Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMOH8VY)

Drug Name
Dacomitinib Drug Info
Synonyms PF-00299804
Cross-matching ID
PubChem CID
11511120
ChEBI ID
CHEMBL2110732
CAS Number
CAS 1110813-31-4
TTD Drug ID
D06XXH
VARIDT Drug ID
DR00109
INTEDE Drug ID
DR0407
ACDINA Drug ID
D00982

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.38 0.00e+0 19/20 (95%) MSMO1;DHCR24;EBP;...
Primary immunodeficiency 2.10 0.00e+0 33/38 (86.84%) IL7R;IL2RG;CD3D;...
Arginine biosynthesis 2.02 3.37e-3 17/22 (77.27%) GLUL;ASS1;GOT1;...
Synthesis and degradation of ketone bodies 1.98 2.53e-3 9/10 (90%) HMGCS1;ACAT2
Cysteine and methionine metabolism 1.95 4.04e-3 43/50 (86%) PHGDH;CBS;CTH;...
Ferroptosis 1.94 3.37e-3 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
Terpenoid backbone biosynthesis 1.87 4.33e-3 18/22 (81.82%) HMGCS1;ACAT2;HMGCR;...
Pantothenate and CoA biosynthesis 1.86 3.79e-3 14/21 (66.67%) ALDH2;ALDH3A2;DPYD;...
One carbon pool by folate 1.79 1.24e-2 15/20 (75%) MTHFD2;SHMT2;SHMT1;...
Pentose phosphate pathway 1.76 2.02e-2 25/30 (83.33%) G6PD;TKT;PGD;...
Metabolism of xenobiotics by cytochrome P450 1.72 2.57e-2 49/77 (63.64%) ALDH3A1;EPHX1;CYP1B1;...
Alanine, aspartate and glutamate metabolism 1.72 2.53e-2 27/37 (72.97%) ASNS;GLUL;ASS1;...
Tryptophan metabolism 1.72 2.41e-2 35/42 (83.33%) ALDH2;ACAT2;IDO1;...
Glycolysis / Gluconeogenesis 1.72 2.24e-2 56/67 (83.58%) ALDH2;PCK2;ALDH3A1;...
Glutathione metabolism 1.69 2.70e-2 43/57 (75.44%) CHAC1;IDH1;G6PD;...
mTOR signaling pathway 1.69 2.97e-2 114/154 (74.03%) DDIT4;RRAGD;KRAS;...
Biosynthesis of unsaturated fatty acids 1.66 3.98e-2 21/27 (77.78%) SCD;FADS2;ELOVL6;...
Lysosome 1.64 4.49e-2 115/128 (89.84%) ASAH1;NEU1;CTSD;...
Malaria -1.74 4.81e-2 44/50 (88%) SDC2;TGFB2;THBS2;...
PI3K-Akt signaling pathway -1.78 2.64e-2 317/354 (89.55%) PTEN;GNG7;NTRK2;...
Proteoglycans in cancer -1.82 1.78e-2 172/205 (83.9%) ARHGEF1;TIAM1;PLCG1;...
AGE-RAGE signaling pathway in diabetic complications -1.84 1.48e-2 97/100 (97%) PLCB3;PIK3CD;PLCD1;...
Amoebiasis -1.94 3.30e-3 99/102 (97.06%) IL1R2;LAMC3;RAB5A;...
Focal adhesion -2.27 0.00e+0 180/201 (89.55%) FLT4;PTEN;RHOA;...
ECM-receptor interaction -2.33 0.00e+0 80/88 (90.91%) ITGAV;AGRN;HMMR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H