Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ0X7I)

Drug Name
IOX2 Drug Info
Synonyms compound 6
Cross-matching ID
PubChem CID
54685215
ChEBI ID
CHEMBL3186774
CAS Number
CAS 931398-72-0
TTD Drug ID
D0WA3E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pentose phosphate pathway 2.06 0.00e+0 25/30 (83.33%) ALDOC;ALDOA;GPI;...
Glycolysis / Gluconeogenesis 2.02 0.00e+0 56/67 (83.58%) ALDOC;HK2;ENO2;...
Spliceosome 1.99 0.00e+0 101/150 (67.33%) FUS;THOC2;PRPF3;...
Fructose and mannose metabolism 1.96 0.00e+0 30/33 (90.91%) ALDOC;HK2;ALDOA;...
HIF-1 signaling pathway 1.91 1.40e-3 105/109 (96.33%) ALDOC;HK2;ENO2;...
Starch and sucrose metabolism 1.89 3.50e-3 25/36 (69.44%) HK2;GPI;GYS1;...
Fanconi anemia pathway 1.86 3.99e-3 36/54 (66.67%) USP1;BRCA1;FAAP100;...
Lysine degradation 1.83 1.14e-2 51/63 (80.95%) PLOD2;PLOD1;ACAT2;...
DNA replication 1.78 1.32e-2 34/36 (94.44%) FEN1;POLE;RFC5;...
Glyoxylate and dicarboxylate metabolism 1.78 1.19e-2 23/30 (76.67%) GLUL;GLDC;ACAT2;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.73 1.72e-2 9/11 (81.82%) VKORC1;HPD;NQO1;...
Homologous recombination 1.68 2.68e-2 35/41 (85.37%) BRCA1;RAD54B;POLD1;...
Progesterone-mediated oocyte maturation 1.66 3.01e-2 75/100 (75%) PLK1;BUB1;MAPK13;...
Galactose metabolism 1.64 3.35e-2 26/31 (83.87%) HK2;PFKL;UGP2;...
Amino sugar and nucleotide sugar metabolism 1.62 3.91e-2 38/48 (79.17%) HK2;GPI;GMDS;...
RNA degradation 1.61 4.11e-2 53/79 (67.09%) ENO2;ENO1;PFKL;...
Central carbon metabolism in cancer 1.60 4.73e-2 67/70 (95.71%) HK2;PFKL;FGFR3;...
Glycine, serine and threonine metabolism 1.58 4.97e-2 31/40 (77.5%) PGAM1;GLDC;ALAS2;...
Pertussis -1.65 4.79e-2 64/76 (84.21%) MYD88;SFTPA2;IRF1;...
Systemic lupus erythematosus -1.67 4.08e-2 45/135 (33.33%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Nicotinate and nicotinamide metabolism -1.70 3.23e-2 25/35 (71.43%) PNP;SIRT2;NMRK1;...
Phagosome -1.74 1.85e-2 118/152 (77.63%) ATP6V1F;HLA-A;CYBA;...
Hematopoietic cell lineage -1.74 1.97e-2 90/99 (90.91%) TNF;FLT3;ITGA6;...
Asthma -1.77 1.54e-2 25/31 (80.65%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Metabolism of xenobiotics by cytochrome P450 -1.79 1.21e-2 49/77 (63.64%) UGT2B17;GSTO1;ADH1C;...
Viral myocarditis -1.84 7.46e-3 53/60 (88.33%) HLA-A;ABL2;CD40;...
Amoebiasis -1.86 7.07e-3 99/102 (97.06%) RAB5B;SERPINB4;CSF2;...
Autoimmune thyroid disease -1.86 7.72e-3 46/53 (86.79%) CTLA4;IFNA7;HLA-A;...
Retinol metabolism -1.89 6.06e-3 41/68 (60.29%) UGT2B17;ADH1C;CYP3A4;...
Antigen processing and presentation -1.91 6.74e-3 60/78 (76.92%) HLA-DRB1;HLA-DPB1;CREB1;...
Steroid hormone biosynthesis -1.93 7.58e-3 43/61 (70.49%) CYP7A1;SULT2B1;CYP11A1;...
Allograft rejection -1.96 5.20e-3 32/38 (84.21%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Linoleic acid metabolism -1.97 6.06e-3 21/29 (72.41%) PLA2G1B;PLA2G12A;CYP2J2;...
Type I diabetes mellitus -2.01 2.42e-3 38/43 (88.37%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Staphylococcus aureus infection -2.13 0.00e+0 72/95 (75.79%) KRT13;KRT16;HLA-DRB1;...
Graft-versus-host disease -2.15 0.00e+0 32/42 (76.19%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Complement and coagulation cascades -2.17 0.00e+0 76/85 (89.41%) CFHR5;CFHR4;C9;...
Arachidonic acid metabolism -2.20 0.00e+0 48/61 (78.69%) CYP2C8;CYP2C9;ALOX15B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 3.33uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H