Details of the Drug

General Information of Drug (ID: DMQF982)

Drug Name
AEW-541
Synonyms
AECDBHGVIIRMOI-UHFFFAOYSA-N; NVP-AEW541; 475489-16-8; 475488-34-7; AEW541; NVP-AEW 541; UNII-97QB5037VR; AEW 541; AVP-AEW541; 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; CHEMBL1614712; 97QB5037VR; 7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE; C27H29N5O; 7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, 7-[CIS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 439.6
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C27H29N5O
IUPAC Name
7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
Canonical SMILES
C1CN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
InChI
InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)
InChIKey
AECDBHGVIIRMOI-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11476171
CAS Number
475488-34-7
TTD ID
D07HPJ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Inhibitor [2]
Insulin-like growth factor I receptor (IGF1R) TTHRID2 IGF1R_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Protein Interaction/Cellular Processes [4]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Protein Interaction/Cellular Processes [4]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Post-Translational Modifications [4]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Post-Translational Modifications [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Multiple myeloma
ICD Disease Classification 2A83
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Insulin receptor (INSR) DTT INSR 1.03E-05 0.26 0.66
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH CCLE -0.7489 2.9711 -1.0834 33.5668
SiMa CCLE -0.7147 3.4806 -1.1948 33.8377
KP-N-SI9s CCLE 0.1703 3.1524 -0.1311 25.6502
CHP-212 CCLE 0.4475 3.7088 -0.0069 23.9937
SK-N-DZ CCLE 0.5353 3.6052 0.1236 23.0484
SK-N-FI CCLE 1.019 4.2331 0.4101 19.8809
IMR-32 CCLE 1.3649 3.424 1.0841 15.3385
SK-N-AS CCLE 2.1464 5.5283 0.9692 13.3176
SK-N-BE(2) CCLE 2.1963 7.2146 0.1905 17.1793
Kelly CCLE 3.0768 6.1678 1.4796 8.0463
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CCLE 3.831 8.461 0.9273 9.2769
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-ES-1 CCLE 0.5614 3.9101 0.0445 23.3189
MHH-ES-1 CCLE 0.7762 3.0568 0.5573 20.0871
A-673 CCLE 1.0836 5.0275 0.1443 20.9459
SaOS-2 CCLE 1.215 5.0276 0.2791 19.8337
U2OS CCLE 1.5087 4.3243 0.8868 15.7948
MG-63 CCLE 1.7683 4.6943 0.9907 14.3933
SJSA-1 CCLE 1.9057 5.3346 0.8303 14.7806
CAL-78 CCLE 2.4394 5.0857 1.4597 9.8534
TC-71 CCLE 3.0425 4.6233 2.2235 4.1032
HOS CCLE 3.1943 5.3969 1.9593 5.1737
SW1353 CCLE 3.4899 7.2196 1.2833 8.1408
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CCLE -0.5064 1.1825 -0.5223 30.1819
MDA-MB-468 CCLE 1.0383 4.7737 0.2069 20.8009
CAL-85-1 CCLE 1.3407 5.2213 0.3207 19.2013
HMC-1-8 CCLE 1.7859 4.451 1.1175 13.6855
MDA-MB-453 CCLE 1.9911 5.65 0.7626 14.8676
MDA-MB-157 CCLE 2.1144 5.4075 0.997 13.2688
ZR-75-1 CCLE 2.1934 4.6581 1.4303 10.7505
BT-549 CCLE 2.3812 4.4736 1.7003 8.7503
HDQ-P1 CCLE 2.5849 4.4541 1.9035 7.0617
MDA-MB-415 CCLE 2.6256 6.1824 1.087 11.3234
HCC1806 CCLE 2.7491 3.9228 2.3159 4.3824
HCC1954 CCLE 2.7993 5.4419 1.608 8.0566
HCC70 CCLE 2.8217 4.6635 2.0153 5.7964
Hs 739.T CCLE 2.8629 4.92 1.9235 6.1838
MDA-MB-436 CCLE 3.0192 8.8722 0.0798 15.4902
BT-474 CCLE 3.0885 6.3688 1.3887 8.5082
BT-20 CCLE 3.095 6.4959 1.3306 8.8055
UACC-812 CCLE 3.1858 6.0187 1.6426 6.9049
EFM-19 CCLE 3.2063 7.5124 0.9133 10.7642
AU565 CCLE 3.2853 6.6065 1.4287 7.8256
SK-BR-3 CCLE 3.3094 6.9806 1.2613 8.6677
CAMA-1 CCLE 3.4085 6.8365 1.4107 7.6418
T-47D CCLE 3.7569 9.8075 0.2046 13.1047
HCC1569 CCLE 3.8053 7.4195 1.4202 6.7454
HCC1395 CCLE 3.8338 7.6993 1.3038 7.3002
Hs 578T CCLE 3.8379 7.4592 1.4243 6.658
MDA-MB-175-VII CCLE 4.1555 10.5329 0.1478 12.506
HCC1187 CCLE 4.317 8.9119 1.0567 7.633
ZR-75-30 CCLE 5.5309 7.8291 2.2295 0.7655
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8-MG-BA CCLE 1.6941 3.6544 1.3548 12.8097
LN-18 CCLE 1.9247 4.5838 1.1984 12.8132
42-MG-BA CCLE 2.1111 4.5752 1.3882 11.2294
SF126 CCLE 2.2263 3.2578 2.0735 7.3543
KNS-42 CCLE 2.3043 8.2327 -0.2166 18.8441
KNS-81 CCLE 2.3477 6.5169 0.6722 14.2868
T98G CCLE 2.5183 4.3706 1.8811 7.3781
Hs 683 CCLE 2.755 4.1496 2.2101 4.9313
LN-229 CCLE 2.9824 8.6218 0.1744 15.1181
GB-1 CCLE 3.0891 6.1222 1.5125 7.8387
1321N1 CCLE 3.1371 7.3555 0.9354 10.815
CAS-1 CCLE 3.2045 6.7781 1.2786 8.8215
KNS-60 CCLE 3.235 11.4002 -1.0059 19.8491
H4 CCLE 3.3073 5.9591 1.7681 5.948
U-118MG CCLE 3.4259 6.2923 1.6939 6.0846
GI-1 CCLE 3.4729 6.7965 1.48 7.1275
SF295 CCLE 3.6482 8.9306 0.5561 11.5908
DBTRG-05MG CCLE 3.7259 8.4619 0.8479 9.9157
Daoy CCLE 3.8677 9.2846 0.5482 11.1445
DK-MG CCLE 4.0086 8.4652 1.0556 8.2419
SW1088 CCLE 4.0169 6.9913 1.775 4.4922
M059J CCLE 4.1618 8.5833 1.1073 7.6707
GMS-10 CCLE 4.2554 9.9334 0.5157 10.4904
GaMG CCLE 4.2577 9.4326 0.7621 9.2479
ONS-76 CCLE 4.3778 9.4013 0.8622 8.5062
U-87MG ATCC CCLE 4.4904 6.2082 2.4021 0.9303
MOG-G-CCM CCLE 4.5144 9.7329 0.7968 8.5749
KALS-1 CCLE 4.5488 8.5557 1.3825 5.5654
YKG-1 CCLE 4.7989 11.1219 0.3229 10.3639
A-172 CCLE 4.9592 10.8677 0.5548 8.948
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 CCLE 1.4986 2.7137 1.4298 13.199
RL95-2 CCLE 2.2456 6.047 0.8097 13.8614
TEN CCLE 2.6005 7.6373 0.3406 15.2907
HEC-1-B CCLE 2.6271 4.4075 1.9656 7.7197
MFE-296 CCLE 2.7425 8.0577 0.2535 15.3485
MFE-319 CCLE 2.7542 6.6341 0.9743 11.58
HEC-1-A CCLE 3.3913 5.7329 1.9444 4.8167
EFE-184 CCLE 3.4842 7.6155 1.0824 9.2214
HEC-59 CCLE 3.5886 5.7811 2.0642 3.7802
HEC-6 CCLE 3.6083 5.5485 2.1902 3.0854
MFE-280 CCLE 3.8373 6.9155 1.6885 5.272
JHUEM-2 CCLE 3.9437 9.3522 0.572 10.8599
KLE CCLE 3.9488 6.3867 2.017 3.3763
HEC-265 CCLE 4.0479 6.5634 1.9975 3.3109
HEC-151 CCLE 4.1177 5.893 2.3445 1.5527
HEC-251 CCLE 4.8031 7.6414 1.9538 2.4541
AN3-CA CCLE 5.0935 9.6496 1.2157 5.5093
EN CCLE 6.3232 15.84 -0.9064 13.03
Ishikawa (Heraklio) 02 ER- CCLE 3.1642 5.7634 1.7527 6.3606
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KHM-1B CCLE -1.9266 -0.3385 -1.9282 42.3172
F-36P CCLE -1.6257 0.3809 -1.6371 39.7719
KMS-11 CCLE -1.106 4.0267 -1.7981 37.6738
LP-1 CCLE -1.0197 2.9616 -1.3764 35.8991
KMS-34 CCLE -0.8785 0.8566 -0.89 33.3589
Karpas-620 CCLE -0.6938 1.2151 -0.7182 31.8283
L-363 CCLE -0.4064 1.7276 -0.463 29.4996
AMO1 CCLE -0.1537 2.2494 -0.2697 27.5918
SIG-M5 CCLE -0.0325 3.4324 -0.4369 27.8337
MOLP-8 CCLE 0.4498 5.2743 -0.6177 26.7401
Mono-Mac-1 CCLE 0.4603 2.8851 0.2589 22.7133
KMM-1 CCLE 0.8255 4.0242 0.2855 21.1887
OCI-AML-5 CCLE 0.8476 5.0455 -0.1072 22.9786
CMK-86 CCLE 1.4019 4.4741 0.7121 17.0395
ALL-SIL CCLE 1.4161 3.9559 0.9412 15.8484
RPMI-8402 CCLE 1.4749 4.2652 0.8766 15.9629
SU-DHL-4 CCLE 1.6914 2.6608 1.6481 11.4289
HD-MY-Z CCLE 1.7558 3.8648 1.3369 12.679
Karpas-422 CCLE 1.8155 2.9585 1.7184 10.6089
MJ CCLE 1.8974 6.649 0.1912 18.064
DEL CCLE 1.94 2.6275 1.9196 9.1927
KMS-26 CCLE 1.9609 2.7114 1.9297 9.061
HuT 78 CCLE 2.0524 4.4575 1.3841 11.439
697 CCLE 2.085 5.0661 1.1318 12.6517
SU-DHL-10 CCLE 2.1632 2.7701 2.1377 7.2989
KMS-12-BM CCLE 2.1922 10.4603 -1.423 24.2894
SU-DHL-6 CCLE 2.2148 2.9511 2.1559 7.0076
Jurkat CCLE 2.2652 3.3802 2.0696 7.2309
SU-DHL-8 CCLE 2.3115 3.2097 2.1825 6.5103
MOLT-16 CCLE 2.4053 3.6577 2.1013 6.5848
DoHH2 CCLE 2.4432 3.5228 2.1989 5.9601
NCO2 CCLE 2.4523 4.5475 1.733 8.3612
Reh CCLE 2.4692 4.7414 1.6552 8.7243
Pfeiffer CCLE 2.6648 4.2242 2.0902 5.8328
Kasumi-2 CCLE 2.6885 6.3241 1.0717 11.2353
SK-MM-2 CCLE 2.6994 6.2031 1.1416 10.8327
Mino CCLE 2.744 4.3517 2.1005 5.5511
KG-1 CCLE 2.7999 4.2866 2.1832 4.9505
KCL-22 CCLE 2.8161 4.2477 2.217 4.7239
JVM-3 CCLE 2.8298 4.1947 2.2555 4.4786
OCI-AML-2 CCLE 2.9229 8.3102 0.2803 14.7423
Granta-519 CCLE 2.9365 6.2885 1.3025 9.3504
BDCM CCLE 2.9438 5.2671 1.8193 6.5388
P12-Ichikawa CCLE 2.9531 5.6961 1.6127 7.6336
U-937 CCLE 2.9972 6.5058 1.2447 9.5085
EM-2 CCLE 3.0001 6.2382 1.381 8.7679
KO52 CCLE 3.0014 6.6194 1.1915 9.7841
Ci-1 CCLE 3.0605 4.3112 2.3942 3.1352
BL-70 CCLE 3.2167 4.3737 2.4843 2.2991
MEC-1 CCLE 3.2295 5.89 1.7415 6.2687
Karpas-299 CCLE 3.2451 5.276 2.0593 4.519
P31/FUJ CCLE 3.307 5.7131 1.89 5.2926
MEG-01 CCLE 3.3289 6.2637 1.6335 6.6242
Toledo CCLE 3.3718 7.3092 1.1469 9.1348
Ku812 CCLE 3.4098 6.1445 1.7549 5.7925
BL-41 CCLE 3.4511 6.5723 1.5744 6.6702
L-428 CCLE 3.4866 6.5494 1.6127 6.3878
OPM-2 CCLE 3.5332 6.9855 1.4323 7.2511
Raji CCLE 3.6651 6.9841 1.5314 6.4443
SUP-T1 CCLE 3.828 8.0125 1.1458 8.1418
P3HR-1 CCLE 3.9259 9.5634 0.4544 11.4908
HEL 92.1.7 CCLE 3.9339 8.5973 0.9364 9.0133
KE-97 CCLE 4.1126 10.0863 0.3359 11.6791
SUP-M2 CCLE 4.1419 7.2409 1.739 4.4577
EB1 CCLE 4.2046 7.1413 1.8265 3.9109
OCI-Ly10 CCLE 4.2273 8.3671 1.2576 6.7719
MC116 CCLE 4.267 5.1937 2.6974 0.1752
HT CCLE 4.3051 8.6303 1.1843 7.0028
JM-1 CCLE 4.7208 6.3424 2.4535 0.5875
EB2 CCLE 4.9489 6.5467 2.4715 0.4141
HH [Human lymphoma] CCLE 4.9778 7.2559 2.2071 1.2325
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CCLE -0.3169 1.0337 -0.3225 28.5105
KMRC-1 CCLE 1.7732 7.8441 -0.5076 21.7554
KMRC-2 CCLE 2.4502 3.5477 2.1955 5.9535
ACHN CCLE 2.9213 5.3098 1.7788 6.8153
786-O CCLE 2.9603 4.8226 2.0553 5.2184
VMRC-RCZ CCLE 3.0009 4.3231 2.3392 3.5784
BFTC-909 CCLE 3.0391 8.7394 0.1628 15.031
769-P CCLE 3.2796 9.2746 0.0925 14.7781
Caki-2 CCLE 5.479 13.6595 -0.432 12.5462
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS513 CCLE -0.5956 2.0155 -0.7057 31.3519
SW48 CCLE -0.0473 3.5117 -0.4782 28.0753
COLO 320 CCLE 0.2347 4.5087 -0.5314 27.1873
HT-29 CCLE 0.2559 2.6429 0.0947 24.2818
SW403 CCLE 0.5435 4.9372 -0.3781 25.3337
SW620 CCLE 1.2022 6.3529 -0.3378 22.8201
LS411N CCLE 1.2805 4.0722 0.7512 17.2708
COLO205 CCLE 1.3523 3.7314 0.96 15.9866
C2BBe1 CCLE 1.6477 4.9548 0.751 16.0153
NCI-H747 CCLE 1.8524 4.4131 1.2022 13.0312
SW1417 CCLE 1.8715 6.6087 0.1863 18.1672
HCT 15 CCLE 1.8863 2.9956 1.7858 10.0176
COLO201 CCLE 2.0912 6.494 0.4479 16.1884
SK-CO-1 CCLE 2.2752 6.1541 0.7846 13.9073
RKO CCLE 2.459 5.2991 1.3734 10.2574
SNU-C2B CCLE 2.5816 7.1902 0.5468 14.2869
SW480 CCLE 2.6164 8.8568 -0.254 18.1516
COLO 678 CCLE 2.648 6.3467 1.025 11.5933
CCK-81 CCLE 2.7698 4.9511 1.8266 6.955
LS123 CCLE 2.9609 5.3636 1.7855 6.6787
T84 CCLE 2.9899 4.7389 2.1221 4.7822
HCT 116 CCLE 3.0737 5.33 1.8958 5.8021
HCC-56 CCLE 3.2534 6.8258 1.294 8.6236
SNU-C2A CCLE 4.3725 11.2052 -0.0225 12.8599
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-7 CCLE 0.9332 2.855 0.7824 18.4255
HuH-1 CCLE 1.0966 4.1966 0.5068 19.1299
Hep-G2 CCLE 1.1579 4.7042 0.3607 19.6302
Hep 3B2.1-7 CCLE 1.3397 3.5737 1.0044 15.8166
JHH-5 CCLE 1.5551 4.3863 0.9085 15.5265
Hep-G2/C3A CCLE 1.7646 6.3933 0.189 18.4833
SNU-475 CCLE 2.1796 5.7186 0.9083 13.5383
SNU-449 CCLE 2.6007 5.0322 1.6346 8.4557
HLF CCLE 2.8149 3.7801 2.4466 3.4933
JHH-4 CCLE 2.8717 4.2556 2.2623 4.3284
PLC/PRF/5 CCLE 3.0224 5.432 1.8026 6.4324
SNU-182 CCLE 3.1424 5.9772 1.6284 7.0842
SK-HEP-1 CCLE 3.224 7.0559 1.1556 9.4341
JHH-2 CCLE 3.2699 7.2216 1.1097 9.5704
SNU-387 CCLE 3.373 6.225 1.6869 6.2385
JHH-6 CCLE 3.6914 5.7846 2.1332 3.2294
SNU-398 CCLE 4.2677 7.6816 1.6127 4.883
HLE CCLE 4.5192 10.9461 0.2109 11.449
SNU-423 CCLE 4.6742 11.9137 -0.1503 12.8356
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 94 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-12T CCLE -0.4885 2.8388 -0.7644 31.1392
LUDLU-1 CCLE 0.4751 6.1064 -0.9544 28.0496
NCI-H2122 CCLE 0.7545 3.3338 0.4507 20.6701
A-549 CCLE 0.9181 2.9199 0.7493 18.6383
Lu-99 CCLE 0.9624 3.7768 0.5245 19.5333
SK-MES-1 CCLE 0.9826 2.4748 0.9163 17.6179
COLO 699 CCLE 1.0968 6.9171 -0.706 24.8105
DMS 114 CCLE 1.1621 7.5053 -0.9217 25.4967
Calu-6 CCLE 1.2716 3.2697 1.0338 15.9315
PC-14 CCLE 1.3673 3.7811 0.9572 15.9451
NCI-H1341 CCLE 1.3701 3.7456 0.9736 15.8549
NCI-H2023 CCLE 1.4042 5.9822 0.0344 20.3938
NCI-H727 CCLE 1.4578 3.9022 1.0066 15.3762
NCI-H3255 CCLE 1.4826 3.1626 1.2969 13.8777
NCI-H1666 CCLE 1.5246 3.4631 1.2433 13.9749
SW1573 CCLE 1.5487 5.1121 0.5799 17.2107
NCI-H322 CCLE 1.5725 3.753 1.187 14.0745
NCI-H211 CCLE 1.8705 4.1556 1.3341 12.2973
SW1271 CCLE 1.9903 3.713 1.6458 10.312
NCI-H23 CCLE 2.1249 6.7589 0.3493 16.59
NCI-H810 CCLE 2.1483 6.5126 0.4917 15.7961
EBC-1 CCLE 2.1782 4.6874 1.4016 10.9482
NCI-H2172 CCLE 2.1799 13.429 -2.9128 29.1276
SBC-5 CCLE 2.1832 4.4014 1.5403 10.2075
NCI-H1299 CCLE 2.188 6.2281 0.6678 14.7706
NCI-H1792 CCLE 2.2569 5.8654 0.9091 13.3065
NCI-H441 CCLE 2.3465 6.6044 0.6279 14.5202
NCI-H460 CCLE 2.5216 5.5719 1.2964 10.4907
NCI-H1693 CCLE 2.6134 6.7517 0.793 12.9157
NCI-H2030 CCLE 2.6199 5.1464 1.5956 8.6112
HCC44 CCLE 2.6263 6.209 1.0744 11.3888
NCI-H661 CCLE 2.6389 5.7415 1.3178 10.051
NCI-H358 CCLE 2.675 6.1176 1.1627 10.7853
COR-L23 CCLE 2.7524 5.9251 1.3263 9.7001
NCI-H1648 CCLE 2.7538 6.3091 1.136 10.7179
NCI-H1355 CCLE 2.7581 6.436 1.0764 11.0251
NCI-H650 CCLE 2.7947 6.9312 0.8608 12.0756
NCI-H1793 CCLE 2.7951 6.0853 1.2835 9.8176
RERF-LC-A1 CCLE 2.7951 4.8294 1.9094 6.4399
NCI-H1155 CCLE 2.8168 5.529 1.5798 8.1628
NCI-H1573 CCLE 2.8255 7.1349 0.7854 12.3926
NCI-H2087 CCLE 2.8983 6.3988 1.2152 9.9175
Calu-3 CCLE 2.9109 4.7497 2.0498 5.3745
SK-LU-1 CCLE 2.9141 6.3514 1.2522 9.6785
HCC827 CCLE 2.9428 4.2864 2.3086 3.8913
HCC4006 CCLE 2.9847 6.0753 1.4496 8.4362
Sq-1 CCLE 3.0038 7.0349 0.9858 10.8771
GLC-82 CCLE 3.0336 7.4314 0.8122 11.7214
NCI-H2228 CCLE 3.0629 6.9093 1.0976 10.1341
NCI-H1092 CCLE 3.0691 5.1655 1.9742 5.3887
NCI-H2170 CCLE 3.0791 6.0496 1.5406 7.7113
NCI-H1944 CCLE 3.1287 7.0669 1.0728 10.1053
NCI-H1694 CCLE 3.1788 7.9076 0.6935 11.9841
IA-LM CCLE 3.2192 5.9693 1.6939 6.5496
NCI-H1975 CCLE 3.2238 8.6727 0.3479 13.6462
NCI-H520 CCLE 3.226 8.325 0.5235 12.7481
NCI-H2009 CCLE 3.2597 6.9539 1.235 8.9247
NCI-H1568 CCLE 3.27 10.0389 -0.2971 16.6573
DV-90 CCLE 3.2853 6.446 1.5086 7.3956
NCI-H1563 CCLE 3.3058 10.2447 -0.3708 16.9084
HCC15 CCLE 3.3532 7.6568 0.959 10.1746
NCI-H2444 CCLE 3.3706 7.6911 0.9557 10.1515
NCI-H1651 CCLE 3.3837 8.6196 0.5032 12.4732
COLO 677 CCLE 3.4095 6.2082 1.7231 5.9641
NCI-H1048 CCLE 3.4204 5.6592 2.0025 4.4448
NCI-H2286 CCLE 3.4907 6.9181 1.4334 7.3382
NCI-H1650 CCLE 3.5355 6.5495 1.6494 6.0876
NCI-H2085 CCLE 3.5388 6.0419 1.9014 4.7385
LCLC-103H CCLE 3.6146 8.2059 0.8898 9.9426
VMRC-LCD CCLE 3.6759 8.9571 0.5643 11.4868
NCI-H1184 CCLE 3.6973 6.4601 1.811 4.9
MOR/CPR CCLE 3.7143 7.4104 1.358 7.2606
NCI-H1915 CCLE 3.7491 9.2551 0.4727 11.7875
COR-L105 CCLE 3.7906 7.8392 1.2035 7.9165
NCI-H1339 CCLE 3.7974 7.1663 1.5382 6.1394
SW900 CCLE 3.8271 6.3093 1.9735 3.8094
LC-1/sq-SF CCLE 3.8521 8.6522 0.8488 9.6391
HCC2935 CCLE 3.9242 8.179 1.1345 8.0029
KNS-62 CCLE 3.9773 8.1038 1.2096 7.5036
NCI-H226 CCLE 3.9868 13.573 -1.4883 19.9566
HARA [Human squamous cell lung carcinoma] CCLE 4.0227 7.3506 1.6068 5.349
T3M-10 CCLE 4.0322 6.6372 1.9529 3.5609
RERF-LC-MS CCLE 4.0565 8.7816 0.9354 8.7662
HCC78 CCLE 4.0857 8.2662 1.2077 7.3
NCI-H1869 CCLE 4.1064 8.7475 0.988 8.3949
NCI-H1373 CCLE 4.2144 9.7151 0.5928 10.1887
NCI-H1581 CCLE 4.2613 6.1589 2.3065 1.5484
LOU-NH91 CCLE 4.3432 7.0331 1.9625 3.0282
NCI-H1703 CCLE 4.4148 8.6198 1.2637 6.3976
NCI-H522 CCLE 4.5694 9.4916 0.9507 7.7005
Hs 229.T CCLE 5.0041 9.2025 1.3671 4.9159
NCI-H647 CCLE 5.0874 7.5772 2.1281 1.4315
SHP-77 CCLE 5.4359 7.1492 2.4425 0.2883
Calu-1 CCLE 6.1515 12.2845 0.6469 6.5967
⏷ Show the Full List of 94 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-70 CCLE 0.3109 1.5962 0.2992 23.145
TE-11 CCLE 0.7957 2.3008 0.743 19.1618
KYSE-140 CCLE 0.9509 3.6414 0.5607 19.4023
TE-15 CCLE 1.0085 5.1737 0.0032 21.886
KYSE-180 CCLE 1.6281 3.9526 1.1667 13.9772
OE21 CCLE 1.9121 4.0122 1.4388 11.6244
KYSE-410 CCLE 2.1208 6.0103 0.7114 14.7425
KYSE-510 CCLE 2.3127 4.6436 1.5531 9.7358
OE33 CCLE 2.3552 3.6992 2.0318 7.1079
KYSE-520 CCLE 2.4832 5.5394 1.2776 10.6999
TE-1 CCLE 2.5062 5.0103 1.5586 9.1319
TE-9 CCLE 3.0511 5.4312 1.8268 6.2309
KYSE-30 CCLE 3.2228 6.7499 1.3073 8.6241
KYSE-150 CCLE 3.459 5.7554 1.9836 4.4651
KYSE-450 CCLE 3.8744 7.7333 1.3166 7.1503
TE-5 CCLE 4.1021 8.1661 1.2678 6.9566
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FU-OV-1 CCLE 1.2215 5.0677 0.268 19.8656
JHOS-4 CCLE 1.5181 4.3212 0.8979 15.7067
Kuramochi CCLE 1.542 4.4411 0.8714 15.7579
TYK-nu CCLE 1.9439 2.7653 1.902 9.255
DOV13 CCLE 2.0369 3.1285 1.9112 8.845
JHOS-2 CCLE 2.1271 7.854 -0.188 19.22
MCAS CCLE 2.2833 4.4829 1.6008 9.5761
OV-90 CCLE 2.4512 4.8382 1.5913 9.1175
OVMANA CCLE 2.4808 6.0973 0.9999 12.1861
COV504 CCLE 2.894 5.7991 1.5111 9.7312
OVCAR-8 CCLE 2.9789 4.7236 2.1206 4.8181
TOV-21G CCLE 3.0233 5.6826 1.678 7.1048
OVSAHO CCLE 3.0464 5.2189 1.929 5.6889
A2780 CCLE 3.0612 6.496 1.3027 9.0382
EFO-21 CCLE 3.0838 8.4842 0.3274 14.0964
OVCAR-3 CCLE 3.1385 5.0792 2.0735 4.6862
COV318 CCLE 3.4342 7.0008 1.349 7.9145
ONCO-DG-1 CCLE 3.4752 8.1457 0.8117 10.6658
HEY A8 CCLE 3.5296 8.0285 0.9123 10.0155
TOV-112D CCLE 3.5667 6.6826 1.607 6.2478
ES-2 CCLE 3.6881 8.0526 1.0217 9.0901
OC 316 CCLE 3.9918 6.2369 2.1145 2.8192
SK-OV-3 CCLE 4.0799 9.6105 0.5459 10.7025
OVCAR-4 CCLE 4.1092 7.2955 1.6915 4.7571
OC 315 CCLE 4.3207 6.289 2.282 1.5859
IGROV-1 CCLE 4.3521 9.143 0.9693 8.0117
EFO-27 CCLE 4.9672 10.4779 0.746 8.0039
OVTOKO CCLE 5.2207 11.0808 0.6266 8.1448
OC 314 CCLE 6.476 13.2242 0.4121 7.1807
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AsPC-1 CCLE 0.6188 3.59 0.2193 22.2798
KCI-MOH1 CCLE 0.917 2.9371 0.7436 18.6689
Panc 02.03 CCLE 1.1036 4.482 0.3977 19.6394
HPAF-II CCLE 1.2318 4.0183 0.7209 17.5947
Capan-2 CCLE 1.3167 3.7267 0.9236 16.294
QGP-1 CCLE 1.4001 4.6079 0.6527 17.3431
PaTu 8902 CCLE 1.4503 4.3958 0.7957 16.4535
HPAC CCLE 1.4882 4.1229 0.9497 15.5516
MIA PaCa-2 CCLE 1.541 4.4416 0.8701 15.7684
Panc 04.03 CCLE 1.5785 5.6951 0.3403 18.3197
KP-4 CCLE 2.0227 4.2955 1.4277 11.3105
PK-45H CCLE 2.0963 5.3838 0.991 13.3552
SUIT-2 CCLE 2.1471 5.7272 0.8736 13.8172
HuP-T4 CCLE 2.3803 6.8546 0.5346 14.9074
PL45 CCLE 2.5861 4.9413 1.6659 8.329
Panc 10.05 CCLE 2.625 5.644 1.3539 9.8955
PK-59 CCLE 2.7186 5.8254 1.3465 9.6814
KP-2 CCLE 2.7428 7.7058 0.4295 14.457
PK-1 CCLE 2.7529 4.8189 1.8772 6.7278
BxPC-3 CCLE 3.0263 6.8883 1.0777 10.3309
HuP-T3 CCLE 3.0346 5.2689 1.8942 5.906
SU.86.86 CCLE 3.041 7.2454 0.9113 11.1796
KP-1N CCLE 3.0832 7.1816 0.9781 10.721
Panc 03.27 CCLE 3.1796 5.5417 1.8756 5.6603
Hs 766T CCLE 3.2688 5.0102 2.2092 3.6611
PSN1 CCLE 3.3267 6.4662 1.5311 7.18
SW1990 CCLE 3.5104 7.9798 0.9216 10.0099
KP-3 CCLE 3.7547 9.2802 0.4645 11.8163
KP-1NL CCLE 4.443 9.3586 0.9281 8.0484
L3.3 CCLE 4.711 12.4264 -0.3745 13.7771
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CCLE 2.5597 7.1656 0.5398 14.383
NCI-H2052 CCLE 2.8155 8.3033 0.1931 15.4576
IST-Mes1 CCLE 2.9345 7.2734 0.8085 11.9906
MPP 89 CCLE 3.4921 10.0173 -0.1075 15.2281
NCI-H2452 CCLE 3.6695 10.1076 -0.0124 14.358
MSTO-211H CCLE 4.0043 7.2914 1.6226 5.3009
IST-Mes2 CCLE 4.2969 8.5541 1.2153 6.8592
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CCLE 1.0349 5.637 -0.1759 22.6409
DU145 CCLE 2.6844 6.9109 0.7757 12.8162
PC-3 CCLE 3.1516 6.3331 1.458 7.9824
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CCLE 4.7405 9.7445 0.9447 7.4229
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM983B CCLE 0.7367 3.9273 0.2266 21.8003
Malme-3M CCLE 1.2851 4.3976 0.6228 17.8902
A-375 CCLE 1.3163 4.3425 0.6785 17.5044
Hs 852.T CCLE 1.3751 4.5339 0.6587 17.3988
WM88 CCLE 1.4374 4.7015 0.6504 17.2277
COLO 741 CCLE 1.5559 4.9895 0.6427 16.8688
G-361 CCLE 1.5724 3.2906 1.354 13.264
WM793 CCLE 1.6109 3.0084 1.4818 12.5123
SK-MEL-5 CCLE 1.6245 8.3079 -0.8723 23.7977
SK-MEL-24 CCLE 1.6888 2.7576 1.6272 11.534
IGR-37 CCLE 1.7331 2.8801 1.6482 11.2595
K029AX CCLE 1.7897 2.6074 1.762 10.5154
Mel Ho CCLE 1.9595 2.6439 1.9382 9.0288
A2058 CCLE 1.9911 2.8154 1.9433 8.8762
SK-MEL-30 CCLE 1.9949 2.9858 1.9069 9.0284
IPC-298 CCLE 2.0714 3.508 1.8137 9.19
HMCB CCLE 2.0957 3.0165 2.0086 8.1595
SK-MEL-31 CCLE 2.2582 2.881 2.2196 6.542
MDA-MB-435S CCLE 2.3734 6.6311 0.639 14.3865
Hs 294T CCLE 2.4534 4.1855 1.9071 7.4389
Hs 695T CCLE 2.4601 6.0663 0.9966 12.2617
HT-144 CCLE 2.4717 4.8385 1.6103 8.9564
RPMI-7951 CCLE 2.6245 4.4988 1.9186 6.8664
WT2-iPS CCLE 2.6486 3.709 2.3224 4.6511
UACC-62 CCLE 2.7432 6.3853 1.0889 10.9981
CHL-1 CCLE 2.8078 4.755 1.9576 6.1457
Hs 895.T CCLE 2.8593 3.9861 2.3853 3.6985
SF8657 CCLE 2.9197 5.6856 1.5897 7.8428
IGR-39 CCLE 3.0189 5.188 1.9217 5.7958
Hs 944.T CCLE 3.0506 7.8148 0.6346 12.6072
WM1799 CCLE 3.2017 5.2934 2.0167 4.8469
COLO 679 CCLE 3.2764 10.3413 -0.4429 17.3097
UACC-257 CCLE 3.4717 7.0865 1.3353 7.9035
LOX-IMVI CCLE 3.5194 7.3556 1.2385 8.3142
MeWo CCLE 3.8005 6.9806 1.631 5.6454
WM266-4 CCLE 3.8027 7.7244 1.2688 7.5481
Hs 936.T CCLE 3.813 6.2451 1.9948 3.7251
SK-MEL-2 CCLE 4.1147 5.2223 2.6237 0.4501
WM115 CCLE 4.1907 10.3577 0.2602 11.8857
Hs 938.T CCLE 4.4422 6.4204 2.2895 1.4194
RVH-421 CCLE 4.4823 9.3951 0.9376 7.927
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CCLE 0.5129 3.3726 0.1756 22.892
Rh30 CCLE 0.8315 3.1241 0.5984 19.6791
SK-LMS-1 CCLE 1.2479 3.3928 0.9678 16.3356
RD CCLE 1.3797 4.2447 0.7855 16.7503
GCT CCLE 1.7948 4.0298 1.3094 12.6807
KYM-1 CCLE 1.8171 5.6372 0.6008 16.2408
Hs 729.T CCLE 1.8634 5.7842 0.5757 16.2249
A-204 CCLE 2.6025 5.8561 1.2285 10.6297
TE 617.T CCLE 2.6881 7.8202 0.3253 15.1323
HT-1080 CCLE 2.7681 5.3317 1.6357 7.99
RKN CCLE 3.7253 7.1002 1.5185 6.3892
G-402 CCLE 4.0462 8.6001 1.0167 8.3674
MES-SA CCLE 4.7835 11.3461 0.2036 10.9634
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AZ-521 CCLE 0.0657 3.9565 -0.5064 27.7438
RERF-GC-1B CCLE 0.8593 3.0776 0.6422 19.3662
BGC-823 CCLE 1.0743 4.2167 0.4752 19.3646
KE-39 CCLE 1.5798 4.3333 0.9568 15.1984
MKN74 CCLE 1.9823 4.9227 1.099 13.1443
HGC-27 CCLE 2.0571 3.0612 1.9536 8.5676
Fu97 CCLE 2.1452 4.2385 1.5771 10.1388
SNU-1 CCLE 2.4454 5.7816 1.1237 11.6275
SNU-16 CCLE 2.503 4.3389 1.8817 7.4209
Hs 746.T CCLE 2.6855 4.8858 1.7837 7.4174
IM95 CCLE 2.8668 10.6376 -0.9304 20.4806
NCI-N87 CCLE 3.0286 6.2863 1.3806 8.6992
SH-10-TC CCLE 3.0435 4.9174 2.0773 4.8922
MKN45 CCLE 3.1994 7.9177 0.7052 11.8731
NUGC-4 CCLE 3.2011 8.0609 0.6351 12.2331
GCIY CCLE 3.2802 7.9273 0.7658 11.3621
MKN7 CCLE 3.2999 4.9954 2.2399 3.43
OCUM-1 CCLE 3.7111 8.5898 0.7733 10.3347
NUGC-3 CCLE 3.8519 10.0588 0.153 13.1433
SNG-M CCLE 3.6359 7.0145 1.4949 6.6987
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT2609-C02 CCLE 0.9468 5.5161 -0.2112 23.1126
B-CPAP CCLE 2.1525 5.4363 1.0194 13.0361
8305C CCLE 2.2322 5.3754 1.1244 12.2437
8505C CCLE 4.358 8.5454 1.2611 6.5134
SW579 CCLE 4.6919 10.0546 0.7637 8.4099
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-27 CCLE 2.0219 2.8915 1.9601 8.6759
SCC-9 CCLE 2.1883 4.1728 1.6504 9.6199
Hs 840.T CCLE 3.191 6.1517 1.5803 7.2289
HSC-2 CCLE 3.8571 6.0259 2.1278 2.9706
FaDu CCLE 3.922 8.2573 1.0946 8.2154
Detroit 562 CCLE 4.7588 10.054 0.8092 8.0627
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 CCLE -0.0555 2.4485 -0.2018 26.8846
JMSU-1 CCLE 1.356 5.1472 0.3695 18.9075
HT-1197 CCLE 1.5324 5.0115 0.6091 17.1171
639V CCLE 1.854 8.3626 -0.6875 22.3032
SW780 CCLE 2.0432 5.278 0.9906 13.5194
5637 CCLE 2.3661 5.6492 1.116 11.8956
HT-1376 CCLE 2.8397 6.1708 1.2791 9.7245
SCaBER CCLE 2.9824 5.943 1.5138 8.0946
RT-4 CCLE 3.1885 6.617 1.3461 8.4971
T24 CCLE 3.5545 7.2413 1.3219 7.7932
J82 CCLE 3.68 6.7302 1.6668 5.6963
TCCSUP CCLE 3.8751 6.8485 1.7472 4.8944
KMBC-2 CCLE 4.5066 10.259 0.5365 9.8863
UM-UC-3 CCLE 5.6894 7.4857 2.4182 0.2569
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug

References

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3 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
4 Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. doi: 10.3892/ijo_00000712.
5 Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res. 2009 May 15;69(10):4192-201. doi: 10.1158/0008-5472.CAN-09-0042. Epub 2009 May 12.