Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQKNLN)

Drug Name
CX-5461 Drug Info
Synonyms RNA ppolymerase I inhibitor (oral, cancer), Cylene
Cross-matching ID
PubChem CID
25257557
ChEBI ID
CHEMBL95090
CAS Number
CAS 1138549-36-6
TTD Drug ID
D0B7LU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.44 0.00e+0 93/133 (69.92%) NDUFB2;ATP5MC1;NDUFB1;...
p53 signaling pathway 2.12 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;SESN1;...
Mineral absorption 2.04 0.00e+0 48/60 (80%) MT1F;MT1E;MT1G;...
Epstein-Barr virus infection 1.96 2.77e-3 189/202 (93.56%) CDKN1A;DDB2;ISG15;...
Small cell lung cancer 1.93 6.65e-3 90/92 (97.83%) CDKN1A;DDB2;LAMC2;...
Propanoate metabolism 1.91 5.54e-3 30/34 (88.24%) ABAT;SUCLG2;ECHS1;...
ECM-receptor interaction 1.86 7.91e-3 80/88 (90.91%) LAMC2;ITGA6;COL4A2;...
Huntington disease 1.84 1.11e-2 233/306 (76.14%) GPX3;GPX1;NDUFB2;...
Thermogenesis 1.83 9.85e-3 173/232 (74.57%) NDUFB2;ATP5MC1;NDUFB1;...
Other glycan degradation 1.81 1.33e-2 13/18 (72.22%) FUCA1;HEXB;ENGASE;...
Type I diabetes mellitus 1.77 1.91e-2 38/43 (88.37%) FAS;HLA-DMB;PTPRN2;...
Parkinson disease 1.76 1.94e-2 176/249 (70.68%) NDUFB2;ATP5MC1;NDUFB1;...
Butanoate metabolism 1.75 2.05e-2 23/28 (82.14%) ABAT;BDH1;BDH2;...
Autoimmune thyroid disease 1.75 1.98e-2 46/53 (86.79%) FAS;HLA-DMB;HLA-DOB;...
Melanoma 1.72 2.29e-2 68/72 (94.44%) CDKN1A;DDB2;MDM2;...
Proteasome 1.71 2.29e-2 44/46 (95.65%) PSMD14;PSMB8;PSME2;...
Collecting duct acid secretion 1.70 2.54e-2 22/27 (81.48%) ATP6V1D;ATP6V1F;ATP6V0E2;...
Valine, leucine and isoleucine degradation 1.69 2.77e-2 42/48 (87.5%) ABAT;MCCC2;HSD17B10;...
Glioma 1.69 2.80e-2 67/75 (89.33%) CDKN1A;DDB2;MDM2;...
Basal cell carcinoma 1.66 3.60e-2 41/63 (65.08%) CDKN1A;DDB2;PTCH1;...
Amyotrophic lateral sclerosis 1.65 3.69e-2 267/364 (73.35%) GPX3;GPX1;NDUFB2;...
Allograft rejection 1.65 3.63e-2 32/38 (84.21%) FAS;HLA-DMB;HLA-DOB;...
Herpes simplex virus 1 infection 1.63 4.05e-2 165/498 (33.13%) OAS2;TAP1;OAS1;...
Linoleic acid metabolism 1.62 4.29e-2 21/29 (72.41%) PLA2G2A;CYP1A2;PLA2G4C;...
Synthesis and degradation of ketone bodies 1.61 4.25e-2 9/10 (90%) BDH1;BDH2;OXCT1;...
Influenza A 1.61 4.26e-2 156/172 (90.7%) TNFRSF10B;MX1;MX2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H