Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQF982)

• Drug Name: AEW-541 Drug Info
• Synonyms: AECDBHGVIIRMOI-UHFFFAOYSA-N; NVP-AEW541; 475489-16-8; 475488-34-7; AEW541; NVP-AEW 541; UNII-97QB5037VR; AEW 541; AVP-AEW541; 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; CHEMBL1614712; 97QB5037VR; 7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE; C27H29N5O; 7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, 7-[CIS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 11476171
  CAS Number: CAS 475488-34-7
  TTD Drug ID: D07HPJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.47	0.00e+0	19/20 (95%)	MSMO1;DHCR24;FDFT1;...
Retinol metabolism	2.25	0.00e+0	41/68 (60.29%)	ALDH1A3;AOX1;ADH1B;...
Drug metabolism	2.11	0.00e+0	78/151 (51.66%)	AOX1;FMO5;ADH1B;...
Terpenoid backbone biosynthesis	2.00	0.00e+0	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
Metabolism of xenobiotics by cytochrome P450	1.99	0.00e+0	49/77 (63.64%)	ADH1B;CYP1B1;UGT2B4;...
Steroid hormone biosynthesis	1.91	1.61e-3	43/61 (70.49%)	HSD17B7;CYP1B1;HSD17B6;...
Wnt signaling pathway	1.76	2.49e-2	124/166 (74.7%)	SFRP4;PPP3CA;SMAD3;...
Nicotinate and nicotinamide metabolism	1.75	2.30e-2	25/35 (71.43%)	AOX1;ENPP1;NT5E;...
Complement and coagulation cascades	1.72	3.77e-2	76/85 (89.41%)	CFH;PROCR;PLAT;...
Cellular senescence	1.71	4.46e-2	139/156 (89.1%)	PPP3CA;TGFBR2;SMAD3;...
Th1 and Th2 cell differentiation	-1.80	3.13e-2	80/92 (86.96%)	IFNG;HLA-DOA;IL2RG;...
ABC transporters	-1.84	3.13e-2	37/45 (82.22%)	TAP1;ABCC10;ABCG2;...
Antigen processing and presentation	-1.85	4.69e-2	60/78 (76.92%)	TAP1;PSME3;CD74;...
Asthma	-2.02	0.00e+0	25/31 (80.65%)	HLA-DQB1;PRG2;HLA-DPB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Hide ▲
SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼
Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 3.33uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	24H	Show ▼