Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPK32V)

Drug Name
BMS-754807 Drug Info
Synonyms
BMS-754807; 1001350-96-4; BMS 754807; BMS754807; UNII-W9E3353E8J; CHEMBL575448; CHEBI:88339; W9E3353E8J; 1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide; W-204348; J-501009; 2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-, (2S)-;2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridin
Cross-matching ID
PubChem CID
24785538
ChEBI ID
CHEMBL88339
CAS Number
CAS 1001350-96-4
TTD Drug ID
D02QWY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.11 0.00e+0 80/88 (90.91%) LAMA4;LAMB1;THBS3;...
Steroid hormone biosynthesis 1.94 0.00e+0 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Notch signaling pathway 1.89 0.00e+0 49/59 (83.05%) HEY1;CREBBP;HES1;...
TGF-beta signaling pathway 1.75 3.16e-2 81/94 (86.17%) ID2;ID1;TGIF1;...
Sulfur metabolism 1.74 2.95e-2 9/10 (90%) SELENBP1;TST;MPST;...
Regulation of lipolysis in adipocytes 1.72 3.16e-2 52/55 (94.55%) FABP4;IRS2;IRS1;...
Protein digestion and absorption 1.72 2.71e-2 78/103 (75.73%) COL15A1;SLC38A2;COL3A1;...
Metabolism of xenobiotics by cytochrome P450 1.68 4.88e-2 49/77 (63.64%) AKR1C1;CYP1B1;ADH1B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.61 4.92e-2 62/70 (88.57%) EGFR;MAPK13;CASP3;...
Legionellosis -1.63 4.34e-2 51/57 (89.47%) IL18;MYD88;CR1;...
Amyotrophic lateral sclerosis -1.64 4.03e-2 267/364 (73.35%) NDUFB3;PSMA7;ATP5F1B;...
Arginine and proline metabolism -1.65 3.68e-2 39/50 (78%) P4HA1;ALDH1B1;OAT;...
Prion disease -1.66 3.81e-2 209/273 (76.56%) GSK3B;NDUFB3;CAV2;...
Terpenoid backbone biosynthesis -1.67 3.60e-2 18/22 (81.82%) DHDDS;FDPS;IDI1;...
Nucleotide excision repair -1.73 2.10e-2 40/47 (85.11%) GTF2H4;XPA;RBX1;...
Cell cycle -1.89 3.40e-3 110/124 (88.71%) ORC1;MYC;GADD45A;...
Fanconi anemia pathway -1.92 2.80e-3 36/54 (66.67%) BRIP1;RPA3;ATR;...
RNA polymerase -1.95 2.08e-3 23/31 (74.19%) POLR3F;POLR3B;POLR3D;...
Steroid biosynthesis -1.95 2.34e-3 19/20 (95%) NSDHL;SOAT1;LSS;...
Pyrimidine metabolism -2.05 0.00e+0 40/56 (71.43%) DHODH;DCTD;DTYMK;...
Mismatch repair -2.09 0.00e+0 22/23 (95.65%) LIG1;POLD2;MSH2;...
RNA transport -2.29 0.00e+0 128/186 (68.82%) KPNB1;RPP38;EIF4A3;...
Proteasome -2.29 0.00e+0 44/46 (95.65%) PSMB7;PSMA5;PSMA7;...
Spliceosome -2.39 0.00e+0 101/150 (67.33%) SRSF4;DDX46;SRSF6;...
DNA replication -2.50 0.00e+0 34/36 (94.44%) POLD3;POLE;PRIM1;...
Ribosome biogenesis in eukaryotes -2.53 0.00e+0 52/108 (48.15%) TBL3;NHP2;MPHOSPH10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H