General Information of Drug (ID: DMP2BWX)

Drug Name
Ispinesib Drug Info
Synonyms SB-715992; Ispinesib (SB-715992 /CK0238273); SB-715992, CK0238273,Ispinesib; N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
6851740
ChEBI ID
CHEMBL228814
CAS Number
CAS 336113-53-2
TTD Drug ID
D0PW4N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.50 0.00e+0 19/20 (95%) SQLE;DHCR24;MSMO1;...
TNF signaling pathway 2.34 0.00e+0 103/112 (91.96%) CXCL2;CXCL3;CCL20;...
Ferroptosis 2.13 0.00e+0 36/41 (87.8%) SLC7A11;HMOX1;SLC39A8;...
AMPK signaling pathway 2.10 0.00e+0 106/120 (88.33%) SCD;HMGCR;FASN;...
Legionellosis 2.10 0.00e+0 51/57 (89.47%) CXCL2;CXCL8;CXCL3;...
NF-kappa B signaling pathway 2.09 0.00e+0 90/104 (86.54%) CXCL2;CXCL8;CXCL3;...
Protein processing in endoplasmic reticulum 2.01 1.58e-3 127/171 (74.27%) HERPUD1;DDIT3;ATF4;...
IL-17 signaling pathway 2.01 1.39e-3 84/94 (89.36%) CXCL2;CXCL8;CXCL3;...
Rheumatoid arthritis 1.89 8.63e-3 78/93 (83.87%) CXCL2;CXCL8;CXCL3;...
Selenocompound metabolism 1.84 1.33e-2 11/17 (64.71%) CTH;PAPSS2;TXNRD1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.83 1.61e-2 62/70 (88.57%) CXCL2;CXCL8;CXCL3;...
Lipid and atherosclerosis 1.81 1.66e-2 190/215 (88.37%) CXCL2;CXCL8;CXCL3;...
Mineral absorption 1.81 1.54e-2 48/60 (80%) HMOX1;FTH1;ATP2B1;...
Mitophagy 1.80 1.66e-2 56/68 (82.35%) SQSTM1;ATF4;EIF2AK3;...
Terpenoid backbone biosynthesis 1.77 2.14e-2 18/22 (81.82%) HMGCS1;HMGCR;FDPS;...
Apoptosis 1.75 2.43e-2 126/168 (75%) DDIT3;ATF4;CASP10;...
Autophagy 1.74 2.35e-2 113/169 (66.86%) DDIT4;SQSTM1;IRS2;...
Pathogenic Escherichia coli infection 1.72 2.96e-2 152/197 (77.16%) CXCL8;ARHGEF2;NFKBIA;...
Viral protein interaction with cytokine and cytokine re... 1.71 2.86e-2 84/100 (84%) CXCL2;CXCL8;CXCL3;...
Parathyroid hormone synthesis, secretion and action 1.71 2.83e-2 98/106 (92.45%) JUND;ATF4;ATF2;...
Cortisol synthesis and secretion 1.70 3.22e-2 58/65 (89.23%) ATF4;LDLR;ATF2;...
Kaposi sarcoma-associated herpesvirus infection 1.69 3.13e-2 172/193 (89.12%) CXCL2;CXCL8;CXCL3;...
Osteoclast differentiation 1.66 4.20e-2 117/127 (92.13%) JUND;SQSTM1;RELB;...
Longevity regulating pathway 1.65 4.21e-2 90/151 (59.6%) ATF4;IRS2;SOD2;...
FoxO signaling pathway 1.65 4.26e-2 118/131 (90.08%) IRS2;SOD2;PLK1;...
NOD-like receptor signaling pathway 1.63 4.61e-2 145/181 (80.11%) CXCL2;CXCL8;CXCL3;...
Neurotrophin signaling pathway 1.62 4.76e-2 107/119 (89.92%) ATF4;NFKBIA;NFKB1;...
ErbB signaling pathway 1.62 4.67e-2 79/85 (92.94%) EIF4EBP1;CBLB;ERBB4;...
Glycine, serine and threonine metabolism 1.61 4.78e-2 31/40 (77.5%) CTH;PHGDH;PSAT1;...
Diabetic cardiomyopathy -1.62 4.60e-2 162/203 (79.8%) PPIF;PDK2;CD36;...
Metabolism of xenobiotics by cytochrome P450 -1.63 4.56e-2 49/77 (63.64%) CYP1A2;HPGDS;CYP2D6;...
Parkinson disease -1.65 3.67e-2 176/249 (70.68%) MFN2;GNAI3;PPIF;...
Non-homologous end-joining -1.68 2.67e-2 11/13 (84.62%) DCLRE1C;FEN1;DNTT;...
Propanoate metabolism -1.71 2.35e-2 30/34 (88.24%) SUCLA2;DBT;SUCLG2;...
Huntington disease -1.75 1.51e-2 233/306 (76.14%) COX7B;SDHB;CASP3;...
Ribosome -1.75 1.63e-2 113/158 (71.52%) RPLP2;MRPL9;RPS14;...
Purine metabolism -1.78 1.38e-2 102/129 (79.07%) PDE9A;IMPDH2;PDE5A;...
Pyrimidine metabolism -1.81 1.07e-2 40/56 (71.43%) NME7;UCK2;RRM1;...
Glutathione metabolism -1.82 1.09e-2 43/57 (75.44%) HPGDS;GSTP1;GSTA3;...
Drug metabolism -1.90 5.56e-3 78/151 (51.66%) CYP1A2;HPGDS;CYP2D6;...
Nucleotide excision repair -1.92 5.09e-3 40/47 (85.11%) XPA;RFC4;RFC3;...
Mismatch repair -1.94 5.93e-3 22/23 (95.65%) MLH3;MLH1;MSH6;...
RNA polymerase -1.99 3.56e-3 23/31 (74.19%) POLR3B;POLR1E;POLR2H;...
Proteasome -2.01 0.00e+0 44/46 (95.65%) PSMB5;PSMD14;PSMB10;...
Ribosome biogenesis in eukaryotes -2.11 0.00e+0 52/108 (48.15%) RAN;RPP38;BMS1;...
Oxidative phosphorylation -2.16 0.00e+0 93/133 (69.92%) ATP5ME;NDUFS6;ATP12A;...
DNA replication -2.29 0.00e+0 34/36 (94.44%) PRIM2;DNA2;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H