Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ52JG)

• Drug Name: Phenformin Drug Info
• Synonyms: Azucaps; Cronoformin; DBI; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; Meltrol; Normoglucina; Pedg; Phenethyldiguanide; Phenformine; Phenforminum; Phenformix; Phenylethylbiguanide; Retardo; D Bretard; DB Comb; DBI monohydrochloride; Phenformine HCl; Phenoformine hydrochloride; W 32; Beta-PEBG; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; Db-retard; Debeone (TN); Fenformina [INN-Spanish]; Meltrol-50; N-Phenethylbiguanide hydrochloride; Phenformin (BAN); Phenformin [INN:BAN]; Phenformine [INN-French]; Phenforminum [INN-Latin]; N'-beta-Fenetilformamidiniliminourea; N'-beta-Fenetilformamidiniliminourea [Italian]; N'-beta-Phenethylformamidinylliminourea; N-(2-Phenylethyl)imidodicarbonimidic diamide; PHENFORMIN (SEE ALSO PHENFORMIN HYDROCHLORIDE 834-28-6); 1-(diaminomethylidene)-2-phenethylguanidine; 1-Phenethylbiguanide
• Therapeutic Class: Hypoglycemic Agents
• Cross-matching ID:
  PubChem CID: 8249
  ChEBI ID: CHEMBL170988
  CAS Number: CAS 114-86-3
  TTD Drug ID: D07XPE
  VARIDT Drug ID: DR00561
  INTEDE Drug ID: DR1273

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Toll-like receptor signaling pathway	-1.65	4.13e-2	94/104 (90.38%)	LBP;CXCL9;PIK3R1;...
Coronavirus disease	-1.70	3.35e-2	215/232 (92.67%)	RPS29;RPS4X;RPL13A;...
Epstein-Barr virus infection	-1.70	3.46e-2	189/202 (93.56%)	PIK3R1;TAP1;ADRM1;...
Herpes simplex virus 1 infection	-1.71	2.78e-2	165/498 (33.13%)	PIK3R1;TAP1;IRF9;...
Mitophagy	-1.73	2.47e-2	56/68 (82.35%)	NRAS;MAPK10;RPS27A;...
Natural killer cell mediated cytotoxicity	-1.73	2.46e-2	99/131 (75.57%)	PIK3R1;GRB2;NRAS;...
Alcoholism	-1.74	2.54e-2	86/186 (46.24%)	ATF2;GNG11;PPP1CB;...
Human immunodeficiency virus 1 infection	-1.75	2.25e-2	189/212 (89.15%)	TNFRSF1B;PIK3R1;TAP1;...
Rheumatoid arthritis	-1.78	1.72e-2	78/93 (83.87%)	TNF;HLA-DOB;ATP6V0A1;...
Ribosome	-1.79	1.86e-2	113/158 (71.52%)	RPL17;MRPL17;RPS29;...
B cell receptor signaling pathway	-1.82	1.31e-2	71/81 (87.65%)	BCL10;PIK3R1;CD72;...
Intestinal immune network for IgA production	-1.82	1.18e-2	38/48 (79.17%)	HLA-DRB1;TNFSF13;PIGR;...
Ferroptosis	-1.84	1.31e-2	36/41 (87.8%)	ALOX15;SLC3A2;ATG5;...
Protein export	-1.94	6.57e-3	17/23 (73.91%)	SRP14;SEC61A1;SEC61G;...
Antigen processing and presentation	-1.97	7.51e-3	60/78 (76.92%)	HLA-DRA;PDIA3;NFYC;...
Autoimmune thyroid disease	-1.99	6.57e-3	46/53 (86.79%)	HLA-DOB;TG;HLA-G;...
Allograft rejection	-2.02	5.26e-3	32/38 (84.21%)	TNF;HLA-DOB;HLA-G;...
Steroid biosynthesis	-2.06	0.00e+0	19/20 (95%)	FDFT1;SC5D;NSDHL;...
Type I diabetes mellitus	-2.10	0.00e+0	38/43 (88.37%)	TNF;HLA-DOB;HLA-G;...
Graft-versus-host disease	-2.16	0.00e+0	32/42 (76.19%)	TNF;HLA-DOB;IL6;...
Oxidative phosphorylation	-2.18	0.00e+0	93/133 (69.92%)	COX17;NDUFS3;NDUFB11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	8uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	12uM - 100uM	48H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	1.25uM - 100uM	3H, 6H, 24H, 48H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM - 30uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼