Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQIBZD)

Drug Name
Silmitasertib Drug Info
Synonyms CX-4945; CX4945; CX-4945 (Silmitasertib); CX 4945; UNII-C6RWP0N0L2; W-204393
Therapeutic ClassAntiviral Agents
Cross-matching ID
PubChem CID
24748573
ChEBI ID
CHEMBL1230165
CAS Number
CAS 1009820-21-6
TTD Drug ID
D0CP8N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.08 0.00e+0 110/124 (88.71%) PLK1;CCNB1;CDC20;...
MicroRNAs in cancer 1.93 5.34e-3 146/310 (47.1%) DDIT4;MMP9;SLC7A1;...
Oocyte meiosis 1.85 1.42e-2 90/129 (69.77%) PLK1;CCNB1;CDC20;...
Protein digestion and absorption 1.80 3.20e-2 78/103 (75.73%) COL5A2;COL11A1;SLC3A2;...
Fructose and mannose metabolism -1.58 4.25e-2 30/33 (90.91%) HK1;HK2;SORD;...
beta-Alanine metabolism -1.59 4.04e-2 25/30 (83.33%) CNDP2;DPYS;ACOX3;...
Primary bile acid biosynthesis -1.59 4.12e-2 15/17 (88.24%) CYP39A1;CYP27A1;SCP2;...
Phagosome -1.60 4.27e-2 118/152 (77.63%) DYNC1I2;RAB5C;HLA-DMB;...
Arachidonic acid metabolism -1.62 3.44e-2 48/61 (78.69%) CBR1;PTGS1;LTA4H;...
Fatty acid degradation -1.62 3.57e-2 40/43 (93.02%) ACAA1;ACOX3;ACADL;...
Proteasome -1.62 3.68e-2 44/46 (95.65%) PSME1;PSME3;PSMA3;...
Retinol metabolism -1.66 2.51e-2 41/68 (60.29%) CYP3A5;ADH5;CYP1A1;...
Fatty acid biosynthesis -1.67 2.54e-2 16/18 (88.89%) FASN;ACACA;ACSL3;...
Steroid hormone biosynthesis -1.68 2.44e-2 43/61 (70.49%) CYP11A1;SRD5A1;HSD17B12;...
Amino sugar and nucleotide sugar metabolism -1.68 2.47e-2 38/48 (79.17%) HK1;PGM1;HK2;...
Glycolysis / Gluconeogenesis -1.70 2.35e-2 56/67 (83.58%) HK1;AKR1A1;PGM1;...
Cholesterol metabolism -1.71 2.12e-2 44/50 (88%) SCARB1;LIPG;LDLR;...
Valine, leucine and isoleucine degradation -1.72 1.97e-2 42/48 (87.5%) MMUT;HMGCL;ACAA1;...
Peroxisome -1.72 2.09e-2 72/82 (87.8%) MVK;HAO2;PMVK;...
Pertussis -1.73 1.92e-2 64/76 (84.21%) CD14;LY96;C4BPB;...
Systemic lupus erythematosus -1.76 1.80e-2 45/135 (33.33%) HLA-DRA;SNRPB;HLA-DMB;...
Propanoate metabolism -1.78 1.50e-2 30/34 (88.24%) LDHA;HADHA;PCCA;...
Drug metabolism -1.81 1.16e-2 78/151 (51.66%) CYP2E1;CES2;RRM1;...
Pyruvate metabolism -1.82 1.18e-2 41/47 (87.23%) PDHA1;FH;GLO1;...
Histidine metabolism -1.84 1.12e-2 16/22 (72.73%) HAL;HDC;ALDH9A1;...
Galactose metabolism -1.86 1.03e-2 26/31 (83.87%) HK1;MGAM;PGM1;...
Hematopoietic cell lineage -1.87 1.16e-2 90/99 (90.91%) CD1B;ITGA4;CD5;...
Tryptophan metabolism -1.88 1.33e-2 35/42 (83.33%) ECHS1;ALDH9A1;DLD;...
Phenylalanine metabolism -1.94 9.31e-3 14/17 (82.35%) GOT2;AOC3;ALDH3B1;...
Metabolism of xenobiotics by cytochrome P450 -1.95 7.45e-3 49/77 (63.64%) CYP2A6;GSTA3;CBR1;...
Tyrosine metabolism -2.13 0.00e+0 30/36 (83.33%) GOT2;TYRP1;TYR;...
Steroid biosynthesis -2.41 0.00e+0 19/20 (95%) EBP;CYP51A1;LIPA;...
Staphylococcus aureus infection -2.42 0.00e+0 72/95 (75.79%) DEFB1;PTAFR;HLA-DMB;...
Complement and coagulation cascades -2.46 0.00e+0 76/85 (89.41%) PROCR;CFHR2;C4BPB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H