Details of the Drug

General Information of Drug (ID: DMQIBZD)

Drug Name
Silmitasertib
Synonyms CX-4945; CX4945; CX-4945 (Silmitasertib); CX 4945; UNII-C6RWP0N0L2; W-204393
Indication
Disease Entry ICD 11 Status REF
Cholangiocarcinoma 2C12.10 Phase 1/2 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Therapeutic Class
Antiviral Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 349.8
Logarithm of the Partition Coefficient (xlogp) 4.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C19H12ClN3O2
IUPAC Name
5-(3-chloroanilino)benzo[c][2,6]naphthyridine-8-carboxylic acid
Canonical SMILES
C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)O)C4=C2C=CN=C4
InChI
InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
InChIKey
MUOKSQABCJCOPU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
24748573
CAS Number
1009820-21-6
UNII
C6RWP0N0L2
DrugBank ID
DB15408
TTD ID
D0CP8N
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN casein kinase II (CSK2) TTDT8RP CSK21_HUMAN ; CSK22_HUMAN ; CSK23_HUMAN ; CSK2B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Post-Translational Modifications [4]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Gene/Protein Processing [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [4]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 127 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 2.0116 4.2322 1.9749 26.9904
JK1 CTRP2 8.2916 11.506 4.8809 1.8997
JM1 CTRP2 1.9401 3.4429 1.9367 27.3549
MOLT-13 CTRP2 -1.4822 -0.8828 -1.4822 50.1434
KMS-11 CTRP2 -1.4419 0.0896 -1.442 49.875
Reh CTRP2 -1.366 -0.8462 -1.366 49.3694
SUP-T1 CTRP2 -1.3236 0.2336 -1.3236 49.0867
GDM-1 CTRP2 -1.1265 0.2196 -1.1265 47.7737
BV-173 CTRP2 -0.4124 0.8401 -0.4124 43.0163
EoL-1 CTRP2 -0.1638 2.2676 -0.1719 41.3844
KMS-34 CTRP2 0.8617 2.0618 0.8616 34.5283
Pfeiffer CTRP2 1.2537 4.0609 1.195 32.1114
MV4-11 CTRP2 1.3851 3.2228 1.3787 31.0622
ST486 CTRP2 1.464 3.27 1.4578 30.5359
KMS-12-BM CTRP2 1.5943 2.546 1.5943 29.6471
GA-10 CTRP2 1.618 3.079 1.6163 29.4948
EB1 CTRP2 1.6404 3.9816 1.6067 29.4528
KMS-27 CTRP2 1.6661 3.3036 1.6619 29.1831
OPM-2 CTRP2 1.7175 5.0957 1.5434 29.4128
BL-70 CTRP2 1.7242 2.6737 1.7242 28.7817
NALM-6 CTRP2 1.8924 4.065 1.8632 27.7592
AML-193 CTRP2 1.9878 3.3049 1.9864 27.0305
KE-37 CTRP2 2.0344 3.7071 2.0266 26.741
Mino CTRP2 2.0676 2.823 2.0676 26.4942
KMS-21-BM CTRP2 2.1124 3.2566 2.1118 26.1974
THP-1 CTRP2 2.1238 3.5932 2.1201 26.1319
EM-2 CTRP2 2.168 3.347 2.1672 25.8279
SUP-T11 CTRP2 2.2571 4.4895 2.2094 25.392
JeKo-1 CTRP2 2.2611 3.1442 2.261 25.2051
DB CTRP2 2.2762 4.1675 2.2549 25.1757
JVM-3 CTRP2 2.2886 3.7541 2.2838 25.0375
MOLM-13 CTRP2 2.3067 4.1139 2.2894 24.959
Daudi CTRP2 2.3316 3.2174 2.3315 24.7357
EJM CTRP2 2.4449 4.9913 2.3454 24.3185
DEL CTRP2 2.4871 3.0828 2.4871 23.6994
KHM-1B CTRP2 2.4941 4.6272 2.4452 23.8176
L-428 CTRP2 2.5055 4.2376 2.488 23.6353
MOTN-1 CTRP2 2.5467 5.7813 2.2958 24.1694
KMS-18 CTRP2 2.5727 4.6167 2.5291 23.2759
SEM CTRP2 2.5969 3.4275 2.5968 22.9679
RL CTRP2 2.5988 4.0704 2.5911 22.9808
KMS-26 CTRP2 2.7194 3.3486 2.7194 22.1517
OCI-AML-3 CTRP2 2.8128 3.7868 2.8121 21.5317
NU-DHL-1 CTRP2 2.8144 4.4154 2.7973 21.5759
TALL-1 [Human adult T-ALL] CTRP2 2.8527 4.7524 2.8106 21.4056
MOLP-2 CTRP2 2.8666 5.1431 2.7743 21.4851
P12-Ichikawa CTRP2 2.8851 4.2773 2.8765 21.0767
OCI-Ly19 CTRP2 2.9948 6.1022 2.7003 21.3466
JURL-MK1 CTRP2 3.0345 4.522 3.0188 20.1048
U-937 CTRP2 3.1365 4.2334 3.1335 19.3829
Kasumi-2 CTRP2 3.2291 9.1721 1.7839 24.0083
TF-1 CTRP2 3.27 6.6438 2.834 20.0352
Mono-Mac-1 CTRP2 3.274 6.4226 2.9099 19.7447
OCI-Ly3 CTRP2 3.2869 5.6786 3.1265 18.9247
HDLM-2 CTRP2 3.3423 6.9939 2.7908 19.9838
HD-MY-Z CTRP2 3.3974 6.109 3.1378 18.5444
RS4;11 CTRP2 3.3991 7.1296 2.8024 19.777
KO52 CTRP2 3.4413 6.9837 2.9012 19.2866
U266B1 CTRP2 3.7878 13.8314 0.1408 27.7284
A4/Fukuda CTRP2 3.8339 7.6732 3.0519 17.6128
SET-2 CTRP2 4.0155 5.4827 3.9544 13.7248
HPB-ALL CTRP2 4.0976 5.248 4.0728 13.0534
KMS-28BM CTRP2 4.1794 6.7224 3.7907 13.8279
KYO-1 CTRP2 4.1894 5.4077 4.1516 12.4861
Granta-519 CTRP2 4.6263 7.4858 3.9568 11.9611
MHH-CALL-3 CTRP2 4.6402 12.0592 1.7994 20.3558
MOLP-8 CTRP2 4.9309 7.0161 4.4739 9.1223
F-36P CTRP2 5.0088 15.938 0.2101 24.6601
CML-T1 CTRP2 5.0781 8.7502 3.8209 11.3928
SIG-M5 CTRP2 5.3584 11.1105 2.9192 14.45
KMS-20 CTRP2 5.3619 12.5821 2.1907 17.288
SUP-HD1 CTRP2 5.4907 9.9628 3.6066 11.357
MOLT-16 CTRP2 5.5243 9.8251 3.7049 10.8782
RCH-ACV CTRP2 5.8619 10.7314 3.5471 10.8361
Karpas-620 CTRP2 5.8915 7.2722 5.2988 3.4422
OCI-Ly10 CTRP2 5.9591 9.4425 4.2738 7.608
SUP-B15 CTRP2 5.9768 9.7359 4.142 8.1259
HuNS1 CTRP2 6.0684 14.771 1.7011 17.6239
PF-382 CTRP2 6.1459 10.343 3.9791 8.4827
WSU-DLCL2 CTRP2 6.1701 10.2121 4.0644 8.0801
SU-DHL-10 CTRP2 6.4124 8.7332 4.993 3.7582
MOLM-16 CTRP2 6.4153 11.2451 3.7463 8.9538
NU-DUL-1 CTRP2 6.4994 11.2836 3.7937 8.6062
REC-1 CTRP2 6.5169 9.3196 4.782 4.4613
LP-1 CTRP2 6.6351 10.2742 4.3993 5.8544
Karpas-422 CTRP2 6.6551 10.1437 4.4788 5.4913
Mono-Mac-6 CTRP2 6.6858 12.1224 3.522 9.3981
L-540 CTRP2 6.6976 8.8792 5.1275 2.7608
DND-41 CTRP2 6.8247 14.5833 2.4065 13.5829
SU-DHL-6 CTRP2 6.8967 8.7539 5.3169 1.7515
Ci-1 CTRP2 6.9262 7.8771 5.7171 0.3533
HL-60 CTRP2 6.9428 13.4555 3.0584 10.8286
Ri-1 CTRP2 7.0151 11.3296 4.1607 6.2258
Kasumi-1 CTRP2 7.1735 11.7424 4.0728 6.3396
Hs 611.T CTRP2 7.2567 13.5069 3.269 9.4616
SU-DHL-4 CTRP2 7.2572 8.5432 5.603 0.4625
KM-H2 CTRP2 7.2992 8.9687 5.4482 0.888
K-562 CTRP2 7.3553 12.821 3.6767 7.6659
MOLM-6 CTRP2 7.3684 9.2396 5.3686 1.0873
OCI-M1 CTRP2 7.4151 9.6704 5.2061 1.5968
ALL-SIL CTRP2 7.5226 15.8578 2.3085 12.7455
MHH-CALL-4 CTRP2 7.5561 11.5889 4.4081 4.4474
P31/FUJ CTRP2 7.6054 8.7005 5.6882 0.1418
SU-DHL-1 CTRP2 7.6086 8.6027 5.7237 0.0935
CMK CTRP2 7.639 8.623 5.7276 0.0836
HT CTRP2 7.6416 9.1749 5.5262 0.449
MC116 CTRP2 7.6429 14.0925 3.2622 8.8783
HEL CTRP2 7.7253 8.9404 5.648 0.1722
NCO2 CTRP2 7.7589 9.2382 5.5519 0.3383
AMO1 CTRP2 7.7633 9.0242 5.6325 0.1866
Jurkat CTRP2 7.7788 9.2421 5.5586 0.3166
P3HR-1 CTRP2 7.7913 9.5599 5.4418 0.5795
SU-DHL-8 CTRP2 7.8366 9.0616 5.6469 0.1463
RPMI-8402 CTRP2 7.8394 9.5959 5.4491 0.5359
MM1.S CTRP2 7.8721 9.1817 5.6175 0.1808
HEL 92.1.7 CTRP2 7.916 14.4635 3.2742 8.4207
RPMI-6666 CTRP2 7.9409 9.5423 5.5127 0.3472
KE-97 CTRP2 8.0607 14.0771 3.5587 7.1014
L-1236 CTRP2 8.1749 14.1744 3.5884 6.8285
Ki-JK CTRP2 8.3259 9.816 5.5627 0.1537
LAMA-84 CTRP2 8.3479 10.2568 5.4121 0.3946
EHEB CTRP2 8.4512 10.0123 5.54 0.1573
KCL-22 CTRP2 8.5178 9.9775 5.5759 0.1057
Ku812 CTRP2 8.8153 10.6039 5.4667 0.1773
M-07e CTRP2 8.8424 16.7398 2.8103 8.8787
JJN-3 CTRP2 9.0008 22.4828 0.1399 17.5312
OCI-AML-5 CTRP2 9.6014 22.6024 0.5097 15.5561
⏷ Show the Full List of 127 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 3.2239 6.565 2.8099 20.2597
TE8 CTRP2 3.8306 6.23 3.5753 15.6486
KYSE-30 CTRP2 2.4625 4.5721 2.4175 24.0149
KYSE-510 CTRP2 2.5944 4.1292 2.5845 23.0176
KYSE-410 CTRP2 2.7337 5.7808 2.4997 22.8666
OE21 CTRP2 3.0221 5.628 2.8498 20.7294
TE-5 CTRP2 3.2025 5.7105 3.0273 19.5391
TE-6 CTRP2 3.4666 4.7898 3.4502 17.2288
EC-GI-10 CTRP2 3.8348 10.5975 1.7393 22.5488
KYSE-150 CTRP2 4.145 8.6579 2.9454 17.2022
TE-11 CTRP2 5.4134 13.2544 1.9009 18.2548
KYSE-520 CTRP2 6.0492 10.8446 3.6483 10.0475
TE-4 CTRP2 7.0717 12.2138 3.7683 7.7411
TE-9 CTRP2 7.0937 8.6732 5.4671 1.0005
TE-1 CTRP2 7.5156 10.0991 5.0721 1.9713
KYSE-180 CTRP2 7.7848 14.2902 3.2664 8.6461
TE-10 CTRP2 7.8441 13.257 3.8053 6.4345
OE19 CTRP2 7.9483 9.0765 5.6822 0.0829
TE-14 CTRP2 7.9543 13.9168 3.5637 7.2307
COLO 680N CTRP2 8.3135 13.5608 3.9669 5.1897
KYSE-140 CTRP2 8.7364 14.576 3.7587 5.4629
KYSE-70 CTRP2 8.8031 10.116 5.6273 0.0392
KYSE-450 CTRP2 10.2852 17.8782 3.1764 5.8306
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.6088 11.7628 4.3602 4.5657
Panc 08.13 CTRP2 1.8007 10.1016 -0.0922 33.9436
KP-4 CTRP2 2.2539 4.3024 2.2225 25.3581
Capan-2 CTRP2 2.8121 6.304 2.4427 22.8292
HuP-T4 CTRP2 3.1583 9.3408 1.6371 24.7212
SU.86.86 CTRP2 3.2839 4.9967 3.2399 18.5394
MIA PaCa-2 CTRP2 3.5288 5.9616 3.3212 17.4832
Panc 10.05 CTRP2 3.8417 6.7496 3.4168 16.2024
PSN1 CTRP2 4.0116 7.2431 3.4132 15.7359
Panc 04.03 CTRP2 4.1934 7.7744 3.3848 15.3522
SW1990 CTRP2 4.2055 6.6101 3.8588 13.4969
DAN-G CTRP2 4.2663 8.6466 3.0728 16.3903
BxPC-3 CTRP2 4.5763 9.1977 3.1235 15.4174
HPAF-II CTRP2 4.9898 9.1934 3.5232 12.8168
PaTu 8988s CTRP2 5.1901 8.1541 4.2141 9.5182
PaTu 8902 CTRP2 5.2564 7.6431 4.5209 8.1071
HuP-T3 CTRP2 5.9078 14.6392 1.6327 18.1895
AsPC-1 CTRP2 6.0058 8.8493 4.6097 6.1054
SNU-410 CTRP2 6.1416 10.2732 4.0105 8.3595
Panc 03.27 CTRP2 6.5715 10.926 4.0277 7.5073
KP-2 CTRP2 6.5873 10.2943 4.3532 6.1261
PaTu 8988t CTRP2 6.6246 11.8558 2.8487 7.0344
CFPAC-1 CTRP2 7.0248 8.6658 5.4324 1.1857
QGP-1 CTRP2 7.3068 8.9435 4.5104 0.2491
PK-45H CTRP2 7.6841 11.4202 4.5691 3.6581
Hs 766T CTRP2 7.7101 15.1171 2.8102 10.5383
YAPC CTRP2 7.7398 8.968 5.6436 0.1752
KP-3 CTRP2 7.9292 12.3356 4.2965 4.4033
SNU-213 CTRP2 7.9488 9.141 5.6602 0.1065
SUIT-2 CTRP2 8.0767 9.5751 5.5546 0.225
HPAC CTRP2 8.1593 10.2006 5.3539 0.6048
Panc 02.03 CTRP2 8.2553 9.788 5.5464 0.1913
Panc 05.04 CTRP2 8.4811 10.3013 5.4486 0.2839
TCC-Pan2 CTRP2 8.6089 9.9561 5.6148 0.0618
PK-59 CTRP2 8.6185 10.2381 5.5223 0.1472
L3.3 CTRP2 13.3509 25.7176 1.4229 8.3473
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 9.0621 25.0006 -1.0514 20.6163
WM115 CTRP2 1.9824 4.5242 1.9153 27.2878
WM266-4 CTRP2 2.0431 4.4515 1.9875 26.8445
MeWo CTRP2 3.1322 5.8685 2.9125 20.1648
Malme-3M CTRP2 3.1438 8.9224 1.8049 24.1711
SK-MEL-1 CTRP2 3.204 6.0305 2.9483 19.8164
HT-144 CTRP2 3.2271 5.7237 3.0511 19.3779
WM88 CTRP2 3.3129 5.2137 3.2423 18.4375
WT2-iPS CTRP2 3.4372 6.9563 2.9067 19.2777
COLO 829 CTRP2 3.6012 6.9804 3.0745 18.1778
RPMI-7951 CTRP2 3.6056 5.2294 3.553 16.426
UACC-62 CTRP2 3.789 5.5475 3.6987 15.335
RVH-421 CTRP2 4.2165 7.371 3.5781 14.5377
Hs 940.T CTRP2 4.2766 9.5648 2.6577 17.9951
IGR-37 CTRP2 4.2773 6.2095 4.0684 12.5099
WM983B CTRP2 4.3271 8.5457 3.1799 15.8123
UACC-257 CTRP2 4.5551 6.4467 4.2938 10.8581
Hs 895.T CTRP2 4.7788 7.2862 4.2006 10.5989
Hs 688(A).T CTRP2 5.0012 12.7886 1.7679 19.6417
Hs 934.T CTRP2 5.2102 12.5308 2.0822 18.0249
CJM [Human melanoma] CTRP2 5.7655 9.8374 3.9108 9.5172
Hs 839.T CTRP2 6.0691 10.6666 3.7539 9.5696
A2058 CTRP2 6.3775 7.8517 4.5348 0.6154
SK-MEL-5 CTRP2 6.3932 10.5349 4.0828 7.5926
SK-MEL-3 CTRP2 6.4712 10.4969 4.163 7.1191
COLO 741 CTRP2 6.4865 14.2076 2.3251 14.5144
A101D CTRP2 6.62 7.795 4.6599 0.1954
SK-MEL-28 CTRP2 6.6982 12.0439 3.5706 9.1771
SK-MEL-31 CTRP2 6.9989 13.4127 3.1224 10.477
HMCB CTRP2 7.0267 12.9311 2.6056 7.4466
Hs 944.T CTRP2 7.2446 11.1629 4.4031 4.8961
K029AX CTRP2 7.2943 9.0607 5.4064 1.0265
IGR-39 CTRP2 7.3096 9.2866 5.3167 1.3139
LOX-IMVI CTRP2 7.385 9.6898 5.1805 1.7173
Hs 294T CTRP2 7.4771 12.1251 4.0993 5.7833
Mel Ho CTRP2 7.5166 10.4415 4.9179 2.5351
MDA-MB-435S CTRP2 7.5464 8.8698 5.6026 0.3184
SK-MEL-2 CTRP2 7.6202 8.6712 5.704 0.1161
SK-MEL-30 CTRP2 7.7535 8.8315 5.6969 0.0988
Hs 936.T CTRP2 7.7787 8.6956 5.7519 0.0432
COLO 800 CTRP2 7.807 13.4368 3.694 6.9265
IPC-298 CTRP2 7.8975 12.666 4.1212 5.1224
G-361 CTRP2 7.9067 9.2412 5.6094 0.1843
WM793 CTRP2 7.9703 9.4127 5.5721 0.2267
Hs 852.T CTRP2 7.9897 9.3357 5.6071 0.167
A-375 CTRP2 8.3985 9.9717 5.5348 0.1749
WM1799 CTRP2 8.7444 16.5854 2.8187 8.9819
COLO 792 CTRP2 9.4344 18.1056 2.5508 9.0384
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 3.2563 6.2382 2.9466 19.6637
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 0.3143 2.584 0.3063 38.2006
MHH-NB-11 CTRP2 1.5762 3.1753 1.5731 29.7783
SK-N-BE(2) CTRP2 2.436 5.5752 2.2239 24.7689
NH-6 CTRP2 2.5854 7.6747 1.726 26.0662
SK-N-SH CTRP2 5.873 12.6062 1.9299 12.2313
CHP-126 CTRP2 7.0364 9.3533 5.1255 2.315
SK-N-FI CTRP2 7.4631 21.9357 -0.7521 22.4636
KP-N-YN CTRP2 8.3684 10.1627 5.455 0.3072
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 2.226 5.0369 2.1027 25.8579
HuH-28 CTRP2 2.5875 5.7204 2.3551 23.8329
HuCC-T1 CTRP2 3.6508 5.5848 3.5418 16.321
SNU-869 CTRP2 4.4587 9.2277 2.9945 16.2194
SNU-308 CTRP2 4.9019 7.5773 4.1981 10.29
SNU-1079 CTRP2 7.0803 10.7239 4.5016 4.7368
SNU-1196 CTRP2 7.3534 9.4585 5.2653 1.45
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-78 CTRP2 -1.3524 -0.6833 -1.3524 49.2786
SK-ES-1 CTRP2 2.2427 3.8129 2.2357 25.3507
U2OS CTRP2 2.273 6.1324 1.9042 26.399
TC71 CTRP2 2.6578 6.701 2.1504 24.3462
A-673 CTRP2 2.7002 4.8306 2.6404 22.4818
SaOS-2 CTRP2 3.5729 8.1145 2.595 20.073
Hs 888.T CTRP2 4.52 7.3236 3.9159 12.4038
MG-63 CTRP2 5.2941 10.447 3.1903 13.4926
Hs 822.T CTRP2 5.4796 10.6024 3.2791 12.7301
HOS CTRP2 5.8427 12.6749 2.5596 14.8654
SK-N-MC CTRP2 6.2577 11.087 3.6986 9.4419
MHH-ES-1 CTRP2 7.306 8.9855 5.4445 0.8941
SW1353 CTRP2 7.6607 9.1043 5.5615 0.3587
SJSA-1 CTRP2 8.1137 9.9491 5.431 0.4487
G-292 clone A141B1 CTRP2 8.6277 15.1981 3.3998 6.9518
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 2.1298 3.4687 2.1279 26.086
BT-20 CTRP2 2.2608 4.2799 2.2313 25.306
HCC1806 CTRP2 2.4204 4.105 2.407 24.1884
MDA-MB-157 CTRP2 2.5234 4.9938 2.4293 23.7772
HCC1954 CTRP2 2.5378 5.3335 2.3856 23.8824
AU565 CTRP2 2.802 6.351 2.4176 22.9506
Hs 578Bst CTRP2 3.0206 8.5503 1.8354 24.4111
CAL-85-1 CTRP2 3.219 6.1809 2.9227 19.8632
MDA-MB-453 CTRP2 3.3781 5.7991 3.1977 18.3884
HCC1500 CTRP2 3.4403 7.4933 2.7079 20.0141
HCC1428 CTRP2 3.551 5.7574 3.396 17.1476
SK-BR-3 CTRP2 3.75 15.6642 -0.7898 30.1786
MDA-MB-361 CTRP2 4.035 9.121 2.6242 18.7355
CAL-120 CTRP2 4.0434 6.3068 3.7838 14.2501
EFM-192A CTRP2 4.2879 8.2193 3.2873 15.4881
HCC1419 CTRP2 4.7406 7.3669 4.1262 10.9927
ZR-75-30 CTRP2 5.1549 8.4126 4.0565 10.247
Hs 578T CTRP2 5.3053 12.7258 2.0694 17.8655
HDQ-P1 CTRP2 6.0612 12.43 2.8656 13.2213
T-47D CTRP2 6.3571 13.0747 2.7864 12.9678
KPL-1 CTRP2 6.9541 7.7672 5.7724 0.2024
HCC1937 CTRP2 7.1566 12.5742 3.6537 8.0716
HCC38 CTRP2 7.3417 13.6114 3.2801 9.2798
MCF-7 CTRP2 7.4747 9.0924 4.5206 0.1901
BT-474 CTRP2 7.551 8.9582 5.5707 0.3878
JIMT-1 CTRP2 7.6213 9.8115 5.2559 1.2417
HMC-1-8 CTRP2 7.7774 8.886 5.6866 0.1066
ZR-75-1 CTRP2 7.9542 9.2742 5.6156 0.1633
CAL-51 CTRP2 7.958 9.9759 5.3524 0.7177
HCC1395 CTRP2 8.0471 10.5263 5.1705 1.177
HCC2218 CTRP2 8.0759 13.0091 4.0745 5.0746
HCC202 CTRP2 8.0878 11.1059 4.9453 1.8638
CAL-148 CTRP2 8.1253 9.7652 5.5044 0.297
MDA-MB-468 CTRP2 9.4089 16.9439 3.0782 7.1665
HCC1143 CTRP2 9.447 11.5901 5.3535 0.1955
BT-549 CTRP2 9.4829 19.9428 1.7098 11.9029
CAMA-1 CTRP2 10.7004 24.3633 -0.4065 13.18
BT 416 CTRP2 0.9449 2.7441 0.9416 33.9845
BT 504 CTRP2 2.534 6.5131 2.0758 24.9883
BT 271 CTRP2 2.7331 3.8854 2.7312 22.0664
BT 286 CTRP2 2.8243 3.989 2.8219 21.4609
BT147 CTRP2 3.0922 5.0669 3.0273 19.8879
BT 172 CTRP2 3.2111 4.9027 3.1732 19.0035
BT 330 CTRP2 3.322 5.2646 3.2442 18.4019
BT 245 CTRP2 3.4575 5.6988 3.3075 17.7522
BT 145 CTRP2 3.5759 5.521 3.4731 16.7979
BT 232 CTRP2 3.6289 6.0882 3.3962 16.9077
BT 131 CTRP2 3.7067 5.5549 3.6083 15.9115
BT 482 CTRP2 3.7773 6.5472 3.4168 16.3898
BT 248 CTRP2 3.8031 8.7322 2.5652 19.567
BT 428 CTRP2 3.8076 5.5999 3.7087 15.2412
BT 440 CTRP2 3.927 7.6406 3.163 16.931
BT 359 CTRP2 4.1905 7.2423 3.6031 14.5121
BT 340 CTRP2 4.2817 8.1005 3.3337 15.3207
BT 216 CTRP2 4.4172 8.2106 3.4224 14.6204
BT 239 CTRP2 4.6661 10.7264 2.4747 17.7648
BT 333 CTRP2 4.6705 9.197 3.2153 14.8209
BT 422 CTRP2 4.8677 11.4147 2.325 17.8735
BT 444 CTRP2 5.2667 9.7792 3.495 12.3047
BT 328 CTRP2 5.3381 10.9062 3.0024 14.159
BT 179 CTRP2 5.3681 10.0471 3.4549 12.2475
BT 231 CTRP2 5.8254 12.9683 2.3983 15.526
BT 112 CTRP2 6.9045 8.4485 5.4609 1.2067
BT164 CTRP2 6.9682 8.4451 5.4984 1.0099
BT 320 CTRP2 7.2416 12.7674 3.6209 8.0693
BT 139 CTRP2 7.296 17.4981 1.3242 16.6344
BT 224 CTRP2 7.572 9.2516 5.4644 0.6474
BT 187 CTRP2 8.2269 16.3776 2.5643 10.6754
BT 228 CTRP2 9.6367 23.493 0.1023 16.6932
BT 159 CTRP2 10.842 27.1043 -0.805 17.4607
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.1542 13.012 3.4367 8.9544
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 1.3549 2.4459 1.3549 31.2421
SF539 CTRP2 1.5116 4.1117 1.4613 30.3665
KNS-60 CTRP2 2.0715 3.9936 2.0531 26.5297
SF268 CTRP2 2.1278 5.4392 1.9188 26.8067
GB-1 CTRP2 2.2652 4.9444 2.1599 25.535
SNU-466 CTRP2 2.3133 7.8602 1.3645 28.1212
Daoy CTRP2 2.6142 4.2877 2.5975 22.9083
KG-1-C CTRP2 2.6512 8.061 1.6462 26.1472
ONS-76 CTRP2 2.7449 4.7429 2.6978 22.1406
SF126 CTRP2 3.256 6.073 2.9934 19.4954
SF295 CTRP2 3.3046 7.2754 2.6467 20.6293
SNB-75 CTRP2 3.3991 8.1761 2.3876 21.3319
U-251MG CTRP2 3.5142 9.5231 1.9175 22.7517
KALS-1 CTRP2 3.7334 7.8426 2.8764 18.5611
CAS-1 CTRP2 3.789 6.8421 3.3269 16.6916
NMC-G1 CTRP2 4.2855 7.4501 3.6178 14.1965
GaMG CTRP2 4.3708 8.2618 3.3524 15.0171
Hs 683 CTRP2 4.3765 7.1913 3.82 13.1651
SW1088 CTRP2 4.5803 7.3613 3.9627 12.0596
U-118MG CTRP2 5.8419 10.0654 3.8627 9.563
TM-31 CTRP2 6.3413 11.8706 3.3749 10.6226
SW1783 CTRP2 6.5381 11.5229 3.7049 8.9049
SNU-1105 CTRP2 6.5846 7.6906 4.6838 0.1647
42-MG-BA CTRP2 6.6171 14.0271 2.5197 13.5267
GMS-10 CTRP2 6.6199 7.9991 4.5843 0.3501
YH-13 CTRP2 6.9698 11.9819 3.019 5.8083
DBTRG-05MG CTRP2 6.9782 13.6204 3.0037 10.9857
8-MG-BA CTRP2 7.0096 14.768 1.7071 11.1479
KNS-81 CTRP2 7.4368 13.2128 3.544 8.0738
Becker CTRP2 7.4649 16.0206 2.185 13.2998
SNU-738 CTRP2 7.4702 15.7405 2.3272 12.7629
LN-18 CTRP2 7.5385 8.5476 5.7173 0.116
CCF-STTG1 CTRP2 7.6537 8.8073 5.6684 0.1595
A-172 CTRP2 7.6681 10.9466 4.7779 2.8855
M059K CTRP2 7.6698 13.7187 2.6511 6.358
SNU-489 CTRP2 7.7938 16.4889 2.1987 12.7068
SNU-201 CTRP2 7.8799 14.3 3.3281 8.2626
SNU-626 CTRP2 7.9329 16.811 2.1423 12.689
DK-MG CTRP2 8.0172 13.0495 4.0178 5.3691
U-87MG ATCC CTRP2 8.0344 9.2796 5.6432 0.1111
LN-229 CTRP2 8.1924 13.4166 3.9578 5.3764
T98G CTRP2 8.5161 10.2041 5.4966 0.2011
GOS-3 CTRP2 8.5654 10.7453 5.3184 0.5013
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-1 CTRP2 2.4019 4.5126 2.3595 24.4098
MFE-296 CTRP2 2.6999 4.9631 2.6227 22.5433
HEC-151 CTRP2 3.1921 4.2422 3.1897 19.0105
HEC-1-A CTRP2 3.7003 8.3717 2.6176 19.6408
KLE CTRP2 4.2466 8.4124 3.1589 16.1011
EFE-184 CTRP2 4.5649 7.3662 3.9446 12.1718
AN3-CA CTRP2 5.4885 11.867 2.6578 15.2133
HEC-265 CTRP2 6.7805 8.3527 5.4308 1.4568
HEC-108 CTRP2 7.2205 8.6362 5.5479 0.6414
HEC-251 CTRP2 7.3186 15.7811 2.1929 13.5189
JHUEM-7 CTRP2 7.3722 9.3655 5.3162 1.2581
HEC-59 CTRP2 7.4159 20.311 0.0194 20.4714
MFE-319 CTRP2 7.5995 11.6129 4.425 4.3241
EN CTRP2 7.9942 9.7322 5.4632 0.4299
ESS-1 CTRP2 8.0367 13.4108 3.8598 5.9583
HEC-6 CTRP2 8.1169 9.4794 5.6037 0.1436
HEC-1-B CTRP2 8.2683 16.2506 1.8462 8.7161
RL95-2 CTRP2 8.3828 9.9288 5.5441 0.166
JHUEM-2 CTRP2 8.4405 10.0496 5.523 0.1817
HEC-50B CTRP2 15.7385 34.2913 -1.0516 12.5618
Ishikawa (Heraklio) 02 ER- CTRP2 14.9686 33.7157 -1.2505 13.7772
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 2.0111 7.2111 1.2768 29.3536
BFTC-909 CTRP2 3.7727 6.5138 3.4228 16.3812
769-P CTRP2 4.5801 6.1021 4.4302 10.2817
SNU-1272 CTRP2 4.973 6.5631 4.7016 8.1259
KMRC-2 CTRP2 5.0939 8.4074 4.0004 10.6204
RCC10RGB CTRP2 5.1027 6.7278 4.7739 7.4898
VMRC-RCZ CTRP2 5.4123 10.2301 3.404 12.3613
TUHR10TKB CTRP2 6.3772 9.7451 4.4635 6.0293
TUHR4TKB CTRP2 6.9317 14.3601 2.6009 12.6462
VMRC-RCW CTRP2 7.0106 11.3459 4.1494 6.2792
Caki-1 CTRP2 7.0999 11.7276 4.0272 6.639
TUHR14TKB CTRP2 7.1753 12.766 3.5732 8.368
786-O CTRP2 7.7429 13.567 3.5873 7.4414
Caki-2 CTRP2 7.9858 13.4216 2.979 4.6757
KMRC-20 CTRP2 8.1591 9.9176 5.4616 0.3668
OS-RC-2 CTRP2 8.2718 9.7497 5.566 0.1605
KMRC-3 CTRP2 8.4446 16.4611 2.6752 9.9398
ACHN CTRP2 8.5041 13.5991 4.0669 4.5841
KMRC-1 CTRP2 8.9655 14.4982 3.9324 4.5604
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 CTRP2 -4.0846 17.1566 -9.2225 56.43
KM12 CTRP2 -1.357 3.7133 -1.5366 49.3608
SW620 CTRP2 1.9467 4.7982 1.8407 27.6577
COLO 320 CTRP2 2.2606 4.127 2.241 25.2738
NCI-H747 CTRP2 2.3022 4.1887 2.2805 25.0037
COLO 678 CTRP2 2.8929 7.2225 2.2242 23.3792
SNU-C5 CTRP2 2.9981 6.007 2.73 21.2301
DLD-1 CTRP2 3.5284 4.9205 3.505 16.8405
SNU-C1 CTRP2 3.5352 5.7604 3.378 17.2604
CL-11 CTRP2 3.9157 5.9052 3.7578 14.7304
LS1034 CTRP2 3.9768 6.761 3.5584 15.2825
SW48 CTRP2 4.0857 7.393 3.4315 15.4613
HCT 8 CTRP2 4.1933 6.1181 4.0037 12.9979
SNU-C2A CTRP2 4.3321 8.1664 3.3558 15.1032
SW948 CTRP2 4.6559 6.9922 4.1955 10.9488
SNU-503 CTRP2 4.905 8.1649 3.9311 11.3573
SNU-61 CTRP2 5.1527 9.2467 3.6506 11.92
HCC-56 CTRP2 5.3772 6.1898 5.2719 4.8205
C2BBe1 CTRP2 5.5067 6.7783 5.1698 4.8656
T84 CTRP2 6.4203 10.6441 4.0498 7.6818
LS123 CTRP2 6.4238 10.207 4.2703 6.7549
SW1417 CTRP2 6.9004 11.868 3.8116 7.8436
GP2d CTRP2 6.935 13.1671 3.1953 10.2937
HT-29 CTRP2 7.5044 9.0591 5.5103 0.5638
LS411N CTRP2 7.548 8.6507 5.6841 0.1631
OUMS-23 CTRP2 7.652 8.737 5.6927 0.1245
SNU-407 CTRP2 7.6766 11.7375 4.416 4.2593
LoVo CTRP2 7.7522 10.1336 5.1864 1.3577
SNU-C4 CTRP2 7.7813 8.7799 5.7244 0.0656
RCM-1 [Human ESC] CTRP2 7.7908 9.26 5.5568 0.3155
HT115 CTRP2 7.8476 9.1674 5.6133 0.194
COLO205 CTRP2 7.9802 9.2369 5.6383 0.127
HT-55 CTRP2 8.0025 14.5848 3.2754 8.2896
HCT 15 CTRP2 8.0666 17.452 1.9256 13.2557
LS180 CTRP2 8.0873 9.9327 5.4261 0.4711
SNU-1033 CTRP2 8.1213 17.6569 1.8649 13.384
MDST8 CTRP2 8.2726 9.4219 5.6782 0.0489
LS513 CTRP2 8.3576 10.2441 5.4207 0.3741
SK-CO-1 CTRP2 8.3797 9.8615 5.5664 0.1387
NCI-H716 CTRP2 8.8052 10.6179 5.4582 0.1902
HCT 116 CTRP2 10.8031 23.7312 0.783 13.1019
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Li-7 CTRP2 1.2542 6.3869 0.7193 33.6018
SNU-886 CTRP2 1.3857 5.1748 1.1685 31.7549
SNU-878 CTRP2 2.0533 7.3413 1.2765 29.2208
SNU-182 CTRP2 2.7603 4.0179 2.7567 21.8911
HuH-6 CTRP2 3.009 4.789 2.9717 20.3478
JHH-5 CTRP2 3.2496 6.3886 2.8938 19.8764
SNU-387 CTRP2 3.5123 6.2545 3.2209 17.8962
JHH-2 CTRP2 3.7516 8.2569 2.7201 19.1109
SNU-761 CTRP2 3.7575 7.8339 2.9053 18.3844
SNU-449 CTRP2 3.7958 6.1322 3.5659 15.7877
SNU-423 CTRP2 5.1607 10.0066 3.286 13.3967
HuH-1 CTRP2 6.9428 8.6529 4.4717 0.4647
JHH-6 CTRP2 7.3322 8.3053 5.7255 0.1569
PLC/PRF/5 CTRP2 7.5432 10.987 4.6825 3.3955
Hep-G2 CTRP2 7.5906 9.0226 5.5629 0.3871
JHH-4 CTRP2 7.6194 11.0374 4.7065 3.2116
HLF CTRP2 7.6913 10.5123 4.9878 2.0934
JHH-1 CTRP2 7.752 8.9494 5.6549 0.1548
SNU-475 CTRP2 7.7957 9.7999 5.3477 0.8312
Hep 3B2.1-7 CTRP2 7.952 19.7926 0.6881 17.5681
SK-HEP-1 CTRP2 10.6139 20.063 2.3781 8.2037
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 137 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H441 CTRP2 -1.274 1.8652 -1.2909 48.7691
EPLC-272H CTRP2 0.099 4.7481 -0.1415 40.24
NCI-H1666 CTRP2 1.3836 5.0654 1.1879 31.6988
HOP-62 CTRP2 1.7891 6.1736 1.3646 29.7781
NCI-H1385 CTRP2 1.7957 7.2051 1.0458 30.7872
NCI-H209 CTRP2 1.8935 11.0552 -0.4138 34.4078
NCI-H1581 CTRP2 1.9086 4.4447 1.8462 27.7631
NCI-H841 CTRP2 1.9511 6.6593 1.3954 29.1538
NCI-H2087 CTRP2 1.9604 4.8443 1.8484 27.5872
HCC44 CTRP2 1.975 3.7365 1.965 27.1444
Lu-99 CTRP2 2.1555 4.1579 2.1303 25.9928
Sq-1 CTRP2 2.2287 4.1794 2.2048 25.5008
NCI-H1694 CTRP2 2.2724 3.5999 2.27 25.1376
NCI-H810 CTRP2 2.2943 3.3416 2.2939 24.985
NCI-H1355 CTRP2 2.3761 5.8899 2.0822 25.4535
NCI-H1155 CTRP2 2.3999 4.3434 2.3716 24.3753
NCI-H1573 CTRP2 2.4061 5.2835 2.2527 24.7636
NCI-H522 CTRP2 2.4153 4.0999 2.4019 24.2226
HCC4006 CTRP2 2.4622 5.7633 2.208 24.7425
DMS 53 CTRP2 2.5342 4.218 2.5187 23.4374
NCI-H2286 CTRP2 2.5489 6.247 2.1725 24.5994
NCI-H446 CTRP2 2.55 4.2765 2.5319 23.3408
NCI-H2081 CTRP2 2.557 5.2377 2.4245 23.686
Calu-3 CTRP2 2.5652 5.7704 2.3187 24.0311
DV-90 CTRP2 2.6729 4.0484 2.6672 22.4805
NCI-H520 CTRP2 2.6797 4.0782 2.6733 22.4372
SBC-5 CTRP2 2.7401 3.2294 2.7401 22.0135
RERF-LC-A1 CTRP2 2.8232 5.327 2.6956 21.8967
NCI-H2009 CTRP2 2.861 7.3779 2.1328 23.8043
HARA [Human squamous cell lung carcinoma] CTRP2 2.8977 4.6437 2.8679 21.0639
NCI-H211 CTRP2 2.9405 3.8528 2.94 20.6801
NCI-H358 CTRP2 3.002 5.3565 2.8834 20.6747
NCI-H1944 CTRP2 3.016 5.7755 2.8088 20.8937
NCI-H292 CTRP2 3.0347 5.75 2.8353 20.7416
HCC15 CTRP2 3.0384 5.0233 2.9758 20.2382
HCC1195 CTRP2 3.0528 5.8941 2.8194 20.7419
SK-MES-1 CTRP2 3.0635 6.1786 2.7536 20.946
NCI-H1793 CTRP2 3.0641 8.6589 1.835 24.2887
COLO 668 CTRP2 3.1305 5.3055 3.0314 19.7511
LCLC-97TM1 CTRP2 3.1313 5.5134 2.9929 19.8833
KNS-62 CTRP2 3.1753 5.5597 3.031 19.611
NCI-H1915 CTRP2 3.3101 5.7584 3.1334 18.828
COLO 699 CTRP2 3.3652 6.8198 2.8773 19.5959
NCI-H1650 CTRP2 3.4028 6.5435 3.0113 18.9899
Lu-65 CTRP2 3.6203 6.583 3.2344 17.526
HOP-92 CTRP2 3.6254 10.8006 1.4387 24.1417
LUDLU-1 CTRP2 3.6378 6.372 3.3217 17.1525
NCI-H1563 CTRP2 3.6398 7.2139 3.0286 18.2413
HCC2935 CTRP2 3.8083 7.0257 3.2801 16.8126
DMS 454 CTRP2 3.8281 7.5386 3.1007 17.4413
NCI-H1838 CTRP2 3.8748 6.7339 3.4581 15.9523
ChaGo-K-1 CTRP2 3.9345 5.6707 3.832 14.4088
NCI-H647 CTRP2 3.9934 6.3 3.7314 14.591
LK2 CTRP2 4.0142 5.3368 3.9743 13.6608
NCI-H2110 CTRP2 4.1624 6.401 3.8831 13.5321
DMS 114 CTRP2 4.3193 7.1275 3.7854 13.4554
NCI-H2106 CTRP2 4.3208 7.2777 3.7262 13.6802
EKVX CTRP2 4.3831 8.822 3.1091 15.9515
NCI-H2170 CTRP2 4.3902 6.2893 4.1667 11.8129
NCI-H2228 CTRP2 4.4281 6.5812 4.1094 11.9156
NCI-H196 CTRP2 4.4945 7.0116 4.0171 12.0804
NCI-H2444 CTRP2 4.5052 8.0012 3.6056 13.6665
NCI-H2141 CTRP2 4.5205 8.0215 3.612 13.6021
NCI-H322 CTRP2 4.5878 7.6907 3.8277 12.5717
HCC1438 CTRP2 4.5991 8.6188 3.4175 14.1824
NCI-H1755 CTRP2 4.7046 11.2455 2.2574 18.5078
NCI-H1092 CTRP2 4.7667 9.9286 2.9564 15.631
COR-L88 CTRP2 4.8487 8.6448 3.6502 12.633
EBC-1 CTRP2 4.9341 10.5329 2.8188 15.7928
NCI-H2029 CTRP2 5.0303 13.3181 1.5313 20.4154
SW1271 CTRP2 5.0995 9.2707 3.5891 12.2939
RERF-LC-MS CTRP2 5.131 9.2287 3.6391 12.0168
Calu-1 CTRP2 5.3282 11.541 2.6786 15.4738
HCC1171 CTRP2 5.3377 10.0839 3.4092 12.5013
NCI-H2196 CTRP2 5.6236 11.5956 2.9108 13.9229
SW1573 CTRP2 5.626 15.6753 0.876 21.3167
NCI-H1341 CTRP2 5.6412 10.099 3.672 10.7686
NCI-H1568 CTRP2 6.1307 12.0368 3.1198 12.0625
NCI-H1869 CTRP2 6.1947 12.8047 2.7887 13.2682
SK-LU-1 CTRP2 6.2144 12.0589 3.1776 11.6673
T3M-10 CTRP2 6.2652 11.7022 3.3973 10.6727
NCI-H526 CTRP2 6.2707 10.5738 3.9654 8.3062
LOU-NH91 CTRP2 6.5709 11.9847 3.5009 9.6875
PC-14 CTRP2 6.6039 11.1618 3.9357 7.8333
NCI-H1734 CTRP2 6.723 8.557 5.2987 2.0413
COR-L95 CTRP2 6.8086 14.1163 2.6263 12.7667
BEN CTRP2 6.9808 8.5427 5.4623 1.1239
A-549 CTRP2 7.0747 11.2455 4.2445 5.791
NCI-H1435 CTRP2 7.15 9.0315 5.3405 1.3859
HCC2108 CTRP2 7.1527 10.0687 4.864 3.1859
NCI-H69 CTRP2 7.2229 12.0145 3.9754 6.6602
RERF-LC-Ad1 CTRP2 7.2409 8.2162 5.722 0.1932
NCI-H226 CTRP2 7.296 12.0535 4.0082 6.416
HCC827 CTRP2 7.3 10.8524 4.5891 4.0755
NCI-H2085 CTRP2 7.3377 22.5225 -1.1432 23.6491
NCI-H23 CTRP2 7.3378 11.6884 4.214 5.5231
LCLC-103H CTRP2 7.3722 8.847 5.5343 0.5793
HCC95 CTRP2 7.3878 15.4348 2.4163 12.5664
MOR/CPR CTRP2 7.3938 8.1832 5.7912 0.0553
LC-1/sq-SF CTRP2 7.4036 8.8 5.5675 0.4716
NCI-H889 CTRP2 7.4151 12.7342 3.7615 7.2325
NCI-H838 CTRP2 7.4238 12.2135 4.02 6.1788
NCI-H2030 CTRP2 7.4332 10.1413 5.005 2.3049
COR-L105 CTRP2 7.4997 12.2658 4.0471 5.9602
RERF-LC-Ad2 CTRP2 7.6127 9.2697 5.4759 0.5917
NCI-H650 CTRP2 7.6983 9.4983 4.4607 0.2247
VMRC-LCD CTRP2 7.7563 10.5897 4.99 2.0205
SHP-77 CTRP2 7.7648 9.0553 5.6218 0.2037
NCI-H1373 CTRP2 7.7808 11.762 4.4705 3.9179
NCI-H2122 CTRP2 7.8625 16.4901 2.2483 12.4136
CAL-12T CTRP2 7.8682 10.1008 5.259 1.0404
IA-LM CTRP2 7.8868 15.3322 2.832 10.179
HCC2279 CTRP2 7.923 11.0376 4.885 2.2255
NCI-H2291 CTRP2 7.9577 11.0066 4.9179 2.0768
NCI-H2126 CTRP2 7.9779 8.9284 5.742 0.0328
NCI-H1703 CTRP2 7.9809 13.1481 3.9477 5.6896
HCC1833 CTRP2 8.0544 15.7714 2.7372 10.2849
NCI-H2342 CTRP2 8.0688 13.4123 3.8801 5.8366
HCC78 CTRP2 8.1516 10.8888 5.0712 1.4033
Calu-6 CTRP2 8.1561 14.9175 3.2205 8.2815
NCI-H1623 CTRP2 8.1909 13.643 3.8504 5.7924
HCC1588 CTRP2 8.198 9.595 5.593 0.1408
HCC366 CTRP2 8.2849 10.755 5.1911 0.9568
NCI-H2172 CTRP2 8.2974 9.6058 5.6249 0.0892
DMS 273 CTRP2 8.3239 10.1337 5.448 0.3343
NCI-H1184 CTRP2 8.3535 10.3518 5.3788 0.4605
NCI-H1651 CTRP2 8.4328 14.0226 3.8266 5.5764
NCI-H1339 CTRP2 8.5811 14.2003 3.8367 5.3566
NCI-H1792 CTRP2 8.605 10.6744 5.361 0.4008
NCI-H1299 CTRP2 8.7094 10.4163 5.4935 0.1649
NCI-H2023 CTRP2 8.7639 10.1608 5.5993 0.0584
NCI-H727 CTRP2 8.8802 10.4429 5.5449 0.0871
LXF 289 CTRP2 9.0072 10.7828 5.474 0.1359
NCI-H2405 CTRP2 9.1725 10.8601 5.5055 0.0864
NCI-H661 CTRP2 10.6555 23.1215 0.9752 12.7066
NCI-H460 CTRP2 12.35 27.8947 -0.1791 13.9374
Hs 888.Lu CTRP2 6.7483 10.4739 4.3854 5.7256
⏷ Show the Full List of 137 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.3038 16.7887 1.6823 15.3877
Aska-SS CTRP2 10.3359 22.8274 0.9036 13.3444
Rh18 CTRP2 -1.3634 -0.7965 -1.3634 49.3519
KYM-1 CTRP2 1.4258 3.1653 1.4212 30.7853
A-204 CTRP2 1.4597 4.9757 1.287 31.1191
GCT CTRP2 1.4871 4.8947 1.3311 30.8819
MES-SA CTRP2 2.7835 5.5589 2.6056 22.3372
HT-1080 CTRP2 4.0223 6.8833 3.5628 15.1359
Hs 729.T CTRP2 4.2256 7.745 3.4308 15.0871
TE 617.T CTRP2 4.3253 6.0602 4.1639 12.0179
G-401 CTRP2 4.5506 7.9731 3.6642 13.3172
SK-LMS-1 CTRP2 5.7677 9.5871 4.0375 8.9828
G-402 CTRP2 6.0904 9.8615 4.174 7.7719
Rh41 CTRP2 6.7382 11.6141 3.8145 8.1039
BT-12 CTRP2 7.3174 8.0495 5.8098 0.0481
SK-UT-1 CTRP2 7.609 14.488 3.0449 9.7855
Tm87-16 CTRP2 7.6432 12.1271 4.2101 5.1114
BT-16 CTRP2 7.8401 9.2684 5.5736 0.2652
RKN CTRP2 8.2025 9.5169 5.6217 0.1066
RD CTRP2 8.5626 14.3933 3.7354 5.7617
TTC-709 CTRP2 8.662 18.9616 1.6159 13.4105
SW982 CTRP2 8.7277 18.3863 1.9414 12.1859
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 7.5082 9.1259 5.4853 0.6295
H-STS CTRP2 7.5819 8.5288 5.7397 0.0799
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 8.1728 10.4342 5.2679 0.8165
MCAS CTRP2 -1.1736 4.6317 -1.497 48.2987
IGROV-1 CTRP2 -0.0825 9.8106 -1.9468 43.7614
A2780 CTRP2 1.8038 3.6453 1.7933 28.2866
SNU-119 CTRP2 2.0249 4.7689 1.9288 27.1033
OC 314 CTRP2 2.4759 3.0146 2.4759 23.7741
TYK-nu CTRP2 2.5096 5.4224 2.337 24.1415
OVCAR-5 CTRP2 2.5561 6.7513 2.0234 25.1072
ONCO-DG-1 CTRP2 2.6835 9.2803 1.1747 27.6329
TOV-112D CTRP2 3.0515 6.795 2.5462 21.7368
SNU-840 CTRP2 3.2117 6.0245 2.9584 19.7569
DOV13 CTRP2 3.2711 6.2888 2.9477 19.6153
EFO-21 CTRP2 4.6299 8.5917 3.4606 13.9329
COV362 CTRP2 4.6848 8.5991 3.5113 13.5938
Kuramochi CTRP2 4.7205 9.4513 3.1422 14.9949
OAW42 CTRP2 4.7251 6.8104 4.3415 10.1951
EFO-27 CTRP2 4.8307 7.1001 4.3339 9.9378
Caov-3 CTRP2 4.8336 10.9684 2.5126 17.228
HEY A8 CTRP2 4.8529 11.1156 2.4583 17.3945
JHOS-2 CTRP2 4.9005 9.9736 3.0606 14.9017
OV7 CTRP2 5.5328 17.5953 -0.1628 24.5766
COV434 CTRP2 6.5634 12.2403 3.3677 10.2465
OV56 CTRP2 7.2977 8.3058 5.7117 0.1928
COV644 CTRP2 7.425 10.1212 5.0093 2.2982
OVK18 CTRP2 7.6411 10.8492 4.8063 2.8104
FU-OV-1 CTRP2 7.7293 9.483 5.4442 0.6079
RMG-I CTRP2 7.7773 15.0578 2.8876 10.1344
TOV-21G CTRP2 7.7873 9.7933 5.3463 0.8406
ES2 CTRP2 7.9638 13.1346 3.943 5.7308
SK-OV-3 CTRP2 7.9691 9.9913 5.3513 0.7142
OVISE CTRP2 8.1863 14.5061 3.438 7.3967
OAW28 CTRP2 8.3293 13.2388 4.1261 4.567
OVSAHO CTRP2 8.3441 10.313 5.3895 0.4418
OV-90 CTRP2 8.3539 9.8226 5.5706 0.1385
OVCAR-8 CTRP2 8.6169 19.2656 1.4358 14.088
SNU-8 CTRP2 8.7093 15.0873 3.5039 6.4535
OVTOKO CTRP2 8.8359 14.1403 4.0183 4.3898
JHOC-5 CTRP2 14.6916 27.3398 1.4467 7.0848
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 2.4081 4.3708 2.3781 24.326
NCI-H2452 CTRP2 2.9008 7.2494 2.2229 23.3608
ACC-MESO-1 CTRP2 6.3036 10.3704 4.0934 7.7106
MSTO-211H CTRP2 6.3819 10.883 3.9002 8.3745
NCI-H2052 CTRP2 8.3261 10.1633 5.4379 0.3524
JL-1 CTRP2 8.4224 9.951 5.5509 0.1494
IST-Mes1 CTRP2 8.6471 10.6411 5.39 0.3341
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 3.2062 5.2003 3.1299 19.1678
DU145 CTRP2 4.6602 8.7048 3.4376 13.9509
LNCaP clone FGC CTRP2 4.8136 8.3749 3.7429 12.3426
PaCa-3 CTRP2 4.8738 8.0726 3.9432 11.3851
VCaP CTRP2 7.1464 11.6917 4.0781 6.3593
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 4.0814 8.3521 3.0178 17.0837
YD-15 CTRP2 4.5848 9.6995 2.893 16.3159
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 CTRP2 -0.3255 1.9143 -0.3295 42.449
NCC-StC-K140 CTRP2 1.5968 6.026 1.1956 30.9626
HGC-27 CTRP2 2.2966 3.8586 2.2893 24.9925
SNU-16 CTRP2 2.4283 3.1265 2.4283 24.0912
MKN74 CTRP2 2.5754 8.676 1.317 27.4863
SNU-1 CTRP2 2.5817 4.4694 2.5517 23.1698
SNU-216 CTRP2 2.6556 6.1077 2.3286 23.7163
MKN1 CTRP2 4.1277 7.1397 3.5773 14.785
MKN7 CTRP2 4.217 8.0192 3.3032 15.6096
GSS CTRP2 4.6919 6.9589 4.2469 10.6514
OCUM-1 CTRP2 4.8902 6.1621 4.7508 8.1819
HuG1-N CTRP2 5.3858 12.7708 2.1178 17.5109
Hs 746.T CTRP2 5.7501 6.3765 5.5968 2.5393
SH-10-TC CTRP2 5.9046 9.82 4.0389 8.7009
LMSU CTRP2 6.8201 13.6284 2.8778 11.7602
GSU CTRP2 6.9236 7.6272 5.8123 0.1328
SNU-668 CTRP2 7.0693 8.4695 5.5419 0.7748
ECC12 CTRP2 7.3242 8.3905 5.691 0.2235
IM95 CTRP2 7.4527 9.9313 5.1113 1.8959
AGS CTRP2 7.662 9.5451 5.3878 0.8052
SNU-601 CTRP2 7.715 14.0272 3.345 8.4417
SNU-5 CTRP2 7.8771 8.9387 5.7041 0.0717
SNU-620 CTRP2 8.1448 9.3666 5.6526 0.0838
23132/87 CTRP2 8.213 14.9442 3.2463 8.101
KE-39 CTRP2 8.2694 15.8404 2.8538 9.5224
NUGC-4 CTRP2 8.435 10.022 5.5307 0.1726
NUGC-3 CTRP2 8.6445 9.9652 5.6238 0.0526
SNU-719 CTRP2 8.6557 10.2754 5.5228 0.1401
MKN45 CTRP2 11.2042 25.9087 0.0133 14.8132
SNG-M CTRP2 -1.2991 3.4988 -1.4453 48.9906
SNU-685 CTRP2 7.5665 10.6181 4.8671 2.668
SNU-1077 CTRP2 8.2852 9.9322 5.5062 0.2452
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 2.6774 5.7627 2.4428 23.243
SW579 CTRP2 2.9163 5.3716 2.788 21.2794
ML-1 [Human leukemia] CTRP2 3.791 6.6402 3.4001 16.4117
CAL-62 CTRP2 4.0609 6.1424 3.8522 13.9479
TT2609-C02 CTRP2 6.0389 13.2113 2.4563 14.8742
CGTH-W-1 CTRP2 6.9682 9.6264 4.9524 3.0831
BHT-101 CTRP2 7.1585 10.1944 4.8083 3.3978
FTC-133 CTRP2 7.415 15.5042 2.4025 12.5728
B-CPAP CTRP2 7.4586 13.2787 3.5274 8.1066
TT CTRP2 7.9684 13.5049 3.7701 6.4014
FTC-238 CTRP2 8.3656 15.8087 2.114 7.558
8305C CTRP2 8.4424 15.3494 3.2066 7.9339
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 CTRP2 -1.3149 0.8843 -1.3162 49.0298
SCC-4 CTRP2 1.3335 5.6092 1.0153 32.4229
PE/CA-PJ49 CTRP2 1.8001 4.6877 1.7 28.6133
HSC-4 CTRP2 1.8962 4.5792 1.8171 27.9028
PE/CA-PJ34 (clone C12) CTRP2 2.4589 4.6965 2.4003 24.085
FaDu CTRP2 2.8476 5.549 2.6774 21.8834
PE/CA-PJ15 CTRP2 3.2382 5.8402 3.0352 19.4002
CAL-33 CTRP2 3.2949 5.2341 3.2198 18.5729
BICR 56 CTRP2 3.335 6.9108 2.8127 19.9237
HSC-2 CTRP2 3.4431 6.5639 3.0483 18.7348
PE/CA-PJ41 (clone D2) CTRP2 3.8488 8.9687 2.5058 19.6735
YD-8 CTRP2 3.9734 6.1305 3.7602 14.5459
SCC-9 CTRP2 4.4837 11.0733 2.1347 19.4926
BICR 6 CTRP2 4.8305 8.5516 3.6765 12.5706
CAL-27 CTRP2 5.882 10.9495 2.7575 8.6648
BICR 31 CTRP2 6.2422 11.2812 3.589 9.9253
SNU-899 CTRP2 6.4427 7.9604 5.3946 2.0517
BICR 22 CTRP2 6.4919 11.2191 3.8198 8.511
SNU-1076 CTRP2 6.5207 13.5988 2.6564 13.1732
SNU-1214 CTRP2 6.9288 12.0764 3.73 8.1313
SNU-46 CTRP2 7.3641 11.1875 4.4721 4.4528
BICR 18 CTRP2 7.4527 12.1523 4.0695 5.9377
Detroit 562 CTRP2 7.7684 18.4474 0.4551 14.5772
BHY CTRP2 7.821 15.7168 2.597 11.1777
HSC-3 CTRP2 8.0918 9.4587 5.6017 0.1515
SNU-1066 CTRP2 8.2117 10.8285 5.1261 1.1917
BICR 16 CTRP2 8.3074 16.9011 2.3668 11.2857
SNU-1041 CTRP2 8.372 10.1521 5.4603 0.2968
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 CTRP2 -0.4367 3.2422 -0.5051 43.3402
U-BLC1 CTRP2 1.7943 5.5949 1.5207 29.2393
253J CTRP2 2.3945 3.5567 2.3934 24.32
TCCSUP CTRP2 2.5986 4.8113 2.5349 23.172
BFTC-905 CTRP2 2.8274 3.8609 2.8264 21.4353
KMBC-2 CTRP2 2.8524 6.2222 2.5108 22.4622
UM-UC-1 CTRP2 3.2323 5.5018 3.1048 19.1723
UM-UC-3 CTRP2 3.5223 6.3313 3.2086 17.9111
CAL-29 CTRP2 3.7916 5.7593 3.6575 15.4719
T24 CTRP2 3.7952 8.6741 2.5829 19.52
HT-1197 CTRP2 3.8811 6.8745 3.4143 16.0991
SCaBER CTRP2 4.2626 9.5581 2.1069 14.8684
253J-BV CTRP2 4.7863 6.2294 4.6168 8.9824
BC-3C CTRP2 5.0233 8.8875 3.7026 12.0051
VM-CUB-1 CTRP2 5.2522 9.7697 3.4864 12.3723
5637 CTRP2 5.7907 12.6622 2.5218 15.1186
JMSU-1 CTRP2 6.7803 11.6986 3.8047 8.073
KU-19-19 CTRP2 7.7407 16.0359 2.3822 12.1134
647V CTRP2 7.7677 9.2431 5.5536 0.3311
639V CTRP2 7.8617 8.9159 5.7064 0.0716
J82 CTRP2 7.9918 13.3173 3.8747 5.9601
HT-1376 CTRP2 8.1949 14.3636 3.5116 7.0992
RT-4 CTRP2 8.3228 10.0134 5.4914 0.2586
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.3253 8.5356 5.6363 0.3422

References

1 ClinicalTrials.gov (NCT02128282) Study of CX-4945 in Combination With Gemcitabine and Cisplatin for Frontline Treatment of Cholangiocarcinoma. U.S. National Institutes of Health.
2 News report, company report or official report of Senhwa Biosciences, Inc. Senhwa Biosciences Silmitasertib Named as Potential COVID-19 Therapy. 2020 March 31.
3 MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer. Int J Biol Sci. 2015 Feb 23;11(4):411-22. doi: 10.7150/ijbs.10745. eCollection 2015.
4 Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem. 2011 Jan 27;54(2):635-54.