Details of the Drug

General Information of Drug (ID: DMP2BWX)

Drug Name
Ispinesib
Synonyms SB-715992; Ispinesib (SB-715992 /CK0238273); SB-715992, CK0238273,Ispinesib; N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
Indication
Disease Entry ICD 11 Status REF
Head and neck cancer 2D42 Phase 2 [1]
Ovarian cancer 2C73 Phase 2 [1]
Renal cell carcinoma 2C90 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 517.1
Logarithm of the Partition Coefficient (xlogp) 5.3
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C30H33ClN4O2
IUPAC Name
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
Canonical SMILES
CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C
InChI
InChI=1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1
InChIKey
QJZRFPJCWMNVAV-HHHXNRCGSA-N
Cross-matching ID
PubChem CID
6851740
ChEBI ID
CHEBI:94692
CAS Number
336113-53-2
UNII
BKT5F9C2NI
DrugBank ID
DB06188
TTD ID
D0PW4N
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Head and neck cancer
ICD Disease Classification 2D42
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Kinesin-like protein KIF11 (KIF11) DTT KIF11 5.72E-26 -1.17 -1.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -4.4871 1.819 -6.72 32.0505
MHH-ES-1 GDSC1 -7.0736 -6.2655 -7.0736 51.3479
ES7 GDSC1 -6.887 -4.2057 -6.9814 49.0866
EW-1 GDSC1 -6.6492 -4.743 -6.6738 46.1229
ES8 GDSC1 -6.5375 -5.6606 -6.5376 44.6467
EW-18 GDSC1 -6.3475 -4.7819 -6.3598 42.335
A-673 GDSC1 -6.2185 -5.549 -6.2185 40.6594
ES5 GDSC1 -5.8858 -2.961 -6.1538 37.8974
TC-71 GDSC1 -5.4743 -4.4738 -5.478 31.3798
EW-16 GDSC1 -5.2902 -3.6143 -5.3594 29.4915
ES1 GDSC1 -4.6883 -1.9588 -5.1919 24.8968
SK-PN-DW GDSC1 -4.6625 -3.0597 -4.7927 22.0578
SJSA-1 GDSC1 -4.5564 0.7113 -6.2541 30.3335
SK-ES-1 GDSC1 -4.3954 -1.9963 -4.8669 21.0996
EW-7 GDSC1 -4.2517 -1.6956 -4.8428 20.1871
EW-13 GDSC1 -4.1394 -0.6831 -5.1886 22.0465
HuO9 GDSC1 -4.0767 -0.8087 -5.0682 20.9169
CADO-ES1 GDSC1 -3.8591 -2.0811 -4.2708 14.0618
NY GDSC1 -3.1391 1.4196 -5.3046 18.4928
EW-3 GDSC1 -2.8908 0.9266 -4.8498 14.3822
NOS-1 [Human HNSCC] GDSC1 -2.767 3.8567 -6.2128 22.4925
EW-11 GDSC1 -1.8834 6.3087 -6.7347 22.1184
HuO-3N1 GDSC1 -1.2145 3.6412 -4.9485 9.9827
ES6 GDSC1 -1.051 2.4989 -4.3154 5.3432
H-EMC-SS GDSC1 -0.8433 3.678 -4.7296 7.6551
ES4 GDSC1 -0.1434 7.0966 -5.8841 13.062
SaOS-2 GDSC1 0.0064 1.959 -3.5973 0.385
MG-63 GDSC1 0.142 2.6031 -3.7766 0.8465
HOS GDSC1 0.3347 2.059 -3.5155 0.1451
CAL-72 GDSC1 0.4405 2.2097 -3.5298 0.1454
EW-24 GDSC1 0.5102 2.1948 -3.5013 0.1024
CHSA0011 GDSC1 0.6031 3.1998 -3.8135 0.7032
CAL-78 GDSC1 0.6578 2.4513 -3.5364 0.1197
CHSA0108 GDSC1 0.7589 3.3577 -3.8107 0.6202
CHSA8926 GDSC1 0.8063 2.7722 -3.5925 0.1638
U2OS GDSC1 0.9165 3.35 -3.75 0.4095
G-292 clone A141B1 GDSC1 1.0392 12.2554 -7.5532 18.1836
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -4.5102 -3.6512 -4.5249 19.3977
MOLP-8 GDSC1 -8.4737 -5.9374 -8.4931 67.3939
RPMI-8402 GDSC1 -7.8995 -5.7913 -7.9106 61.2599
SU-DHL-10 GDSC1 -7.7569 -7.0949 -7.7569 59.8894
MV4-11 GDSC1 -7.6256 -6.8787 -7.6256 58.2471
KE-37 GDSC1 -7.377 -5.5327 -7.3858 55.0503
Sc-1 GDSC1 -7.3005 -5.4391 -7.3106 54.1088
CTV-1 GDSC1 -7.2756 -4.6921 -7.3343 53.6206
697 GDSC1 -7.2336 -6.4711 -7.2336 53.3478
SUP-B15 GDSC1 -7.1683 -3.6546 -7.3841 52.1471
ATN-1 GDSC1 -7.1324 -5.6297 -7.1355 52.0712
Hs 445 GDSC1 -7.1259 -5.3284 -7.1359 51.9712
PF-382 GDSC1 -7.0476 -4.9478 -7.0739 50.9922
SR GDSC1 -6.9895 -3.979 -7.1277 50.2664
NB4 GDSC1 -6.8696 -3.8192 -7.0272 48.926
RPMI-6666 GDSC1 -6.8351 -4.8462 -6.86 48.4058
NALM-6 GDSC1 -6.8147 -5.8395 -6.8148 48.1116
SU-DHL-6 GDSC1 -6.7972 -5.7324 -6.7976 47.8938
SU-DHL-5 GDSC1 -6.7393 -5.7517 -6.7395 47.1698
Loucy GDSC1 -6.6986 -5.4235 -6.7005 46.6671
EB2 GDSC1 -6.6522 -4.7955 -6.6735 46.15
BC-1 GDSC1 -6.651 -5.7808 -6.651 46.0653
RS4;11 GDSC1 -6.595 -5.4967 -6.5957 45.3684
Karpas-45 GDSC1 -6.5787 -5.0237 -6.5873 45.1972
OCI-Ly19 GDSC1 -6.5476 -5.7183 -6.5477 44.7731
Ku812 GDSC1 -6.5378 -5.4608 -6.5385 44.6537
NKM-1 GDSC1 -6.5372 -5.4844 -6.5378 44.6456
OCI-AML-3 GDSC1 -6.5358 -5.9699 -6.5358 44.6252
MHH-PREB-1 GDSC1 -6.4658 -5.6989 -6.4658 43.7499
BV-173 GDSC1 -6.4573 -5.4236 -6.4578 43.6466
NU-DUL-1 GDSC1 -6.419 -5.5863 -6.4191 43.1662
MOLT-13 GDSC1 -6.3725 -5.3476 -6.3731 42.5876
KCL-22 GDSC1 -6.3427 -5.0771 -6.3459 42.229
MC116 GDSC1 -6.3034 -5.884 -6.3034 41.7206
OPM-2 GDSC1 -6.281 -4.8295 -6.2897 41.4875
SU-DHL-16 GDSC1 -6.2785 -5.5723 -6.2785 41.4085
ML-2 GDSC1 -6.2745 -4.1956 -6.3302 41.6295
L-363 GDSC1 -6.2623 -5.2837 -6.2629 41.2099
Namalwa GDSC1 -6.2501 -4.9648 -6.2544 41.0786
OCI-AML-5 GDSC1 -6.2127 -5.2136 -6.2135 40.5912
ST486 GDSC1 -6.1626 -5.1125 -6.1638 39.9671
MOLM-13 GDSC1 -6.1113 -3.8752 -6.1999 39.7773
SUP-M2 GDSC1 -6.0989 -3.0046 -6.3746 40.4242
P12-Ichikawa GDSC1 -6.0581 -4.474 -6.0776 38.7661
Jiyoye GDSC1 -6.0554 -3.3069 -6.2509 39.5841
WIL2 NS GDSC1 -6.0279 -3.5768 -6.1627 38.9785
MOLT-16 GDSC1 -5.987 -2.2122 -6.4957 40.0266
KOPN-8 GDSC1 -5.9815 -4.8203 -5.985 37.7179
QIMR-WIL GDSC1 -5.9525 -4.6617 -5.9598 37.3783
Farage GDSC1 -5.9523 -4.6553 -5.9597 37.3762
GDM-1 GDSC1 -5.9006 -3.7645 -5.9912 37.1985
BL-41 GDSC1 -5.8977 -4.4804 -5.9113 36.7313
ALL-SIL GDSC1 -5.891 -4.6178 -5.8984 36.6109
TK [Human B-cell lymphoma] GDSC1 -5.8636 -4.1396 -5.9017 36.4487
P30/OHK GDSC1 -5.8361 -4.831 -5.8379 35.89
CESS GDSC1 -5.8273 -4.5923 -5.8341 35.8107
AMO1 GDSC1 -5.7911 -4.0217 -5.8379 35.5972
Reh GDSC1 -5.7464 -4.4837 -5.7555 34.8141
HDLM-2 GDSC1 -5.7429 -1.584 -6.4607 38.1697
P32/ISH GDSC1 -5.6493 -4.2271 -5.6695 33.6686
HC-1 GDSC1 -5.6477 -4.1255 -5.676 33.6983
SU-DHL-4 GDSC1 -5.6192 -4.7307 -5.6204 33.1751
A3/Kawakami GDSC1 -5.5706 -0.4101 -6.7606 38.1172
CCRF-CEM GDSC1 -5.5654 -4.7481 -5.5661 32.4991
SCC-3 GDSC1 -5.5577 -4.7093 -5.5586 32.4046
VAL GDSC1 -5.5439 -3.92 -5.5877 32.498
Ramos.2G6.4C10 GDSC1 -5.531 -4.8413 -5.5312 32.0663
DND-41 GDSC1 -5.5218 -0.1211 -6.8361 38.0667
PL-21 GDSC1 -5.4928 -3.4616 -5.6058 32.2844
OCI-AML-2 GDSC1 -5.4868 -4.9981 -5.4868 31.5132
JJN-3 GDSC1 -5.4789 -4.1282 -5.4992 31.5404
TUR GDSC1 -5.4599 -4.8514 -5.46 31.1772
Kasumi-1 GDSC1 -5.4393 -3.2478 -5.5937 31.8723
KM-H2 GDSC1 -5.4203 -3.1041 -5.608 31.8389
NOMO-1 GDSC1 -5.3889 -3.667 -5.4571 30.7164
SIG-M5 GDSC1 -5.3804 -5.0378 -5.3804 30.1825
SUP-T1 GDSC1 -5.3765 -1.6869 -6.0302 33.8753
HH [Human lymphoma] GDSC1 -5.3275 0.9395 -7.1186 37.8202
BE-13 GDSC1 -5.2986 -3.1788 -5.4568 30.1554
RPMI-8226 GDSC1 -5.2473 -3.4773 -5.337 29.0868
MY-M12 GDSC1 -5.2373 -3.3701 -5.3472 29.0908
BC-3 GDSC1 -5.198 -4.3917 -5.1997 27.9135
KMS-12-BM GDSC1 -5.1545 -4.1904 -5.1604 27.3963
CA46 GDSC1 -5.1286 -0.5875 -6.2282 33.3216
LP-1 GDSC1 -5.1147 -3.1523 -5.2628 27.8099
MOLT-4 GDSC1 -5.0919 -2.9302 -5.2959 27.8863
H9 GDSC1 -5.0883 -1.9531 -5.6203 29.8771
HT GDSC1 -5.0052 -0.345 -6.2097 32.5264
LC4-1 GDSC1 -4.9562 1.6999 -7.1112 35.8152
MLMA GDSC1 -4.875 -0.2505 -6.1207 31.3691
DB GDSC1 -4.7558 -0.8939 -5.7114 28.5168
SUP-HD1 GDSC1 -4.7235 -1.822 -5.2837 25.6954
K-562 GDSC1 -4.657 0.0462 -6.0395 29.7836
KMS-11 GDSC1 -4.5888 -2.0972 -5.0318 23.2745
Granta-519 GDSC1 -4.5201 -0.5267 -5.6385 26.8323
LAMA-84 GDSC1 -4.5069 -1.1649 -5.3371 24.882
ARH-77 GDSC1 -4.4986 -3.0949 -4.6052 19.8537
JURL-MK1 GDSC1 -4.4531 -1.8848 -4.9731 22.1442
VL51 GDSC1 -4.4466 0.5883 -6.0893 28.9603
SU-DHL-8 GDSC1 -4.4351 2.4924 -6.9988 32.8835
DEL GDSC1 -4.4086 -2.5371 -4.6753 19.8273
ALL-PO GDSC1 -4.3875 1.9464 -6.6882 31.4447
GR-ST GDSC1 -4.3322 -1.1107 -5.1838 22.9671
HAL-01 GDSC1 -4.2596 -3.2921 -4.3039 16.4568
HL-60 GDSC1 -4.1865 -3.4461 -4.2041 15.3706
EJM GDSC1 -4.1641 -1.2748 -4.9399 20.4397
BALL-1 GDSC1 -4.1117 -0.4065 -5.2921 22.6083
NK-92MI GDSC1 -3.9884 -2.1352 -4.3821 15.5248
Mono-Mac-6 GDSC1 -3.8057 -0.4195 -4.9923 19.1253
DG-75 GDSC1 -3.788 -1.691 -4.3726 14.4762
OCI-M1 GDSC1 -3.7415 1.4175 -5.8333 24.2675
EoL-1 GDSC1 -3.4268 2.2395 -5.9619 23.666
Karpas-299 GDSC1 -3.3938 -0.6468 -4.4988 13.699
CTB-1 GDSC1 -3.3677 7.2619 -8.4183 33.0567
HEL GDSC1 -3.309 -1.4765 -4.0127 9.5891
MEG-01 GDSC1 -3.2873 0.2072 -4.8275 15.732
WSU-NHL GDSC1 -3.2773 0.1659 -4.7982 15.4766
Karpas-620 GDSC1 -3.2715 0.6335 -5.0262 17.101
RL GDSC1 -3.1557 0.582 -4.9003 15.7446
WSU-DLCL2 GDSC1 -3.092 2.5152 -5.8122 21.4838
KG-1 GDSC1 -2.8629 -0.888 -3.9203 7.1619
RPMI-8866 GDSC1 -2.7603 0.2932 -4.4273 10.7565
L-540 GDSC1 -2.7598 5.3336 -6.9451 25.933
KMOE-2 GDSC1 -2.7466 2.1831 -5.3599 17.3923
EM-2 GDSC1 -2.3611 1.5669 -4.75 11.8474
THP-1 GDSC1 -2.3498 4.8475 -6.3717 21.8634
JSC-1 GDSC1 -2.0361 8.4692 -7.9282 27.3121
L-428 GDSC1 -1.6524 4.9974 -5.9129 17.1929
Raji GDSC1 -1.2538 6.5226 -6.3699 18.4894
A4/Fukuda GDSC1 -1.1436 10.0856 -8.0421 25.1774
ROS-50 GDSC1 -1.0823 4.721 -5.3754 12.3942
U-698-M GDSC1 -0.9653 3.4374 -4.6935 7.6877
KY821 GDSC1 -0.9065 5.2888 -5.5287 12.878
SK-MM-2 GDSC1 -0.6913 5.435 -5.4555 11.9005
Daudi GDSC1 -0.3096 2.979 -4.125 2.9147
YT GDSC1 -0.3058 5.6562 -5.3131 10.1456
SU-DHL-1 GDSC1 -0.2047 2.2218 -3.7757 1.088
MN-60 GDSC1 -0.1674 8.7646 -6.6945 17.2365
L-1236 GDSC1 -0.02 2.9204 -3.9654 1.751
P31/FUJ GDSC1 0.0387 3.4682 -4.1576 2.64
JVM-2 GDSC1 0.0499 3.564 -4.1913 2.804
RC-K8 GDSC1 0.0756 1.5653 -3.4395 0.0949
JVM-3 GDSC1 0.2467 2.6833 -3.7646 0.7441
ME1 GDSC1 0.3385 8.4026 -6.1887 13.5856
U266B1 GDSC1 0.4422 1.9619 -3.4477 0.0624
Karpas-422 GDSC1 0.8096 9.1917 -6.2603 12.9423
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 -5.9977 -2.3559 -6.4592 39.974
OACM5.1 C GDSC1 -5.686 -0.9297 -6.6614 38.5167
KYSE-50 GDSC1 -3.8203 3.7159 -7.043 30.3584
FLO-1 GDSC1 -3.6787 -1.9953 -4.1242 12.0948
ESO-51 GDSC1 -3.4708 0.0928 -4.9339 17.2548
OACP4 C GDSC1 -3.4078 -0.9988 -4.3381 12.524
TE-12 GDSC1 -2.3892 0.5656 -4.277 8.4027
HCE-4 GDSC1 -1.7723 2.1346 -4.6029 9.05
KYSE-220 GDSC1 -0.4539 5.9372 -5.5384 11.8252
SK-GT-4 GDSC1 -0.2066 8.0366 -6.3722 15.7708
KYAE-1 GDSC1 0.4575 10.7352 -7.2162 18.0867
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -2.9465 3.8764 -6.3708 23.9561
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 -7.7135 -6.9905 -7.7135 59.346
IMR-5 GDSC1 -6.794 -5.0688 -6.8059 47.8796
CHP-134 GDSC1 -5.92 -1.4022 -6.7197 40.2895
TGW GDSC1 -5.5797 -3.7529 -5.6485 33.0971
GI-ME-N GDSC1 -5.4255 1 -7.2441 38.731
KP-N-YS GDSC1 -5.4227 -4.3304 -5.4298 30.7556
Kelly GDSC1 -5.1319 -4.2302 -5.136 27.102
NB69 GDSC1 -4.7854 -3.1982 -4.8933 23.4427
MHH-NB-11 GDSC1 -4.7319 -2.8728 -4.9194 23.3068
SK-N-AS GDSC1 -4.1294 -1.7318 -4.701 18.5544
SJNB-5 GDSC1 -3.775 -2.0602 -4.1933 13.0754
SK-N-BE(2)-M17 GDSC1 -3.729 -1.2806 -4.506 15.2048
SJNB-7 GDSC1 -3.6873 -0.8326 -4.6804 16.3244
SJNB-10 GDSC1 -3.4847 0.7278 -5.261 19.5938
SK-N-FI GDSC1 -3.4372 -1.0512 -4.3396 12.6586
SJNB-6 GDSC1 -3.345 0.8531 -5.1998 18.6034
NH-12 GDSC1 -3.3024 -1.1798 -4.1528 10.6521
SJNB-14 GDSC1 -2.7058 0.4498 -4.4621 10.8355
SK-N-SH GDSC1 -2.5796 0.1306 -4.2051 8.4447
SiMa GDSC1 -2.1838 2.7837 -5.2177 14.5466
CHP-212 GDSC1 -1.9984 1.7572 -4.5777 9.4953
NB(TU)1 GDSC1 -1.7121 2.132 -4.5607 8.5877
GOTO GDSC1 -0.7546 3.3879 -4.5439 6.2499
SJNB-13 GDSC1 -0.7528 2.146 -3.9981 2.8178
SJNB-12 GDSC1 -0.6472 7.559 -6.4436 17.2249
KP-N-YN GDSC1 -0.2997 2.9204 -4.0958 2.7402
SK-N-DZ GDSC1 -0.1349 2.2025 -3.7397 0.8977
SJNB-17 GDSC1 0.263 3.2119 -3.9553 1.4449
LA-N-6 GDSC1 1.0754 3.0593 -3.5967 0.1277
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -0.4504 7.4911 -6.2756 15.8787
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-468 GDSC1 -7.3602 -6.2266 -7.3604 54.9259
HCC1954 GDSC1 -6.9201 -3.7057 -7.1041 49.4988
HCC1187 GDSC1 -6.6977 -5.3494 -6.7005 46.6591
OCUB-M GDSC1 -6.6026 -4.3902 -6.6556 45.6314
CAL-85-1 GDSC1 -6.3385 -0.6103 -7.4785 44.9543
BT-20 GDSC1 -6.0479 -2.2968 -6.5332 40.61
HCC1806 GDSC1 -5.908 -3.3884 -6.0719 37.6657
HCC1599 GDSC1 -5.8078 -4.2688 -5.8317 35.6703
MDA-MB-453 GDSC1 -5.0485 -1.6444 -5.6986 30.0998
HCC70 GDSC1 -4.7398 -1.2124 -5.5557 27.505
JIMT-1 GDSC1 -4.6302 -2.3829 -4.9692 23.0723
DU4475 GDSC1 -4.5949 -1.7616 -5.1728 24.2621
MDA-MB-415 GDSC1 -3.7258 1.1227 -5.6734 23.258
CAMA-1 GDSC1 -3.6307 2.4763 -6.259 26.0882
ZR-75-30 GDSC1 -3.5427 1.482 -5.6871 22.5553
MDA-MB-231 GDSC1 -3.268 1.4972 -5.4539 19.977
AU565 GDSC1 -3.1183 3.0821 -6.1177 23.2946
BT-549 GDSC1 -3.0112 0.8402 -4.9067 15.2394
CAL-51 GDSC1 -2.6652 2.3128 -5.3589 17.0962
MRK-nu-1 GDSC1 -2.6379 0.4871 -4.4272 10.341
Evsa-T GDSC1 -2.5768 3.2813 -5.7714 19.3547
HCC202 GDSC1 -2.5566 5.5468 -6.8861 24.9788
HCC2157 GDSC1 -2.0053 1.6148 -4.5134 9.0459
HCC38 GDSC1 -1.642 10.0346 -8.3983 27.6851
CAL-120 GDSC1 -1.1369 3.525 -4.8429 9.0865
BT-474 GDSC1 -0.964 4.1185 -5.0109 9.7762
COLO 824 GDSC1 -0.9481 4.5184 -5.1895 10.8852
HCC2218 GDSC1 -0.8934 10.4227 -8.0212 24.4471
T-47D GDSC1 -0.8793 6.9647 -6.318 17.1995
UACC-893 GDSC1 -0.7286 6.2496 -5.8687 14.3976
HCC1569 GDSC1 -0.6532 5.2337 -5.3357 11.0811
HDQ-P1 GDSC1 -0.483 4.6229 -4.9449 8.2607
HCC1419 GDSC1 -0.3434 4.3304 -4.7296 6.6212
EFM-19 GDSC1 -0.3084 7.4464 -6.1586 14.9236
UACC-812 GDSC1 -0.2849 3.1775 -4.1956 3.2785
HCC1500 GDSC1 -0.199 5.0505 -4.9704 7.8298
MDA-MB-157 GDSC1 -0.1981 3.9595 -4.4847 4.8477
CAL-148 GDSC1 -0.0643 2.687 -3.8939 1.4684
HCC1937 GDSC1 0.1206 7.6178 -5.9597 12.871
Hs 578T GDSC1 0.126 3.6859 -4.2047 2.7794
MDA-MB-330 GDSC1 0.1579 4.3797 -4.4779 4.2409
EFM-192A GDSC1 0.167 5.4341 -4.9316 6.8907
HCC1395 GDSC1 0.2337 8.861 -6.4725 15.2351
BT-483 GDSC1 0.3331 1.894 -3.4616 0.085
MFM-223 GDSC1 0.3337 2.3229 -3.6051 0.292
MCF-7 GDSC1 0.3737 2.5491 -3.6689 0.4171
YMB-1-E GDSC1 0.4583 4.953 -4.5671 4.299
MDA-MB-175-VII GDSC1 0.4711 2.324 -3.5574 0.1775
HCC1428 GDSC1 0.5147 2.2736 -3.5258 0.1286
MDA-MB-361 GDSC1 0.516 3.4855 -3.953 1.2349
MDA-MB-436 GDSC1 0.7073 14.2451 -8.7356 23.0092
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 683 GDSC1 -6.1832 -4.8026 -6.1907 40.2608
Becker GDSC1 -6.1747 -4.1815 -6.226 40.3792
H4 GDSC1 -6.0411 -4.446 -6.0618 38.562
GaMG GDSC1 -6.0326 -4.9573 -6.0344 38.346
Daoy GDSC1 -5.9923 -4.6351 -6.0014 37.8863
D-336MG GDSC1 -5.9639 -3.7187 -6.0672 38.0434
GI-1 GDSC1 -5.6728 -3.8956 -5.7278 34.1729
U-251MG GDSC1 -5.4094 -4.9657 -5.4094 30.5448
SK-MG-1 GDSC1 -5.2534 -1.3879 -6.0186 33.0546
YKG-1 GDSC1 -5.1772 -0.75 -6.2074 33.5103
YH-13 GDSC1 -4.8065 -2.0881 -5.2676 26.0517
MOG-G-CCM GDSC1 -4.4624 -1.8626 -4.992 22.3244
SF295 GDSC1 -4.4279 -1.3657 -5.1678 23.3486
PFSK-1 GDSC1 -4.3494 -1.5724 -4.997 21.7719
M059J GDSC1 -4.3013 -1.8177 -4.8422 20.4364
SF539 GDSC1 -4.099 -2.739 -4.2711 15.3155
KALS-1 GDSC1 -4.0742 0.9858 -5.9273 26.2979
AM-38 GDSC1 -3.541 -0.9127 -4.5039 14.3577
SF268 GDSC1 -3.4505 1.7421 -5.7349 22.4571
GB-1 GDSC1 -3.2194 2.4116 -5.8687 22.3071
SF126 GDSC1 -3.0633 -1.2354 -3.9135 7.8347
DBTRG-05MG GDSC1 -3.0353 0.0635 -4.5388 12.5963
KS-1 [Human Krukenberg tumour] GDSC1 -3.0072 1.7246 -5.3456 18.2585
NMC-G1 GDSC1 -2.7868 -0.3858 -4.1099 8.3877
KNS-42 GDSC1 -2.6219 0.4775 -4.4099 10.156
D-423MG GDSC1 -2.2663 2.0604 -4.9224 12.7809
MOG-G-UVW GDSC1 -2.256 1.5368 -4.6564 10.8343
ONS-76 GDSC1 -2.1806 4.9165 -6.2732 20.7997
T98G GDSC1 -1.8046 1.6452 -4.3901 7.6013
LNZTA3WT4 GDSC1 -1.8003 1.9057 -4.512 8.4722
D-392MG GDSC1 -1.5403 2.8718 -4.7991 9.8096
CAS-1 GDSC1 -1.2742 3.4838 -4.9132 9.8979
KINGS-1 GDSC1 -1.1276 5.7392 -5.8978 15.6125
Onda 11 GDSC1 -0.9348 4.5865 -5.213 11.0016
LN-229 GDSC1 -0.8158 2.1692 -4.0403 3.1635
8-MG-BA GDSC1 -0.5264 5.2465 -5.2607 10.3251
Onda 10 GDSC1 -0.4745 5.4474 -5.3217 10.5784
D-502MG GDSC1 -0.2489 4.2899 -4.6578 5.9955
SNB-75 GDSC1 0.0216 5.5059 -5.0471 7.8572
LN-405 GDSC1 0.0418 7.4076 -5.9114 12.7875
U-87MG ATCC GDSC1 0.1028 1.9383 -3.5553 0.2618
SW1088 GDSC1 0.136 5.2602 -4.8719 6.5921
D-566MG GDSC1 0.1714 2.1605 -3.6073 0.3482
D-542MG GDSC1 0.188 2.7452 -3.8106 0.9363
U-118MG GDSC1 0.1997 2.1752 -3.6022 0.3275
D-247MG GDSC1 0.2185 7.1716 -5.6905 11.1873
D283 Med GDSC1 0.2455 3.2417 -3.9742 1.5407
A-172 GDSC1 0.2898 2.8947 -3.825 0.9206
DK-MG GDSC1 0.3504 2.0011 -3.4911 0.113
LN-18 GDSC1 0.5239 1.7356 -3.3485 0.0123
42-MG-BA GDSC1 0.5857 2.9995 -3.7487 0.5308
SW1783 GDSC1 0.6564 2.6909 -3.6168 0.2291
KNS-81-FD GDSC1 0.662 2.6358 -3.5963 0.1961
D-263MG GDSC1 0.6952 2.8913 -3.6713 0.3164
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 -3.8276 -0.2704 -5.0852 19.8775
ETK-1 GDSC1 -3.6213 0.0883 -5.0684 18.8496
TGBC1TKB GDSC1 0.4169 2.5114 -3.6401 0.3379
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 -6.9882 -5.4949 -6.9919 50.2789
EN GDSC1 -2.238 0.8776 -4.3199 8.277
MFE-280 GDSC1 -1.4535 3.429 -5.0075 10.998
ESS-1 GDSC1 -1.0426 8.4746 -7.1731 21.615
MFE-296 GDSC1 -0.5831 6.09 -5.6951 13.0478
RL95-2 GDSC1 -0.5474 4.4407 -4.9002 8.1158
KLE GDSC1 -0.5338 4.9422 -5.1235 9.4932
AN3-CA GDSC1 0.294 4.2743 -4.3654 3.4206
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -6.5423 -3.8599 -6.6662 45.0987
769-P GDSC1 -6.1303 -3.3655 -6.319 40.4467
KTCTL-140 GDSC1 -4.5007 -0.9244 -5.4382 25.4985
KTCTL-21 GDSC1 -4.3813 -0.018 -5.7384 26.7122
SW13 GDSC1 -3.8274 1.1973 -5.8028 24.4706
VMRC-RCZ GDSC1 -3.7993 -0.0216 -5.1795 20.402
KTCTL-1M GDSC1 -3.187 2.2529 -5.7617 21.556
BB65-RCC GDSC1 -2.4338 2.2551 -5.1472 14.8866
BFTC-909 GDSC1 -2.3204 1.8913 -4.8797 12.6503
KTCTL-26A GDSC1 -2.3176 2.2571 -5.0587 13.8966
SN12C GDSC1 -2.1288 1.3552 -4.4747 9.1147
LB1047-RCC GDSC1 -1.6933 3.4963 -5.2075 12.9929
Caki-1 GDSC1 -1.3805 3.6531 -5.0654 11.189
RXF 393L GDSC1 -1.2553 5.9255 -6.0791 16.9676
CAL-54 GDSC1 -1.2084 2.6754 -4.491 6.8672
LB996-RCC GDSC1 -1.1797 3.2594 -4.7455 8.5341
UO-31 GDSC1 -1.0232 4.9757 -5.4575 12.7472
HA7-RCC GDSC1 -0.9357 5.4022 -5.6027 13.3948
KMRC-20 GDSC1 -0.8471 3.5041 -4.6519 7.1517
OS-RC-2 GDSC1 -0.7478 4.8312 -5.2071 10.5106
VMRC-RCW GDSC1 -0.5513 2.0603 -3.8652 1.8288
SW156 GDSC1 -0.5385 4.9626 -5.136 9.5811
ACHN GDSC1 -0.4158 6.5698 -5.8126 13.3088
KTCTL-195 GDSC1 -0.3331 4.6247 -4.8563 7.3932
KTCTL-13 GDSC1 0.0791 2.8971 -3.9131 1.4241
A-498 GDSC1 0.1712 2.7661 -3.8252 1.0007
TK-10 GDSC1 0.2829 4.4715 -4.4531 3.9177
KMRC-1 GDSC1 0.4196 7.9207 -5.913 11.971
RCC10RGB GDSC1 0.5357 2.0635 -3.45 0.0563
NCC021 GDSC1 0.7871 2.7906 -3.6052 0.1844
A-704 GDSC1 0.7919 2.7211 -3.5804 0.1509
LB2241-RCC GDSC1 0.8653 2.8548 -3.6 0.1634
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1 -8.017 -5.597 -8.0393 62.3647
CCK-81 GDSC1 -6.1503 -4.1263 -6.2066 40.1024
RKO GDSC1 -5.6938 -2.6191 -6.0444 36.0286
SNU-175 GDSC1 -5.6868 -4.2885 -5.7043 34.1206
HCC2998 GDSC1 -5.5697 -3.5017 -5.6812 33.2279
HT-29 GDSC1 -4.8262 -2.4872 -5.1444 25.3506
GP5d GDSC1 -4.7966 -1.7763 -5.3794 26.7187
COLO205 GDSC1 -4.5442 -2.0622 -4.9981 22.8021
SW626 GDSC1 -4.5195 1.4829 -6.5882 31.6606
KM12 GDSC1 -4.4549 -1.2586 -5.2426 23.9898
LS180 GDSC1 -4.3217 -0.2355 -5.5776 25.4556
SNU-C2B GDSC1 -4.3058 2.1066 -6.6901 31.0688
SW620 GDSC1 -4.263 -1.202 -5.0727 21.8599
SW48 GDSC1 -4.0663 0.3094 -5.5915 24.3042
LS411N GDSC1 -3.653 1.8773 -5.9814 24.7184
SNU-407 GDSC1 -3.57 -0.163 -4.8979 17.4133
SNU-1040 GDSC1 -3.5317 3.7692 -6.8158 28.2645
T84 GDSC1 -3.5233 -1.2202 -4.3378 13.0141
SNU-81 GDSC1 -3.3862 0.2093 -4.916 16.7755
CaR-1 GDSC1 -2.7319 -0.0863 -4.2156 9.0259
SW837 GDSC1 -2.578 4.0919 -6.1769 21.6339
LS1034 GDSC1 -2.5429 1.6962 -4.9544 13.9134
NCI-H716 GDSC1 -2.3205 4.1832 -6.0178 19.8902
LoVo GDSC1 -2.166 1.7966 -4.7178 11.0062
COLO 320HSR GDSC1 -1.6634 4.9216 -5.8837 17.0595
SW1463 GDSC1 -1.4225 4.5972 -5.5511 14.3973
SW948 GDSC1 -1.0168 2.6449 -4.3615 5.5805
SNU-61 GDSC1 -1.0001 6.8276 -6.3367 17.6194
HCT 15 GDSC1 -0.7369 1.8729 -3.8767 2.1127
MDST8 GDSC1 -0.7058 5.0917 -5.3027 11.0041
LS513 GDSC1 -0.4882 8.8589 -6.9622 19.2501
NCI-H747 GDSC1 -0.1652 9.4241 -7.0106 18.6619
HT-55 GDSC1 -0.0075 2.8237 -3.9222 1.5416
SNU-C5 GDSC1 -0.005 3.8334 -4.3301 3.6401
RCM-1 [Human ESC] GDSC1 0.0691 2.9601 -3.9417 1.5577
LS123 GDSC1 0.1181 4.1425 -4.398 3.8457
HT115 GDSC1 0.1881 1.8448 -3.4941 0.1427
COLO 678 GDSC1 0.3211 2.5686 -3.6952 0.504
C2BBe1 GDSC1 0.6167 2.8081 -3.6707 0.3386
SW1417 GDSC1 0.6335 2.9818 -3.7249 0.4525
SW1116 GDSC1 0.8059 2.4966 -3.502 0.0712
CL-11 GDSC1 0.8574 2.8055 -3.5863 0.1476
CW-2 GDSC1 0.8847 3.0151 -3.6469 0.2262
SNU-C1 GDSC1 1.2316 10.9505 -6.8145 14.6932
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -4.6746 1.1233 -6.5644 32.335
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -6.13 -4.3248 -6.1642 39.7405
HLE GDSC1 -4.8161 0.1069 -6.2254 31.556
SNU-423 GDSC1 -3.8228 1.1127 -5.7569 24.1824
JHH-7 GDSC1 -3.569 0.511 -5.2294 19.7357
JHH-6 GDSC1 -2.4403 -0.7533 -3.6707 3.9196
JHH-1 GDSC1 -2.3588 2.1948 -5.0593 14.0354
JHH-4 GDSC1 -2.2168 0.369 -4.0578 6.2397
JHH-2 GDSC1 -2.1606 1.1583 -4.4014 8.6623
SNU-475 GDSC1 -1.8112 1.1553 -4.1619 5.9603
SK-HEP-1 GDSC1 -1.703 3.3638 -5.1499 12.6407
SNU-387 GDSC1 -0.6825 2.0628 -3.9285 2.3251
Huh-7 GDSC1 0.1683 1.766 -3.4747 0.1213
HuH-1 GDSC1 0.3339 2.2735 -3.5881 0.2595
Hep 3B2.1-7 GDSC1 0.447 2.9757 -3.7928 0.7222
SNU-449 GDSC1 0.665 2.5349 -3.5616 0.1482
Hep-G2/C3A GDSC1 0.8163 2.983 -3.6599 0.2633
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H847 GDSC1 -7.2415 -6.5273 -7.2415 53.446
NCI-H1703 GDSC1 -7.1996 -3.9433 -7.3608 52.5527
DMS 273 GDSC1 -6.8522 -5.0698 -6.8655 48.6004
PC-14 GDSC1 -6.7327 -5.6841 -6.733 47.0875
Lu-139 GDSC1 -6.6342 -2.7408 -7.0329 46.6436
NCI-H446 GDSC1 -6.2743 -3.4363 -6.4597 42.1355
NCI-H2171 GDSC1 -6.2023 -3.1059 -6.4606 41.5553
NCI-H524 GDSC1 -6.0829 -2.4599 -6.5181 40.8231
NCI-H520 GDSC1 -6.0013 -2.1348 -6.5377 40.279
NCI-H3122 GDSC1 -5.9643 -4.4334 -5.9829 37.5914
NCI-H1648 GDSC1 -5.9289 -3.4832 -6.0744 37.8284
NCI-H69 GDSC1 -5.9077 -1.5546 -6.648 39.9744
LC-2/ad GDSC1 -5.7736 -3.5838 -5.8861 35.7526
NCI-H358 GDSC1 -5.6929 -3.837 -5.7573 34.4782
EPLC-272H GDSC1 -5.6337 -2.0411 -6.1736 36.2315
LK-2 GDSC1 -5.6223 -3.8423 -5.6812 33.5675
NCI-H810 GDSC1 -5.5561 -2.6793 -5.8758 34.2384
CAL-12T GDSC1 -5.5435 -3.7952 -5.6035 32.5928
NCI-H841 GDSC1 -5.5404 -1.535 -6.2638 36.0163
COR-L321 GDSC1 -5.5246 -3.9712 -5.5615 32.2146
NCI-H1437 GDSC1 -5.4564 -3.9995 -5.4867 31.3228
NCI-H1944 GDSC1 -5.4436 -1.8705 -6.0318 34.3096
SBC-3 GDSC1 -5.4258 -2.0669 -5.9403 33.7323
EBC-1 GDSC1 -5.4147 -2.2267 -5.8713 33.2976
NCI-H647 GDSC1 -5.3576 -1.7631 -5.9806 33.5068
NCI-H64 GDSC1 -5.2709 -4.7926 -5.271 28.8145
NCI-H211 GDSC1 -5.1787 0.0096 -6.5449 34.9772
NCI-H1048 GDSC1 -5.177 -3.6053 -5.2393 28.0355
HCC44 GDSC1 -5.1556 -1.1555 -6.0121 32.4327
NCI-H2227 GDSC1 -5.1521 -3.7424 -5.1933 27.5896
Ms-1 GDSC1 -5.0131 -3.544 -5.0729 25.9729
NCI-H2110 GDSC1 -4.9926 -2.1761 -5.4344 28.1821
ChaGo-K-1 GDSC1 -4.979 -1.6869 -5.6081 29.1657
IST-SL2 GDSC1 -4.9237 -0.0817 -6.2465 32.2433
SK-MES-1 GDSC1 -4.9162 -1.2434 -5.7254 29.4907
NCI-H2087 GDSC1 -4.8206 -0.5603 -5.9259 30.0665
COR-L23 GDSC1 -4.788 -1.8814 -5.3283 26.3429
UMC-11 GDSC1 -4.7813 -0.9431 -5.7158 28.6823
NCI-H522 GDSC1 -4.7628 -1.9933 -5.2575 25.7416
NCI-H661 GDSC1 -4.7112 -1.8576 -5.2564 25.4491
A-427 GDSC1 -4.6642 1.444 -6.7077 32.8715
LXF 289 GDSC1 -4.6563 -1.5484 -5.3258 25.6035
NCI-H1915 GDSC1 -4.6351 -1.3683 -5.3803 25.8402
NCI-H2122 GDSC1 -4.6118 0.0735 -6.0075 29.3803
EMC-BAC-2 GDSC1 -4.553 -2.2955 -4.9181 22.2989
NCI-H1836 GDSC1 -4.4178 -2.363 -4.7479 20.3837
HOP-62 GDSC1 -4.374 0.4596 -5.9579 27.9063
NCI-H2030 GDSC1 -4.3605 -1.4929 -5.043 22.1476
RERF-LC-KJ GDSC1 -4.3459 -0.4319 -5.5094 25.1551
Lu-65 GDSC1 -4.2827 -1.6206 -4.9073 20.8018
HARA [Human squamous cell lung carcinoma] GDSC1 -4.2705 0.0523 -5.6639 25.7234
SHP-77 GDSC1 -4.2677 -3.1365 -4.3439 16.7676
IST-SL1 GDSC1 -4.1925 1.1906 -6.1378 27.9736
LCLC-97TM1 GDSC1 -4.1855 6.636 -8.8175 36.9102
Calu-6 GDSC1 -4.1616 -0.8678 -5.1244 21.7157
HCC78 GDSC1 -4.1307 -0.9287 -5.0654 21.1583
SBC-5 GDSC1 -4.0972 -1.9023 -4.594 17.6169
NCI-H1436 GDSC1 -4.0276 1.1312 -5.9549 26.2337
COR-L311 GDSC1 -3.9582 -2.3524 -4.2615 14.4953
NCI-H3255 GDSC1 -3.9302 1.1872 -5.8921 25.4407
PaCa-3 GDSC1 -3.9199 0.7725 -5.6794 24.1597
NCI-H2170 GDSC1 -3.8987 -0.2919 -5.1422 20.596
NCI-H526 GDSC1 -3.8757 -0.6117 -4.9665 19.2592
NCI-H23 GDSC1 -3.795 0.2597 -5.3127 21.2802
NCI-H82 GDSC1 -3.7583 0.0269 -5.1649 20.1188
ABC-1 GDSC1 -3.6795 -0.666 -4.7537 16.8337
NCI-H1155 GDSC1 -3.4423 -2.094 -3.8425 8.8585
NCI-H2081 GDSC1 -3.4251 -1.0165 -4.3454 12.653
NCI-H1581 GDSC1 -3.3301 -0.3385 -4.5941 14.163
NCI-H2085 GDSC1 -3.2008 0.258 -4.7775 15.0211
NCI-H1304 GDSC1 -3.1707 -1.6104 -3.821 7.5259
NCI-H2141 GDSC1 -3.1384 0.195 -4.6922 14.1457
LCLC-103H GDSC1 -3.1365 1.2655 -5.2253 17.95
NCI-H292 GDSC1 -3.13 1.1057 -5.1399 17.3407
Lu-134-A GDSC1 -3.0877 1.2206 -5.1614 17.3257
NCI-H748 GDSC1 -2.9772 1.9023 -5.4093 18.5623
NCI-H460 GDSC1 -2.8949 1.1753 -4.9776 15.3165
NCI-H650 GDSC1 -2.8926 1.258 -5.017 15.5873
NCI-H1355 GDSC1 -2.8292 4.4039 -6.5374 24.3414
CPC-N GDSC1 -2.817 1.9343 -5.293 17.2047
EMC-BAC-1 GDSC1 -2.7414 9.0128 -8.7692 31.9437
NCI-H1876 GDSC1 -2.7395 0.562 -4.5448 11.579
HCC33 GDSC1 -2.7354 3.2589 -5.8883 20.5979
NCI-H209 GDSC1 -2.7286 1.3682 -4.9384 14.4399
NCI-H2196 GDSC1 -2.6751 1.6949 -5.0585 15.0997
NCI-H1694 GDSC1 -2.641 5.8698 -7.1159 26.2342
A-549 GDSC1 -2.5804 2.5229 -5.3959 17.0402
NCI-H1092 GDSC1 -2.5153 2.9022 -5.5333 17.6909
Lu-99A GDSC1 -2.4655 3.8188 -5.9507 20.0059
COLO 668 GDSC1 -2.4456 2.4095 -5.2332 15.5069
NCI-H2369 GDSC1 -2.4422 0.4609 -4.2647 8.4712
NCI-H1770 GDSC1 -2.3766 1.739 -4.847 12.5975
NCI-H2228 GDSC1 -2.3513 2.7723 -5.3402 15.9
NCI-H2029 GDSC1 -2.2101 1.9723 -4.8368 11.9972
NCI-H2135 GDSC1 -2.1818 0.6672 -4.1777 7.046
NCI-H2731 GDSC1 -2.1506 0.9365 -4.2864 7.7745
NCI-H596 GDSC1 -2.1235 3.2991 -5.427 15.7199
NCI-H2595 GDSC1 -2.09 5.8206 -6.6522 22.3819
NCI-H510A GDSC1 -2.0126 2.5907 -4.9952 12.5042
NCI-H441 GDSC1 -1.9545 3.7462 -5.5208 15.7804
NCI-H1568 GDSC1 -1.8986 4.8975 -6.0473 18.6932
NCI-H727 GDSC1 -1.8931 1.6105 -4.4335 8.1515
COR-L88 GDSC1 -1.8554 5.5745 -6.3495 20.1607
LC-1/sq GDSC1 -1.7831 2.9913 -5.0255 12.0346
NCI-H1651 GDSC1 -1.7713 1.0793 -4.1007 5.4228
NCI-H226 GDSC1 -1.7471 3.7919 -5.3907 14.334
NCI-H1975 GDSC1 -1.7342 8.8019 -7.8574 26.1821
NCI-H2405 GDSC1 -1.6801 2.2502 -4.5957 8.7526
NCI-H720 GDSC1 -1.525 1.4792 -4.1332 5.0944
IA-LM GDSC1 -1.2846 6.0019 -6.1374 17.3643
COR-L105 GDSC1 -1.1454 4.2975 -5.2153 11.5484
BEN GDSC1 -1.0602 5.1744 -5.5781 13.5737
COR-L303 GDSC1 -0.9028 4.7872 -5.2872 11.3888
NCI-H196 GDSC1 -0.8836 4.3028 -5.0459 9.8103
LB647-SCLC GDSC1 -0.8615 11.2483 -8.4044 25.6307
SW1271 GDSC1 -0.6778 3.3406 -4.4781 5.6718
NCI-H2795 GDSC1 -0.6292 4.7859 -5.1105 9.6272
NCI-H1563 GDSC1 -0.5911 5.1015 -5.2339 10.3091
NCI-H1693 GDSC1 -0.5264 4.6605 -4.9886 8.6302
SK-LU-1 GDSC1 -0.5222 3.2184 -4.3372 4.4976
RERF-LC-MS GDSC1 -0.4996 5.2641 -5.252 10.21
NCI-H1869 GDSC1 -0.4601 2.4551 -3.9822 2.3305
NCI-H2347 GDSC1 -0.4159 3.1555 -4.2535 3.8135
RERF-LC-Sq1 GDSC1 -0.3538 4.8448 -4.9686 8.1367
SBC-1 GDSC1 -0.3321 5.166 -5.1028 8.922
NCI-H1993 GDSC1 -0.2914 3.4611 -4.3192 4.0087
HCC15 GDSC1 -0.2574 6.8344 -5.8343 13.0532
NCI-H1688 GDSC1 -0.2073 8.1211 -6.4131 15.9762
NCI-H1734 GDSC1 -0.1595 7.4468 -6.0602 14.0492
NCI-H187 GDSC1 -0.1258 6.32 -5.5093 10.9059
NCI-H290 GDSC1 -0.1133 3.054 -4.0613 2.3233
SW1573 GDSC1 -0.0776 3.3333 -4.1581 2.7889
NCI-H1650 GDSC1 -0.076 3.5864 -4.2622 3.3586
NCI-H1573 GDSC1 -0.0277 4.2345 -4.5127 4.7332
NCI-H1666 GDSC1 -0.0174 6.3356 -5.4494 10.3217
COR-L95 GDSC1 0.0566 9.5465 -6.9176 17.7203
NCI-H513 GDSC1 0.0852 3.1633 -4.014 1.8727
NCI-H2009 GDSC1 0.1057 4.6836 -4.6357 5.2412
NCI-H2818 GDSC1 0.128 2.8696 -3.8819 1.2527
NCI-H345 GDSC1 0.1392 1.2233 -3.3082 0.0114
NCI-H2342 GDSC1 0.1493 2.5682 -3.7609 0.7888
Lu-165 GDSC1 0.184 2.5573 -3.7433 0.7114
NCI-H1793 GDSC1 0.2198 4.4603 -4.4804 4.1625
HCC827 GDSC1 0.2282 4.2637 -4.3935 3.6639
NCI-H1435 GDSC1 0.2294 2.5068 -3.7077 0.5803
Calu-3 GDSC1 0.2367 2.5349 -3.715 0.5978
NCI-H2803 GDSC1 0.2391 3.8469 -4.2165 2.7031
NCI-H2869 GDSC1 0.2728 7.5079 -5.8127 11.7436
NCI-H1623 GDSC1 0.2728 2.7185 -3.7672 0.7378
NCI-H838 GDSC1 0.2823 1.8326 -3.4584 0.0879
NCI-H1299 GDSC1 0.3222 6.5947 -5.3634 9.123
HOP-92 GDSC1 0.3425 3.6588 -4.094 1.9874
NCI-H2023 GDSC1 0.3578 2.4583 -3.6431 0.3637
NCI-H2591 GDSC1 0.3579 2.8532 -3.783 0.7403
NCI-H1755 GDSC1 0.3587 2.3653 -3.6107 0.2957
Lu-135 GDSC1 0.381 6.0215 -5.072 7.3243
NCI-H2444 GDSC1 0.3994 2.0359 -3.4861 0.101
DMS 114 GDSC1 0.4122 1.9251 -3.4456 0.0635
NCI-H2373 GDSC1 0.4178 2.5877 -3.6662 0.3948
NCI-H1838 GDSC1 0.4195 2.3663 -3.5896 0.24
NCI-H2722 GDSC1 0.4457 2.1975 -3.5239 0.1372
DMS 79 GDSC1 0.4557 3.0503 -3.8164 0.7915
LOU-NH91 GDSC1 0.4833 3.0252 -3.7966 0.7148
NCI-H2461 GDSC1 0.4835 2.6532 -3.6651 0.3696
EKVX GDSC1 0.5562 3.9033 -4.0953 1.7887
NCI-H1781 GDSC1 0.5622 9.0042 -6.3282 13.8002
NCI-H2291 GDSC1 0.6134 3.0159 -3.7442 0.5078
DMS 53 GDSC1 0.6688 2.8921 -3.681 0.3435
NCI-H2172 GDSC1 0.7102 5.6234 -4.7219 4.7869
NCI-H2804 GDSC1 0.8339 3.2497 -3.7451 0.4267
NCI-H1792 GDSC1 0.9204 8.5758 -5.9096 10.9339
NCI-H322M GDSC1 0.96 4.4107 -4.1175 1.5392
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -1.7175 4.9549 -5.9401 17.5416
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 -6.2368 -2.2535 -6.7527 42.7303
KYSE-180 GDSC1 -5.5392 -2.2555 -5.9959 34.7505
KYSE-140 GDSC1 -3.4021 1.4112 -5.5277 20.9889
TE-11 GDSC1 -3.3308 -0.1182 -4.7041 14.9931
TE-10 GDSC1 -2.978 2.5591 -5.7384 20.6147
KYSE-410 GDSC1 -2.835 3.5281 -6.1044 22.1626
T.T GDSC1 -2.3136 -0.0916 -3.9023 5.3294
TE-6 GDSC1 -2.158 2.7555 -5.1843 14.2411
KYSE-270 GDSC1 -1.9241 5.1087 -6.1712 19.444
KYSE-150 GDSC1 -0.7753 4.7371 -5.1805 10.4091
TE-4 GDSC1 -0.0157 4.2157 -4.4983 4.6291
TE-1 GDSC1 0.0587 6.3742 -5.4206 9.9923
KYSE-520 GDSC1 0.0712 4.4936 -4.572 4.9224
TE-5 GDSC1 0.1156 7.9779 -6.1321 13.7919
KYSE-70 GDSC1 0.1329 9.109 -6.657 16.3487
COLO 680N GDSC1 0.136 9.087 -6.6444 16.2822
TE-8 GDSC1 0.1698 2.6135 -3.7694 0.8049
OE33 GDSC1 0.1726 3.8969 -4.2687 3.0598
EC-GI-10 GDSC1 0.1741 2.5113 -3.7305 0.6767
TE-9 GDSC1 0.3444 1.9691 -3.4825 0.1045
OE19 GDSC1 0.4103 2.0389 -3.4834 0.0969
OE21 GDSC1 0.4674 3.3558 -3.9244 1.1614
TE-15 GDSC1 0.9845 3.0496 -3.6243 0.1743
KYSE-510 GDSC1 1.4716 12.0952 -7.1975 15.863
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 -8.6038 -7.193 -8.604 70.276
OC 314 GDSC1 -6.5169 -4.3633 -6.5679 44.5813
A2780 GDSC1 -6.1949 -3.5834 -6.3425 41.0489
TOV-21G GDSC1 -6.0621 -1.5575 -6.8121 41.5751
IGROV-1 GDSC1 -6.0037 -2.0634 -6.565 40.389
SK-OV-3 GDSC1 -5.7213 -0.4139 -6.915 39.5565
OVCAR-8 GDSC1 -4.9235 -2.1384 -5.3741 27.4021
Caov-3 GDSC1 -4.5702 -3.2355 -4.6511 20.5774
OAW28 GDSC1 -4.2725 -0.472 -5.4184 24.2142
EFO-21 GDSC1 -3.6596 0.3239 -5.2195 20.058
OVCAR-5 GDSC1 -3.641 -0.1233 -4.9826 18.3277
RMG-I GDSC1 -3.2534 2.045 -5.7147 21.5381
ES-2 GDSC1 -2.2499 0.663 -4.2237 7.5862
OV56 GDSC1 -1.217 3.8226 -5.0365 10.5715
OV-90 GDSC1 -1.0984 7.2507 -6.6137 19.2583
EFO-27 GDSC1 -1.0815 5.6217 -5.8087 14.9814
OVISE GDSC1 -0.9746 7.1481 -6.4747 18.2435
FU-OV-1 GDSC1 -0.9338 5.4733 -5.6355 13.5843
OAW42 GDSC1 -0.4704 5.9036 -5.5332 11.8336
Kuramochi GDSC1 -0.3441 5.001 -5.0343 8.5244
OVTOKO GDSC1 -0.2724 7.6266 -6.2204 15.1578
TYK-nu GDSC1 -0.2034 3.289 -4.2015 3.1963
Caov-4 GDSC1 -0.1333 7.1885 -5.9209 13.2395
OVCAR-4 GDSC1 0.1596 4.853 -4.6804 5.4146
JHOS-2 GDSC1 0.2458 2.5892 -3.731 0.6403
OVCAR-3 GDSC1 0.3502 2.6506 -3.7133 0.5397
OVKATE GDSC1 0.3946 2.2207 -3.5491 0.1806
DOV13 GDSC1 0.422 2.6036 -3.6702 0.4025
OVK18 GDSC1 0.4903 2.1876 -3.5056 0.1095
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-1N GDSC1 -7.8596 -4.6547 -7.9581 59.7505
KP-4 GDSC1 -7.3515 -6.1945 -7.3518 54.8167
HuP-T4 GDSC1 -5.7815 -2.2924 -6.2457 37.5646
PaTu 8988t GDSC1 -5.6042 -3.8263 -5.664 33.3478
MZ-PC-1 GDSC1 -4.7784 -1.7693 -5.3629 26.5118
PSN1 GDSC1 -4.7036 -2.6677 -4.9514 23.3613
KP-2 GDSC1 -4.649 -1.7268 -5.2439 25.0279
Panc 10.05 GDSC1 -4.5256 -2.8893 -4.6896 20.5773
HPAC GDSC1 -4.3984 -1.9671 -4.8818 21.2198
MIA PaCa-2 GDSC1 -3.631 2.9546 -6.4971 27.2474
KP-3 GDSC1 -3.5975 0.6013 -5.2998 20.3305
Panc 02.03 GDSC1 -3.3724 0.2916 -4.9446 16.9258
HPAF-II GDSC1 -3.1631 2.8215 -6.0255 22.9676
DAN-G GDSC1 -2.971 1.4816 -5.1938 17.1047
HuP-T3 GDSC1 -2.9357 -0.4641 -4.1917 9.5489
SUIT-2 GDSC1 -2.8361 -0.1575 -4.2634 9.7541
PaTu 8902 GDSC1 -2.3971 0.7934 -4.3951 9.3233
Capan-1 GDSC1 -2.3815 1.1464 -4.5576 10.4948
CFPAC-1 GDSC1 -2.3412 0.462 -4.1912 7.6052
SU.86.86 GDSC1 -1.9542 2.214 -4.7687 10.7431
Panc 03.27 GDSC1 -1.6013 2.5665 -4.694 9.2387
Panc 04.03 GDSC1 -1.3896 2.4708 -4.5096 7.4164
BxPC-3 GDSC1 -0.8299 4.4943 -5.1014 10.038
Capan-2 GDSC1 -0.6542 4.0214 -4.7725 7.526
QGP-1 GDSC1 -0.0507 7.9275 -6.2167 14.6116
SW1990 GDSC1 -0.0492 4.2904 -4.5483 4.9804
Panc 08.13 GDSC1 0.0469 2.3526 -3.7224 0.7223
YAPC GDSC1 0.1247 4.5227 -4.5562 4.744
Hs 766T GDSC1 0.2488 2.139 -3.5723 0.2532
AsPC-1 GDSC1 0.4747 3.4826 -3.969 1.3287
PL4 GDSC1 0.7592 2.8702 -3.6416 0.2461
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -0.572 2.4156 -4.0204 2.6888
IST-Mes1 GDSC1 -0.4051 2.6052 -4.0172 2.4493
NCI-H2452 GDSC1 -0.1882 3.7599 -4.3932 4.2838
NCI-H2052 GDSC1 0.3922 3.6997 -4.088 1.9106
MSTO-211H GDSC1 0.4267 3.2855 -3.9147 1.1543
NCI-H28 GDSC1 0.7295 3.5066 -3.8754 0.8254
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 -3.6193 6.8352 -8.421 33.9397
PC-3 GDSC1 -3.5714 1.1644 -5.555 21.8662
VCaP GDSC1 -3.5235 -1.4789 -4.2131 12.0586
22Rv1 GDSC1 -3.4656 2.4376 -6.0945 24.5486
DU145 GDSC1 -1.0567 2.9349 -4.5177 6.7116
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -3.2165 1.2963 -5.3092 18.8268
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-375 GDSC1 -6.2342 -5.217 -6.2349 40.8594
A2058 GDSC1 -6.2292 -3.7204 -6.3532 41.3649
A-431 GDSC1 -6.1634 -4.8237 -6.1698 40.0072
IGR-1 GDSC1 -6.1555 -2.019 -6.7447 42.0799
WM35 GDSC1 -6.0875 -3.7192 -6.2004 39.6005
COLO 800 GDSC1 -6.0693 -1.7989 -6.7302 41.393
Mel JuSo GDSC1 -6.0192 -2.9826 -6.2935 39.4919
WM1552C GDSC1 -5.9589 -3.6848 -6.0678 38.0102
RPMI-7951 GDSC1 -5.0687 -2.1591 -5.5224 29.1723
SK-MEL-2 GDSC1 -4.9922 -2.7416 -5.2423 26.9514
G-361 GDSC1 -4.8927 0.1248 -6.31 32.3668
M14 GDSC1 -4.2623 -0.0071 -5.6278 25.4667
CHL-1 GDSC1 -4.2592 -2.6363 -4.4793 17.6441
A-388 GDSC1 -4.237 -1.821 -4.7739 19.6209
A101D GDSC1 -4.2036 -1.079 -5.0688 21.5385
COLO 792 GDSC1 -4.1435 -0.4049 -5.3237 22.9699
Mel Ho GDSC1 -4.1006 0.1686 -5.5562 24.2491
RVH-421 GDSC1 -3.7056 1.6155 -5.8988 24.4845
IGR-37 GDSC1 -3.6472 -0.9531 -4.5843 15.428
SK-MEL-30 GDSC1 -3.1607 1.0813 -5.154 17.5568
WM278 GDSC1 -3.1286 1.6056 -5.3886 19.0057
DJM-1 GDSC1 -2.8771 -0.6554 -4.048 8.2148
HT-144 GDSC1 -2.8419 1.7914 -5.2419 16.9541
IPC-298 GDSC1 -2.7715 1.5441 -5.061 15.458
LB2518-MEL GDSC1 -2.7351 1.743 -5.1308 15.8124
CP66-MEL GDSC1 -2.3205 2.7104 -5.2857 15.4401
HMV-II GDSC1 -2.2438 4.455 -6.093 20.0487
IST-MEL1 GDSC1 -2.0961 2.7286 -5.1247 13.6456
MZ-MEL-7 GDSC1 -2.063 4.6936 -6.0716 19.345
COLO 679 GDSC1 -1.8634 2.9426 -5.0592 12.4977
WT2-iPS GDSC1 -1.3914 3.9983 -5.2391 12.3531
MZ-MEL-2 GDSC1 -1.3908 6.4509 -6.4347 19.2057
SK-MEL-5 GDSC1 -1.2254 2.5718 -4.4536 6.6494
WM793 GDSC1 -1.107 8.4438 -7.2053 21.925
G-mel GDSC1 -0.928 7.1158 -6.4258 17.8748
SK-MEL-3 GDSC1 -0.9091 2.4048 -4.1927 4.2693
LOX-IMVI GDSC1 -0.8862 5.4707 -5.6021 13.2638
GAK GDSC1 -0.6592 7.2655 -6.3101 16.5839
MMAc-SF GDSC1 -0.5762 5.346 -5.339 10.9194
WM115 GDSC1 -0.4234 7.6556 -6.3362 16.1201
UACC-257 GDSC1 -0.2885 5.4934 -5.227 9.5872
SK-MEL-28 GDSC1 -0.2492 5.1688 -5.054 8.4466
LB373-MEL-D GDSC1 -0.1335 6.7965 -5.7367 12.2215
CP50-MEL-B GDSC1 -0.1083 4.6076 -4.7197 6.1183
MeWo GDSC1 -0.0996 4.6894 -4.7511 6.2932
SK-MEL-1 GDSC1 -0.095 3.4646 -4.2209 3.1546
COLO 783 GDSC1 -0.0637 4.8007 -4.7803 6.4049
UACC-62 GDSC1 -0.042 6.9055 -5.7295 11.9749
SH-4 GDSC1 -0.0088 3.4014 -4.153 2.6745
Hs 940.T GDSC1 0.0993 2.6156 -3.7983 0.9517
Hs 938.T GDSC1 0.2513 8.1138 -6.1089 13.367
COLO 829 GDSC1 0.2635 6.7589 -5.4732 9.8694
SK-MEL-24 GDSC1 0.3064 2.2689 -3.5963 0.2826
VMRC-MELG GDSC1 0.3333 2.2475 -3.5795 0.2441
451Lu GDSC1 0.4903 2.9538 -3.7683 0.6276
EquiPSC Line K2 GDSC1 -2.202 2.5428 -5.1124 13.8945
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -6.632 -4.8706 -6.6484 45.886
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1 -6.3984 -5.7369 -6.3985 42.9084
G-401 GDSC1 -6.2058 -0.9418 -7.2046 43.5404
STS-0421 GDSC1 -5.9085 -3.7944 -5.9948 37.2728
RKN GDSC1 -5.0325 -3.4601 -5.108 26.3161
SW982 GDSC1 -4.8573 -1.6085 -5.5115 27.8869
Hs 633.T GDSC1 -4.5865 -2.973 -4.7326 21.2157
SK-UT-1 GDSC1 -4.5462 -1.6488 -5.1687 23.9743
SK-LMS-1 GDSC1 -4.5324 -2.7929 -4.7257 20.8614
MES-SA GDSC1 -4.0881 -1.2138 -4.8915 19.7246
Rh41 GDSC1 -3.7485 -2.7107 -3.9011 10.8141
SW872 GDSC1 -3.4926 -1.9893 -3.941 9.8388
HT-1080 GDSC1 -3.2079 0.3992 -4.854 15.6113
TE 441.T GDSC1 -3.1979 0.5127 -4.9021 15.9217
KYM-1 GDSC1 -3.0944 -1.5306 -3.7932 7.0061
RD GDSC1 -2.3914 0.8119 -4.3999 9.3424
VA-ES-BJ GDSC1 -0.4934 3.5372 -4.4613 5.2199
Rh30 GDSC1 -0.4217 4.3701 -4.793 7.175
SW684 GDSC1 -0.1591 1.8616 -3.6247 0.5309
MFH-ino GDSC1 -0.1076 3.6374 -4.2995 3.6149
A-204 GDSC1 0.0082 6.0501 -5.3025 9.4066
G-402 GDSC1 0.3979 9.4718 -6.6543 15.7323
Rh18 GDSC1 0.4227 2.2458 -3.5479 0.1732
GCT GDSC1 0.4502 2.1735 -3.5144 0.125
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC1 -6.2926 -3.6324 -6.4385 42.2089
HSC-39 GDSC1 -5.6339 -1.0057 -6.5754 37.8724
IM95 GDSC1 -5.358 -1.7254 -5.9956 33.5859
Hs 746.T GDSC1 -4.2424 -1.083 -5.1059 21.9858
MKN7 GDSC1 -3.5943 -2.3903 -3.8638 9.7459
23132/87 GDSC1 -3.2607 1.2121 -5.3053 18.9761
HGC-27 GDSC1 -2.7216 1.3836 -4.9405 14.4303
SNU-5 GDSC1 -2.6203 -0.29 -4.0278 7.1996
GCIY GDSC1 -2.1369 0.8384 -4.2292 7.3075
SNU-1 GDSC1 -1.7909 5.5915 -6.3091 19.7554
MKN1 GDSC1 -1.7219 3.3232 -5.1435 12.6523
AGS GDSC1 -1.6505 4.2494 -5.5446 15.0118
ECC10 GDSC1 -1.5705 3.2431 -4.9983 11.2531
OCUM-1 GDSC1 -1.5509 2.4001 -4.581 8.3139
TMK-1 GDSC1 -1.5027 3.0169 -4.8432 10.0139
MKN45 GDSC1 -1.4696 4.906 -5.7351 15.6328
SNU-16 GDSC1 -1.4098 2.4396 -4.5079 7.4527
RERF-GC-1B GDSC1 -1.2078 5.2906 -5.7365 14.9068
NUGC-3 GDSC1 -1.0169 2.4707 -4.283 5.0599
Fu97 GDSC1 -1.0156 1.9488 -4.0512 3.5579
NUGC-4 GDSC1 -0.1932 3.4328 -4.2567 3.4948
MKN28 GDSC1 -0.1415 6.4312 -5.5709 11.2972
SCH GDSC1 0.0102 1.4491 -3.4232 0.0865
TGBC11TKB GDSC1 0.4437 4.5651 -4.4124 3.475
NCI-N87 GDSC1 0.765 2.7976 -3.6151 0.203
SNG-M GDSC1 -7.1152 -6.1029 -7.1153 51.8672
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 -6.7903 -5.1251 -6.8 47.8293
KMH-2 GDSC1 -5.7214 -4.0811 -5.7578 34.6669
CAL-62 GDSC1 -4.1992 -1.9654 -4.6735 18.7085
K5 GDSC1 -3.9824 -1.1775 -4.8031 18.5807
TT2609-C02 GDSC1 -3.8279 0.4667 -5.4445 22.287
HTC-C3 GDSC1 -3.086 -0.8468 -4.1271 9.5981
BHT-101 GDSC1 -2.3254 -0.3663 -3.7784 4.426
8505C GDSC1 -1.193 4.3716 -5.2829 12.1028
ML-1 [Human leukemia] GDSC1 -0.8586 3.9971 -4.887 8.7213
B-CPAP GDSC1 -0.2331 2.8838 -4.0488 2.4023
8305C GDSC1 -0.0635 2.3115 -3.7513 0.8911
ASH-3 GDSC1 -0.021 2.7055 -3.8824 1.3797
WRO GDSC1 0.4357 2.5389 -3.6428 0.3375
FTC-133 GDSC1 0.4477 2.4634 -3.6127 0.2743
CGTH-W-1 GDSC1 0.6858 8.0106 -5.7919 10.776
TT GDSC1 0.7195 2.6645 -3.5862 0.1708
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HO-1-N-1 GDSC1 -6.797 -5.5527 -6.7983 47.8933
CAL-27 GDSC1 -6.2704 -4.4491 -6.3006 41.4618
Ca9-22 GDSC1 -6.1722 -4.6159 -6.1874 40.1653
SCC-9 GDSC1 -6.1221 -2.7768 -6.4638 40.9348
NCI-H3118 GDSC1 -6.1043 -3.9376 -6.1829 39.6438
JHU-011 GDSC1 -5.761 -3.3432 -5.9222 35.8639
BB30-HNC GDSC1 -5.7279 -4.0369 -5.7693 34.7786
PCI-06A GDSC1 -5.6096 -2.8385 -5.8868 34.6516
OSC-20 GDSC1 -5.4063 -1.5506 -6.1152 34.4774
PCI-04B GDSC1 -5.3442 -1.1506 -6.2114 34.5384
CAL-33 GDSC1 -5.0144 -0.7894 -6.0225 31.6604
SCC-25 GDSC1 -4.3778 -1.798 -4.9303 21.4522
OSC-19 GDSC1 -4.1776 -1.7955 -4.7231 18.9559
BHY GDSC1 -3.7372 0.9173 -5.5825 22.7532
PCI-15A GDSC1 -2.5953 5.3878 -6.838 24.8998
UPCI-SCC-090 GDSC1 -2.4475 4.2171 -6.135 20.9595
LB771-HNC GDSC1 -2.4302 3.6687 -5.8479 19.297
BB49-HNC GDSC1 -1.9281 1.5642 -4.4352 8.2586
SCC-15 GDSC1 -1.9091 3.3026 -5.2688 14.032
SAS GDSC1 -1.6209 4.0985 -5.4494 14.3354
BICR 10 GDSC1 -1.4139 1.9188 -4.2678 5.7871
PCI-38 GDSC1 -1.3145 7.8719 -7.0776 21.9633
HSC-3 GDSC1 -0.7974 3.7764 -4.7469 7.6678
FaDu GDSC1 -0.7824 4.0337 -4.8565 8.3498
SCC-4 GDSC1 -0.7336 2.9729 -4.3459 4.9288
HSC-2 GDSC1 -0.685 3.885 -4.7287 7.3077
SAT [Human HNSCC] GDSC1 -0.3843 2.9048 -4.1312 3.0533
DOK GDSC1 -0.3627 3.026 -4.1712 3.2512
BICR 78 GDSC1 -0.2826 6.2669 -5.5835 11.6894
BICR 31 GDSC1 -0.2746 2.413 -3.8796 1.6039
HSC-4 GDSC1 -0.2294 3.3764 -4.2513 3.517
Detroit 562 GDSC1 -0.2125 4.5959 -4.7734 6.6421
HO-1-u-1 GDSC1 0.0382 3.0063 -3.9732 1.7296
SKN-3 GDSC1 0.1821 4.613 -4.5649 4.7035
KON GDSC1 0.3414 3.723 -4.1198 2.1096
PE/CA-PJ15 GDSC1 0.4489 3.4906 -3.9829 1.405
BICR 22 GDSC1 0.6803 2.3872 -3.5078 0.0885
PCI-30 GDSC1 0.7657 2.6332 -3.5602 0.1309
JHU-022 GDSC1 0.9449 6.8806 -5.1386 6.7227
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1 -5.5431 -3.7208 -5.6142 32.6555
UM-UC-3 GDSC1 -4.9826 -1.6633 -5.6214 29.2651
RT-112 GDSC1 -4.9072 -3.1137 -5.046 25.1661
RT-4 GDSC1 -4.6621 -2.7814 -4.8705 22.5788
5637 GDSC1 -4.3153 -2.2189 -4.6933 19.4524
SW1710 GDSC1 -3.4902 -1.7559 -4.0488 10.6509
HT-1197 GDSC1 -2.4123 0.605 -4.3135 8.7515
T24 GDSC1 -2.3282 0.4399 -4.1709 7.4127
647V GDSC1 -1.7339 1.7653 -4.4003 7.4923
HT-1376 GDSC1 -1.1715 3.5837 -4.8931 9.5061
639V GDSC1 -0.7279 1.9341 -3.8975 2.2142
CAL-29 GDSC1 -0.6686 2.1453 -3.9558 2.4579
TCCSUP GDSC1 0.3395 2.2462 -3.5769 0.2379
SW780 GDSC1 0.3876 2.1446 -3.526 0.1497
KU-19-19 GDSC1 0.6452 2.2151 -3.4633 0.0568
J82 GDSC1 0.8139 2.7952 -3.5976 0.1691
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW954 GDSC1 -7.2432 -5.919 -7.2442 53.4577
PA-1 GDSC1 -6.9705 -5.5602 -6.973 50.0583
BPH-1 GDSC1 -6.4238 -4.6664 -6.4448 43.323
Ca Ski GDSC1 -6.117 -0.8642 -7.1419 42.7836
ME-180 GDSC1 -5.4943 -2.8152 -5.7678 33.2405
KGN GDSC1 -5.3108 -1.4931 -6.0367 33.4977
JAR GDSC1 -4.9606 -1.8858 -5.51 28.4663
C-33 A GDSC1 -4.8494 -1.4423 -5.572 28.2115
SiSo GDSC1 -4.4266 -1.5378 -5.0917 22.824
MS751 GDSC1 -4.2282 -0.1532 -5.5253 24.6718
NCC-IT GDSC1 -3.7397 1.5625 -5.9033 24.6578
HeLa GDSC1 -3.3101 -1.1169 -4.1908 10.9797
PEO1 GDSC1 -3.3038 -0.9426 -4.2713 11.5787
C-4-I GDSC1 -3.1798 -0.6314 -4.3158 11.4307
OV17R GDSC1 -2.413 0.5486 -4.2863 8.5462
LB831-BLC GDSC1 -2.1282 1.2133 -4.4051 8.5965
CAL-39 GDSC1 -2.106 1.3234 -4.4429 8.8135
UWB1.289 GDSC1 -1.8835 2.192 -4.7078 10.1069
OMC-1 [Human cervical carcinoma] GDSC1 -1.5934 3.3646 -5.073 11.8182
DoTc2 4510 GDSC1 -1.3831 3.0252 -4.7672 9.1831
SKN GDSC1 -0.7045 4.1698 -4.8714 8.2731
HEY GDSC1 -0.6784 2.7915 -4.2358 4.1361
JEG-3 GDSC1 -0.5088 3.1566 -4.3031 4.265
HEC-1 GDSC1 -0.4704 4.1543 -4.724 6.8362
SW962 GDSC1 -0.4594 4.0962 -4.6914 6.608
OVCA420 GDSC1 -0.4113 3.2334 -4.2845 3.992
HT-3 GDSC1 -0.2276 5.2134 -5.0614 8.4473
SiHa GDSC1 -0.2033 2.0695 -3.718 0.8649
OVCA433 GDSC1 -0.0764 3.34 -4.1602 2.7986
ACC-OV7 GDSC1 0.0129 4.4456 -4.5824 5.0797
OVMIU GDSC1 0.1471 7.0239 -5.6663 11.2051
NEC8 GDSC1 0.188 4.278 -4.4196 3.8665
DSH1 GDSC1 0.2201 2.5271 -3.7185 0.6164
NT2-D1 GDSC1 0.2387 3.1777 -3.9525 1.4541
SKG-IIIa GDSC1 0.3947 2.4308 -3.6204 0.3042
SW756 GDSC1 0.4999 2.193 -3.5042 0.1067
JHOS-3 GDSC1 0.5062 2.7987 -3.7076 0.4595
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT00095628) SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer. U.S. National Institutes of Health.
2 Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.