0.5193 43.7284
KYSE-140 CTRP2 -0.4115 2.0835 -0.4192 43.032
TE-1 CTRP2 -0.2528 2.8142 -0.2831 42.0364
EC-GI-10 CTRP2 -0.0762 1.9693 -0.0788 40.7844
KYSE-450 CTRP2 0.208 1.8103 0.2075 38.8847
OE19 CTRP2 2.6284 8.2785 1.5351 26.5963
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 -0.2842 1.1768 -0.2843 42.1622
SU.86.86 CTRP2 -2.3619 0.8371 -2.3709 55.9305
BxPC-3 CTRP2 -1.4969 -0.245 -1.4969 50.2409
Panc 05.04 CTRP2 -1.3037 0.9161 -1.3051 48.9553
HPAC CTRP2 -1.196 3.7716 -1.3728 48.3601
PaTu 8988s CTRP2 -1.1482 2.3685 -1.1836 47.9563
MIA PaCa-2 CTRP2 -1.1223 0.6867 -1.1226 47.746
Panc 08.13 CTRP2 -0.8692 0.7263 -0.8693 46.0595
KP-4 CTRP2 -0.8068 0.3012 -0.8068 45.6439
Capan-2 CTRP2 -0.7787 2.1042 -0.7931 45.4875
YAPC CTRP2 -0.7731 1.2342 -0.7741 45.4218
PK-59 CTRP2 -0.7716 0.9591 -0.7719 45.4098
KP-3 CTRP2 -0.7366 1.9228 -0.7455 45.1968
Hs 766T CTRP2 -0.7321 1.4278 -0.7341 45.1511
HuP-T4 CTRP2 -0.5115 1.3149 -0.5121 43.6781
AsPC-1 CTRP2 -0.3707 2.0039 -0.3764 42.7547
KP-2 CTRP2 -0.2806 1.6089 -0.2817 42.1416
Panc 10.05 CTRP2 -0.2788 1.498 -0.2795 42.1283
Panc 04.03 CTRP2 -0.2168 2.657 -0.2385 41.7748
L3.3 CTRP2 -0.1793 1.253 -0.1794 41.4633
PK-45H CTRP2 -0.0514 2.0267 -0.0544 40.6204
HuP-T3 CTRP2 -0.0511 2.1576 -0.0557 40.6235
SW1990 CTRP2 0.1043 3.1859 0.0642 39.6937
TCC-Pan2 CTRP2 0.2071 3.3304 0.1611 39.0284
Capan-1 CTRP2 0.2191 2.0947 0.2172 38.8153
HPAF-II CTRP2 0.265 3.7448 0.1847 38.743
SUIT-2 CTRP2 0.6503 4.0785 0.5549 36.2368
QGP-1 CTRP2 0.8819 4.5398 0.7384 34.8519
CFPAC-1 CTRP2 1.0499 11.0091 -1.2596 38.7924
PaTu 8902 CTRP2 1.2258 4.1105 1.1606 32.3185
SNU-213 CTRP2 1.8803 6.9093 1.2375 29.8999
SNU-410 CTRP2 4.6162 7.2471 4.0484 11.6284
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 0.8187 4.3438 0.6997 37.7788
G-361 CTRP2 -2.7785 0.8006 -2.7929 58.587
Hs 944.T CTRP2 -1.6146 0.6166 -1.6156 51.0237
LOX-IMVI CTRP2 -1.5407 -0.1553 -1.5407 50.533
A-375 CTRP2 -0.799 -0.0045 -0.799 45.5914
CJM [Human melanoma] CTRP2 -0.7861 0.7247 -0.7862 45.5061
Mel Ho CTRP2 -0.7572 1.5223 -0.7601 45.3205
RPMI-7951 CTRP2 -0.7095 0.4127 -0.7095 44.9957
UACC-257 CTRP2 -0.6834 2.729 -0.7237 44.9066
WM266-4 CTRP2 -0.6348 0.9331 -0.6349 44.4981
A2058 CTRP2 -0.5112 2.8866 -0.5552 43.7785
MeWo CTRP2 -0.5025 1.3863 -0.5033 43.6189
IGR-37 CTRP2 -0.482 0.7468 -0.482 43.4797
WM88 CTRP2 -0.4521 2.8982 -0.4945 43.3846
IPC-298 CTRP2 -0.3827 2.2344 -0.3934 42.8481
SK-MEL-5 CTRP2 -0.3809 1.2544 -0.3811 42.8068
Hs 688(A).T CTRP2 -0.2621 0.1675 -0.2621 42.0147
WM1799 CTRP2 -0.1962 0.5044 -0.1962 41.5758
SK-MEL-30 CTRP2 -0.1916 1.6054 -0.1924 41.5478
Mel JuSo CTRP2 -0.1645 2.4076 -0.1761 41.3993
MDA-MB-435S CTRP2 -0.1375 1.4251 -0.1378 41.1856
SK-MEL-3 CTRP2 -0.0776 3.2502 -0.1299 40.9329
UACC-62 CTRP2 -0.0137 0.9345 -0.0137 40.3599
WM983B CTRP2 0.0267 2.8189 0.0045 40.1579
COLO 829 CTRP2 0.0524 3.2448 0.0061 43.0024
COLO 800 CTRP2 0.0634 4.151 -0.0803 40.2381
WM115 CTRP2 0.0637 1.741 0.0631 39.8465
RVH-421 CTRP2 0.197 1.4884 0.197 38.9561
IGR-1 CTRP2 0.2496 2.975 0.2266 41.5375
K029AX CTRP2 0.2565 2.6327 0.2463 38.5925
WM793 CTRP2 0.5565 4.3605 0.4169 36.9886
SK-MEL-28 CTRP2 0.5807 1.7617 0.5807 36.3998
SK-MEL-1 CTRP2 0.6051 1.7952 0.6051 36.2375
Hs 940.T CTRP2 0.6141 1.517 0.6141 36.1774
Malme-3M CTRP2 0.6379 2.5674 0.6342 36.0309
SK-MEL-31 CTRP2 0.7378 1.5427 0.7378 35.3533
Hs 839.T CTRP2 1.0201 1.6783 1.0201 33.4727
Hs 895.T CTRP2 1.2047 1.8656 1.2047 32.2429
SK-MEL-24 CTRP2 1.3317 2.5242 1.3315 31.3971
Hs 934.T CTRP2 1.5772 2.3013 1.5772 29.7612
Hs 852.T CTRP2 3.1318 8.2724 2.0676 23.2605
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly CTRP2 -3.4458 -0.5435 -3.4478 63.0982
KP-N-SI9s CTRP2 -2.471 -1.9093 -2.471 56.7309
NB1 CTRP2 -2.1429 -0.478 -2.143 54.5447
SK-N-FI CTRP2 -1.4931 0.0414 -1.4932 50.2162
SK-N-AS CTRP2 -1.357 0.0466 -1.357 49.3094
CHP-212 CTRP2 -1.2891 -0.2995 -1.2891 48.8568
IMR-32 CTRP2 -1.2839 -0.7162 -1.2839 48.8221
MHH-NB-11 CTRP2 -0.7674 0.675 -0.7674 45.3811
SK-N-BE(2) CTRP2 -0.4452 1.0976 -0.4453 43.2351
NH-6 CTRP2 -0.2307 2.0518 -0.2357 41.8208
CHP-126 CTRP2 -0.1847 1.5948 -0.1854 41.5013
KP-N-YN CTRP2 2.6752 5.9894 2.3824 23.4643
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-28 CTRP2 -1.3803 -0.3708 -1.3803 49.4646
HuCC-T1 CTRP2 -0.9666 0.2026 -0.9666 46.708
SNU-478 CTRP2 -0.8943 0.1116 -0.8943 46.2265
SNU-308 CTRP2 -0.815 0.79 -0.8151 45.6985
SNU-1079 CTRP2 -0.4257 0.3839 -0.4257 43.1044
SNU-1196 CTRP2 -0.2531 4.0608 -0.4059 42.3201
SNU-245 CTRP2 0.3777 3.4455 0.3303 37.8999
SNU-869 CTRP2 0.4729 2.4617 0.4691 37.1306
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 -2.5799 -2.1479 -2.5799 61.7144
TC71 CTRP2 -2.5186 1.3308 -2.5448 56.8449
SJSA-1 CTRP2 -2.2325 0.9945 -2.2429 55.0773
CAL-78 CTRP2 -1.8073 0.1369 -1.8075 52.3081
CADO-ES1 CTRP2 -1.6037 -0.6108 -1.6037 50.9527
SK-ES-1 CTRP2 -1.5453 -0.3473 -1.5453 50.5634
MHH-ES-1 CTRP2 -1.4919 0.0255 -1.492 50.2081
A-673 CTRP2 -1.3432 -0.8118 -1.3432 49.217
SaOS-2 CTRP2 -0.958 -0.0608 -0.958 46.6509
G-292 clone A141B1 CTRP2 -0.9194 0.7989 -0.9196 46.3946
Hs 822.T CTRP2 -0.3029 0.1487 -0.3029 42.2865
SW1353 CTRP2 0.0226 2.2261 0.0177 40.1336
MG-63 CTRP2 0.5633 1.1642 0.5633 36.5158
Hs 888.T CTRP2 0.7149 2.0825 0.7147 35.5066
U2OS CTRP2 0.8782 5.7921 0.4733 35.6462
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 64 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-453 CTRP2 -1.9534 1.1503 -1.9632 53.2496
HCC1806 CTRP2 -1.3819 0.6228 -1.3824 49.4751
MDA-MB-468 CTRP2 -1.3654 0.5853 -1.3658 53.0209
MDA-MB-157 CTRP2 -1.279 -0.0307 -1.2791 48.7899
HCC2218 CTRP2 -1.1998 0.0232 -1.1998 48.2618
AU565 CTRP2 -1.1933 1.0142 -1.1948 48.2209
SK-BR-3 CTRP2 -1.1308 4.7261 -1.4695 48.0507
HMC-1-8 CTRP2 -0.9483 0.2439 -0.9483 46.5865
BT-549 CTRP2 -0.9073 1.0886 -0.9082 46.3155
HCC38 CTRP2 -0.8175 1.5168 -0.8208 45.7228
MDA-MB-415 CTRP2 -0.7418 0.7406 -0.7419 45.2109
HCC1954 CTRP2 -0.7365 1.2009 -0.7373 45.1775
JIMT-1 CTRP2 -0.6737 1.2099 -0.6744 44.7588
ZR-75-1 CTRP2 -0.6284 2.8275 -0.673 44.5524
CAL-85-1 CTRP2 -0.6018 1.7005 -0.6055 44.2881
HCC1143 CTRP2 -0.5477 3.4011 -0.6371 44.1089
T-47D CTRP2 -0.5015 2.4051 -0.5202 43.6577
MDA-MB-231 CTRP2 -0.438 1.9568 -0.4437 43.2029
HCC1419 CTRP2 -0.416 3.6813 -0.5292 43.2965
BT-20 CTRP2 -0.3649 1.5686 -0.3661 42.7036
Hs 578Bst CTRP2 -0.3285 0.3644 -0.3285 42.457
HCC1937 CTRP2 -0.3119 1.872 -0.3153 42.3568
MDA-MB-361 CTRP2 -0.3113 3.3778 -0.3858 42.529
EFM-192A CTRP2 -0.2962 1.9348 -0.3001 42.2535
CAL-51 CTRP2 -0.1966 0.7441 -0.1966 41.5783
ZR-75-30 CTRP2 -0.0739 3.2517 -0.1261 40.908
HDQ-P1 CTRP2 -0.071 2.135 -0.0756 40.756
CAL-120 CTRP2 -0.0135 0.8685 -0.0135 40.3583
KPL-1 CTRP2 0.1542 0.7753 0.1542 39.2412
HCC202 CTRP2 0.4922 5.7862 0.0536 38.2032
HCC1428 CTRP2 0.5843 2.4843 0.5812 36.3864
HCC1395 CTRP2 1.0107 4.5269 0.8786 33.9634
CAL-148 CTRP2 1.1398 2.2593 1.1397 32.6756
CAMA-1 CTRP2 1.457 10.3893 -0.5715 36.1442
BT-474 CTRP2 1.6035 4.7556 1.4792 30.003
MCF-7 CTRP2 2.4155 11.2364 0.0336 31.7444
BT 145 CTRP2 -1.7267 -0.9178 -1.7267 51.7723
BT164 CTRP2 -1.6089 -1.1104 -1.6089 50.9874
BT 428 CTRP2 -1.471 -0.7286 -1.471 50.0687
BT 239 CTRP2 -1.4612 -1.0626 -1.4612 50.0031
BT 112 CTRP2 -1.4106 -0.964 -1.4106 49.6661
BT 416 CTRP2 -1.3729 -0.5541 -1.3729 49.4154
BT 179 CTRP2 -1.3625 -1.0349 -1.3625 49.3457
BT 422 CTRP2 -1.3036 -0.7555 -1.3036 48.9534
BT 504 CTRP2 -1.303 -0.7834 -1.303 48.9492
BT 359 CTRP2 -1.1584 0.7236 -1.1587 47.9865
BT 216 CTRP2 -1.1395 0.2841 -1.1395 47.8602
BT 224 CTRP2 -1.1273 -0.451 -1.1273 47.7786
BT 245 CTRP2 -0.9431 2.3965 -0.9734 46.6014
BT 482 CTRP2 -0.9403 0.2214 -0.9403 46.533
BT 444 CTRP2 -0.8711 -0.0796 -0.8711 46.0721
BT 131 CTRP2 -0.861 -0.0078 -0.861 46.0048
BT 286 CTRP2 -0.8462 -0.0675 -0.8462 45.9059
BT 333 CTRP2 -0.8193 0.402 -0.8193 45.7268
BT 248 CTRP2 -0.7366 0.9238 -0.7368 45.1767
BT 172 CTRP2 -0.7203 0.2732 -0.7203 45.0671
BT147 CTRP2 -0.6248 0.0557 -0.6248 44.4314
BT 440 CTRP2 -0.5381 -0.0881 -0.5381 43.8533
BT 498 CTRP2 -0.4176 0.0784 -0.4176 43.0507
BT 320 CTRP2 -0.2814 0.1572 -0.2814 42.1434
BT 340 CTRP2 -0.2779 0.1797 -0.2779 42.1199
BT 330 CTRP2 0.5649 1.0615 0.5649 36.505
BT 328 CTRP2 0.6511 1.4104 0.6511 35.9307
BT 232 CTRP2 0.6659 1.3847 0.6659 35.8323
⏷ Show the Full List of 64 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -0.9958 -0.3888 -0.9958 46.9028
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 -2.154 0.0402 -2.1545 54.6134
KNS-60 CTRP2 -2.1217 0.1473 -2.1225 54.3974
LN-18 CTRP2 -1.5035 -0.424 -1.5035 50.2854
SF539 CTRP2 -1.4834 -0.9934 -1.4834 50.151
SF268 CTRP2 -1.4683 -0.0209 -1.4683 50.0507
Daoy CTRP2 -1.0312 0.2547 -1.0312 47.1387
42-MG-BA CTRP2 -1.0182 -0.1451 -1.0182 47.052
SF126 CTRP2 -0.8804 0.2636 -0.8804 46.134
GB-1 CTRP2 -0.8014 1.5529 -0.805 45.6163
KNS-42 CTRP2 -0.7185 1.3544 -0.72 45.0593
SNB-75 CTRP2 -0.6976 0.2658 -0.6976 44.916
U-251MG CTRP2 -0.6928 0.625 -0.6928 44.8842
SNU-738 CTRP2 -0.6872 0.4331 -0.6872 44.8468
ONS-76 CTRP2 -0.504 0.6091 -0.504 43.626
LN-229 CTRP2 -0.4787 1.9082 -0.4841 43.4729
SNU-201 CTRP2 -0.4189 -0.0242 -0.4189 43.0595
SNU-1105 CTRP2 -0.3946 -0.0745 -0.3946 42.8975
SNU-626 CTRP2 -0.3515 0.2216 -0.3515 42.6106
SW1088 CTRP2 -0.2886 1.6896 -0.2901 42.196
KNS-81 CTRP2 -0.2823 1.2698 -0.2825 42.15
Hs 683 CTRP2 -0.2254 1.0661 -0.2255 41.7707
T98G CTRP2 -0.1713 2.6941 -0.1933 44.5336
U-118MG CTRP2 -0.0645 2.425 -0.0748 43.7435
KG-1-C CTRP2 -0.0641 0.8143 -0.0641 40.6958
KALS-1 CTRP2 -0.0472 2.7993 -0.0705 40.6521
DBTRG-05MG CTRP2 -0.0067 2.3045 -0.0134 40.3341
SNU-489 CTRP2 0.1473 1.0959 0.1473 39.2873
SF295 CTRP2 0.1513 1.7751 0.1508 39.2624
GaMG CTRP2 0.2147 2.1958 0.2119 38.8474
YKG-1 CTRP2 0.4474 2.1291 0.4464 37.2915
CAS-1 CTRP2 0.5754 1.1039 0.5754 36.4352
A-172 CTRP2 0.6227 3.0328 0.6071 38.8498
NMC-G1 CTRP2 0.669 1.2728 0.669 35.812
CCF-STTG1 CTRP2 0.9158 2.5985 0.9139 34.1739
U-87MG ATCC CTRP2 1.5831 5.1067 1.3959 30.3487
SW1783 CTRP2 1.6287 3.5566 1.6174 29.4557
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA CTRP2 -1.6663 -0.4218 -1.6663 55.1766
HEC-151 CTRP2 -1.5333 0.4994 -1.5338 50.4835
JHUEM-1 CTRP2 -1.3377 -0.8052 -1.3377 49.1807
HEC-50B CTRP2 -1.3278 5.7436 -1.921 49.2714
MFE-296 CTRP2 -1.3209 0.491 -1.3212 49.0691
RL95-2 CTRP2 -1.3104 0.3321 -1.3105 48.9991
JHUEM-2 CTRP2 -1.1157 0.2395 -1.1157 47.7016
HEC-1-A CTRP2 -0.7895 0.8852 -0.7897 45.5289
HEC-108 CTRP2 -0.5955 0.1336 -0.5955 44.236
JHUEM-3 CTRP2 -0.3777 1.524 -0.3787 42.7881
HEC-265 CTRP2 -0.3122 0.23 -0.3122 42.3487
KLE CTRP2 -0.1417 1.6601 -0.1426 41.2156
EFE-184 CTRP2 0.0736 1.3329 0.0736 39.7782
EN CTRP2 0.2075 2.5403 0.1988 41.7957
HEC-1-B CTRP2 0.6077 6.4793 -0.0131 37.9196
HEC-6 CTRP2 0.6646 4.5867 0.4974 36.3571
HEC-59 CTRP2 0.7322 6.4122 0.1426 37.0666
HEC-251 CTRP2 2.9286 9.1708 1.4752 25.9262
Ishikawa (Heraklio) 02 ER- CTRP2 -0.2956 1.5717 -0.2966 42.2409
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 -1.5033 -0.5494 -1.5033 50.2841
OS-RC-2 CTRP2 -0.5191 0.1191 -0.5191 43.7266
786-O CTRP2 -0.4216 1.6929 -0.4239 43.0842
KMRC-20 CTRP2 -0.4185 2.0867 -0.4263 43.0784
BFTC-909 CTRP2 -0.3917 0.8384 -0.3917 42.8779
TUHR4TKB CTRP2 -0.3 0.568 -0.3 42.2672
A-498 CTRP2 -0.1036 2.3934 -0.1137 40.9894
769-P CTRP2 -0.1031 4.3932 -0.2966 41.4373
SNU-1272 CTRP2 -0.0874 2.7052 -0.1077 40.911
KMRC-1 CTRP2 -0.0318 1.5755 -0.0322 43.4818
VMRC-RCW CTRP2 0.0662 3.8533 -0.038 40.1195
VMRC-RCZ CTRP2 0.405 2.8574 0.3908 37.6163
RCC10RGB CTRP2 0.6267 2.085 0.6263 36.0946
CAL-54 CTRP2 0.8006 2.5017 0.7988 34.941
ACHN CTRP2 0.9475 3.459 0.9214 36.563
TUHR14TKB CTRP2 1.0962 3.1739 -2.6177 0.5302
KMRC-2 CTRP2 1.3388 2.1649 1.3388 31.3495
Caki-1 CTRP2 1.968 3.4613 1.9646 27.1689
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO201 CTRP2 -1.925 -0.4051 -1.925 53.093
SW48 CTRP2 -1.688 -0.6339 -1.688 51.5145
CCK-81 CTRP2 -1.6878 2.3526 -1.7419 51.4627
HT-55 CTRP2 -1.6575 0.6302 -1.6588 51.3092
KM12 CTRP2 -1.5888 2.2115 -1.6302 50.8315
GP2d CTRP2 -1.57 0.5658 -1.5708 50.7278
COLO 320 CTRP2 -1.5612 0.1497 -1.5613 50.6695
SNU-81 CTRP2 -1.549 0.0286 -1.549 50.5883
LS513 CTRP2 -1.4358 0.1554 -1.4358 49.834
SW620 CTRP2 -1.3987 1.2225 -1.4034 49.5887
NCI-H508 CTRP2 -1.386 2.0977 -1.4149 49.5108
SNU-C5 CTRP2 -1.3526 2.104 -1.3809 49.292
SNU-C1 CTRP2 -1.273 1.2131 -1.2765 48.7529
HT115 CTRP2 -1.2403 0.7015 -1.2408 48.5326
RKO CTRP2 -1.2255 1.2204 -1.2287 48.4369
COLO205 CTRP2 -1.2125 0.287 -1.2125 48.3463
T84 CTRP2 -1.2117 0.7692 -1.2123 48.3422
CL-11 CTRP2 -1.129 2.0513 -1.1492 47.815
HCT 8 CTRP2 -1.1023 -0.4162 -1.1023 47.6124
SNU-407 CTRP2 -1.0825 1.7098 -1.0918 47.4945
HCT 15 CTRP2 -1.0592 0.2007 -1.0593 47.3255
LS1034 CTRP2 -0.9871 1.4171 -0.9906 46.8514
SK-CO-1 CTRP2 -0.9705 0.4198 -0.9705 46.7341
SNU-C4 CTRP2 -0.9402 -0.0349 -0.9402 46.5327
SW948 CTRP2 -0.9219 0.4158 -0.9219 46.4103
LoVo CTRP2 -0.9159 1.3737 -0.9185 46.3759
LS180 CTRP2 -0.9087 2.1866 -0.9288 46.3591
CW-2 CTRP2 -0.6705 3.1162 -0.7392 44.8739
DLD-1 CTRP2 -0.4987 0.2271 -0.4987 43.5914
LS411N CTRP2 -0.4817 0.226 -0.4817 43.4777
SW1463 CTRP2 -0.4101 1.1768 -0.4103 43.0011
OUMS-23 CTRP2 -0.3951 1.3155 -0.3955 42.9019
NCI-H716 CTRP2 -0.2535 1.3253 -0.2537 41.9582
C2BBe1 CTRP2 -0.2196 2.7439 -0.2453 41.8037
LS123 CTRP2 -0.0573 1.7094 -0.0582 40.6533
SNU-175 CTRP2 -0.0169 3.7115 -0.1097 40.637
SW1116 CTRP2 0.0096 1.5894 0.0093 40.2058
SW1417 CTRP2 0.06 2.1979 0.0559 39.8821
COLO 678 CTRP2 0.0912 2.9155 0.0664 39.7366
RCM-1 [Human ESC] CTRP2 0.1512 2.8329 0.1319 39.3213
MDST8 CTRP2 0.4143 1.3563 0.4143 37.5085
SNU-C2A CTRP2 0.5259 3.4488 0.4845 36.8968
HCT 116 CTRP2 0.6001 6.1642 0.0697 37.7483
HCC-56 CTRP2 0.8789 2.3485 0.8783 34.4151
SNU-503 CTRP2 1.2073 3.0299 1.2024 32.2417
HT-29 CTRP2 2.587 12.5101 -0.3829 32.28
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-761 CTRP2 -2.3042 0.3354 -2.3065 59.6707
HLF CTRP2 -1.7301 -0.1531 -1.7301 51.7947
PLC/PRF/5 CTRP2 -1.5296 0.522 -1.5302 50.459
SNU-182 CTRP2 -1.3425 0.3314 -1.3426 49.2125
Li-7 CTRP2 -1.1435 0.8563 -1.1442 47.888
Hep 3B2.1-7 CTRP2 -0.9864 0.859 -0.9868 46.841
JHH-5 CTRP2 -0.984 2.8922 -1.0485 46.9142
SNU-398 CTRP2 -0.93 1.7764 -0.9385 46.4808
SNU-423 CTRP2 -0.6697 1.2792 -0.6706 44.7329
JHH-4 CTRP2 -0.6311 1.0343 -0.6313 47.769
SNU-878 CTRP2 -0.5831 1.0418 -0.5833 44.1537
SNU-886 CTRP2 -0.4739 4.4097 -0.6989 50.1535
SNU-449 CTRP2 -0.4251 1.1628 -0.4253 43.1014
Hep-G2 CTRP2 -0.0563 1.6257 -0.0568 40.6451
SK-HEP-1 CTRP2 0.5348 1.7519 0.5348 39.4257
SNU-387 CTRP2 1.1773 3.708 1.1441 32.5356
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 125 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2087 CTRP2 -3.3679 -0.7851 -3.3687 62.6423
PC-14 CTRP2 -3.1933 1.0568 -3.2257 61.0155
COR-L47 CTRP2 -3.021 4.6954 -3.516 61.1543
DV-90 CTRP2 -2.5859 -0.3758 -2.5862 57.4854
NCI-H524 CTRP2 -2.5766 -0.2203 -2.5773 57.4181
NCI-H1355 CTRP2 -2.4229 1.369 -2.4482 56.2383
NCI-H1666 CTRP2 -2.3484 0.8656 -2.3578 55.8402
NCI-H23 CTRP2 -2.3022 -0.8672 -2.3022 59.726
NCI-H841 CTRP2 -2.2724 -1.1807 -2.2724 59.5139
NCI-H1341 CTRP2 -2.1274 -0.561 -2.1275 54.4417
EBC-1 CTRP2 -2.0983 0.9505 -2.1061 54.2085
NCI-H211 CTRP2 -1.9158 -0.5178 -1.9158 53.032
NCI-H1155 CTRP2 -1.8763 -0.9662 -1.8763 52.7691
NCI-H146 CTRP2 -1.865 -0.0178 -1.8652 52.693
HCC44 CTRP2 -1.8405 -0.2574 -1.8405 52.5301
NCI-H1373 CTRP2 -1.714 0.9727 -1.7183 51.6804
RERF-LC-A1 CTRP2 -1.712 1.1875 -1.7193 51.6627
NCI-H810 CTRP2 -1.6976 -0.5738 -1.6976 51.5784
NCI-H2171 CTRP2 -1.6252 -0.7563 -1.6252 51.0958
NCI-H2228 CTRP2 -1.6173 2.1252 -1.6548 51.0183
HCC1438 CTRP2 -1.6141 -1.0142 -1.6141 51.022
NCI-H522 CTRP2 -1.6051 1.4204 -1.6157 50.9537
DMS 53 CTRP2 -1.5662 0.3624 -1.5665 50.7024
COLO 668 CTRP2 -1.5576 0.8553 -1.5598 50.6444
NCI-H661 CTRP2 -1.5471 1.8889 -1.5713 50.5665
NCI-H2029 CTRP2 -1.4586 0.6299 -1.4593 49.9858
NCI-H2444 CTRP2 -1.4477 1.739 -1.4642 53.5536
LXF 289 CTRP2 -1.4403 0.7565 -1.4415 49.8646
NCI-H520 CTRP2 -1.4047 0.445 -1.4049 49.627
NCI-H1693 CTRP2 -1.4021 0.2896 -1.4022 49.6094
NCI-H838 CTRP2 -1.3795 -0.8975 -1.3795 49.4588
ChaGo-K-1 CTRP2 -1.3683 1.0564 -1.371 49.3859
Lu-99 CTRP2 -1.3124 -0.1174 -1.3124 49.0118
LK2 CTRP2 -1.3009 -0.9975 -1.3009 48.9356
HOP-62 CTRP2 -1.2989 -0.2556 -1.2989 48.9223
HCC1588 CTRP2 -1.2934 1.4864 -1.301 48.8911
NCI-H1694 CTRP2 -1.2564 -0.2484 -1.2564 48.6392
NCI-H1581 CTRP2 -1.2559 0.1247 -1.2559 48.6356
NCI-H358 CTRP2 -1.2326 0.3973 -1.2327 48.4806
NCI-H1944 CTRP2 -1.2107 0.336 -1.2107 48.3346
HOP-92 CTRP2 -1.2075 0.1423 -1.2075 48.3131
NCI-H1703 CTRP2 -1.173 0.4057 -1.173 48.0832
SK-MES-1 CTRP2 -1.1718 1.1737 -1.1743 48.0789
HCC366 CTRP2 -1.1655 0.3462 -1.1655 48.0333
NCI-H2023 CTRP2 -1.1433 1.9776 -1.1612 47.9069
EKVX CTRP2 -1.1403 0.0249 -1.1403 47.8652
HCC15 CTRP2 -1.0957 0.9047 -1.0964 47.5698
DMS 454 CTRP2 -1.0759 1.6535 -1.0839 47.4486
NCI-H1793 CTRP2 -1.073 1.1828 -1.075 47.4203
NCI-H2122 CTRP2 -1.0696 1.9666 -1.0856 47.4177
NCI-H2196 CTRP2 -1.0617 0.3903 -1.0617 47.3416
HCC4006 CTRP2 -1.0537 0.3499 -1.0537 47.2884
SHP-77 CTRP2 -1.0301 -0.0739 -1.0301 47.1313
NCI-H1915 CTRP2 -1.0171 0.3014 -1.0171 47.0448
NCI-H1838 CTRP2 -0.9988 0.4691 -0.9988 46.923
NCI-H1734 CTRP2 -0.9987 0.2217 -0.9987 46.922
Lu-65 CTRP2 -0.9859 2.7219 -1.0375 50.2985
CAL-12T CTRP2 -0.9766 5.3783 -1.4467 47.2245
NCI-H1651 CTRP2 -0.9503 0.4556 -0.9503 46.5997
HCC827 CTRP2 -0.9151 2.7274 -0.9642 46.4443
NCI-H647 CTRP2 -0.8781 0.923 -0.8785 46.1198
NCI-H446 CTRP2 -0.8307 0.5899 -0.8307 45.8031
NCI-H2126 CTRP2 -0.7856 0.7643 -0.7857 45.5028
COR-L95 CTRP2 -0.7777 1.4634 -0.7802 45.4557
MOR/CPR CTRP2 -0.7719 2.9439 -0.8309 45.5211
NCI-H1435 CTRP2 -0.7716 1.2556 -0.7727 45.4118
HCC2108 CTRP2 -0.768 2.2482 -0.7871 45.4257
Calu-1 CTRP2 -0.7559 1.0122 -0.7562 45.3053
HCC78 CTRP2 -0.7489 0.7083 -0.749 45.2581
NCI-H1092 CTRP2 -0.7267 1.0383 -0.727 45.1107
NCI-H2342 CTRP2 -0.7061 10.3578 -2.8256 48.9827
Calu-3 CTRP2 -0.6894 1.0189 -0.6897 44.8622
T3M-10 CTRP2 -0.6883 0.7985 -0.6884 44.8544
NCI-H2106 CTRP2 -0.6856 0.315 -0.6856 44.8362
NCI-H1563 CTRP2 -0.6621 1.3295 -0.6632 44.6829
DMS 79 CTRP2 -0.6556 0.7227 -0.6557 44.6367
NCI-H650 CTRP2 -0.6502 0.4188 -0.6502 44.6004
NCI-H1975 CTRP2 -0.6399 0.9423 -0.64 44.5322
VMRC-LCD CTRP2 -0.623 1.6559 -0.6263 44.4278
NCI-H526 CTRP2 -0.6181 0.2057 -0.6181 44.3866
LUDLU-1 CTRP2 -0.5986 1.6518 -0.6018 44.2653
NCI-H292 CTRP2 -0.5856 -0.028 -0.5856 44.1698
NCI-H1869 CTRP2 -0.5304 1.8536 -0.5354 43.8159
NCI-H889 CTRP2 -0.5117 0.7562 -0.5117 43.6774
NCI-H2030 CTRP2 -0.4976 1.5365 -0.4992 43.5882
HARA [Human squamous cell lung carcinoma] CTRP2 -0.4946 0.7333 -0.4946 43.5637
LOU-NH91 CTRP2 -0.4569 1.5242 -0.4582 43.3163
NCI-H2170 CTRP2 -0.4544 0.8138 -0.4544 43.2958
DMS 114 CTRP2 -0.4411 1.1794 -0.4413 43.2078
NCI-H196 CTRP2 -0.4335 0.3288 -0.4335 43.1568
Sq-1 CTRP2 -0.3403 1.262 -0.3405 42.5365
HCC2279 CTRP2 -0.3203 1.1938 -0.3205 42.4031
HCC2935 CTRP2 -0.2904 1.7486 -0.2924 42.2096
SW1271 CTRP2 -0.2844 1.5448 -0.2852 42.166
NCI-H69 CTRP2 -0.2645 0.7554 -0.2645 42.031
RERF-LC-Ad2 CTRP2 -0.2471 1.1022 -0.2471 41.915
HCC1195 CTRP2 -0.2367 1.067 -0.2367 41.8454
NCI-H226 CTRP2 -0.2035 1.777 -0.2053 41.6299
NCI-H2110 CTRP2 -0.1994 1.5921 -0.2002 41.5995
A-549 CTRP2 -0.1986 3.3875 -0.2683 41.7759
NCI-H1650 CTRP2 -0.1868 2.5815 -0.2046 41.5648
HCC95 CTRP2 -0.1797 1.3014 -0.1798 41.466
KNS-62 CTRP2 -0.1537 1.9801 -0.157 41.3029
SBC-5 CTRP2 -0.1317 0.6493 -0.1317 41.1458
RERF-LC-Ad1 CTRP2 -0.1143 0.3568 -0.1143 41.0302
NCI-H1395 CTRP2 -0.0764 2.9628 -0.1091 40.8724
NCI-H460 CTRP2 -0.0346 4.5364 -0.2473 41.0375
NCI-H2405 CTRP2 -0.0313 3.959 -0.155 40.8084
EPLC-272H CTRP2 -0.0127 2.6205 -0.0279 40.3992
NCI-H1568 CTRP2 0.0174 1.4775 0.0173 40.153
NCI-H322 CTRP2 0.0338 2.4817 0.0237 40.0751
NCI-H2172 CTRP2 0.0766 4.1278 -0.0629 40.1411
NCI-H2085 CTRP2 0.2 4.3159 0.0414 39.3824
NCI-H1623 CTRP2 0.2553 4.1855 0.12 38.9584
IA-LM CTRP2 0.3857 2.4921 0.3804 37.7164
NCI-H1792 CTRP2 0.4538 4.0083 0.3548 37.5484
COLO 699 CTRP2 0.4898 3.5476 0.4393 37.165
LCLC-103H CTRP2 0.6147 6.5255 -0.0192 37.9072
NCI-H441 CTRP2 0.6658 6.684 -0.0118 37.6953
SK-LU-1 CTRP2 0.8393 2.447 0.8381 34.6814
NCI-H1299 CTRP2 1.1454 4.2969 1.0541 32.9386
HCC1171 CTRP2 1.5059 3.6443 1.4877 30.2972
NCI-H2291 CTRP2 1.6843 6.3978 1.185 30.7079
BEN CTRP2 4.8531 20.6507 -2.2738 30.7932
Hs 888.Lu CTRP2 1.2946 2.6566 1.294 31.6456
⏷ Show the Full List of 125 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -1.5679 -1.1363 -1.5679 50.7143
P-STS CTRP2 -1.5598 0.1395 -1.5599 50.6602
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 -0.9515 1.8164 -0.9612 46.6258
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 CTRP2 -3.2202 -0.2396 -3.2231 61.6019
TYK-nu CTRP2 -2.1484 0.2652 -2.1497 54.571
OAW28 CTRP2 -2.0574 0.1522 -2.058 53.9702
OVCAR-4 CTRP2 -1.5693 1.7705 -1.5895 50.7134
RMG-I CTRP2 -1.5612 1.3912 -1.5705 50.6645
OC 314 CTRP2 -1.484 -0.9176 -1.484 50.1552
MCAS CTRP2 -1.4786 2.7811 -1.5571 50.1147
OVCAR-8 CTRP2 -1.3866 1.0719 -1.3895 49.5075
IGROV-1 CTRP2 -1.1818 1.8586 -1.1966 48.1582
SNU-119 CTRP2 -1.1708 0.9558 -1.1719 48.0701
COV434 CTRP2 -1.1205 0.7012 -1.1208 47.7343
SNU-8 CTRP2 -1.0485 0.3813 -1.0485 47.2541
OV-90 CTRP2 -0.9788 1.8335 -0.9893 50.2545
OVTOKO CTRP2 -0.8996 -0.0178 -0.8996 46.2622
JHOM-1 CTRP2 -0.8762 0.7761 -0.8763 46.1062
OAW42 CTRP2 -0.8483 1.4241 -0.8509 45.9263
ONCO-DG-1 CTRP2 -0.6668 1.0914 -0.6672 44.7122
HEY A8 CTRP2 -0.5619 0.8122 -0.5619 44.0121
TOV-112D CTRP2 -0.4511 1.0586 -0.4513 43.2746
OVK18 CTRP2 -0.4319 0.5996 -0.4319 43.1463
OVCAR-5 CTRP2 -0.3652 1.3473 -0.3657 42.7032
JHOC-5 CTRP2 -0.3148 0.0852 -0.3148 42.3662
SK-OV-3 CTRP2 -0.2907 2.4015 -0.3045 42.2444
SNU-840 CTRP2 -0.2368 1.5303 -0.2375 41.8485
Kuramochi CTRP2 0.0235 1.5152 0.0233 40.1128
OVSAHO CTRP2 0.0382 4.0021 -0.0866 40.3555
COV362 CTRP2 0.1283 2.8926 0.1056 39.4837
ES2 CTRP2 0.2499 3.9128 0.1498 38.8984
EFO-27 CTRP2 0.3073 3.005 0.2845 38.2933
COV644 CTRP2 0.3194 1.8101 0.3191 40.9683
DOV13 CTRP2 0.4011 4.4287 0.2397 38.0722
Caov-3 CTRP2 0.4636 4.2485 0.3336 37.5733
EFO-21 CTRP2 0.6039 2.6019 0.5993 36.2603
FU-OV-1 CTRP2 0.8059 8.3139 -0.4205 38.0812
JHOS-2 CTRP2 1.2695 2.5345 1.2692 31.8122
OVISE CTRP2 3.3262 16.5855 -1.6333 33.0035
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 -2.6683 0.3387 -2.673 57.9701
NCI-H28 CTRP2 -1.4038 0.0368 -1.4038 49.6208
MPP 89 CTRP2 -0.4817 1.8358 -0.486 43.4898
ACC-MESO-1 CTRP2 -0.4129 0.4192 -0.4129 43.0195
NCI-H2452 CTRP2 -0.1693 2.2541 -0.1772 41.4202
NCI-H2052 CTRP2 0.3348 3.7499 0.2578 38.2718
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 CTRP2 -1.2382 -0.513 -1.2382 48.5176
LNCaP clone FGC CTRP2 -1.2372 1.1021 -1.2395 48.5139
PaCa-3 CTRP2 -0.1059 1.6083 -0.1065 40.9762
DU145 CTRP2 0.2312 2.268 0.2277 38.7398
VCaP CTRP2 0.7977 2.3373 0.7969 34.9571
22Rv1 CTRP2 1.8809 6.9721 1.2172 29.9639
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -1.8745 -0.7274 -1.8745 52.7566
A-253 CTRP2 -0.5752 6.414 -1.284 45.1291
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh18 CTRP2 -1.9363 0.9482 -1.9423 53.1471
Rh41 CTRP2 -1.4548 -0.1907 -1.4548 49.9605
KYM-1 CTRP2 -1.426 -0.5965 -1.426 49.7691
A-204 CTRP2 -1.4014 0.378 -1.4016 49.6051
G-401 CTRP2 -1.3363 0.7719 -1.3371 49.1716
SK-UT-1 CTRP2 -1.3088 0.2621 -1.3088 52.618
TTC-709 CTRP2 -1.3068 0.4997 -1.3076 45.335
GCT CTRP2 -1.1758 -0.284 -1.1758 48.1021
RKN CTRP2 -0.445 -0.0265 -0.445 43.2334
HT-1080 CTRP2 -0.3395 1.4436 -0.3402 42.5327
TE 617.T CTRP2 -0.2597 1.8778 -0.2627 42.0081
Hs 729.T CTRP2 0.1969 1.8704 0.1962 38.9589
MES-SA CTRP2 7.3285 8.5649 5.6264 0.3643
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-3 CTRP2 -2.361 -0.3721 -2.3612 55.9946
MKN74 CTRP2 -2.2149 3.813 -2.4727 54.4061
GSS CTRP2 -1.9648 -0.9909 -1.9648 53.3587
SNU-16 CTRP2 -1.766 -1.0113 -1.766 52.0339
SNU-1 CTRP2 -1.7173 0.0384 -1.7174 51.709
NCI-N87 CTRP2 -1.6939 0.0475 -1.694 51.5533
NUGC-4 CTRP2 -1.4329 0.6824 -1.4338 49.8152
HGC-27 CTRP2 -1.3413 -0.5689 -1.3413 49.2043
23132/87 CTRP2 -1.3266 -0.1683 -1.3266 49.1068
SNU-620 CTRP2 -1.2466 -0.1068 -1.2466 48.5739
SNU-216 CTRP2 -1.187 0.2289 -1.187 48.1767
SNU-601 CTRP2 -1.1617 0.1936 -1.1617 48.008
MKN7 CTRP2 -0.9591 2.8189 -1.0167 46.7436
SNU-719 CTRP2 -0.8641 1.5584 -0.8682 46.0344
AGS CTRP2 -0.7776 1.4482 -0.78 45.4549
ECC12 CTRP2 -0.7248 0.0006 -0.7248 45.0976
ECC10 CTRP2 -0.5686 2.5174 -0.5937 44.1168
HuG1-N CTRP2 -0.5492 0.9923 -0.5493 43.9277
Fu97 CTRP2 -0.4859 1.5945 -0.4878 43.5115
SNU-668 CTRP2 -0.3527 0.709 -0.3527 42.6185
KATO III CTRP2 -0.3335 2.8322 -0.3675 42.5806
KE-39 CTRP2 -0.1021 3.2595 -0.1562 41.0995
GSU CTRP2 0.0027 0.6201 0.0027 40.2507
MKN1 CTRP2 0.1168 1.4684 0.1167 39.4911
MKN45 CTRP2 0.365 12.8478 -2.7686 43.0012
LMSU CTRP2 0.4592 1.6438 0.4592 37.2095
SNG-M CTRP2 -1.1132 2.8096 -1.1769 47.7535
SNU-1077 CTRP2 -0.4193 0.6521 -0.4193 43.0623
SNU-685 CTRP2 -0.2542 0.8671 -0.2542 41.9619
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 -0.981 1.9089 -0.9935 46.8257
TT CTRP2 -0.834 1.4036 -0.8364 45.8304
B-CPAP CTRP2 -0.7466 0.8167 -0.7467 45.2429
8305C CTRP2 -0.704 0.8521 -0.7041 44.9591
CGTH-W-1 CTRP2 -0.6673 0.3727 -0.6673 44.714
BHT-101 CTRP2 -0.2293 2.2193 -0.2373 41.8202
SW579 CTRP2 -0.1699 1.0244 -0.1699 41.4006
CAL-62 CTRP2 -0.0651 0.7797 -0.0651 40.7023
TT2609-C02 CTRP2 0.3219 2.9414 0.3024 38.186
ML-1 [Human leukemia] CTRP2 1.294 3.7192 1.2646 31.7457
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 CTRP2 -2.3436 -0.1024 -2.3442 55.8738
YD-10B CTRP2 -1.8005 -0.9218 -1.8005 52.2637
HSC-3 CTRP2 -1.6068 -0.3087 -1.6068 50.9733
BHY CTRP2 -1.3173 0.0486 -1.3173 49.0444
PE/CA-PJ49 CTRP2 -1.119 0.021 -1.119 47.7232
PE/CA-PJ15 CTRP2 -1.0001 1.0511 -1.0011 46.9333
CAL-33 CTRP2 -0.9096 0.6038 -0.9096 46.3286
SNU-1076 CTRP2 -0.8972 -0.168 -0.8972 46.246
SCC-4 CTRP2 -0.8633 1.4655 -0.8664 46.0271
BICR 16 CTRP2 -0.8589 1.7726 -0.8664 46.0064
PE/CA-PJ34 (clone C12) CTRP2 -0.783 0.6334 -0.7831 45.4854
HSC-4 CTRP2 -0.7098 1.1731 -0.7104 44.9992
Detroit 562 CTRP2 -0.609 1.9868 -0.6175 44.3475
SNU-46 CTRP2 -0.3722 0.1959 -0.3722 42.7483
YD-8 CTRP2 -0.3597 1.128 -0.3598 42.6652
FaDu CTRP2 -0.2193 1.5556 -0.22 41.7321
BICR 6 CTRP2 -0.0617 1.4663 -0.0619 40.6803
PE/CA-PJ41 (clone D2) CTRP2 0.0768 2.0407 0.0746 39.7641
BICR 22 CTRP2 0.1023 2.2475 0.0979 39.6013
BICR 18 CTRP2 0.4932 2.8569 0.4809 37.0228
BICR 31 CTRP2 0.6492 3.5742 0.6037 36.0898
BICR 56 CTRP2 0.8284 5.3163 0.533 35.6572
SNU-1066 CTRP2 1.2349 5.6363 0.9012 33.1179
SNU-899 CTRP2 1.3826 4.9847 1.202 31.6558
SNU-1041 CTRP2 1.7066 6.235 1.257 30.4008
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 CTRP2 -2.2724 -0.8937 -2.2724 55.4076
JMSU-1 CTRP2 -1.7507 -0.9498 -1.7507 51.9321
RT-4 CTRP2 -1.5443 0.0999 -1.5444 50.5571
U-BLC1 CTRP2 -1.3943 0.2029 -1.3943 49.5576
TCCSUP CTRP2 -1.3905 1.3174 -1.3964 49.5347
J82 CTRP2 -1.3787 1.7656 -1.3946 53.0708
HT-1197 CTRP2 -1.3666 -0.4246 -1.3666 49.3733
SW1710 CTRP2 -1.3605 3.3331 -1.4899 49.371
5637 CTRP2 -1.1465 0.0638 -1.1465 47.907
HT-1376 CTRP2 -0.9553 2.6979 -1.004 46.7072
KMBC-2 CTRP2 -0.9103 -0.0707 -0.9103 46.3329
KU-19-19 CTRP2 -0.6734 0.0149 -0.6734 44.7546
CAL-29 CTRP2 -0.5557 0.7935 -0.5557 43.971
639V CTRP2 -0.5141 -0.0454 -0.5141 43.6936
BFTC-905 CTRP2 -0.4563 0.414 -0.4563 43.3088
UM-UC-3 CTRP2 -0.2709 0.5487 -0.2709 42.0736
253J CTRP2 -0.2531 0.6796 -0.2531 41.9545
253J-BV CTRP2 -0.0915 1.1997 -0.0916 40.8786
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 -1.349 -0.9537 -1.349 49.2558

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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